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Encorafenib, Binimetinib, and Cetuximab in BRAF V600E–Mutated Colorectal Cancer
Author / Creator:Kopetz, Scott ; Grothey, Axel ; Yaeger, Rona ; Van Cutsem, Eric ; Desai, Jayesh ; Yoshino, Takayuki ; Wasan, Harpreet ; Ciardiello, Fortunato ; Loupakis, Fotios ; Hong, Yong Sang ; Steeghs, Neeltje ; Guren, Tormod K ; Arkenau, Hendrik-Tobias ; Garcia-Alfonso, Pilar ; Pfeiffer, Per ; Orlov, Sergey ; Lonardi, Sara ; Elez, Elena ; Kim, Tae-Won ; Schellens, Jan H.M ; Guo, Christina ; Krishnan, Asha ; Dekervel, Jeroen ; Morris, Van ; Calvo Ferrandiz, Aitana ; Tarpgaard, L.S ; Braun, Michael ; Gollerkeri, Ashwin ; Keir, Christopher ; Maharry, Kati ; Pickard, Michael ; Christy-Bittel, Janna ; Anderson, Lisa ; Sandor, Victor ; Tabernero, Josep
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2019-10, Vol.381 (17), p.1632-1643
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Design of amidobenzimidazole STING receptor agonists with systemic activity
Author / Creator:Ramanjulu, Joshi M. ; Pesiridis, G. Scott ; Yang, Jingsong ; Concha, Nestor ; Singhaus, Robert ; Zhang, Shu-Yun ; Tran, Jean-Luc ; Moore, Patrick ; Lehmann, Stephanie ; Eberl, H. Christian ; Muelbaier, Marcel ; Schneck, Jessica L. ; Clemens, Jim ; Adam, Michael ; Mehlmann, John ; Romano, Joseph ; Morales, Angel ; Kang, James ; Leister, Lara ; Graybill, Todd L. ; Charnley, Adam K. ; Ye, Guosen ; Nevins, Neysa ; Behnia, Kamelia ; Wolf, Amaya I. ; Kasparcova, Viera ; Nurse, Kelvin ; Wang, Liping ; Puhl, Ana C. ; Li, Yue ; Klein, Michael ; Hopson, Christopher B. ; Guss, Jeffrey ; Bantscheff, Marcus ; Bergamini, Giovanna ; Reilly, Michael A. ; Lian, Yiqian ; Duffy, Kevin J. ; Adams, Jerry ; Foley, Kevin P. ; Gough, Peter J. ; Marquis, Robert W. ; Smothers, James ; Hoos, Axel ; Bertin, John
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2018-12, Vol.564 (7736), p.439-443
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Activity of Selumetinib in Neurofibromatosis Type 1–Related Plexiform Neurofibromas
Author / Creator:Dombi, Eva ; Baldwin, Andrea ; Marcus, Leigh J ; Fisher, Michael J ; Weiss, Brian ; Kim, AeRang ; Whitcomb, Patricia ; Martin, Staci ; Aschbacher-Smith, Lindsey E ; Rizvi, Tilat A ; Wu, Jianqiang ; Ershler, Rachel ; Wolters, Pamela ; Therrien, Janet ; Glod, John ; Belasco, Jean B ; Schorry, Elizabeth ; Brofferio, Alessandra ; Starosta, Amy J ; Gillespie, Andrea ; Doyle, Austin L ; Ratner, Nancy ; Widemann, Brigitte C
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2016-12, Vol.375 (26), p.2550-2560
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Binimetinib versus dacarbazine in patients with advanced NRAS-mutant melanoma (NEMO): a multicentre, open-label, randomised, phase 3 trial
Author / Creator:Dummer, Reinhard, Prof ; Schadendorf, Dirk, Prof ; Ascierto, Paolo A, MD ; Arance, Ana, MD ; Dutriaux, Caroline, MD ; Di Giacomo, Anna Maria, MD ; Rutkowski, Piotr, Prof ; Del Vecchio, Michele, MD ; Gutzmer, Ralf, Prof ; Mandala, Mario, MD ; Thomas, Luc, Prof ; Demidov, Lev, Prof ; Garbe, Claus, Prof ; Hogg, David, MD ; Liszkay, Gabriella, Prof ; Queirolo, Paola, MD ; Wasserman, Ernesto, MD ; Ford, James, MS ; Weill, Marine, MSc ; Sirulnik, L Andres, MD ; Jehl, Valentine, MSc ; Bozón, Viviana, MD ; Long, Georgina V, Prof ; Flaherty, Keith, MD
Publisher:England: Elsevier Ltd
Journal title:The lancet oncology, 2017-04, Vol.18 (4), p.435-445
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Blood-Pressure Lowering in Intermediate-Risk Persons without Cardiovascular Disease
Author / Creator:Lonn, Eva M ; Bosch, Jackie ; López-Jaramillo, Patricio ; Zhu, Jun ; Liu, Lisheng ; Pais, Prem ; Diaz, Rafael ; Xavier, Denis ; Sliwa, Karen ; Dans, Antonio ; Avezum, Alvaro ; Piegas, Leopoldo S ; Keltai, Katalin ; Keltai, Matyas ; Chazova, Irina ; Peters, Ron J.G ; Held, Claes ; Yusoff, Khalid ; Lewis, Basil S ; Jansky, Petr ; Parkhomenko, Alexander ; Khunti, Kamlesh ; Toff, William D ; Reid, Christopher M ; Varigos, John ; Leiter, Lawrence A ; Molina, Dora I ; McKelvie, Robert ; Pogue, Janice ; Wilkinson, Joanne ; Jung, Hyejung ; Dagenais, Gilles ; Yusuf, Salim
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2016-05, Vol.374 (21), p.2009-2020
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Adaptive Randomization of Veliparib–Carboplatin Treatment in Breast Cancer
Author / Creator:Rugo, Hope S ; Olopade, Olufunmilayo I ; DeMichele, Angela ; Yau, Christina ; van ’t Veer, Laura J ; Buxton, Meredith B ; Hogarth, Michael ; Hylton, Nola M ; Paoloni, Melissa ; Perlmutter, Jane ; Symmans, W. Fraser ; Yee, Douglas ; Chien, A. Jo ; Wallace, Anne M ; Kaplan, Henry G ; Boughey, Judy C ; Haddad, Tufia C ; Albain, Kathy S ; Liu, Minetta C ; Isaacs, Claudine ; Khan, Qamar J ; Lang, Julie E ; Viscusi, Rebecca K ; Pusztai, Lajos ; Moulder, Stacy L ; Chui, Stephen Y ; Kemmer, Kathleen A ; Elias, Anthony D ; Edmiston, Kirsten K ; Euhus, David M ; Haley, Barbara B ; Nanda, Rita ; Northfelt, Donald W ; Tripathy, Debasish ; Wood, William C ; Ewing, Cheryl ; Schwab, Richard ; Lyandres, Julia ; Davis, Sarah E ; Hirst, Gillian L ; Sanil, Ashish ; Berry, Donald A ; Esserman, Laura J
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2016-07, Vol.375 (1), p.23-34
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Randomized comparison of low dose cytarabine with or without glasdegib in patients with newly diagnosed acute myeloid leukemia or high-risk myelodysplastic syndrome
Author / Creator:Cortes, Jorge E. ; Heidel, Florian H. ; Hellmann, Andrzej ; Fiedler, Walter ; Smith, B. Douglas ; Robak, Tadeusz ; Montesinos, Pau ; Pollyea, Daniel A. ; DesJardins, Pierre ; Ottmann, Oliver ; Ma, Weidong Wendy ; Shaik, M. Naveed ; Laird, A. Douglas ; Zeremski, Mirjana ; O’Connell, Ashleigh ; Chan, Geoffrey ; Heuser, Michael
Publisher:London: Nature Publishing Group UK
Journal title:Leukemia, 2019-02, Vol.33 (2), p.379-389
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Glecaprevir plus pibrentasvir for chronic hepatitis C virus genotype 1, 2, 4, 5, or 6 infection in adults with compensated cirrhosis (EXPEDITION-1): a single-arm, open-label, multicentre phase 3 trial
Author / Creator:Forns, Xavier ; Lee, Samuel S ; Valdes, Joaquin ; Lens, Sabela ; Ghalib, Reem ; Aguilar, Humberto ; Felizarta, Franco ; Hassanein, Tarek ; Hinrichsen, Holger ; Rincon, Diego ; Morillas, Rosa ; Zeuzem, Stefan ; Horsmans, Yves ; Nelson, David R ; Yu, Yao ; Krishnan, Preethi ; Lin, Chih-Wei ; Kort, Jens J ; Mensa, Federico J
Publisher:United States: Elsevier Ltd
Journal title:The Lancet infectious diseases, 2017-10, Vol.17 (10), p.1062-1068
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ArticlesPeer ReviewedFull Text
Dabigatran versus Warfarin in Patients with Mechanical Heart Valves
Author / Creator:Eikelboom, John W ; Connolly, Stuart J ; Brueckmann, Martina ; Granger, Christopher B ; Kappetein, Arie P ; Mack, Michael J ; Blatchford, Jon ; Devenny, Kevin ; Friedman, Jeffrey ; Guiver, Kelly ; Harper, Ruth ; Khder, Yasser ; Lobmeyer, Maximilian T ; Maas, Hugo ; Voigt, Jens-Uwe ; Simoons, Maarten L ; Van de Werf, Frans
Publisher:Waltham, MA: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2013-09, Vol.369 (13), p.1206-1214
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ArticlesPeer ReviewedFull Text
Ledipasvir and Sofosbuvir for Previously Treated HCV Genotype 1 Infection
Author / Creator:Afdhal, Nezam ; Reddy, K. Rajender ; Nelson, David R ; Lawitz, Eric ; Gordon, Stuart C ; Schiff, Eugene ; Nahass, Ronald ; Ghalib, Reem ; Gitlin, Norman ; Herring, Robert ; Lalezari, Jacob ; Younes, Ziad H ; Pockros, Paul J ; Di Bisceglie, Adrian M ; Arora, Sanjeev ; Subramanian, G. Mani ; Zhu, Yanni ; Dvory-Sobol, Hadas ; Yang, Jenny C ; Pang, Phillip S ; Symonds, William T ; McHutchison, John G ; Muir, Andrew J ; Sulkowski, Mark ; Kwo, Paul
Publisher:Waltham, MA: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2014-04, Vol.370 (16), p.1483-1493
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Blood-Pressure and Cholesterol Lowering in Persons without Cardiovascular Disease
Author / Creator:Yusuf, Salim ; Lonn, Eva ; Pais, Prem ; Bosch, Jackie ; López-Jaramillo, Patricio ; Zhu, Jun ; Xavier, Denis ; Avezum, Alvaro ; Leiter, Lawrence A ; Piegas, Leopoldo S ; Parkhomenko, Alexander ; Keltai, Matyas ; Keltai, Katalin ; Sliwa, Karen ; Chazova, Irina ; Peters, Ron J.G ; Held, Claes ; Yusoff, Khalid ; Lewis, Basil S ; Jansky, Petr ; Khunti, Kamlesh ; Toff, William D ; Reid, Christopher M ; Varigos, John ; Accini, Jose L ; McKelvie, Robert ; Pogue, Janice ; Jung, Hyejung ; Liu, Lisheng ; Diaz, Rafael ; Dans, Antonio ; Dagenais, Gilles
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2016-05, Vol.374 (21), p.2032-2043
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Sofosbuvir and ledipasvir fixed-dose combination with and without ribavirin in treatment-naive and previously treated patients with genotype 1 hepatitis C virus infection (LONESTAR): an open-label, ra...
Author / Creator:Lawitz, Eric, Prof ; Poordad, Fred F, Prof ; Pang, Phillip S, MD ; Hyland, Robert H, DPhil ; Ding, Xiao, PhD ; Mo, Hongmei, PhD ; Symonds, William T, PharmD ; McHutchison, John G, MD ; Membreno, Fernando E, MD
Publisher:Kidlington: Elsevier Ltd
Journal title:The Lancet (British edition), 2014-02, Vol.383 (9916), p.515-523
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Safety, tolerability, and efficacy of idarucizumab for the reversal of the anticoagulant effect of dabigatran in healthy male volunteers: a randomised, placebo-controlled, double-blind phase 1 trial
Author / Creator:Glund, Stephan, Dr ; Stangier, Joachim, PhD ; Schmohl, Michael, PhD ; Gansser, Dietmar, PhD ; Norris, Stephen, PhD ; van Ryn, Joanne, PhD ; Lang, Benjamin, Dipl Math oec ; Ramael, Steven, MD ; Moschetti, Viktoria, MD ; Gruenenfelder, Fredrik, DVM ; Reilly, Paul, PhD ; Kreuzer, Jörg, Prof
Publisher:England: Elsevier Ltd
Journal title:The Lancet (British edition), 2015-08, Vol.386 (9994), p.680-690
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Abemaciclib plus trastuzumab with or without fulvestrant versus trastuzumab plus standard-of-care chemotherapy in women with hormone receptor-positive, HER2-positive advanced breast cancer (monarcHER)...
Author / Creator:Tolaney, Sara M, MD ; Wardley, Andrew M, Prof ; Zambelli, Stefania, MD ; Hilton, John F, MD ; Troso-Sandoval, Tiffany A, MD ; Ricci, Francesco, MD ; Im, Seock-Ah, Prof ; Kim, Sung-Bae, MD ; Johnston, Stephen RD, MD ; Chan, Arlene, Prof ; Goel, Shom, MD ; Catron, Kristen, BS ; Chapman, Sonya C, PhD ; Price, Gregory L, MPH ; Yang, Zhengyu, PhD ; Gainford, M Corona, MB BCh BAO ; André, Fabrice, MD
Publisher:England: Elsevier Ltd
Journal title:The lancet oncology, 2020-06, Vol.21 (6), p.763-775
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Selumetinib plus docetaxel for KRAS -mutant advanced non-small-cell lung cancer: a randomised, multicentre, placebo-controlled, phase 2 study
Author / Creator:Jänne, Pasi A, Dr ; Shaw, Alice T, MD ; Pereira, José Rodrigues, MD ; Jeannin, Gaëlle, MD ; Vansteenkiste, Johan, Prof ; Barrios, Carlos, MD ; Franke, Fabio Andre, MD ; Grinsted, Lynda, MSc ; Zazulina, Victoria, MD ; Smith, Paul, PhD ; Smith, Ian, MD ; Crinò, Lucio, Prof
Publisher:England: Elsevier Ltd
Journal title:The lancet oncology, 2013, Vol.14 (1), p.38-47
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MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study
Author / Creator:Ascierto, Paolo A, MD ; Schadendorf, Dirk, Prof ; Berking, Carola, Prof ; Agarwala, Sanjiv S, Prof ; van Herpen, Carla ML, MD ; Queirolo, Paola, MD ; Blank, Christian U, MD ; Hauschild, Axel, Prof ; Beck, J Thaddeus, MD ; St-Pierre, Annie, PhD ; Niazi, Faiz, MPharm ; Wandel, Simon, PhD ; Peters, Malte, MD ; Zubel, Angela, MD ; Dummer, Reinhard, Prof
Publisher:England: Elsevier Ltd
Journal title:The lancet oncology, 2013-03, Vol.14 (3), p.249-256
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Comparative risk of gastrointestinal bleeding with dabigatran, rivaroxaban, and warfarin: population based cohort study
Author / Creator:Abraham, Neena S ; Singh, Sonal ; Alexander, G Caleb ; Heien, Herbert ; Haas, Lindsey R ; Crown, William ; Shah, Nilay D
Publisher:England: British Medical Journal Publishing Group
Journal title:BMJ (Online), 2015-04, Vol.350 (apr24 2), p.h1857-h1857
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Ledipasvir and sofosbuvir fixed-dose combination with and without ribavirin for 12 weeks in treatment-naive and previously treated Japanese patients with genotype 1 hepatitis C: an open-label, randomi...
Author / Creator:Mizokami, Masashi, Prof ; Yokosuka, Osamu, Prof ; Takehara, Tetsuo, Prof ; Sakamoto, Naoya, Prof ; Korenaga, Masaaki, MD ; Mochizuki, Hitoshi, MD ; Nakane, Kunio, MD ; Enomoto, Hirayuki, MD ; Ikeda, Fusao, MD ; Yanase, Mikio, MD ; Toyoda, Hidenori, MD ; Genda, Takuya, MD ; Umemura, Takeji, MD ; Yatsuhashi, Hiroshi, Prof ; Ide, Tatsuya, MD ; Toda, Nobuo, MD ; Nirei, Kazushige ; Ueno, Yoshiyuki, Prof ; Nishigaki, Yoichi, MD ; Betular, Juan, BS ; Gao, Bing, PhD ; Ishizaki, Akinobu, BA ; Omote, Masa, PhD ; Mo, Hongmei, MD ; Garrison, Kim, PhD ; Pang, Phillip S, MD ; Knox, Steven J, BS ; Symonds, William T, PharmD ; McHutchison, John G, MD ; Izumi, Namiki, Prof ; Omata, Masao, Prof
Publisher:United States: Elsevier Ltd
Journal title:The Lancet infectious diseases, 2015-06, Vol.15 (6), p.645-653
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Endocrine treatment versus chemotherapy in postmenopausal women with hormone receptor-positive, HER2-negative, metastatic breast cancer: a systematic review and network meta-analysis
Author / Creator:Giuliano, Mario, MD ; Schettini, Francesco, MD ; Rognoni, Carla, PhD ; Milani, Manuela, MD ; Jerusalem, Guy, Prof ; Bachelot, Thomas, MD ; De Laurentiis, Michelino, MD ; Thomas, Guglielmo, MD ; De Placido, Pietro, MD ; Arpino, Grazia, MD ; De Placido, Sabino, Prof ; Cristofanilli, Massimo, MD ; Giordano, Antonio, MD ; Puglisi, Fabio, MD ; Pistilli, Barbara, MD ; Prat, Aleix, MD ; Del Mastro, Lucia, MD ; Venturini, Sergio, PhD ; Generali, Daniele, MD
Publisher:England: Elsevier Ltd
Journal title:The lancet oncology, 2019-10, Vol.20 (10), p.1360-1369
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Dabigatran versus Warfarin in Patients with Atrial Fibrillation
Author / Creator:Connolly, Stuart J ; Ezekowitz, Michael D ; Yusuf, Salim ; Eikelboom, John ; Oldgren, Jonas ; Parekh, Amit ; Pogue, Janice ; Reilly, Paul A ; Themeles, Ellison ; Varrone, Jeanne ; Wang, Susan ; Alings, Marco ; Xavier, Denis ; Zhu, Jun ; Diaz, Rafael ; Lewis, Basil S ; Darius, Harald ; Diener, Hans-Christoph ; Joyner, Campbell D ; Wallentin, Lars
Publisher:Waltham, MA: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2009-09, Vol.361 (12), p.1139-1151
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Showing 1 to 20 of 833 results

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Encorafenib, Binimetinib, and Cetuximab in BRAF V600E–Mutated Colorectal Cancer

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Design of amidobenzimidazole STING receptor agonists with systemic activity

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Activity of Selumetinib in Neurofibromatosis Type 1–Related Plexiform Neurofibromas

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Binimetinib versus dacarbazine in patients with advanced NRAS-mutant melanoma (NEMO): a multicentre, open-label, randomised, phase 3 trial

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Blood-Pressure Lowering in Intermediate-Risk Persons without Cardiovascular Disease

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Adaptive Randomization of Veliparib–Carboplatin Treatment in Breast Cancer

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Randomized comparison of low dose cytarabine with or without glasdegib in patients with newly diagnosed acute myeloid leukemia or high-risk myelodysplastic syndrome

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Glecaprevir plus pibrentasvir for chronic hepatitis C virus genotype 1, 2, 4, 5, or 6 infection in adults with compensated cirrhosis (EXPEDITION-1): a single-arm, open-label, multicentre phase 3 trial

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Dabigatran versus Warfarin in Patients with Mechanical Heart Valves

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Ledipasvir and Sofosbuvir for Previously Treated HCV Genotype 1 Infection

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Blood-Pressure and Cholesterol Lowering in Persons without Cardiovascular Disease

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Sofosbuvir and ledipasvir fixed-dose combination with and without ribavirin in treatment-naive and previously treated patients with genotype 1 hepatitis C virus infection (LONESTAR): an open-label, ra...

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Safety, tolerability, and efficacy of idarucizumab for the reversal of the anticoagulant effect of dabigatran in healthy male volunteers: a randomised, placebo-controlled, double-blind phase 1 trial

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Abemaciclib plus trastuzumab with or without fulvestrant versus trastuzumab plus standard-of-care chemotherapy in women with hormone receptor-positive, HER2-positive advanced breast cancer (monarcHER)...

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Selumetinib plus docetaxel for KRAS -mutant advanced non-small-cell lung cancer: a randomised, multicentre, placebo-controlled, phase 2 study

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MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study

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Comparative risk of gastrointestinal bleeding with dabigatran, rivaroxaban, and warfarin: population based cohort study

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Ledipasvir and sofosbuvir fixed-dose combination with and without ribavirin for 12 weeks in treatment-naive and previously treated Japanese patients with genotype 1 hepatitis C: an open-label, randomi...

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Endocrine treatment versus chemotherapy in postmenopausal women with hormone receptor-positive, HER2-negative, metastatic breast cancer: a systematic review and network meta-analysis

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Dabigatran versus Warfarin in Patients with Atrial Fibrillation

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