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63 results for Deoxyguanine+Nucleotides+-+metabolism

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ArticlesPeer ReviewedFull Text
Oxidative guanine base damage regulates human telomerase activity
Author / Creator:Fouquerel, Elise ; Lormand, Justin ; Bose, Arindam ; Lee, Hui-Ting ; Kim, Grace S ; Li, Jianfeng ; Sobol, Robert W ; Freudenthal, Bret D ; Myong, Sua ; Opresko, Patricia L
Publisher:New York: Nature Publishing Group US
Journal title:Nature structural & molecular biology, 2016-12, Vol.23 (12), p.1092-1100
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HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase
Author / Creator:Goldstone, David C. ; Ennis-Adeniran, Valerie ; Hedden, Joseph J. ; Groom, Harriet C. T. ; Rice, Gillian I. ; Christodoulou, Evangelos ; Walker, Philip A. ; Kelly, Geoff ; Haire, Lesley F. ; Yap, Melvyn W. ; de Carvalho, Luiz Pedro S. ; Stoye, Jonathan P. ; Crow, Yanick J. ; Taylor, Ian A. ; Webb, Michelle
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2011-12, Vol.480 (7377), p.379-382
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MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool
Author / Creator:Gad, Helge ; Koolmeister, Tobias ; Jemth, Ann-Sofie ; Eshtad, Saeed ; Jacques, Sylvain A. ; Ström, Cecilia E. ; Svensson, Linda M. ; Schultz, Niklas ; Lundbäck, Thomas ; Einarsdottir, Berglind Osk ; Saleh, Aljona ; Göktürk, Camilla ; Baranczewski, Pawel ; Svensson, Richard ; Berntsson, Ronnie P.-A. ; Gustafsson, Robert ; Strömberg, Kia ; Sanjiv, Kumar ; Jacques-Cordonnier, Marie-Caroline ; Desroses, Matthieu ; Gustavsson, Anna-Lena ; Olofsson, Roger ; Johansson, Fredrik ; Homan, Evert J. ; Loseva, Olga ; Bräutigam, Lars ; Johansson, Lars ; Höglund, Andreas ; Hagenkort, Anna ; Pham, Therese ; Altun, Mikael ; Gaugaz, Fabienne Z. ; Vikingsson, Svante ; Evers, Bastiaan ; Henriksson, Martin ; Vallin, Karl S. A. ; Wallner, Olov A. ; Hammarström, Lars G. J. ; Wiita, Elisee ; Almlöf, Ingrid ; Kalderén, Christina ; Axelsson, Hanna ; Djureinovic, Tatjana ; Puigvert, Jordi Carreras ; Häggblad, Maria ; Jeppsson, Fredrik ; Martens, Ulf ; Lundin, Cecilia ; Lundgren, Bo ; Granelli, Ingrid ; Jensen, Annika Jenmalm ; Artursson, Per ; Nilsson, Jonas A. ; Stenmark, Pål ; Scobie, Martin ; Berglund, Ulrika Warpman ; Helleday, Thomas
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2014-04, Vol.508 (7495), p.215-221
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Phenanthriplatin, a monofunctional DNA-binding platinum anticancer drug candidate with unusual potency and cellular activity profile
Author / Creator:Park, Ga Young ; Wilson, Justin J ; Song, Ying ; Lippard, Stephen J
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2012-07, Vol.109 (30), p.11987-11992
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Oligoribonuclease is the primary degradative enzyme for pGpG in Pseudomonas aeruginosa that is required for cyclic-di-GMP turnover
Author / Creator:Orr, Mona W. ; Donaldson, Gregory P. ; Severin, Geoffrey B. ; Wang, Jingxin ; Sintim, Herman O. ; Waters, Christopher M. ; Lee, Vincent T.
Publisher:United States: National Acad Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2015-09, Vol.112 (36), p.E5048-E5057
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Mechanisms of telomerase inhibition by oxidized and therapeutic dNTPs
Author / Creator:Sanford, Samantha L. ; Welfer, Griffin A. ; Freudenthal, Bret D. ; Opresko, Patricia L.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2020-10, Vol.11 (1), p.5288-12, Article 5288
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Discovery and substrate specificity engineering of nucleotide halogenases
Author / Creator:Ni, Jie ; Zhuang, Jingyuan ; Shi, Yiming ; Chiang, Ying-Chih ; Cheng, Gui-Juan
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2024-06, Vol.15 (1), p.5254-12, Article 5254
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Oxidation of the Guanine Nucleotide Pool Underlies Cell Death by Bactericidal Antibiotics
Author / Creator:Foti, James J. ; Devadoss, Babho ; Winkler, Jonathan A. ; Collins, James J. ; Walker, Graham C.
Publisher:Washington, DC: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2012-04, Vol.336 (6079), p.315-319
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Oligoribonuclease is a central feature of cyclic diguanylate signaling in Pseudomonas aeruginosa
Author / Creator:Cohen, Dorit ; Mechold, Undine ; Nevenzal, Hadas ; Yarmiyhu, Yafit ; Randall, Trevor E. ; Bay, Denice C. ; Rich, Jacquelyn D. ; Parsek, Matthew R. ; Kaever, Volkhard ; Harrison, Joe J. ; Banin, Ehud
Publisher:United States: National Acad Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2015-09, Vol.112 (36), p.11359-11364
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Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide
Author / Creator:Freudenthal, Bret D. ; Beard, William A. ; Perera, Lalith ; Shock, David D. ; Kim, Taejin ; Schlick, Tamar ; Wilson, Samuel H.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2015-01, Vol.517 (7536), p.635-639
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Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2
Author / Creator:Carter, Megan ; Jemth, Ann-Sofie ; Hagenkort, Anna ; Page, Brent D. G. ; Gustafsson, Robert ; Griese, Julia J. ; Gad, Helge ; Valerie, Nicholas C. K. ; Desroses, Matthieu ; Boström, Johan ; Warpman Berglund, Ulrika ; Helleday, Thomas ; Stenmark, Pål
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2015-08, Vol.6 (1), p.7871, Article 7871
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Mechanism of allosteric activation of SAMHD1 by dGTP
Author / Creator:Ji, Xiaoyun ; Wu, Ying ; Yan, Junpeng ; Mehrens, Jennifer ; Yang, Haitao ; DeLucia, Maria ; Hao, Caili ; Gronenborn, Angela M ; Skowronski, Jacek ; Ahn, Jinwoo ; Xiong, Yong
Publisher:New York: Nature Publishing Group US
Journal title:Nature structural & molecular biology, 2013-11, Vol.20 (11), p.1304-1309
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Structural basis for proficient oxidized ribonucleotide insertion in double strand break repair
Author / Creator:Jamsen, Joonas A. ; Sassa, Akira ; Perera, Lalith ; Shock, David D. ; Beard, William A. ; Wilson, Samuel H.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-08, Vol.12 (1), p.5055-11, Article 5055
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GTP activator and dNTP substrates of HIV-1 restriction factor SAMHD1 generate a long-lived activated state
Author / Creator:Hansen, Erik C. ; Seamon, Kyle J. ; Cravens, Shannen L. ; Stivers, James T.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2014-05, Vol.111 (18), p.E1843-E1851
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Spontaneous mutation rate is a plastic trait associated with population density across domains of life
Author / Creator:Krašovec, Rok ; Richards, Huw ; Gifford, Danna R. ; Hatcher, Charlie ; Faulkner, Katy J. ; Belavkin, Roman V. ; Channon, Alastair ; Aston, Elizabeth ; McBain, Andrew J. ; Knight, Christopher G.
Publisher:United States: Public Library of Science
Journal title:PLoS biology, 2017-08, Vol.15 (8), p.e2002731
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Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide
Author / Creator:Jamsen, Joonas A. ; Sassa, Akira ; Shock, David D. ; Beard, William A. ; Wilson, Samuel H.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-04, Vol.12 (1), p.2059-12, Article 2059
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Structural insight into dGTP-dependent activation of tetrameric SAMHD1 deoxynucleoside triphosphate triphosphohydrolase
Author / Creator:Zhu, Chunfeng ; Gao, Wenying ; Zhao, Ke ; Qin, Xiaohong ; Zhang, Yinjie ; Peng, Xin ; Zhang, Lei ; Dong, Yuhui ; Zhang, Wenyan ; Li, Peng ; Wei, Wei ; Gong, Yong ; Yu, Xiao-Fang
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2013, Vol.4 (1), p.2722-2722, Article 2722
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Increased and Imbalanced dNTP Pools Symmetrically Promote Both Leading and Lagging Strand Replication Infidelity
Author / Creator:Buckland, Robert J. ; Watt, Danielle L. ; Chittoor, Balasubramanyam ; Nilsson, Anna Karin ; Kunkel, Thomas A. ; Chabes, Andrei
Publisher:United States: Public Library of Science
Journal title:PLoS genetics, 2014-12, Vol.10 (12), p.e1004846
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Trypanosoma cruzi Needs a Signal Provided by Reactive Oxygen Species to Infect Macrophages
Author / Creator:Goes, Grazielle R. ; Rocha, Peter S. ; Diniz, Aline R. S. ; Aguiar, Pedro H. N. ; Machado, Carlos R. ; Vieira, Leda Q.
Publisher:United States: Public Library of Science
Journal title:PLoS neglected tropical diseases, 2016-04, Vol.10 (4), p.e0004555-e0004555
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Pol μ dGTP mismatch insertion opposite T coupled with ligation reveals promutagenic DNA repair intermediate
Author / Creator:Çağlayan, Melike ; Wilson, Samuel H.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2018-10, Vol.9 (1), p.4213-4, Article 4213
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Showing 1 to 20 of 63 results

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Oxidative guanine base damage regulates human telomerase activity

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HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase

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MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

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Phenanthriplatin, a monofunctional DNA-binding platinum anticancer drug candidate with unusual potency and cellular activity profile

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Oligoribonuclease is the primary degradative enzyme for pGpG in Pseudomonas aeruginosa that is required for cyclic-di-GMP turnover

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Mechanisms of telomerase inhibition by oxidized and therapeutic dNTPs

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Discovery and substrate specificity engineering of nucleotide halogenases

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Oxidation of the Guanine Nucleotide Pool Underlies Cell Death by Bactericidal Antibiotics

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Oligoribonuclease is a central feature of cyclic diguanylate signaling in Pseudomonas aeruginosa

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Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide

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Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2

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Mechanism of allosteric activation of SAMHD1 by dGTP

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Structural basis for proficient oxidized ribonucleotide insertion in double strand break repair

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GTP activator and dNTP substrates of HIV-1 restriction factor SAMHD1 generate a long-lived activated state

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Spontaneous mutation rate is a plastic trait associated with population density across domains of life

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Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide

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Structural insight into dGTP-dependent activation of tetrameric SAMHD1 deoxynucleoside triphosphate triphosphohydrolase

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Increased and Imbalanced dNTP Pools Symmetrically Promote Both Leading and Lagging Strand Replication Infidelity

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Trypanosoma cruzi Needs a Signal Provided by Reactive Oxygen Species to Infect Macrophages

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Pol μ dGTP mismatch insertion opposite T coupled with ligation reveals promutagenic DNA repair intermediate

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