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Digoxin derivatives with selectivity for the α2β3 isoform of Na,K-ATPase potently reduce intraocular pressure
Author / Creator:Katz, Adriana ; Tal, Daniel M. ; Heller, Dan ; Habeck, Michael ; Zeev, Efrat Ben ; Rabah, Bilal ; Kana, Yaniv Bar ; Marcovich, Arie L. ; Karlish, Steven J. D.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2015-11, Vol.112 (44), p.13723-13728
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Identification and characterization of Cardiac Glycosides as senolytic compounds
Author / Creator:Triana-Martínez, Francisco ; Picallos-Rabina, Pilar ; Da Silva-Álvarez, Sabela ; Pietrocola, Federico ; Llanos, Susana ; Rodilla, Verónica ; Soprano, Enrica ; Pedrosa, Pablo ; Ferreirós, Alba ; Barradas, Marta ; Hernández-González, Fernanda ; Lalinde, Marta ; Prats, Neus ; Bernadó, Cristina ; González, Patricia ; Gómez, María ; Ikonomopoulou, Maria P. ; Fernández-Marcos, Pablo J. ; García-Caballero, Tomás ; del Pino, Pablo ; Arribas, Joaquín ; Vidal, Anxo ; González-Barcia, Miguel ; Serrano, Manuel ; Loza, María I. ; Domínguez, Eduardo ; Collado, Manuel
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2019-10, Vol.10 (1), p.4731-4731, Article 4731
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Antiviral activity of digoxin and ouabain against SARS-CoV-2 infection and its implication for COVID-19
Author / Creator:Cho, Junhyung ; Lee, Young Jae ; Kim, Je Hyoung ; Kim, Sang il ; Kim, Sung Soon ; Choi, Byeong-Sun ; Choi, Jang-Hoon
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2020-10, Vol.10 (1), p.16200, Article 16200
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Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan
Author / Creator:Wang, Chensu ; Niederstrasser, Hanspeter ; Douglas, Peter M. ; Lin, Rueyling ; Jaramillo, Juan ; Li, Yang ; Oswald, Nathaniel W. ; Zhou, Anwu ; McMillan, Elizabeth A. ; Mendiratta, Saurabh ; Wang, Zhaohui ; Zhao, Tian ; Lin, Zhiqaing ; Luo, Min ; Huang, Gang ; Brekken, Rolf A. ; Posner, Bruce A. ; MacMillan, John B. ; Gao, Jinming ; White, Michael A.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2017-12, Vol.8 (1), p.2270-2270, Article 2270
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Binding of cardiotonic steroids to Na⁺, K⁺-ATPase in the E2P state
Author / Creator:Cornelius, Flemming ; Vilsen, Bente
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2021-01, Vol.118 (1), p.1-12
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Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells
Author / Creator:Schito, Luana ; Rey, Sergio ; Tafani, Marco ; Zhang, Huafeng ; Wong, Carmen Chak-Lui ; Russo, Andrea ; Russo, Matteo A ; Semenza, Gregg L
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2012-10, Vol.109 (40), p.E2707-E2716
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Digoxin targets low density lipoprotein receptor-related protein 4 and protects against osteoarthritis
Author / Creator:Wang, Kai-di ; Ding, Xiang ; Jiang, Nan ; Zeng, Chao ; Wu, Jing ; Cai, Xian-yi ; Hettinghouse, Aubryanna ; Khleborodova, Asya ; Lei, Zi-Ning ; Chen, Zhe-Sheng ; Lei, Guang-hua ; Liu, Chuan-ju
Publisher:England: BMJ Publishing Group Ltd and European League Against Rheumatism
Journal title:Annals of the rheumatic diseases, 2022-04, Vol.81 (4), p.544-555
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Digoxin and exercise effects on skeletal muscle Na+,K+‐ATPase isoform gene expression in healthy humans
Author / Creator:McKenna, Michael J. ; Gong, Xiaofei ; Petersen, Aaron C. ; Sostaric, Simon ; Goodman, Craig A. ; Garnham, Andrew ; Aw, Tai‐Juan ; Steward, Collene H. ; Murphy, Kate T. ; Carey, Kate A. ; Krum, Henry ; Snow, Rodney J. ; Cameron‐Smith, David
Publisher:England: John Wiley & Sons, Inc
Journal title:Experimental physiology, 2024-11, Vol.109 (11), p.1909-1921
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Reversal of P-glycoprotein (P-gp) mediated multidrug resistance in colon cancer cells by cryptotanshinone and dihydrotanshinone of Salvia miltiorrhiza
Author / Creator:Hu, Tao ; To, Kenneth K.W. ; Wang, Lin ; Zhang, Lin ; Lu, Lan ; Shen, Jing ; Chan, Ruby L.Y. ; Li, Mingxing ; Yeung, John H.K. ; Cho, Chi Hin
Publisher:Germany: Elsevier GmbH
Journal title:Phytomedicine (Stuttgart), 2014-09, Vol.21 (11), p.1264-1272
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Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis
Author / Creator:Wong, Carmen Chak-Lui ; Zhang, Huafeng ; Gilkes, Daniele M. ; Chen, Jasper ; Wei, Hong ; Chaturvedi, Pallavi ; Hubbi, Maimon E. ; Semenza, Gregg L.
Publisher:Berlin/Heidelberg: Springer-Verlag
Journal title:Journal of molecular medicine (Berlin, Germany), 2012-07, Vol.90 (7), p.803-815
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VEGF Secreted by Hypoxic Müller Cells Induces MMP-2 Expression and Activity in Endothelial Cells to Promote Retinal Neovascularization in Proliferative Diabetic Retinopathy
Author / Creator:RODRIGUES, Murilo ; XIAOBAN XIN ; SOLOMON, Sharon ; LUTTY, Gerard ; SEMENZA, Gregg L ; MONTANER, Silvia ; SODHI, Akrit ; JEE, Kathleen ; BABAPOOR-FARROKHRAN, Savalan ; KASHIWABUCHI, Fabiana ; TAO MA ; BHUTTO, Imran ; HASSAN, Syed Junaid ; DAOUD, Yassine ; BARANANO, David
Publisher:Alexandria, VA: American Diabetes Association
Journal title:Diabetes (New York, N.Y.), 2013-11, Vol.62 (11), p.3863-3873
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Common cardiac medications potently inhibit ACE2 binding to the SARS-CoV-2 Spike, and block virus penetration and infectivity in human lung cells
Author / Creator:Caohuy, Hung ; Eidelman, Ofer ; Chen, Tinghua ; Liu, Shufeng ; Yang, Qingfeng ; Bera, Alakesh ; Walton, Nathan I. ; Wang, Tony T. ; Pollard, Harvey B.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2021-11, Vol.11 (1), p.22195-14, Article 22195
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Digoxin Induces Human Astrocyte Reaction In Vitro
Author / Creator:Pamies, David ; Vujić, Tatjana ; Schvartz, Domitille ; Boccard, Julien ; Repond, Cendrine ; Nunes, Carolina ; Rudaz, Serge ; Sanchez, Jean-Charles ; González-Ruiz, Víctor ; Zurich, Marie-Gabrielle
Publisher:New York: Springer US
Journal title:Molecular neurobiology, 2023-01, Vol.60 (1), p.84-97
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Inhibitors of Na+/K+ ATPase exhibit antitumor effects on multicellular tumor spheroids of hepatocellular carcinoma
Author / Creator:Song, Yeonhwa ; Lee, Su-Yeon ; Kim, Sanghwa ; Choi, Inhee ; Kim, Se-Hyuk ; Shum, David ; Heo, Jinyeong ; Kim, A-Ram ; Kim, Kang Mo ; Seo, Haeng Ran
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2020-03, Vol.10 (1), p.5318-5318, Article 5318
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Knockout Transporter Cell Lines to Assess Substrate Potential Towards Efflux Transporters
Author / Creator:Volpe, Donna A.
Publisher:Cham: Springer International Publishing
Journal title:The AAPS journal, 2024-07, Vol.26 (4), p.79, Article 79
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Interaction of Odoroside A, A Known Natural Cardiac Glycoside, with Na+/K+-ATPase
Author / Creator:Takada, Yohei ; Kaneko, Kazuhiro ; Kawakami, Yoshiyuki
Publisher:New York: Springer US
Journal title:The Journal of membrane biology, 2023-06, Vol.256 (3), p.229-241
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Clinical Use of Digitalis: A State of the Art Review
Author / Creator:Whayne, Thomas F.
Publisher:Cham: Springer International Publishing
Journal title:American journal of cardiovascular drugs : drugs, devices, and other interventions, 2018-12, Vol.18 (6), p.427-440
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SCF, regulated by HIF-1α, promotes pancreatic ductal adenocarcinoma cell progression
Author / Creator:Gao, Chuntao ; Li, Shasha ; Zhao, Tiansuo ; Chen, Jing ; Ren, He ; Zhang, Huan ; Wang, Xiuchao ; Lang, Mingxiao ; Liu, Jingcheng ; Gao, Song ; Zhao, Xiao ; Sheng, Jun ; Yuan, Zhanna ; Hao, Jihui
Publisher:United States: Public Library of Science
Journal title:PloS one, 2015-03, Vol.10 (3), p.e0121338-e0121338
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Combination of anti-vascular agent - DMXAA and HIF-1α inhibitor - digoxin inhibits the growth of melanoma tumors
Author / Creator:Smolarczyk, Ryszard ; Cichoń, Tomasz ; Pilny, Ewelina ; Jarosz-Biej, Magdalena ; Poczkaj, Aleksandra ; Kułach, Natalia ; Szala, Stanisław
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2018-05, Vol.8 (1), p.7355-9, Article 7355
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Structural Insights into the Interactions of Digoxin and Na + /K + -ATPase and Other Targets for the Inhibition of Cancer Cell Proliferation
Author / Creator:Ren, Yulin ; Wu, Sijin ; Burdette, Joanna E ; Cheng, Xiaolin ; Kinghorn, A Douglas
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2021-06, Vol.26 (12), p.3672
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Digoxin derivatives with selectivity for the α2β3 isoform of Na,K-ATPase potently reduce intraocular pressure

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Identification and characterization of Cardiac Glycosides as senolytic compounds

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Antiviral activity of digoxin and ouabain against SARS-CoV-2 infection and its implication for COVID-19

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Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan

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Binding of cardiotonic steroids to Na⁺, K⁺-ATPase in the E2P state

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Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells

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Digoxin targets low density lipoprotein receptor-related protein 4 and protects against osteoarthritis

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Digoxin and exercise effects on skeletal muscle Na+,K+‐ATPase isoform gene expression in healthy humans

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Reversal of P-glycoprotein (P-gp) mediated multidrug resistance in colon cancer cells by cryptotanshinone and dihydrotanshinone of Salvia miltiorrhiza

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Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis

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VEGF Secreted by Hypoxic Müller Cells Induces MMP-2 Expression and Activity in Endothelial Cells to Promote Retinal Neovascularization in Proliferative Diabetic Retinopathy

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Common cardiac medications potently inhibit ACE2 binding to the SARS-CoV-2 Spike, and block virus penetration and infectivity in human lung cells

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Digoxin Induces Human Astrocyte Reaction In Vitro

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Inhibitors of Na+/K+ ATPase exhibit antitumor effects on multicellular tumor spheroids of hepatocellular carcinoma

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Knockout Transporter Cell Lines to Assess Substrate Potential Towards Efflux Transporters

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Interaction of Odoroside A, A Known Natural Cardiac Glycoside, with Na+/K+-ATPase

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Clinical Use of Digitalis: A State of the Art Review

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SCF, regulated by HIF-1α, promotes pancreatic ductal adenocarcinoma cell progression

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Combination of anti-vascular agent - DMXAA and HIF-1α inhibitor - digoxin inhibits the growth of melanoma tumors

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Structural Insights into the Interactions of Digoxin and Na + /K + -ATPase and Other Targets for the Inhibition of Cancer Cell Proliferation

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