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ArticlesPeer ReviewedFull Text
Cardiovascular and Metabolic Effects of ANGPTL3 Antisense Oligonucleotides
Author / Creator:Graham, Mark J ; Lee, Richard G ; Brandt, Teresa A ; Tai, Li-Jung ; Fu, Wuxia ; Peralta, Raechel ; Yu, Rosie ; Hurh, Eunju ; Paz, Erika ; McEvoy, Bradley W ; Baker, Brenda F ; Pham, Nguyen C ; Digenio, Andres ; Hughes, Steven G ; Geary, Richard S ; Witztum, Joseph L ; Crooke, Rosanne M ; Tsimikas, Sotirios
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2017-07, Vol.377 (3), p.222-232
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ArticlesPeer ReviewedFull Text
Antisense oligonucleotides targeting apolipoprotein(a) in people with raised lipoprotein(a): two randomised, double-blind, placebo-controlled, dose-ranging trials
Author / Creator:Viney, Nicholas J, BSc ; van Capelleveen, Julian C, MD ; Geary, Richard S, PhD ; Xia, Shuting, MS ; Tami, Joseph A, PharmD ; Yu, Rosie Z, PhD ; Marcovina, Santica M, Prof ; Hughes, Steven G, MD ; Graham, Mark J, MS ; Crooke, Rosanne M, PhD ; Crooke, Stanley T, MD ; Witztum, Joseph L, Prof ; Stroes, Erik S, Prof ; Tsimikas, Sotirios, Prof
Publisher:England: Elsevier Ltd
Journal title:The Lancet (British edition), 2016-11, Vol.388 (10057), p.2239-2253
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ArticlesPeer ReviewedFull Text
Targeting APOC3 in the Familial Chylomicronemia Syndrome
Author / Creator:Gaudet, Daniel ; Brisson, Diane ; Tremblay, Karine ; Alexander, Veronica J ; Singleton, Walter ; Hughes, Steven G ; Geary, Richard S ; Baker, Brenda F ; Graham, Mark J ; Crooke, Rosanne M ; Witztum, Joseph L
Publisher:Waltham, MA: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2014-12, Vol.371 (23), p.2200-2206
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ArticlesPeer ReviewedFull Text
Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index
Author / Creator:Shen, Wen ; De Hoyos, Cheryl L. ; Migawa, Michael T. ; Vickers, Timothy A. ; Sun, Hong ; Low, Audrey ; Bell, Thomas A. ; Rahdar, Meghdad ; Mukhopadhyay, Swagatam ; Hart, Christopher E. ; Bell, Melanie ; Riney, Stan ; Murray, Susan F. ; Greenlee, Sarah ; Crooke, Rosanne M. ; Liang, Xue-hai ; Seth, Punit P. ; Crooke, Stanley T.
Publisher:New York: Nature Publishing Group US
Journal title:Nature biotechnology, 2019-06, Vol.37 (6), p.640-650
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ArticlesPeer ReviewedFull Text
Antisense therapy targeting apolipoprotein(a): a randomised, double-blind, placebo-controlled phase 1 study
Author / Creator:Tsimikas, Sotirios, Prof ; Viney, Nicholas J, BSc ; Hughes, Steven G, MBBS ; Singleton, Walter, MD ; Graham, Mark J, MS ; Baker, Brenda F, PhD ; Burkey, Jennifer L, PhD ; Yang, Qingqing, MS ; Marcovina, Santica M, Prof ; Geary, Richard S, PhD ; Crooke, Rosanne M, PhD ; Witztum, Joseph L, Prof
Publisher:England: Elsevier Ltd
Journal title:The Lancet (British edition), 2015-10, Vol.386 (10002), p.1472-1483
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ArticlesPeer ReviewedFull Text
Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis
Author / Creator:Miao, Ji ; Ling, Alisha V. ; Manthena, Praveen V. ; Gearing, Mary E. ; Graham, Mark J. ; Crooke, Rosanne M. ; Croce, Kevin J. ; Esquejo, Ryan M. ; Clish, Clary B. ; Vicent, David ; Biddinger, Sudha B.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2015-04, Vol.6 (1), p.6498-6498, Article 6498
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ArticlesPeer ReviewedFull Text
ApoC-III inhibits clearance of triglyceride-rich lipoproteins through LDL family receptors
Author / Creator:Gordts, Philip L S M ; Nock, Ryan ; Son, Ni-Huiping ; Ramms, Bastian ; Lew, Irene ; Gonzales, Jon C ; Thacker, Bryan E ; Basu, Debapriya ; Lee, Richard G ; Mullick, Adam E ; Graham, Mark J ; Goldberg, Ira J ; Crooke, Rosanne M ; Witztum, Joseph L ; Esko, Jeffrey D
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2016-08, Vol.126 (8), p.2855-2866
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Newsletter articlesFull Text
WIPO PUBLISHES PATENT OF ISIS PHARMACEUTICALS, MULLICK ADAM, CROOKE ROSANNE M., GRAHAM MARK J. FOR "MODULATION OF CD36 EXPRESSION" (AMERICAN INVENTORS)
Publisher:Washington, D.C: HT Digital Streams Limited
Journal title:US Fed News Service, Including US State News, 2012
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ArticlesPeer ReviewedFull Text
Apolipoprotein CIII links islet insulin resistance to β-cell failure in diabetes
Author / Creator:Åvall, Karin ; Ali, Yusuf ; Leibiger, Ingo B. ; Leibiger, Barbara ; Moede, Tilo ; Paschen, Meike ; Dicker, Andrea ; Daré, Elisabetta ; Köhler, Martin ; Ilegems, Erwin ; Abdulreda, Midhat H. ; Graham, Mark ; Crooke, Rosanne M. ; Tay, Vanessa S. Y. ; Refai, Essam ; Nilsson, Stefan K. ; Jacob, Stefan ; Selander, Lars ; Berggren, Per-Olof ; Juntti-Berggren, Lisa
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2015-05, Vol.112 (20), p.E2611-E2619
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ArticlesPeer ReviewedFull Text
Antisense technology: an overview and prospectus
Author / Creator:Crooke, Stanley T. ; Baker, Brenda F. ; Crooke, Rosanne M. ; Liang, Xue-hai
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Drug discovery, 2021-06, Vol.20 (6), p.427-453
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ArticlesPeer ReviewedFull Text
Mouse genome-wide association studies and systems genetics uncover the genetic architecture associated with hepatic pharmacokinetic and pharmacodynamic properties of a constrained ethyl antisense olig...
Author / Creator:Pirie, Elaine ; Ray, Shayoni ; Pan, Calvin ; Fu, Wuxia ; Powers, Andrew F ; Polikoff, Danielle ; Miller, Colton M ; Kudrna, Katrina M ; Harris, Edward N ; Lusis, Aldons J ; Crooke, Rosanne M ; Lee, Richard G
Publisher:United States: Public Library of Science
Journal title:PLoS genetics, 2018-10, Vol.14 (10), p.e1007732
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ArticlesPeer ReviewedFull Text
Acute sterol o-acyltransferase 2 (SOAT2) knockdown rapidly mobilizes hepatic cholesterol for fecal excretion
Author / Creator:Marshall, Stephanie M ; Gromovsky, Anthony D ; Kelley, Kathryn L ; Davis, Matthew A ; Wilson, Martha D ; Lee, Richard G ; Crooke, Rosanne M ; Graham, Mark J ; Rudel, Lawrence L ; Brown, J Mark ; Temel, Ryan E
Publisher:United States: Public Library of Science
Journal title:PloS one, 2014-06, Vol.9 (6), p.e98953-e98953
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ArticlesPeer ReviewedFull Text
Lowering apolipoprotein CIII delays onset of type 1 diabetes
Author / Creator:Holmberg, Rebecka ; Refai, Essam ; HÃ¶Ã¶g, Anders ; Crooke, Rosanne M ; Graham, Mark ; Olivecrona, Gunilla ; Berggren, Per-Olof ; Juntti-Berggren, Lisa
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2011-06, Vol.108 (26), p.10685-10689
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ArticlesPeer ReviewedFull Text
CD40 Generation 2.5 Antisense Oligonucleotide Treatment Attenuates Doxorubicin-induced Nephropathy and Kidney Inflammation
Author / Creator:Donner, Aaron J ; Yeh, Steve T ; Hung, Gene ; Graham, Mark J ; Crooke, Rosanne M ; Mullick, Adam E
Publisher:United States: Elsevier Inc
Journal title:Molecular therapy. Nucleic acids, 2015-12, Vol.4 (12), p.e265-e265, Article e265
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ArticlesPeer ReviewedFull Text
Inhibiting C-Reactive Protein for the Treatment of Cardiovascular Disease: Promising Evidence from Rodent Models
Author / Creator:Henry, Scott P. ; Zanardi, Thomas A. ; Graham, Mark J. ; Crooke, Rosanne M. ; Mazzone, Michelle ; Chen, Yiu-Fai ; Oparil, Suzanne ; Miller, Andrew ; Hage, Fadi G. ; Xing, Dongqi ; McCrory, Mark A. ; Szalai, Alexander J. ; Early, Richard
Publisher:Cairo, Egypt: Hindawi Limiteds
Journal title:Mediators of Inflammation, 2014-01, Vol.2014 (3), p.276-284
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ArticlesPeer ReviewedFull Text
Reduction of VLDL secretion decreases cholesterol excretion in niemann-pick C1-like 1 hepatic transgenic mice
Author / Creator:Marshall, Stephanie M ; Kelley, Kathryn L ; Davis, Matthew A ; Wilson, Martha D ; McDaniel, Allison L ; Lee, Richard G ; Crooke, Rosanne M ; Graham, Mark J ; Rudel, Lawrence L ; Brown, J Mark ; Temel, Ryan E
Publisher:United States: Public Library of Science
Journal title:PloS one, 2014-01, Vol.9 (1), p.e84418-e84418
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ArticlesPeer ReviewedFull Text
Antisense Inhibition of Apolipoprotein C-III in Patients with Hypertriglyceridemia
Author / Creator:Gaudet, Daniel ; Alexander, Veronica J ; Baker, Brenda F ; Brisson, Diane ; Tremblay, Karine ; Singleton, Walter ; Geary, Richard S ; Hughes, Steven G ; Viney, Nicholas J ; Graham, Mark J ; Crooke, Rosanne M ; Witztum, Joseph L ; Brunzell, John D ; Kastelein, John J.P
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2015-07, Vol.373 (5), p.438-447
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ArticlesPeer ReviewedFull Text
Effects of Antisense Oligonucleotides against C-Reactive Protein on the Development of Atherosclerosis in WHHL Rabbits
Author / Creator:Dong, Sijun ; Fan, Jianglin ; Liu, Enqi ; Graham, Mark J. ; Shiomi, Masashi ; Yang, Xianghong ; Ning, Bo ; Waqar, Ahmed Bilal ; Liu, Zhengcao ; Yu, Qi ; Crooke, Rosanne M.
Publisher:Cairo, Egypt: Hindawi Limiteds
Journal title:Mediators of Inflammation, 2014-01, Vol.2014 (10), p.69-76
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ArticlesPeer ReviewedFull Text
A Selective Inhibitor of Human C-reactive Protein Translation Is Efficacious In Vitro and in C-reactive Protein Transgenic Mice and Humans
Author / Creator:Jones, Nicholas R ; Pegues, Melissa A ; McCrory, Mark A ; Singleton, Walter ; Bethune, Claudette ; Baker, Brenda F ; Norris, Daniel A ; Crooke, Rosanne M ; Graham, Mark J ; Szalai, Alexander J
Publisher:United States: Elsevier Inc
Journal title:Molecular therapy. Nucleic acids, 2012-11, Vol.1 (11), p.e52-e52, Article e52
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ArticlesPeer ReviewedFull Text
Evaluation of an anti-tumor necrosis factor therapeutic in a mouse model of Niemann-Pick C liver disease
Author / Creator:Vincent, Melanie ; Sayre, Naomi L ; Graham, Mark J ; Crooke, Rosanne M ; Shealy, David J ; Liscum, Laura
Publisher:United States: Public Library of Science
Journal title:PloS one, 2010-09, Vol.5 (9), p.e12941-e12941
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Cardiovascular and Metabolic Effects of ANGPTL3 Antisense Oligonucleotides

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Antisense oligonucleotides targeting apolipoprotein(a) in people with raised lipoprotein(a): two randomised, double-blind, placebo-controlled, dose-ranging trials

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Targeting APOC3 in the Familial Chylomicronemia Syndrome

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Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index

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Antisense therapy targeting apolipoprotein(a): a randomised, double-blind, placebo-controlled phase 1 study

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Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis

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ApoC-III inhibits clearance of triglyceride-rich lipoproteins through LDL family receptors

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WIPO PUBLISHES PATENT OF ISIS PHARMACEUTICALS, MULLICK ADAM, CROOKE ROSANNE M., GRAHAM MARK J. FOR "MODULATION OF CD36 EXPRESSION" (AMERICAN INVENTORS)

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Apolipoprotein CIII links islet insulin resistance to β-cell failure in diabetes

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Antisense technology: an overview and prospectus

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Mouse genome-wide association studies and systems genetics uncover the genetic architecture associated with hepatic pharmacokinetic and pharmacodynamic properties of a constrained ethyl antisense olig...

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Acute sterol o-acyltransferase 2 (SOAT2) knockdown rapidly mobilizes hepatic cholesterol for fecal excretion

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Lowering apolipoprotein CIII delays onset of type 1 diabetes

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CD40 Generation 2.5 Antisense Oligonucleotide Treatment Attenuates Doxorubicin-induced Nephropathy and Kidney Inflammation

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Inhibiting C-Reactive Protein for the Treatment of Cardiovascular Disease: Promising Evidence from Rodent Models

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Reduction of VLDL secretion decreases cholesterol excretion in niemann-pick C1-like 1 hepatic transgenic mice

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Antisense Inhibition of Apolipoprotein C-III in Patients with Hypertriglyceridemia

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Effects of Antisense Oligonucleotides against C-Reactive Protein on the Development of Atherosclerosis in WHHL Rabbits

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A Selective Inhibitor of Human C-reactive Protein Translation Is Efficacious In Vitro and in C-reactive Protein Transgenic Mice and Humans

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Evaluation of an anti-tumor necrosis factor therapeutic in a mouse model of Niemann-Pick C liver disease

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