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104 results for Diphenylamine+-+pharmacology

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ArticlesPeer ReviewedFull Text
Naive pluripotency is associated with global DNA hypomethylation
Author / Creator:Leitch, Harry G ; McEwen, Kirsten R ; Turp, Aleksandra ; Encheva, Vesela ; Carroll, Tom ; Grabole, Nils ; Mansfield, William ; Nashun, Buhe ; Knezovich, Jaysen G ; Smith, Austin ; Surani, M Azim ; Hajkova, Petra
Publisher:New York: Nature Publishing Group US
Journal title:Nature structural & molecular biology, 2013-03, Vol.20 (3), p.311-316
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MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors
Author / Creator:Jessen, Walter J ; Miller, Shyra J ; Jousma, Edwin ; Wu, Jianqiang ; Rizvi, Tilat A ; Brundage, Meghan E ; Eaves, David ; Widemann, Brigitte ; Kim, Mi-Ok ; Dombi, Eva ; Sabo, Jessica ; Hardiman Dudley, Atira ; Niwa-Kawakita, Michiko ; Page, Grier P ; Giovannini, Marco ; Aronow, Bruce J ; Cripe, Timothy P ; Ratner, Nancy
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2013-01, Vol.123 (1), p.340-347
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ArticlesPeer ReviewedFull Text
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
Author / Creator:Hatzivassiliou, Georgia ; Song, Kyung ; Yen, Ivana ; Brandhuber, Barbara J. ; Anderson, Daniel J. ; Alvarado, Ryan ; Ludlam, Mary J. C. ; Stokoe, David ; Gloor, Susan L. ; Vigers, Guy ; Morales, Tony ; Aliagas, Ignacio ; Liu, Bonnie ; Sideris, Steve ; Hoeflich, Klaus P. ; Jaiswal, Bijay S. ; Seshagiri, Somasekar ; Koeppen, Hartmut ; Belvin, Marcia ; Friedman, Lori S. ; Malek, Shiva
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2010-03, Vol.464 (7287), p.431-435
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A chemical platform for improved induction of human iPSCs
Author / Creator:Lin, Tongxiang ; Ambasudhan, Rajesh ; Yuan, Xu ; Li, Wenlin ; Hilcove, Simon ; Abujarour, Ramzey ; Lin, Xiangyi ; Hahm, Heung Sik ; Hao, Ergeng ; Hayek, Alberto ; Ding, Sheng
Publisher:New York: Nature Publishing Group US
Journal title:Nature methods, 2009-11, Vol.6 (11), p.805-808
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ArticlesPeer ReviewedFull Text
Embryonic stem cell self‐renewal pathways converge on the transcription factor Tfcp2l1
Author / Creator:Ye, Shoudong ; Li, Ping ; Tong, Chang ; Ying, Qi‐Long
Publisher:London: Nature Publishing Group UK
Journal title:The EMBO journal, 2013-10, Vol.32 (19), p.2548-2560
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The ground state of embryonic stem cell self-renewal
Author / Creator:Ying, Qi-Long ; Wray, Jason ; Nichols, Jennifer ; Batlle-Morera, Laura ; Doble, Bradley ; Woodgett, James ; Cohen, Philip ; Smith, Austin
Publisher:London: Nature Publishing Group UK
Journal title:Nature, 2008-05, Vol.453 (7194), p.519-523
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ArticlesPeer ReviewedFull Text
RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner
Author / Creator:Joseph, Eric W ; Pratilas, Christine A ; Poulikakos, Poulikos I ; Tadi, Madhavi ; Wang, Weiqing ; Taylor, Barry S ; Halilovic, Ensar ; Persaud, Yogindra ; Xing, Feng ; Viale, Agnes ; Tsai, James ; Chapman, Paul B ; Bollag, Gideon ; Solit, David B ; Rosen, Neal
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2010-08, Vol.107 (33), p.14903-14908
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ArticlesPeer ReviewedFull Text
Noncanonical TGFβ Signaling Contributes to Aortic Aneurysm Progression in Marfan Syndrome Mice
Author / Creator:Holm, Tammy M. ; Habashi, Jennifer P. ; Doyle, Jefferson J. ; Bedja, Djahida ; Chen, YiChun ; van Erp, Christel ; Lindsay, Mark E. ; Kim, David ; Schoenhoff, Florian ; Cohn, Ronald D. ; Loeys, Bart L. ; Thomas, Craig J. ; Patnaik, Samarjit ; Marugan, Juan J. ; Judge, Daniel P. ; Dietz, Harry C.
Publisher:Washington, DC: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2011-04, Vol.332 (6027), p.358-361
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ArticlesPeer ReviewedFull Text
Small-molecule MAPK inhibitors restore radioiodine incorporation in mouse thyroid cancers with conditional BRAF activation
Author / Creator:Chakravarty, Debyani ; Santos, Elmer ; Ryder, Mabel ; Knauf, Jeffrey A ; Liao, Xiao-Hui ; West, Brian L ; Bollag, Gideon ; Kolesnick, Richard ; Thin, Tin Htwe ; Rosen, Neal ; Zanzonico, Pat ; Larson, Steven M ; Refetoff, Samuel ; Ghossein, Ronald ; Fagin, James A
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2011-12, Vol.121 (12), p.4700-4711
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ArticlesPeer ReviewedFull Text
BRAF mutation predicts sensitivity to MEK inhibition
Author / Creator:Solit, David B. ; Garraway, Levi A. ; Pratilas, Christine A. ; Sawai, Ayana ; Getz, Gad ; Basso, Andrea ; Ye, Qing ; Lobo, Jose M. ; She, Yuhong ; Osman, Iman ; Golub, Todd R. ; Sebolt-Leopold, Judith ; Sellers, William R. ; Rosen, Neal
Publisher:London: Nature Publishing Group UK
Journal title:Nature, 2006-01, Vol.439 (7074), p.358-362
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ArticlesPeer ReviewedFull Text
c-Met activation leads to the establishment of a TGFβ-receptor regulatory network in bladder cancer progression
Author / Creator:Sim, Wen Jing ; Iyengar, Prasanna Vasudevan ; Lama, Dilraj ; Lui, Sarah Kit Leng ; Ng, Hsien Chun ; Haviv-Shapira, Lior ; Domany, Eytan ; Kappei, Dennis ; Tan, Tuan Zea ; Saei, Azad ; Jaynes, Patrick William ; Verma, Chandra Shekhar ; Kumar, Alan Prem ; Rouanne, Mathieu ; Ha, Hong Koo ; Radulescu, Camelia ; ten Dijke, Peter ; Eichhorn, Pieter Johan Adam ; Thiery, Jean Paul
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2019-09, Vol.10 (1), p.4349-19, Article 4349
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ArticlesPeer ReviewedFull Text
Vitamin C and MEK Inhibitor PD0325901 Synergistically Promote Oligodendrocytes Generation by Promoting DNA Demethylation
Author / Creator:Ren, Xinyue ; Yang, Ying ; Wang, Min ; Yuan, Qianting ; Suo, Na ; Xie, Xin
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2024-12, Vol.29 (24), p.5939
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ArticlesPeer ReviewedFull Text
Generation of human antral and fundic gastric organoids from pluripotent stem cells
Author / Creator:Broda, Taylor R. ; McCracken, Kyle W. ; Wells, James M.
Publisher:London: Nature Publishing Group UK
Journal title:Nature protocols, 2019-01, Vol.14 (1), p.28-50
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ArticlesPeer ReviewedFull Text
Quantitative Live Imaging Reveals Phase Dependency of PDAC Patient‐Derived Organoids on ERK and AMPK Activity
Author / Creator:Tsukamoto, Shoko ; Huaze, Ye ; Weisheng, Zhang ; Machinaga, Akihito ; Kakiuchi, Nobuyuki ; Ogawa, Seishi ; Seno, Hiroshi ; Higashiyama, Shigeki ; Matsuda, Michiyuki ; Hiratsuka, Toru
Publisher:England: John Wiley & Sons, Inc
Journal title:Cancer science, 2024-12, Vol.116 (3), p.724-735
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ArticlesPeer ReviewedFull Text
Oncogenic KRAS-associated gene signature defines co-targeting of CDK4/6 and MEK as a viable therapeutic strategy in colorectal cancer
Author / Creator:Pek, M ; Yatim, S M J M ; Chen, Y ; Li, J ; Gong, M ; Jiang, X ; Zhang, F ; Zheng, J ; Wu, X ; Yu, Q
Publisher:London: Nature Publishing Group UK
Journal title:Oncogene, 2017-08, Vol.36 (35), p.4975-4986
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ArticlesPeer ReviewedFull Text
Synthesis and In Vitro Evaluation as Potential Anticancer and Antioxidant Agents of Diphenylamine-Pyrrolidin-2-one-Hydrazone Derivatives
Author / Creator:Zubrickė, Irma ; Jonuškienė, Ilona ; Kantminienė, Kristina ; Tumosienė, Ingrida ; Petrikaitė, Vilma
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2023-12, Vol.24 (23), p.16804
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ArticlesPeer ReviewedFull Text
Ethylene –dependent and –independent superficial scald resistance mechanisms in ‘Granny Smith’ apple fruit
Author / Creator:Karagiannis, Evangelos ; Michailidis, Michail ; Tanou, Georgia ; Samiotaki, Martina ; Karamanoli, Katerina ; Avramidou, Evangelia ; Ganopoulos, Ioannis ; Madesis, Panagiotis ; Molassiotis, Athanassios
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2018-07, Vol.8 (1), p.11436-16, Article 11436
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ArticlesPeer ReviewedFull Text
Dissection of two routes to naïve pluripotency using different kinase inhibitors
Author / Creator:Martinez-Val, Ana ; Lynch, Cian J. ; Calvo, Isabel ; Ximénez-Embún, Pilar ; Garcia, Fernando ; Zarzuela, Eduardo ; Serrano, Manuel ; Munoz, Javier
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-03, Vol.12 (1), p.1863-16, Article 1863
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N-cadherin/FGFR promotes metastasis through epithelial-to-mesenchymal transition and stem/progenitor cell-like properties
Author / Creator:Qian, X ; Anzovino, A ; Kim, S ; Suyama, K ; Yao, J ; Hulit, J ; Agiostratidou, G ; Chandiramani, N ; McDaid, H M ; Nagi, C ; Cohen, H W ; Phillips, G R ; Norton, L ; Hazan, R B
Publisher:London: Nature Publishing Group UK
Journal title:Oncogene, 2014-06, Vol.33 (26), p.3411-3421
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ArticlesPeer ReviewedFull Text
Role of yes-associated protein 1, angiomotin, and mitogen-activated kinase kinase 1/2 in development of the bovine blastocyst
Author / Creator:Negrón-Pérez, Verónica M ; Hansen, Peter J
Publisher:United States: Society for the Study of Reproduction
Journal title:Biology of reproduction, 2018-02, Vol.98 (2), p.170-183
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Naive pluripotency is associated with global DNA hypomethylation

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MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors

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RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

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A chemical platform for improved induction of human iPSCs

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Embryonic stem cell self‐renewal pathways converge on the transcription factor Tfcp2l1

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The ground state of embryonic stem cell self-renewal

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RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner

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Noncanonical TGFβ Signaling Contributes to Aortic Aneurysm Progression in Marfan Syndrome Mice

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Small-molecule MAPK inhibitors restore radioiodine incorporation in mouse thyroid cancers with conditional BRAF activation

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BRAF mutation predicts sensitivity to MEK inhibition

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c-Met activation leads to the establishment of a TGFβ-receptor regulatory network in bladder cancer progression

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Vitamin C and MEK Inhibitor PD0325901 Synergistically Promote Oligodendrocytes Generation by Promoting DNA Demethylation

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Generation of human antral and fundic gastric organoids from pluripotent stem cells

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Quantitative Live Imaging Reveals Phase Dependency of PDAC Patient‐Derived Organoids on ERK and AMPK Activity

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Oncogenic KRAS-associated gene signature defines co-targeting of CDK4/6 and MEK as a viable therapeutic strategy in colorectal cancer

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Synthesis and In Vitro Evaluation as Potential Anticancer and Antioxidant Agents of Diphenylamine-Pyrrolidin-2-one-Hydrazone Derivatives

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Ethylene –dependent and –independent superficial scald resistance mechanisms in ‘Granny Smith’ apple fruit

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Dissection of two routes to naïve pluripotency using different kinase inhibitors

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N-cadherin/FGFR promotes metastasis through epithelial-to-mesenchymal transition and stem/progenitor cell-like properties

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Role of yes-associated protein 1, angiomotin, and mitogen-activated kinase kinase 1/2 in development of the bovine blastocyst

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