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858 results for CHK1+protein

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ArticlesPeer ReviewedFull Text
DNA damage checkpoint kinases in cancer
Author / Creator:Smith, Hannah L. ; Southgate, Harriet ; Tweddle, Deborah A. ; Curtin, Nicola J.
Publisher:Cambridge, UK: Cambridge University Press
Journal title:Expert reviews in molecular medicine, 2020-01, Vol.22, p.e2-e2, Article e2
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State-of-the-art strategies for targeting the DNA damage response in cancer
Author / Creator:Pilié, Patrick G. ; Tang, Chad ; Mills, Gordon B. ; Yap, Timothy A.
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Clinical oncology, 2019-02, Vol.16 (2), p.81-104
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DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells
Author / Creator:Sato, Hiro ; Niimi, Atsuko ; Yasuhara, Takaaki ; Permata, Tiara Bunga Mayang ; Hagiwara, Yoshihiko ; Isono, Mayu ; Nuryadi, Endang ; Sekine, Ryota ; Oike, Takahiro ; Kakoti, Sangeeta ; Yoshimoto, Yuya ; Held, Kathryn D. ; Suzuki, Yoshiyuki ; Kono, Koji ; Miyagawa, Kiyoshi ; Nakano, Takashi ; Shibata, Atsushi
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2017-11, Vol.8 (1), p.1751-11, Article 1751
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The Role of SIRT1 on DNA Damage Response and Epigenetic Alterations in Cancer
Author / Creator:Alves-Fernandes, Débora Kristina ; Jasiulionis, Miriam Galvonas
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2019-06, Vol.20 (13), p.3153
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SAMHD1 acts at stalled replication forks to prevent interferon induction
Author / Creator:Coquel, Flavie ; Silva, Maria-Joao ; Técher, Hervé ; Zadorozhny, Karina ; Sharma, Sushma ; Nieminuszczy, Jadwiga ; Mettling, Clément ; Dardillac, Elodie ; Barthe, Antoine ; Schmitz, Anne-Lyne ; Promonet, Alexy ; Cribier, Alexandra ; Sarrazin, Amélie ; Niedzwiedz, Wojciech ; Lopez, Bernard ; Costanzo, Vincenzo ; Krejci, Lumir ; Chabes, Andrei ; Benkirane, Monsef ; Lin, Yea-Lih ; Pasero, Philippe
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2018-05, Vol.557 (7703), p.57-61
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A mitosis-specific and R loop-driven ATR pathway promotes faithful chromosome segregation
Author / Creator:Kabeche, Lilian ; Nguyen, Hai Dang ; Buisson, Rémi ; Zou, Lee
Publisher:United States: The American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2018-01, Vol.359 (6371), p.108-114
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ArticlesPeer ReviewedFull Text
SARS-CoV-2 infection induces DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence
Author / Creator:Gioia, Ubaldo ; Tavella, Sara ; Martínez-Orellana, Pamela ; Cicio, Giada ; Colliva, Andrea ; Ceccon, Marta ; Cabrini, Matteo ; Henriques, Ana C. ; Fumagalli, Valeria ; Paldino, Alessia ; Presot, Ettore ; Rajasekharan, Sreejith ; Iacomino, Nicola ; Pisati, Federica ; Matti, Valentina ; Sepe, Sara ; Conte, Matilde I. ; Barozzi, Sara ; Lavagnino, Zeno ; Carletti, Tea ; Volpe, Maria Concetta ; Cavalcante, Paola ; Iannacone, Matteo ; Rampazzo, Chiara ; Bussani, Rossana ; Tripodo, Claudio ; Zacchigna, Serena ; Marcello, Alessandro ; d’Adda di Fagagna, Fabrizio
Publisher:London: Nature Publishing Group UK
Journal title:Nature cell biology, 2023-04, Vol.25 (4), p.550-564
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Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models
Author / Creator:Kim, Hyoung ; Xu, Haineng ; George, Erin ; Hallberg, Dorothy ; Kumar, Sushil ; Jagannathan, Veena ; Medvedev, Sergey ; Kinose, Yasuto ; Devins, Kyle ; Verma, Priyanka ; Ly, Kevin ; Wang, Yifan ; Greenberg, Roger A. ; Schwartz, Lauren ; Johnson, Neil ; Scharpf, Robert B. ; Mills, Gordon B. ; Zhang, Rugang ; Velculescu, Victor E. ; Brown, Eric J. ; Simpkins, Fiona
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2020-07, Vol.11 (1), p.3726-3726, Article 3726
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Targeting the ATR-CHK1 Axis in Cancer Therapy
Author / Creator:Rundle, Stuart ; Bradbury, Alice ; Drew, Yvette ; Curtin, Nicola J
Publisher:Switzerland: MDPI AG
Journal title:Cancers, 2017-04, Vol.9 (5), p.41
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ArticlesPeer ReviewedFull Text
An ATR and CHK1 kinase signaling mechanism that limits origin firing during unperturbed DNA replication
Author / Creator:Moiseeva, Tatiana N. ; Yin, Yandong ; Calderon, Michael J. ; Qian, Chenao ; Schamus-Haynes, Sandra ; Sugitani, Norie ; Osmanbeyoglu, Hatice U. ; Rothenberg, Eli ; Watkins, Simon C. ; Bakkenist, Christopher J.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2019-07, Vol.116 (27), p.13374-13383
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FANCM, BRCA1, and BLM cooperatively resolve the replication stress at the ALT telomeres
Author / Creator:Pan, Xiaolei ; Drosopoulos, William C. ; Sethi, Louisa ; Madireddy, Advaitha ; Schildkraut, Carl L. ; Zhang, Dong
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2017-07, Vol.114 (29), p.E5940-E5949
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The role of CDC25C in cell cycle regulation and clinical cancer therapy: a systematic review
Author / Creator:Liu, Kai ; Zheng, Minying ; Lu, Rui ; Du, Jiaxing ; Zhao, Qi ; Li, Zugui ; Li, Yuwei ; Zhang, Shiwu
Publisher:London: BioMed Central
Journal title:Cancer cell international, 2020-06, Vol.20 (1), p.1-213, Article 213
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ArticlesPeer ReviewedFull Text
NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation
Author / Creator:Miao, Kai ; Lei, Josh Haipeng ; Valecha, Monica Vishnu ; Zhang, Aiping ; Xu, Jun ; Wang, Lijian ; Lyu, Xueying ; Chen, Si ; Miao, Zhengqiang ; Zhang, Xin ; Su, Sek Man ; Shao, Fangyuan ; Rajendran, Barani Kumar ; Bao, Jiaolin ; Zeng, Jianming ; Sun, Heng ; Chen, Ping ; Tan, Kaeling ; Chen, Qiang ; Wong, Koon Ho ; Xu, Xiaoling ; Deng, Chu-Xia
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2020-06, Vol.11 (1), p.1-15, Article 3256
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ArticlesPeer ReviewedFull Text
Correction: Rad4 Mainly Functions in Chk1-Mediated DNA Damage Checkpoint Pathway as a Scaffold Protein in the Fission Yeast Schizosaccharomyces pombe
Author / Creator:Yue, Ming ; Zeng, Li ; Singh, Amanpreet ; Xu, Yongjie
Publisher:United States: Public Library of Science
Journal title:PloS one, 2018-09, Vol.13 (9), p.e0204070-e0204070
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H3.3-G34 mutations impair DNA repair and promote cGAS/STING-mediated immune responses in pediatric high-grade glioma models
Author / Creator:Haase, Santiago ; Banerjee, Kaushik ; Mujeeb, Anzar A ; Hartlage, Carson S ; Núñez, Fernando M ; Núñez, Felipe J ; Alghamri, Mahmoud S ; Kadiyala, Padma ; Carney, Stephen ; Barissi, Marcus N ; Taher, Ayman W ; Brumley, Emily K ; Thompson, Sarah ; Dreyer, Justin T ; Alindogan, Caitlin T ; Garcia-Fabiani, Maria B ; Comba, Andrea ; Venneti, Sriram ; Ravikumar, Visweswaran ; Koschmann, Carl ; Carcaboso, Ángel M ; Vinci, Maria ; Rao, Arvind ; Yu, Jennifer S ; Lowenstein, Pedro R ; Castro, Maria G
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2022-11, Vol.132 (22), p.1-20
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Overexpression of Claspin and Timeless protects cancer cells from replication stress in a checkpoint-independent manner
Author / Creator:Bianco, Julien N. ; Bergoglio, Valérie ; Lin, Yea-Lih ; Pillaire, Marie-Jeanne ; Schmitz, Anne-Lyne ; Gilhodes, Julia ; Lusque, Amelie ; Mazières, Julien ; Lacroix-Triki, Magali ; Roumeliotis, Theodoros I. ; Choudhary, Jyoti ; Moreaux, Jérôme ; Hoffmann, Jean-Sébastien ; Tourrière, Hélène ; Pasero, Philippe
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2019-02, Vol.10 (1), p.910-910, Article 910
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Phase II evaluation of LY2603618, a first-generation CHK1 inhibitor, in combination with pemetrexed in patients with advanced or metastatic non-small cell lung cancer
Author / Creator:Scagliotti, Giorgio ; Kang, Jin Hyoung ; Smith, David ; Rosenberg, Richard ; Park, Keunchil ; Kim, Sang-We ; Su, Wu-Chou ; Boyd, Thomas E. ; Richards, Donald A. ; Novello, Silvia ; Hynes, Scott M. ; Myrand, Scott P. ; Lin, Ji ; Smyth, Emily Nash ; Wijayawardana, Sameera ; Lin, Aimee Bence ; Pinder-Schenck, Mary
Publisher:New York: Springer US
Journal title:Investigational new drugs, 2016-10, Vol.34 (5), p.625-635
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AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity
Author / Creator:Maiani, Emiliano ; Milletti, Giacomo ; Nazio, Francesca ; Holdgaard, Søs Grønbæk ; Bartkova, Jirina ; Rizza, Salvatore ; Cianfanelli, Valentina ; Lorente, Mar ; Simoneschi, Daniele ; Di Marco, Miriam ; D’Acunzo, Pasquale ; Di Leo, Luca ; Rasmussen, Rikke ; Montagna, Costanza ; Raciti, Marilena ; De Stefanis, Cristiano ; Gabicagogeascoa, Estibaliz ; Rona, Gergely ; Salvador, Nélida ; Pupo, Emanuela ; Merchut-Maya, Joanna Maria ; Daniel, Colin J. ; Carinci, Marianna ; Cesarini, Valeriana ; O’sullivan, Alfie ; Jeong, Yeon-Tae ; Bordi, Matteo ; Russo, Francesco ; Campello, Silvia ; Gallo, Angela ; Filomeni, Giuseppe ; Lanzetti, Letizia ; Sears, Rosalie C. ; Hamerlik, Petra ; Bartolazzi, Armando ; Hynds, Robert E. ; Pearce, David R. ; Swanton, Charles ; Pagano, Michele ; Velasco, Guillermo ; Papaleo, Elena ; De Zio, Daniela ; Maya-Mendoza, Apolinar ; Locatelli, Franco ; Bartek, Jiri ; Cecconi, Francesco
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2021-04, Vol.592 (7856), p.799-803
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Inhibiting Wee1 and ATR kinases produces tumor-selective synthetic lethality and suppresses metastasis
Author / Creator:Bukhari, Amirali B ; Lewis, Cody W ; Pearce, Joanna J ; Luong, Deandra ; Chan, Gordon K ; Gamper, Armin M
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2019-03, Vol.129 (3), p.1329-1344
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BRD4 prevents the accumulation of R-loops and protects against transcription–replication collision events and DNA damage
Author / Creator:Lam, Fred C. ; Kong, Yi Wen ; Huang, Qiuying ; Vu Han, Tu-Lan ; Maffa, Amanda D. ; Kasper, Ekkehard M. ; Yaffe, Michael B.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2020-08, Vol.11 (1), p.4083-20, Article 4083
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DNA damage checkpoint kinases in cancer

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State-of-the-art strategies for targeting the DNA damage response in cancer

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DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells

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The Role of SIRT1 on DNA Damage Response and Epigenetic Alterations in Cancer

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SAMHD1 acts at stalled replication forks to prevent interferon induction

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A mitosis-specific and R loop-driven ATR pathway promotes faithful chromosome segregation

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SARS-CoV-2 infection induces DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence

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Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models

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Targeting the ATR-CHK1 Axis in Cancer Therapy

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An ATR and CHK1 kinase signaling mechanism that limits origin firing during unperturbed DNA replication

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FANCM, BRCA1, and BLM cooperatively resolve the replication stress at the ALT telomeres

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The role of CDC25C in cell cycle regulation and clinical cancer therapy: a systematic review

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NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation

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Correction: Rad4 Mainly Functions in Chk1-Mediated DNA Damage Checkpoint Pathway as a Scaffold Protein in the Fission Yeast Schizosaccharomyces pombe

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H3.3-G34 mutations impair DNA repair and promote cGAS/STING-mediated immune responses in pediatric high-grade glioma models

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Overexpression of Claspin and Timeless protects cancer cells from replication stress in a checkpoint-independent manner

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Phase II evaluation of LY2603618, a first-generation CHK1 inhibitor, in combination with pemetrexed in patients with advanced or metastatic non-small cell lung cancer

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AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity

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Inhibiting Wee1 and ATR kinases produces tumor-selective synthetic lethality and suppresses metastasis

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BRD4 prevents the accumulation of R-loops and protects against transcription–replication collision events and DNA damage

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