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Galunisertib plus gemcitabine vs. gemcitabine for first-line treatment of patients with unresectable pancreatic cancer
Author / Creator:Melisi, Davide ; Garcia-Carbonero, Rocio ; Macarulla, Teresa ; Pezet, Denis ; Deplanque, Gael ; Fuchs, Martin ; Trojan, Jorg ; Oettle, Helmut ; Kozloff, Mark ; Cleverly, Ann ; Smith, Claire ; Estrem, Shawn T. ; Gueorguieva, Ivelina ; Lahn, Michael M. F. ; Blunt, Al ; Benhadji, Karim A. ; Tabernero, Josep
Publisher:London: Nature Publishing Group UK
Journal title:British journal of cancer, 2018-11, Vol.119 (10), p.1208-1214
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Phase 1 study of the ATR inhibitor berzosertib (formerly M6620, VX-970) combined with gemcitabine ± cisplatin in patients with advanced solid tumours
Author / Creator:Middleton, Mark R. ; Dean, Emma ; Evans, Thomas R. J. ; Shapiro, Geoffrey I. ; Pollard, John ; Hendriks, Bart S. ; Falk, Martin ; Diaz-Padilla, Ivan ; Plummer, Ruth
Publisher:London: Nature Publishing Group UK
Journal title:British journal of cancer, 2021-08, Vol.125 (4), p.510-519
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Activity of Oral ALS-008176 in a Respiratory Syncytial Virus Challenge Study
Author / Creator:DeVincenzo, John P ; McClure, Matthew W ; Symons, Julian A ; Fathi, Hosnieh ; Westland, Christopher ; Chanda, Sushmita ; Lambkin-Williams, Rob ; Smith, Patrick ; Zhang, Qingling ; Beigelman, Leo ; Blatt, Lawrence M ; Fry, John
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2015-11, Vol.373 (21), p.2048-2058
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Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer
Author / Creator:Hessmann, E ; Patzak, M S ; Klein, L ; Chen, N ; Kari, V ; Ramu, I ; Bapiro, T E ; Frese, K K ; Gopinathan, A ; Richards, F M ; Jodrell, D I ; Verbeke, C ; Li, X ; Heuchel, R ; Löhr, J M ; Johnsen, S A ; Gress, T M ; Ellenrieder, V ; Neesse, A
Publisher:England: BMJ Publishing Group LTD
Journal title:Gut, 2018-03, Vol.67 (3), p.497-507
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Phase I/II study with ruthenium compound NAMI-A and gemcitabine in patients with non-small cell lung cancer after first line therapy
Author / Creator:Leijen, Suzanne ; Burgers, Sjaak A. ; Baas, Paul ; Pluim, Dick ; Tibben, Matthijs ; van Werkhoven, Erik ; Alessio, Enzo ; Sava, Gianni ; Beijnen, Jos H. ; Schellens, Jan H. M.
Publisher:Boston: Springer US
Journal title:Investigational new drugs, 2015-02, Vol.33 (1), p.201-214
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Local bacteria affect the efficacy of chemotherapeutic drugs
Author / Creator:Lehouritis, Panos ; Cummins, Joanne ; Stanton, Michael ; Murphy, Carola T. ; McCarthy, Florence O. ; Reid, Gregor ; Urbaniak, Camilla ; Byrne, William L. ; Tangney, Mark
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2015-09, Vol.5 (1), p.14554, Article 14554
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Pharmacokinetics and pharmacogenetics of Gemcitabine as a mainstay in adult and pediatric oncology: an EORTC-PAMM perspective
Author / Creator:Ciccolini, Joseph ; Serdjebi, Cindy ; Peters, Godefridus J. ; Giovannetti, Elisa
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Cancer chemotherapy and pharmacology, 2016-07, Vol.78 (1), p.1-12
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A phase I trial of the γ-secretase inhibitor MK-0752 in combination with gemcitabine in patients with pancreatic ductal adenocarcinoma
Author / Creator:Cook, Natalie ; Basu, Bristi ; Smith, Donna-Michelle ; Gopinathan, Aarthi ; Evans, Jeffry ; Steward, William P ; Palmer, Daniel ; Propper, David ; Venugopal, Balaji ; Hategan, Mirela ; Anthoney, D Alan ; Hampson, Lisa V ; Nebozhyn, Michael ; Tuveson, David ; Farmer-Hall, Hayley ; Turner, Helen ; McLeod, Robert ; Halford, Sarah ; Jodrell, Duncan
Publisher:London: Nature Publishing Group UK
Journal title:British journal of cancer, 2018-03, Vol.118 (6), p.793-801
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Development of Asialoglycoprotein Receptor-Targeted Nanoparticles for Selective Delivery of Gemcitabine to Hepatocellular Carcinoma
Author / Creator:Nair, Anroop B ; Shah, Jigar ; Al-Dhubiab, Bandar E ; Patel, Snehal S ; Morsy, Mohamed A ; Patel, Vimal ; Chavda, Vishal ; Jacob, Shery ; Sreeharsha, Nagaraja ; Shinu, Pottathil ; Attimarad, Mahesh ; Venugopala, Katharigatta N
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2019-12, Vol.24 (24), p.4566
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Novel Approaches to Monitor Pharmacokinetics and Metabolism of Gemcitabine-Ibandronate Conjugate in Mice and Dogs
Author / Creator:Klawitter, Jost ; Easton, Mckay ; Karpeisky, Alexander ; Farrell, Kristen B ; Thamm, Douglas H ; Shokati, Touraj ; Christians, Uwe ; Zinnen, Shawn Patrick
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2025-01, Vol.30 (2), p.354
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ArticlesPeer ReviewedFull Text
Dual pH-sensitive liposomes with low pH-triggered sheddable PEG for enhanced tumor-targeted drug delivery
Author / Creator:Kanamala, Manju ; Palmer, Brian D ; Jamieson, Stephen Mf ; Wilson, William R ; Wu, Zimei
Publisher:England: Future Medicine Ltd
Journal title:Nanomedicine (London, England), 2019-08, Vol.14 (15), p.1971-1989
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Transport properties of pancreatic cancer describe gemcitabine delivery and response
Author / Creator:Koay, Eugene J ; Truty, Mark J ; Cristini, Vittorio ; Thomas, Ryan M ; Chen, Rong ; Chatterjee, Deyali ; Kang, Ya'an ; Bhosale, Priya R ; Tamm, Eric P ; Crane, Christopher H ; Javle, Milind ; Katz, Matthew H ; Gottumukkala, Vijaya N ; Rozner, Marc A ; Shen, Haifa ; Lee, Jeffery E ; Wang, Huamin ; Chen, Yuling ; Plunkett, William ; Abbruzzese, James L ; Wolff, Robert A ; Varadhachary, Gauri R ; Ferrari, Mauro ; Fleming, Jason B
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2014-04, Vol.124 (4), p.1525-1536
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PEG-Benzaldehyde-Hydrazone-Lipid Based PEG-Sheddable pH-Sensitive Liposomes: Abilities for Endosomal Escape and Long Circulation
Author / Creator:Kanamala, Manju ; Palmer, Brian D. ; Ghandehari, Hamidreza ; Wilson, William R. ; Wu, Zimei
Publisher:New York: Springer US
Journal title:Pharmaceutical research, 2018-08, Vol.35 (8), p.154-13, Article 154
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Phase I dose-escalation study of AZD7762, a checkpoint kinase inhibitor, in combination with gemcitabine in US patients with advanced solid tumors
Author / Creator:Sausville, Edward ; LoRusso, Patricia ; Carducci, Michael ; Carter, Judith ; Quinn, Mary F. ; Malburg, Lisa ; Azad, Nilofer ; Cosgrove, David ; Knight, Richard ; Barker, Peter ; Zabludoff, Sonya ; Agbo, Felix ; Oakes, Patricia ; Senderowicz, Adrian
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Cancer chemotherapy and pharmacology, 2014-03, Vol.73 (3), p.539-549
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ArticlesPeer ReviewedFull Text
Chitosan-Pluronic nanoparticles as oral delivery of anticancer gemcitabine: preparation and in vitro study
Author / Creator:Hosseinzadeh, Hosniyeh ; Atyabi, Fatemeh ; Dinarvand, Rassoul ; Ostad, Seyed Naser
Publisher:New Zealand: Taylor & Francis Ltd
Journal title:International journal of nanomedicine, 2012-01, Vol.7, p.1851-1863
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Co-Delivery of Gemcitabine and Paclitaxel in cRGD-Modified Long Circulating Nanoparticles with Asymmetric Lipid Layers for Breast Cancer Treatment
Author / Creator:Zhang, Jing ; Zhang, Peng ; Zou, Qian ; Li, Xiang ; Fu, Jianjiang ; Luo, Ying ; Liang, Xinli ; Jin, Yi
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2018-11, Vol.23 (11), p.2906
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Co-delivery of gemcitabine and simvastatin through PLGA polymeric nanoparticles for the treatment of pancreatic cancer: in-vitro characterization, cellular uptake, and pharmacokinetic studies
Author / Creator:Jamil, Adeeba ; Aamir Mirza, Mohd ; Anwer, Md. Khalid ; Thakur, Pragya S. ; Alshahrani, Saad M. ; Alshetaili, Abdullah S. ; Telegaonkar, Sushama ; Panda, Amulya K. ; Iqbal, Zeenat
Publisher:England: Taylor & Francis
Journal title:Drug development and industrial pharmacy, 2019-05, Vol.45 (5), p.745-753
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Oral Delivery of Photopolymerizable Nanogels Loaded with Gemcitabine for Pancreatic Cancer Therapy: Formulation Design, and in vitro and in vivo Evaluations
Author / Creator:Yugatama, Adi ; Huang, Ya-Lin ; Hsu, Ming-Jen ; Lin, Jia-Pei ; Chao, Fang-Ching ; Lam, Jenny K W ; Hsieh, Chien-Ming
Publisher:New Zealand: Dove Medical Press Limited
Journal title:International journal of nanomedicine, 2024-01, Vol.19, p.3753-3772
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A Microfluidic Perfusion Platform for In Vitro Analysis of Drug Pharmacokinetic-Pharmacodynamic (PK-PD) Relationships
Author / Creator:Guerrero, Yadir A. ; Desai, Diti ; Sullivan, Connor ; Kindt, Erick ; Spilker, Mary E. ; Maurer, Tristan S. ; Solomon, Deepak E. ; Bartlett, Derek W.
Publisher:Cham: Springer International Publishing
Journal title:The AAPS journal, 2020-03, Vol.22 (2), p.53, Article 53
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Novel Long-Acting Drug Combination Nanoparticles Composed of Gemcitabine and Paclitaxel Enhance Localization of Both Drugs in Metastatic Breast Cancer Nodules
Author / Creator:Yu, Jesse ; Mu, Qingxin ; Perazzolo, Simone ; Griffin, James I ; Zhu, Linxi ; McConnachie, Lisa A ; Shen, Danny D ; Ho, Rodney JY
Publisher:New York: Springer US
Journal title:Pharmaceutical research, 2020-10, Vol.37 (10), p.197-197, Article 197
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Galunisertib plus gemcitabine vs. gemcitabine for first-line treatment of patients with unresectable pancreatic cancer

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Phase 1 study of the ATR inhibitor berzosertib (formerly M6620, VX-970) combined with gemcitabine ± cisplatin in patients with advanced solid tumours

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Activity of Oral ALS-008176 in a Respiratory Syncytial Virus Challenge Study

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Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer

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Phase I/II study with ruthenium compound NAMI-A and gemcitabine in patients with non-small cell lung cancer after first line therapy

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Local bacteria affect the efficacy of chemotherapeutic drugs

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Pharmacokinetics and pharmacogenetics of Gemcitabine as a mainstay in adult and pediatric oncology: an EORTC-PAMM perspective

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A phase I trial of the γ-secretase inhibitor MK-0752 in combination with gemcitabine in patients with pancreatic ductal adenocarcinoma

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Development of Asialoglycoprotein Receptor-Targeted Nanoparticles for Selective Delivery of Gemcitabine to Hepatocellular Carcinoma

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Novel Approaches to Monitor Pharmacokinetics and Metabolism of Gemcitabine-Ibandronate Conjugate in Mice and Dogs

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Dual pH-sensitive liposomes with low pH-triggered sheddable PEG for enhanced tumor-targeted drug delivery

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Transport properties of pancreatic cancer describe gemcitabine delivery and response

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PEG-Benzaldehyde-Hydrazone-Lipid Based PEG-Sheddable pH-Sensitive Liposomes: Abilities for Endosomal Escape and Long Circulation

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Phase I dose-escalation study of AZD7762, a checkpoint kinase inhibitor, in combination with gemcitabine in US patients with advanced solid tumors

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Chitosan-Pluronic nanoparticles as oral delivery of anticancer gemcitabine: preparation and in vitro study

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Co-Delivery of Gemcitabine and Paclitaxel in cRGD-Modified Long Circulating Nanoparticles with Asymmetric Lipid Layers for Breast Cancer Treatment

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Co-delivery of gemcitabine and simvastatin through PLGA polymeric nanoparticles for the treatment of pancreatic cancer: in-vitro characterization, cellular uptake, and pharmacokinetic studies

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Oral Delivery of Photopolymerizable Nanogels Loaded with Gemcitabine for Pancreatic Cancer Therapy: Formulation Design, and in vitro and in vivo Evaluations

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A Microfluidic Perfusion Platform for In Vitro Analysis of Drug Pharmacokinetic-Pharmacodynamic (PK-PD) Relationships

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Novel Long-Acting Drug Combination Nanoparticles Composed of Gemcitabine and Paclitaxel Enhance Localization of Both Drugs in Metastatic Breast Cancer Nodules

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