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225 results for Cyclic+Nucleotide+Phosphodiesterases,+Type+4+-+metabolism

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ArticlesPeer ReviewedFull Text
Circadian control of the secretory pathway maintains collagen homeostasis
Author / Creator:Chang, Joan ; Garva, Richa ; Pickard, Adam ; Yeung, Ching-Yan Chloé ; Mallikarjun, Venkatesh ; Swift, Joe ; Holmes, David F. ; Calverley, Ben ; Lu, Yinhui ; Adamson, Antony ; Raymond-Hayling, Helena ; Jensen, Oliver ; Shearer, Tom ; Meng, Qing Jun ; Kadler, Karl E.
Publisher:London: Nature Publishing Group UK
Journal title:Nature cell biology, 2020-01, Vol.22 (1), p.74-86
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circPDE4B prevents articular cartilage degeneration and promotes repair by acting as a scaffold for RIC8A and MID1
Author / Creator:Shen, Shuying ; Yang, Yute ; Shen, Panyang ; Ma, Jun ; Fang, Bin ; Wang, Qingxin ; Wang, Kefan ; Shi, Peihua ; Fan, Shunwu ; Fang, Xiangqian
Publisher:England: Elsevier Limited
Journal title:Annals of the rheumatic diseases, 2021-09, Vol.80 (9), p.1209-1219
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Identification of myeloid cells in the human enthesis as the main source of local IL-23 production
Author / Creator:Bridgewood, Charlie ; Watad, Abdulla ; Russell, Tobias ; Palmer, Timothy M ; Marzo-Ortega, Helena ; Khan, Almas ; Millner, Peter A ; Dunsmuir, Robert ; Rao, Abhay ; Loughenbury, Peter ; Wittmann, Miriam ; Cuthbert, Richard J ; McGonagle, Dennis G
Publisher:United States: BMJ Publishing Group Ltd and European League Against Rheumatism
Journal title:Annals of the rheumatic diseases, 2019-07, Vol.78 (7), p.929-933
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Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases
Author / Creator:Omar, Faisa ; Findlay, Jane E. ; Carfray, Gemma ; Allcock, Robert W. ; Jiang, Zhong ; Moore, Caitlin ; Muir, Amy L. ; Lannoy, Morgane ; Fertig, Bracy A. ; Mai, Deborah ; Day, Jonathan P. ; Bolger, Graeme ; Baillie, George S. ; Schwiebert, Erik ; Klussmann, Enno ; Pyne, Nigel J. ; Ong, Albert C. M. ; Bowers, Keith ; Adam, Julia M. ; Adams, David R. ; Houslay, Miles D. ; Henderson, David J. P.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2019-07, Vol.116 (27), p.13320-13329
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A high-fat diet promotes depression-like behavior in mice by suppressing hypothalamic PKA signaling
Author / Creator:Vagena Eirini ; Ryu, Jae Kyu ; Baeza-Raja Bernat ; Walsh, Nicola M ; Syme Catriona ; Day, Jonathan P ; Houslay Miles D ; Baillie, George S
Publisher:London: Nature Publishing Group
Journal title:Translational psychiatry, 2019-05, Vol.9 (1)
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Sleep deprivation causes memory deficits by negatively impacting neuronal connectivity in hippocampal area CA1
Author / Creator:Havekes, Robbert ; Park, Alan J ; Tudor, Jennifer C ; Luczak, Vincent G ; Hansen, Rolf T ; Ferri, Sarah L ; Bruinenberg, Vibeke M ; Poplawski, Shane G ; Day, Jonathan P ; Aton, Sara J ; Radwańska, Kasia ; Meerlo, Peter ; Houslay, Miles D ; Baillie, George S ; Abel, Ted
Publisher:England: eLife Science Publications, Ltd
Journal title:eLife, 2016-08, Vol.5
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AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B
Author / Creator:Johanns, M. ; Lai, Y.-C. ; Hsu, M.-F. ; Jacobs, R. ; Vertommen, D. ; Van Sande, J. ; Dumont, J. E. ; Woods, A. ; Carling, D. ; Hue, L. ; Viollet, B. ; Foretz, M ; Rider, M H
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2016-03, Vol.7 (1), p.10856-12, Article 10856
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Memory enhancing effects of BPN14770, an allosteric inhibitor of phosphodiesterase-4D, in wild-type and humanized mice
Author / Creator:Zhang, Chong ; Xu, Ying ; Chowdhary, Anirudh ; David Fox 3rd ; Gurney, Mark E ; Han-Ting, Zhang ; Auerbach, Benjamin D ; Salvi, Richard J ; Yang, Mingxin ; Li, Gaowen ; James M O’Donnell
Publisher:New York: Nature Publishing Group
Journal title:Neuropsychopharmacology (New York, N.Y.), 2018-10, Vol.43 (11), p.2299-2309
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Fear memory regulation by the cAMP signaling pathway as an index of reexperiencing symptoms in posttraumatic stress disorder
Author / Creator:Hori, Hiroaki ; Fukushima, Hotaka ; Nagayoshi, Taikai ; Ishikawa, Rie ; Zhuo, Min ; Yoshida, Fuyuko ; Kunugi, Hiroshi ; Okamoto, Kenichi ; Kim, Yoshiharu ; Kida, Satoshi
Publisher:New York: Nature Publishing Group
Journal title:Molecular psychiatry, 2024-07, Vol.29 (7), p.2105-2116
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Ginsenoside Rg5 attenuates hepatic glucagon response via suppression of succinate-associated HIF-1α induction in HFD-fed mice
Author / Creator:Xiao, Na ; Lou, Meng-Die ; Lu, Yi-Tong ; Yang, Le-Le ; Liu, Qun ; Liu, Baolin ; Qi, Lian-Wen ; Li, Ping
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Diabetologia, 2017-06, Vol.60 (6), p.1084-1093
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cAMP-PKA phosphorylation of tau confers risk for degeneration in aging association cortex
Author / Creator:Carlyle, Becky C. ; Nairn, Angus C. ; Wang, Min ; Yang, Yang ; Jin, Lu E. ; Simen, Arthur A. ; Ramos, Brian P. ; Bordner, Kelly A. ; Craft, George E. ; Davies, Peter ; Pletikos, Mihovil ; Sestan, Nenad ; Arnsten, Amy F. T. ; Paspalas, Constantinos D.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2014-04, Vol.111 (13), p.5036-5041
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ArticlesPeer ReviewedFull Text
Inhibition of phosphodiesterase 4 (PDE4) reduces dermal fibrosis by interfering with the release of interleukin-6 from M2 macrophages
Author / Creator:Maier, Christiane ; Ramming, Andreas ; Bergmann, Christina ; Weinkam, Rita ; Kittan, Nicolai ; Schett, Georg ; Distler, Jörg H W ; Beyer, Christian
Publisher:England: Elsevier Limited
Journal title:Annals of the rheumatic diseases, 2017-06, Vol.76 (6), p.1133-1141
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PDE4D: A Multipurpose Pharmacological Target
Author / Creator:Lusardi, Matteo ; Rapetti, Federica ; Spallarossa, Andrea ; Brullo, Chiara
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2024-08, Vol.25 (15), p.8052
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Metabolic effects of resveratrol: addressing the controversies
Author / Creator:Bitterman, Jacob L ; Chung, Jay H
Publisher:Basel: Springer-Verlag
Journal title:Cellular and molecular life sciences : CMLS, 2015-04, Vol.72 (8), p.1473-1488
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Sleep deprivation impairs cAMP signalling in the hippocampus
Author / Creator:Vecsey, Christopher G. ; Baillie, George S. ; Jaganath, Devan ; Havekes, Robbert ; Daniels, Andrew ; Wimmer, Mathieu ; Huang, Ted ; Brown, Kim M. ; Li, Xiang-Yao ; Descalzi, Giannina ; Kim, Susan S. ; Chen, Tao ; Shang, Yu-Ze ; Zhuo, Min ; Houslay, Miles D. ; Abel, Ted
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2009-10, Vol.461 (7267), p.1122-1125
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Phosphodiesterase-4 (PDE4) Molecular Pharmacology and Alzheimer’s Disease
Author / Creator:Gurney, Mark E. ; D’Amato, Emily C. ; Burgin, Alex B.
Publisher:Boston: Springer US
Journal title:Neurotherapeutics, 2015-01, Vol.12 (1), p.49-56
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Allosteric inhibition of phosphodiesterase 4D induces biphasic memory-enhancing effects associated with learning-activated signaling pathways
Author / Creator:Jino, Kohei ; Miyamoto, Keisuke ; Kanbara, Tomoe ; Unemura, Chie ; Horiguchi, Naotaka ; Ago, Yukio
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Psychopharmacology, 2024-04, Vol.241 (4), p.805-816
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Insilico discovery of novel Phosphodiesterase 4 (PDE4) inhibitors for the treatment of psoriasis: Insights from computer aided drug design approaches
Author / Creator:Alanzi, Abdullah R. ; Alsalhi, Mohammed S. ; Mothana, Ramzi A. ; Alqahtani, Jawaher H. ; Alqahtani, Moneerah J.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2024-11, Vol.19 (11), p.e0305934
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A Novel, Pan-PDE Inhibitor Exerts Anti-Fibrotic Effects in Human Lung Fibroblasts via Inhibition of TGF-β Signaling and Activation of cAMP/PKA Signaling
Author / Creator:Wójcik-Pszczoła, Katarzyna ; Chłoń-Rzepa, Grażyna ; Jankowska, Agnieszka ; Ślusarczyk, Marietta ; Ferdek, Paweł E ; Kusiak, Agnieszka A ; Świerczek, Artur ; Pociecha, Krzysztof ; Koczurkiewicz-Adamczyk, Paulina ; Wyska, Elżbieta ; Pękala, Elżbieta ; Gosens, Reinoud
Publisher:Switzerland: MDPI
Journal title:International journal of molecular sciences, 2020-06, Vol.21 (11), p.4008
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PDE4B promotes JNK/NLRP3 activation in the nucleus pulposus and mediates intervertebral disc degeneration
Author / Creator:Xu, Weixing ; Dhar, Rana ; Li, Kaiyue ; Zheng, Danyang ; He, Minxin ; Ding, Weiguo ; Xin, Long ; Xu, Bin ; He, Yuqing ; Peng, Qi ; Tang, Huifang
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2025-02, Vol.15 (1), p.5739-11
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Showing 1 to 20 of 225 results

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Circadian control of the secretory pathway maintains collagen homeostasis

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circPDE4B prevents articular cartilage degeneration and promotes repair by acting as a scaffold for RIC8A and MID1

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Identification of myeloid cells in the human enthesis as the main source of local IL-23 production

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Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases

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A high-fat diet promotes depression-like behavior in mice by suppressing hypothalamic PKA signaling

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Sleep deprivation causes memory deficits by negatively impacting neuronal connectivity in hippocampal area CA1

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AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B

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Memory enhancing effects of BPN14770, an allosteric inhibitor of phosphodiesterase-4D, in wild-type and humanized mice

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Fear memory regulation by the cAMP signaling pathway as an index of reexperiencing symptoms in posttraumatic stress disorder

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Ginsenoside Rg5 attenuates hepatic glucagon response via suppression of succinate-associated HIF-1α induction in HFD-fed mice

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cAMP-PKA phosphorylation of tau confers risk for degeneration in aging association cortex

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Inhibition of phosphodiesterase 4 (PDE4) reduces dermal fibrosis by interfering with the release of interleukin-6 from M2 macrophages

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PDE4D: A Multipurpose Pharmacological Target

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Metabolic effects of resveratrol: addressing the controversies

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Sleep deprivation impairs cAMP signalling in the hippocampus

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Phosphodiesterase-4 (PDE4) Molecular Pharmacology and Alzheimer’s Disease

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Allosteric inhibition of phosphodiesterase 4D induces biphasic memory-enhancing effects associated with learning-activated signaling pathways

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Insilico discovery of novel Phosphodiesterase 4 (PDE4) inhibitors for the treatment of psoriasis: Insights from computer aided drug design approaches

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A Novel, Pan-PDE Inhibitor Exerts Anti-Fibrotic Effects in Human Lung Fibroblasts via Inhibition of TGF-β Signaling and Activation of cAMP/PKA Signaling

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PDE4B promotes JNK/NLRP3 activation in the nucleus pulposus and mediates intervertebral disc degeneration

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