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Gardenia jasminoides has therapeutic effects on L‑NNA‑induced hypertension in vivo
Author / Creator:Chen, Shaocheng ; Sun, Peng ; Zhao, Xin ; Yi, Ruokun ; Qian, Jun ; Shi, Yanhong ; Wang, Rui
Publisher:Greece: Spandidos Publications
Journal title:Molecular medicine reports, 2017-06, Vol.15 (6), p.4360-4373
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ArticlesPeer ReviewedFull Text
Fitness costs linked to dinitroaniline resistance mutation in Setaria
Author / Creator:Darmency, H ; Picard, J C ; Wang, T
Publisher:Cham: Springer International Publishing
Journal title:Heredity, 2011-07, Vol.107 (1), p.80-86
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A selective BCL-X L PROTAC degrader achieves safe and potent antitumor activity
Author / Creator:Khan, Sajid ; Zhang, Xuan ; Lv, Dongwen ; Zhang, Qi ; He, Yonghan ; Zhang, Peiyi ; Liu, Xingui ; Thummuri, Dinesh ; Yuan, Yaxia ; Wiegand, Janet S ; Pei, Jing ; Zhang, Weizhou ; Sharma, Abhisheak ; McCurdy, Christopher R ; Kuruvilla, Vinitha M ; Baran, Natalia ; Ferrando, Adolfo A ; Kim, Yong-Mi ; Rogojina, Anna ; Houghton, Peter J ; Huang, Guangcun ; Hromas, Robert ; Konopleva, Marina ; Zheng, Guangrong ; Zhou, Daohong
Publisher:United States
Journal title:Nature medicine, 2019-12, Vol.25 (12), p.1938
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ArticlesPeer ReviewedFull Text
Resistance mechanisms to osimertinib in EGFR-mutated non-small cell lung cancer
Author / Creator:Leonetti, Alessandro ; Sharma, Sugandhi ; Minari, Roberta ; Perego, Paola ; Giovannetti, Elisa ; Tiseo, Marcello
Publisher:London: Nature Publishing Group UK
Journal title:British journal of cancer, 2019-10, Vol.121 (9), p.725-737
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Co-targeting of BAX and BCL-XL proteins broadly overcomes resistance to apoptosis in cancer
Author / Creator:Lopez, Andrea ; Reyna, Denis E. ; Gitego, Nadege ; Kopp, Felix ; Zhou, Hua ; Miranda-Roman, Miguel A. ; Nordstrøm, Lars Ulrik ; Narayanagari, Swathi-Rao ; Chi, Ping ; Vilar, Eduardo ; Tsirigos, Aristotelis ; Gavathiotis, Evripidis
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2022-03, Vol.13 (1), p.1199-1199, Article 1199
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Selective inhibition of FLT3 by gilteritinib in relapsed or refractory acute myeloid leukaemia: a multicentre, first-in-human, open-label, phase 1–2 study
Author / Creator:Perl, Alexander E, MD ; Altman, Jessica K, MD ; Cortes, Jorge, MD ; Smith, Catherine, MD ; Litzow, Mark, MD ; Baer, Maria R, MD ; Claxton, David, Prof ; Erba, Harry P, Prof ; Gill, Stan, PhD ; Goldberg, Stuart, MD ; Jurcic, Joseph G, Prof ; Larson, Richard A, Prof ; Liu, Chaofeng, PhD ; Ritchie, Ellen, MD ; Schiller, Gary, MD ; Spira, Alexander I, MD ; Strickland, Stephen A, MD ; Tibes, Raoul, MD ; Ustun, Celalettin, MD ; Wang, Eunice S, Prof ; Stuart, Robert, Prof ; Röllig, Christoph, MD ; Neubauer, Andreas, Prof ; Martinelli, Giovanni, Prof ; Bahceci, Erkut, MD ; Levis, Mark, Dr
Publisher:England: Elsevier Ltd
Journal title:The lancet oncology, 2017-08, Vol.18 (8), p.1061-1075
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ArticlesPeer ReviewedFull Text
Virus-induced senescence is a driver and therapeutic target in COVID-19
Author / Creator:Lee, Soyoung ; Yu, Yong ; Trimpert, Jakob ; Benthani, Fahad ; Mairhofer, Mario ; Richter-Pechanska, Paulina ; Wyler, Emanuel ; Belenki, Dimitri ; Kaltenbrunner, Sabine ; Pammer, Maria ; Kausche, Lea ; Firsching, Theresa C. ; Dietert, Kristina ; Schotsaert, Michael ; Martínez-Romero, Carles ; Singh, Gagandeep ; Kunz, Séverine ; Niemeyer, Daniela ; Ghanem, Riad ; Salzer, Helmut J. F. ; Paar, Christian ; Mülleder, Michael ; Uccellini, Melissa ; Michaelis, Edward G. ; Khan, Amjad ; Lau, Andrea ; Schönlein, Martin ; Habringer, Anna ; Tomasits, Josef ; Adler, Julia M. ; Kimeswenger, Susanne ; Gruber, Achim D. ; Hoetzenecker, Wolfram ; Steinkellner, Herta ; Purfürst, Bettina ; Motz, Reinhard ; Di Pierro, Francesco ; Lamprecht, Bernd ; Osterrieder, Nikolaus ; Landthaler, Markus ; Drosten, Christian ; García-Sastre, Adolfo ; Langer, Rupert ; Ralser, Markus ; Eils, Roland ; Reimann, Maurice ; Fan, Dorothy N. Y. ; Schmitt, Clemens A.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2021-11, Vol.599 (7884), p.283-289
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ArticlesPeer ReviewedFull Text
Tissue damage and senescence provide critical signals for cellular reprogramming in vivo
Author / Creator:Mosteiro, Lluc ; Pantoja, Cristina ; Alcazar, Noelia ; Marión, Rosa M. ; Chondronasiou, Dafni ; Rovira, Miguel ; Fernandez-Marcos, Pablo J. ; Muñoz-Martin, Maribel ; Blanco-Aparicio, Carmen ; Pastor, Joaquin ; Gómez-López, Gonzalo ; De Martino, Alba ; Blasco, Maria A. ; Abad, María ; Serrano, Manuel
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2016-11, Vol.354 (6315), p.1020-1020
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ArticlesPeer ReviewedFull Text
Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity
Author / Creator:He, Yonghan ; Zhang, Xuan ; Chang, Jianhui ; Kim, Ha-Neui ; Zhang, Peiyi ; Wang, Yingying ; Khan, Sajid ; Liu, Xingui ; Zhang, Xin ; Lv, Dongwen ; Song, Lin ; Li, Wen ; Thummuri, Dinesh ; Yuan, Yaxia ; Wiegand, Janet S. ; Ortiz, Yuma T. ; Budamagunta, Vivekananda ; Elisseeff, Jennifer H. ; Campisi, Judith ; Almeida, Maria ; Zheng, Guangrong ; Zhou, Daohong
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2020-04, Vol.11 (1), p.1996-14, Article 1996
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ArticlesPeer ReviewedFull Text
Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors
Author / Creator:Zhu, Yi ; Tchkonia, Tamara ; Fuhrmann‐Stroissnigg, Heike ; Dai, Haiming M. ; Ling, Yuanyuan Y. ; Stout, Michael B. ; Pirtskhalava, Tamar ; Giorgadze, Nino ; Johnson, Kurt O. ; Giles, Cory B. ; Wren, Jonathan D. ; Niedernhofer, Laura J. ; Robbins, Paul D. ; Kirkland, James L.
Publisher:England: John Wiley & Sons, Inc
Journal title:Aging cell, 2016-06, Vol.15 (3), p.428-435
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ArticlesPeer ReviewedFull Text
Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
Author / Creator:Chang, Jianhui ; Wang, Yingying ; Shao, Lijian ; Laberge, Remi-Martin ; Demaria, Marco ; Campisi, Judith ; Janakiraman, Krishnamurthy ; Sharpless, Norman E ; Ding, Sheng ; Feng, Wei ; Luo, Yi ; Wang, Xiaoyan ; Aykin-Burns, Nukhet ; Krager, Kimberly ; Ponnappan, Usha ; Hauer-Jensen, Martin ; Meng, Aimin ; Zhou, Daohong
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2016-01, Vol.22 (1), p.78-83
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ArticlesPeer ReviewedFull Text
ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
Author / Creator:Souers, Andrew J ; Leverson, Joel D ; Boghaert, Erwin R ; Ackler, Scott L ; Catron, Nathaniel D ; Chen, Jun ; Dayton, Brian D ; Ding, Hong ; Enschede, Sari H ; Fairbrother, Wayne J ; Huang, David C S ; Hymowitz, Sarah G ; Jin, Sha ; Khaw, Seong Lin ; Kovar, Peter J ; Lam, Lloyd T ; Lee, Jackie ; Maecker, Heather L ; Marsh, Kennan C ; Mason, Kylie D ; Mitten, Michael J ; Nimmer, Paul M ; Oleksijew, Anatol ; Park, Chang H ; Park, Cheol-Min ; Phillips, Darren C ; Roberts, Andrew W ; Sampath, Deepak ; Seymour, John F ; Smith, Morey L ; Sullivan, Gerard M ; Tahir, Stephen K ; Tse, Chris ; Wendt, Michael D ; Xiao, Yu ; Xue, John C ; Zhang, Haichao ; Humerickhouse, Rod A ; Rosenberg, Saul H ; Elmore, Steven W
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2013-02, Vol.19 (2), p.202-208
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ArticlesPeer ReviewedFull Text
Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction
Author / Creator:Walaszczyk, Anna ; Dookun, Emily ; Redgrave, Rachael ; Tual‐Chalot, Simon ; Victorelli, Stella ; Spyridopoulos, Ioakim ; Owens, Andrew ; Arthur, Helen M. ; Passos, João F. ; Richardson, Gavin D.
Publisher:England: John Wiley & Sons, Inc
Journal title:Aging cell, 2019-06, Vol.18 (3), p.e12945-n/a
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ArticlesPeer ReviewedFull Text
FLT3 inhibitors in acute myeloid leukemia: ten frequently asked questions
Author / Creator:Antar, Ahmad I. ; Otrock, Zaher K. ; Jabbour, Elias ; Mohty, Mohamad ; Bazarbachi, Ali
Publisher:London: Nature Publishing Group UK
Journal title:Leukemia, 2020-03, Vol.34 (3), p.682-696
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ArticlesPeer ReviewedFull Text
Galacto‐conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity
Author / Creator:González‐Gualda, Estela ; Pàez‐Ribes, Marta ; Lozano‐Torres, Beatriz ; Macias, David ; Wilson, Joseph R. ; González‐López, Cristina ; Ou, Hui‐Ling ; Mirón‐Barroso, Sofía ; Zhang, Zhenguang ; Lérida‐Viso, Araceli ; Blandez, Juan F. ; Bernardos, Andrea ; Sancenón, Félix ; Rovira, Miguel ; Fruk, Ljiljana ; Martins, Carla P. ; Serrano, Manuel ; Doherty, Gary J. ; Martínez‐Máñez, Ramón ; Muñoz‐Espín, Daniel
Publisher:England: John Wiley & Sons, Inc
Journal title:Aging cell, 2020-04, Vol.19 (4), p.e13142-n/a
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ArticlesPeer ReviewedFull Text
Accelerated growth of B16BL6 tumor in mice through efficient uptake of their own exosomes by B16BL6 cells
Author / Creator:Matsumoto, Akihiro ; Takahashi, Yuki ; Nishikawa, Makiya ; Sano, Kohei ; Morishita, Masaki ; Charoenviriyakul, Chonlada ; Saji, Hideo ; Takakura, Yoshinobu
Publisher:England: John Wiley and Sons Inc
Journal title:Cancer science, 2017-09, Vol.108 (9), p.1803-1810
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ArticlesPeer ReviewedFull Text
Tumor-associated macrophages-derived exosomes promote the migration of gastric cancer cells by transfer of functional Apolipoprotein E
Author / Creator:Zheng, Peiming ; Luo, Qin ; Wang, Weiwei ; Li, Junhua ; Wang, Tingting ; Wang, Ping ; Chen, Lei ; Zhang, Peng ; Chen, Hui ; Liu, Yi ; Dong, Ping ; Xie, Guohua ; Ma, Yanhui ; Jiang, Li ; Yuan, Xiangliang ; Shen, Lisong
Publisher:London: Nature Publishing Group UK
Journal title:Cell death & disease, 2018-03, Vol.9 (4), p.434-14, Article 434
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ArticlesPeer ReviewedFull Text
RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer
Author / Creator:Niederst, Matthew J. ; Sequist, Lecia V. ; Poirier, John T. ; Mermel, Craig H. ; Lockerman, Elizabeth L. ; Garcia, Angel R. ; Katayama, Ryohei ; Costa, Carlotta ; Ross, Kenneth N. ; Moran, Teresa ; Howe, Emily ; Fulton, Linnea E. ; Mulvey, Hillary E. ; Bernardo, Lindsay A. ; Mohamoud, Farhiya ; Miyoshi, Norikatsu ; VanderLaan, Paul A. ; Costa, Daniel B. ; Jänne, Pasi A. ; Borger, Darrell R. ; Ramaswamy, Sridhar ; Shioda, Toshi ; Iafrate, Anthony J. ; Getz, Gad ; Rudin, Charles M. ; Mino-Kenudson, Mari ; Engelman, Jeffrey A.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2015-03, Vol.6 (1), p.6377-6377, Article 6377
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ArticlesPeer ReviewedFull Text
Osimertinib Versus Comparator EGFR TKI as First-Line Treatment for EGFR-Mutated Advanced NSCLC: FLAURA China, A Randomized Study
Author / Creator:Cheng, Ying ; He, Yong ; Li, Wei ; Zhang, He-long ; Zhou, Qing ; Wang, Buhai ; Liu, Chunling ; Walding, Andrew ; Saggese, Matilde ; Huang, Xiangning ; Fan, Minhao ; Wang, Jia ; Ramalingam, Suresh S.
Publisher:Cham: Springer International Publishing
Journal title:Targeted oncology, 2021-03, Vol.16 (2), p.165-176
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Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)
Author / Creator:Leverson, J D ; Zhang, H ; Chen, J ; Tahir, S K ; Phillips, D C ; Xue, J ; Nimmer, P ; Jin, S ; Smith, M ; Xiao, Y ; Kovar, P ; Tanaka, A ; Bruncko, M ; Sheppard, G S ; Wang, L ; Gierke, S ; Kategaya, L ; Anderson, D J ; Wong, C ; Eastham-Anderson, J ; Ludlam, M J C ; Sampath, D ; Fairbrother, W J ; Wertz, I ; Rosenberg, S H ; Tse, C ; Elmore, S W ; Souers, A J
Publisher:London: Nature Publishing Group UK
Journal title:Cell death & disease, 2015-01, Vol.6 (1), p.e1590-e1590
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Gardenia jasminoides has therapeutic effects on L‑NNA‑induced hypertension in vivo

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Fitness costs linked to dinitroaniline resistance mutation in Setaria

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A selective BCL-X L PROTAC degrader achieves safe and potent antitumor activity

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Resistance mechanisms to osimertinib in EGFR-mutated non-small cell lung cancer

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Co-targeting of BAX and BCL-XL proteins broadly overcomes resistance to apoptosis in cancer

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Selective inhibition of FLT3 by gilteritinib in relapsed or refractory acute myeloid leukaemia: a multicentre, first-in-human, open-label, phase 1–2 study

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Virus-induced senescence is a driver and therapeutic target in COVID-19

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Tissue damage and senescence provide critical signals for cellular reprogramming in vivo

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Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity

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Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors

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Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

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ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

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Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction

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FLT3 inhibitors in acute myeloid leukemia: ten frequently asked questions

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Galacto‐conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity

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Accelerated growth of B16BL6 tumor in mice through efficient uptake of their own exosomes by B16BL6 cells

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Tumor-associated macrophages-derived exosomes promote the migration of gastric cancer cells by transfer of functional Apolipoprotein E

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RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer

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Osimertinib Versus Comparator EGFR TKI as First-Line Treatment for EGFR-Mutated Advanced NSCLC: FLAURA China, A Randomized Study

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Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)

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