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Efficacy, durability, and safety of intravitreal faricimab up to every 16 weeks for neovascular age-related macular degeneration (TENAYA and LUCERNE): two randomised, double-masked, phase 3, non-infer...
Author / Creator:Heier, Jeffrey S ; Patel, Vaibhavi ; Viola, Francesco ; Adan Civera, Alfredo ; Agostini, Hansjurgen ; Almony, Arghavan ; Antoszyk, Andrew ; Awh, Carl C. ; Brown, Jamin ; Budzinskaya, Maria ; Buffet, Sylvia ; Byon, Iksoo ; Calzada, Jorge ; Carneiro, Angela ; Chao, Daniel ; Chen, Shih-Jen ; Cheung, Gemmy ; Chexal, Saradha ; Chittum, Mark ; Cornut, Pierre Loic ; Dessouki, Amr ; Dolz, Rosa ; Eldem, Bora ; Escobar, Joan Josep ; Falk, Naomi ; Feiner, Leonard ; Fernandez Vega, Alvaro ; Figueroa, Marta ; Fine, Howard ; Franco, Pablo ; Fraser-Bell, Samantha ; Furno Sola, Federico ; Giunta, Michel ; Gomez Ulla, Francisco ; Gupta, Sunil ; Guthoff, Rainer ; Guymer, Robyn ; Hampton, Robert ; Hayashi, Ken ; Heier, Jeffrey ; Howard, James ; Hu, Allen ; Imaizumi, Hiroko ; Javey, Golnaz ; Javid, Cameron ; Klein-Mascia, Kendra ; Kobayashi, Namie ; Kodjikian, Laurent ; Kulikov, Alexey ; Kwong, Henry ; Kwun, Robert ; Lai, Timothy ; Lai, Chi-Chun ; Lalonde, Laurent ; Lanzetta, Paolo ; Lee, ji Eun ; Lindsell, Lucas ; London, Nikolas ; Lotery, Andrew ; Lozano Rechy, David ; Margherio, Alan ; Masse, Helene ; Michels, Mark ; Mohamed, Quresh ; Montero, Javier ; Morori-Katz, Haia ; Murata, Toshinori ; Muzyka-Wozniak, Maria ; Oleksy, Piotr ; Patel, Apurva ; Pauleikhoff, Daniel ; Pearce, Ian ; Qureshi, Jawad ; Razavi, Hessam ; Reilly, Gayatri ; Saedon, Habiba ; Saeed, Usman ; Sararols, Laura ; Schadlu, Ramin ; Schlottmann, Patricio ; Sekiryu, Tetsuju ; Seres, András ; Sheidow, Thomas ; Sikorski, Bartosz ; Singerman, Lawrence ; Souied, Eric ; Steinmetz, Robert ; Stoller, Glenn ; Taleb, Alexandre ; Tran, Khoi ; Vajas, Attila ; Virgili, Gianni ; Weber, Pamela ; Wells, John A. ; Williams, Thomas ; Yilmaz, Gursel ; Yiu, Glenn ; Yoneda, Ai ; Yoon, Young Hee ; Zeolite, Carlos
Publisher:England: Elsevier Ltd
Journal title:The Lancet (British edition), 2022-02, Vol.399 (10326), p.729-740
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Efficacy, durability, and safety of intravitreal faricimab with extended dosing up to every 16 weeks in patients with diabetic macular oedema (YOSEMITE and RHINE): two randomised, double-masked, phase...
Author / Creator:Abreu, Francis ; Adamis, Anthony P ; Eichenbaum, David A ; Haskova, Zdenka ; Lin, Hugh ; Loewenstein, Anat ; Mohan, Shaun ; Wells, John A ; Willis, Jeffrey R ; Aaberg, Thomas ; Alam, Suhail ; Amini, Payam ; Antoszyk, Andrew ; Asaria, Riaz ; Avila, Marcos ; Awh, Carl C ; Bafalluy, Joaquin ; Bator, Gyorgy ; Burgess, Stuart ; Calzada, Jorge ; Campochiaro, Peter ; Chang, Jonathan ; Chaudhry, Nauman ; Chee, Caroline ; Chittum, Mark ; Chow, David ; Cornut, Pierre Loic ; Eldem, Bora ; Ernest, Jan ; Feiner, Leonard ; Fernandez, Carlos ; Ferrone, Philip ; Figueroa, Marta ; Fine, Howard ; Foxman, Scott ; Fung, Nicholas ; Garcia-Layana, Alfredo ; Gawecki, Maciej ; Ghanchi, Faruque ; Goldberg, Roger ; Gonzalez, Victor ; Higgins, Patrick ; Ho, Allen ; Holekamp, Nancy ; Hsu, Jason ; Ikeda, Yasuhiro ; Jhaveri, Chirag ; Kapoor, Kapil ; Kerenyi, Agnes ; Khanani, Arshad ; Kitano, Shigehiko ; Korobelnik, Jean Francois ; Lalonde, Laurent ; Larsen, Michael ; Laugesen, Caroline ; Lebreton, Olivier ; Lee, Seong ; Liu, Mimi ; Lorenz, Katrin ; Lozano Rechy, David ; Margherio, Alan ; Menon, Geeta ; Michalska-Malecka, Katarzyna ; Morori-Katz, Haia ; Newell, Charles ; Nicolo, Massimo ; Nielsen, Jared ; Osher, James ; Papp, Andras ; Pearce, Ian ; Pertile, Grazia ; Raskauskas, Paul ; Razavi, Hessam ; Rosenblatt, Brett ; Sandner, Dirk ; Sermet, Figen ; Shah, Sandeep ; Sharma, Sumit ; Spital, Georg ; Stern, Jeffrey ; Stone, Cameron ; Stone, Amy ; Sun, Jennifer ; Szalczer, Lajos ; Szecsko, Timea ; Tadayoni, Ramin ; Talks, James ; Tanabe, Teruyo ; Torti, Robert ; Tosheva Guneva, Daniela ; Varma, Deepali ; Vassileva, Petja ; Weber, Pamela ; Wells, John A ; Williams, Thomas ; Wykoff, Charles C ; Yilmaz, Gursel ; Yiu, Glenn ; Yurieva, Tatiana ; Zatorska, Barbara
Publisher:England: Elsevier Ltd
Journal title:The Lancet (British edition), 2022-02, Vol.399 (10326), p.741-755
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Anti-angiopoietin therapy with trebananib for recurrent ovarian cancer (TRINOVA-1): a randomised, multicentre, double-blind, placebo-controlled phase 3 trial
Author / Creator:Monk, Bradley J, Prof ; Poveda, Andrés, MD ; Vergote, Ignace, MD ; Raspagliesi, Francesco, MD ; Fujiwara, Keiichi, MD ; Bae, Duk-Soo, MD ; Oaknin, Ana, MD ; Ray-Coquard, Isabelle, MD ; Provencher, Diane M, MD ; Karlan, Beth Y, MD ; Lhommé, Catherine, MD ; Richardson, Gary, MD ; Rincón, Dolores Gallardo, MD ; Coleman, Robert L, MD ; Herzog, Thomas J, MD ; Marth, Christian, PhD ; Brize, Arija, MD ; Fabbro, Michel, MD ; Redondo, Andrés, MD ; Bamias, Aristotelis, PhD ; Tassoudji, Marjan, MS ; Navale, Lynn, MS ; Warner, Douglas J, MD ; Oza, Amit M, MD
Publisher:England: Elsevier Ltd
Journal title:The lancet oncology, 2014-07, Vol.15 (8), p.799-808
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Targeting key angiogenic pathways with a bispecific CrossMAb optimized for neovascular eye diseases
Author / Creator:Regula, Jörg T ; Lundh von Leithner, Peter ; Foxton, Richard ; Barathi, Veluchamy A ; Cheung, Chui Ming Gemmy ; Bo Tun, Sai Bo ; Wey, Yeo Sia ; Iwata, Daiju ; Dostalek, Miroslav ; Moelleken, Jörg ; Stubenrauch, Kay G ; Nogoceke, Everson ; Widmer, Gabriella ; Strassburger, Pamela ; Koss, Michael J ; Klein, Christian ; Shima, David T ; Hartmann, Guido
Publisher:London: Nature Publishing Group UK
Journal title:EMBO molecular medicine, 2016-11, Vol.8 (11), p.1265-1288
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Angiopoietin-2 exacerbates cardiac hypoxia and inflammation after myocardial infarction
Author / Creator:Lee, Seung-Jun ; Lee, Choong-kun ; Kang, Seok ; Park, Intae ; Kim, Yoo Hyung ; Kim, Seo Ki ; Hong, Seon Pyo ; Bae, Hosung ; He, Yulong ; Kubota, Yoshiaki ; Koh, Gou Young
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2018-11, Vol.128 (11), p.5018-5033
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The role of inflammation in diabetic eye disease
Author / Creator:Mesquida, Marina ; Drawnel, Faye ; Fauser, Sascha
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Seminars in immunopathology, 2019-07, Vol.41 (4), p.427-445
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Optimized antiangiogenic reprogramming of the tumor microenvironment potentiates CD40 immunotherapy
Author / Creator:Kashyap, Abhishek S. ; Schmittnaegel, Martina ; Rigamonti, Nicolò ; Pais-Ferreira, Daniela ; Mueller, Philipp ; Buchi, Melanie ; Ooi, Chia-Huey ; Kreuzaler, Matthias ; Hirschmann, Petra ; Guichard, Alan ; Rieder, Natascha ; Bill, Ruben ; Herting, Frank ; Kienast, Yvonne ; Dirnhofer, Stefan ; Klein, Christian ; Hoves, Sabine ; Ries, Carola H. ; Corse, Emily ; De Palma, Michele ; Zippelius, Alfred
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2020-01, Vol.117 (1), p.541-551
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The Angiopoietin-2 and TIE Pathway as a Therapeutic Target for Enhancing Antiangiogenic Therapy and Immunotherapy in Patients with Advanced Cancer
Author / Creator:Leong, Alessandra ; Kim, Minah
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2020-11, Vol.21 (22), p.8689
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Efficacy of simultaneous VEGF‐A/ANG‐2 neutralization in suppressing spontaneous choroidal neovascularization
Author / Creator:Foxton, Richard H ; Uhles, Sabine ; Grüner, Sabine ; Revelant, Franco ; Ullmer, Christoph
Publisher:London: Nature Publishing Group UK
Journal title:EMBO molecular medicine, 2019-05, Vol.11 (5), p.1-n/a
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Comprehensive biomarker and modeling approach to support dose finding for BI 836880, a VEGF/Ang-2 inhibitor
Author / Creator:Keller, Sascha ; Kunz, Ulrich ; Schmid, Ulrike ; Beusmans, Jack ; Büchert, Martin ; He, Min ; Jayadeva, Girish ; Le Tourneau, Christophe ; Luedtke, Doreen ; Niessen, Heiko G. ; Oum’hamed, Zohra ; Pleiner, Sina ; Wang, Xiaoning ; Graeser, Ralph
Publisher:England: BioMed Central Ltd
Journal title:Journal of translational medicine, 2024-10, Vol.22 (1), p.934-18, Article 934
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Endothelial cell‐derived angiopoietin‐2 is a therapeutic target in treatment‐naive and bevacizumab‐resistant glioblastoma
Author / Creator:Scholz, Alexander ; Harter, Patrick N ; Cremer, Sebastian ; Yalcin, Burak H ; Gurnik, Stefanie ; Yamaji, Maiko ; Di Tacchio, Mariangela ; Sommer, Kathleen ; Baumgarten, Peter ; Bähr, Oliver ; Steinbach, Joachim P ; Trojan, Jörg ; Glas, Martin ; Herrlinger, Ulrich ; Krex, Dietmar ; Meinhardt, Matthias ; Weyerbrock, Astrid ; Timmer, Marco ; Goldbrunner, Roland ; Deckert, Martina ; Braun, Christian ; Schittenhelm, Jens ; Frueh, Jochen T ; Ullrich, Evelyn ; Mittelbronn, Michel ; Plate, Karl H ; Reiss, Yvonne
Publisher:London: Nature Publishing Group UK
Journal title:EMBO molecular medicine, 2016-01, Vol.8 (1), p.39-57
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First-in-human, dose-escalation, phase 1 study of anti-angiopoietin-2 LY3127804 as monotherapy and in combination with ramucirumab in patients with advanced solid tumours
Author / Creator:Martin-Liberal, Juan ; Hollebecque, Antoine ; Aftimos, Philippe ; Jungels, Christiane ; Martin-Romano, Patricia ; Rodon, Jordi ; Kremer, Jill Dolores ; Zhang, Wei ; Bendell, Johanna
Publisher:London: Nature Publishing Group UK
Journal title:British journal of cancer, 2020-10, Vol.123 (8), p.1235-1243
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Phase I study of the VEGF/Ang-2 inhibitor BI 836880 alone or combined with the anti-programmed cell death protein-1 antibody ezabenlimab in Japanese patients with advanced solid tumors
Author / Creator:Yamamoto, Noboru ; Koyama, Takafumi ; Shimizu, Toshio ; Todaka, Akiko ; Kawakami, Takeshi ; Erzen, Damijan ; Sarashina, Akiko ; Li, Bin ; Hou, Jianrui ; Yamazaki, Kentaro
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Cancer chemotherapy and pharmacology, 2023-06, Vol.91 (6), p.469-480
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Targeting Angiopoietin in Retinal Vascular Diseases: A Literature Review and Summary of Clinical Trials Involving Faricimab
Author / Creator:Khan, Majid ; Aziz, Aamir A. ; Shafi, Noah A. ; Abbas, Tayeb ; Khanani, Arshad M.
Publisher:Switzerland: MDPI AG
Journal title:Cells (Basel, Switzerland), 2020-08, Vol.9 (8), p.1869
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Efficacy of a Bispecific Antibody Co-Targeting VEGFA and Ang-2 in Combination with Chemotherapy in a Chemoresistant Colorectal Carcinoma Xenograft Model
Author / Creator:Mueller, Thomas ; Freystein, Juana ; Lucas, Henrike ; Schmoll, Hans-Joachim
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2019-08, Vol.24 (16), p.2865
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Anti‐VEGF‐A/ANG2 combotherapy limits pathological angiogenesis in the eye: a replication study
Author / Creator:Wolf, Anne ; Langmann, Thomas
Publisher:London: Nature Publishing Group UK
Journal title:EMBO molecular medicine, 2019-05, Vol.11 (5), p.1-n/a
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Optical Coherence Tomography Angiography Flow Signal in Non-Treatment-Naïve Patients with Neovascular Age-Related Macular Degeneration Treated with Faricimab
Author / Creator:Brinkmann, Max ; Müller, Tom ; Köster, Marco ; Schweighofer, Jakob ; Danckwardt, Mathis ; Giannaccare, Giuseppe ; Marolo, Paola ; Borrelli, Enrico ; Reibaldi, Michele ; El-Shabrawi, Yosuf ; Toro, Mario Damiano
Publisher:Switzerland: MDPI AG
Journal title:Medicina (Kaunas, Lithuania), 2025-02, Vol.61 (2), p.260
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Combining CTLA-4 and angiopoietin-2 blockade in patients with advanced melanoma: a phase I trial
Author / Creator:Ott, Patrick A ; Nazzaro, Matthew ; Pfaff, Kathleen L ; Gjini, Evisa ; Felt, Kristen D ; Wolff, Jacquelyn O ; Buchbinder, Elizabeth I ; Haq, Rizwan ; Sullivan, Ryan J ; Lawrence, Donald P ; McDermott, David F ; Severgnini, Mariano ; Giobbie-Hurder, Anita ; Rodig, Scott J ; Stephen Hodi, F
Publisher:England: BMJ Publishing Group Ltd
Journal title:Journal for immunotherapy of cancer, 2021-11, Vol.9 (11), p.e003318
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Computational Selection of RNA Aptamer against Angiopoietin-2 and Experimental Evaluation
Author / Creator:Chen, Wen-Yih ; Huang, Chun-Jen ; Kumar, Jangam Vikram ; Hu, Wen-Pin
Publisher:Cairo, Egypt: Hindawi Publishing Corporation
Journal title:BioMed research international, 2015-01, Vol.2015 (2015), p.1-8
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A Novel Angiopoietin-2 Selective Fully Human Antibody with Potent Anti-Tumoral and Anti-Angiogenic Efficacy and Superior Side Effect Profile Compared to Pan-Angiopoietin-1/-2 Inhibitors
Author / Creator:Thomas, Markus ; Kienast, Yvonne ; Scheuer, Werner ; Bähner, Monika ; Kaluza, Klaus ; Gassner, Christian ; Herting, Frank ; Brinkmann, Ulrich ; Seeber, Stefan ; Kavlie, Anita ; Welschof, Martin ; Ries, Stefan ; Weidner, K. Michael ; Regula, Jörg T. ; Klein, Christian
Publisher:United States: Public Library of Science
Journal title:PloS one, 2013-02, Vol.8 (2), p.e54923-e54923
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Efficacy, durability, and safety of intravitreal faricimab up to every 16 weeks for neovascular age-related macular degeneration (TENAYA and LUCERNE): two randomised, double-masked, phase 3, non-infer...

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Efficacy, durability, and safety of intravitreal faricimab with extended dosing up to every 16 weeks in patients with diabetic macular oedema (YOSEMITE and RHINE): two randomised, double-masked, phase...

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Anti-angiopoietin therapy with trebananib for recurrent ovarian cancer (TRINOVA-1): a randomised, multicentre, double-blind, placebo-controlled phase 3 trial

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Targeting key angiogenic pathways with a bispecific CrossMAb optimized for neovascular eye diseases

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Angiopoietin-2 exacerbates cardiac hypoxia and inflammation after myocardial infarction

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The role of inflammation in diabetic eye disease

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Optimized antiangiogenic reprogramming of the tumor microenvironment potentiates CD40 immunotherapy

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The Angiopoietin-2 and TIE Pathway as a Therapeutic Target for Enhancing Antiangiogenic Therapy and Immunotherapy in Patients with Advanced Cancer

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Efficacy of simultaneous VEGF‐A/ANG‐2 neutralization in suppressing spontaneous choroidal neovascularization

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Comprehensive biomarker and modeling approach to support dose finding for BI 836880, a VEGF/Ang-2 inhibitor

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Endothelial cell‐derived angiopoietin‐2 is a therapeutic target in treatment‐naive and bevacizumab‐resistant glioblastoma

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First-in-human, dose-escalation, phase 1 study of anti-angiopoietin-2 LY3127804 as monotherapy and in combination with ramucirumab in patients with advanced solid tumours

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Phase I study of the VEGF/Ang-2 inhibitor BI 836880 alone or combined with the anti-programmed cell death protein-1 antibody ezabenlimab in Japanese patients with advanced solid tumors

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Targeting Angiopoietin in Retinal Vascular Diseases: A Literature Review and Summary of Clinical Trials Involving Faricimab

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Efficacy of a Bispecific Antibody Co-Targeting VEGFA and Ang-2 in Combination with Chemotherapy in a Chemoresistant Colorectal Carcinoma Xenograft Model

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Anti‐VEGF‐A/ANG2 combotherapy limits pathological angiogenesis in the eye: a replication study

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Optical Coherence Tomography Angiography Flow Signal in Non-Treatment-Naïve Patients with Neovascular Age-Related Macular Degeneration Treated with Faricimab

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Combining CTLA-4 and angiopoietin-2 blockade in patients with advanced melanoma: a phase I trial

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Computational Selection of RNA Aptamer against Angiopoietin-2 and Experimental Evaluation

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A Novel Angiopoietin-2 Selective Fully Human Antibody with Potent Anti-Tumoral and Anti-Angiogenic Efficacy and Superior Side Effect Profile Compared to Pan-Angiopoietin-1/-2 Inhibitors

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