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4,454 results for Drug+Resistance,+Neoplasm+-+drug+effects

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ArticlesPeer ReviewedFull Text
Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation
Author / Creator:Nazarian, Ramin ; Shi, Hubing ; Wang, Qi ; Kong, Xiangju ; Koya, Richard C. ; Lee, Hane ; Chen, Zugen ; Lee, Mi-Kyung ; Attar, Narsis ; Sazegar, Hooman ; Chodon, Thinle ; Nelson, Stanley F. ; McArthur, Grant ; Sosman, Jeffrey A. ; Ribas, Antoni ; Lo, Roger S.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2010-12, Vol.468 (7326), p.973-977
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ArticlesPeer ReviewedFull Text
COT drives resistance to RAF inhibition through MAP kinase pathway reactivation
Author / Creator:Johannessen, Cory M. ; Boehm, Jesse S. ; Kim, So Young ; Thomas, Sapana R. ; Wardwell, Leslie ; Johnson, Laura A. ; Emery, Caroline M. ; Stransky, Nicolas ; Cogdill, Alexandria P. ; Barretina, Jordi ; Caponigro, Giordano ; Hieronymus, Haley ; Murray, Ryan R. ; Salehi-Ashtiani, Kourosh ; Hill, David E. ; Vidal, Marc ; Zhao, Jean J. ; Yang, Xiaoping ; Alkan, Ozan ; Kim, Sungjoon ; Harris, Jennifer L. ; Wilson, Christopher J. ; Myer, Vic E. ; Finan, Peter M. ; Root, David E. ; Roberts, Thomas M. ; Golub, Todd ; Flaherty, Keith T. ; Dummer, Reinhard ; Weber, Barbara L. ; Sellers, William R. ; Schlegel, Robert ; Wargo, Jennifer A. ; Hahn, William C. ; Garraway, Levi A.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2010-12, Vol.468 (7326), p.968-972
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ArticlesFull Text
SBI0206965, a novel inhibitor of Ulk1, suppresses non-small cell lung cancer cell growth by modulating both autophagy and apoptosis pathways
Author / Creator:Tang, Fang ; Hu, Pengchao ; Yang, Zetian ; Xue, Chao ; Gong, Jun ; Sun, Shaoxing ; Shi, Liu ; Zhang, Shimin ; Li, Zhenzhen ; Yang, Chunxu ; Zhang, Junhong ; Xie, Conghua
Publisher:Greece: Spandidos Publications
Journal title:Oncology reports, 2017-06, Vol.37 (6), p.3449-3458
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ArticlesPeer ReviewedFull Text
Vemurafenib resistance reprograms melanoma cells towards glutamine dependence
Author / Creator:Hernandez-Davies, Jenny E ; Tran, Thai Q ; Reid, Michael A ; Rosales, Kimberly R ; Lowman, Xazmin H ; Pan, Min ; Moriceau, Gatien ; Yang, Ying ; Wu, Jun ; Lo, Roger S ; Kong, Mei
Publisher:England: BioMed Central Ltd
Journal title:Journal of translational medicine, 2015-07, Vol.13 (1), p.210-210, Article 210
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ArticlesPeer ReviewedFull Text
Dopamine D2 receptor antagonist sulpiride enhances dexamethasone responses in the treatment of drug- resistant and metastatic breast cancer
Author / Creator:Li, Jian ; Yao, Qing-yu ; Xue, Jun-sheng ; Wang, Li-jie ; Yuan, Yin ; Tian, Xiu-yun ; Su, Hong ; Wang, Si-yuan ; Chen, Wen-jun ; Lu, Wei ; Zhou, Tian-yan
Publisher:London: Nature Publishing Group UK
Journal title:Acta pharmacologica Sinica, 2017-09, Vol.38 (9), p.1282-1296
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Metformin reverses stem cell‑like HepG2 sphere formation and resistance to sorafenib by attenuating epithelial‑mesenchymal transformation
Author / Creator:Feng, Yan ; Guo, Xing ; Huang, Xinping ; Wu, Manya ; Li, Xin ; Wu, Shushu ; Luo, Xiaoling
Publisher:Greece: Spandidos Publications
Journal title:Molecular medicine reports, 2018-10, Vol.18 (4), p.3866-3872
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Metformin reverses multidrug resistance in human hepatocellular carcinoma Bel-7402/5-fluorouracil cells
Author / Creator:LING, SUNBIN ; TIAN, YU ; ZHANG, HAIQUAN ; JIA, KAIQI ; FENG, TINGTING ; SUN, DEGUANG ; GAO, ZHENMING ; XU, FEI ; HOU, ZHAOYUAN ; LI, YAN ; WANG, LIMING
Publisher:Greece: D.A. Spandidos
Journal title:Molecular medicine reports, 2014-12, Vol.10 (6), p.2891-2897
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ArticlesPeer ReviewedFull Text
Unlocking the potential of antibody–drug conjugates for cancer therapy
Author / Creator:Drago, Joshua Z. ; Modi, Shanu ; Chandarlapaty, Sarat
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Clinical oncology, 2021-06, Vol.18 (6), p.327-344
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ArticlesPeer ReviewedFull Text
Treatment of relapsed and refractory multiple myeloma: recommendations from the International Myeloma Working Group
Author / Creator:Moreau, Philippe, Prof ; Kumar, Shaji K, Prof ; San Miguel, Jesús, Prof ; Davies, Faith, MD ; Zamagni, Elena, MD ; Bahlis, Nizar, MD ; Ludwig, Heinz, Prof ; Mikhael, Joseph, Prof ; Terpos, Evangelos, Prof ; Schjesvold, Fredrik, MD ; Martin, Thomas, Prof ; Yong, Kwee, Prof ; Durie, Brian G M, MD ; Facon, Thierry, Prof ; Jurczyszyn, Artur, Prof ; Sidana, Surbhi, MD ; Raje, Noopur, Prof ; van de Donk, Niels, Prof ; Lonial, Sagar, Prof ; Cavo, Michele, Prof ; Kristinsson, Sigurdur Y, Prof ; Lentzsch, Suzanne, Prof ; Hajek, Roman, Prof ; Anderson, Kenneth C, Prof ; João, Cristina, Prof ; Einsele, Hermann, Prof ; Sonneveld, Pieter, Prof ; Engelhardt, Monika, Prof ; Fonseca, Rafael, Prof ; Vangsted, Annette, MD ; Weisel, Katja, Prof ; Baz, Rachid, MD ; Hungria, Vania, MD ; Berdeja, Jesus G, MD ; Leal da Costa, Fernando, MD ; Maiolino, Angelo, Prof ; Waage, Anders, Prof ; Vesole, David H, Prof ; Ocio, Enrique M, MD ; Quach, Hang, Prof ; Driessen, Christoph, Prof ; Bladé, Joan, Prof ; Leleu, Xavier, Prof ; Riva, Eloisa, MD ; Bergsagel, Peter Leif, Prof ; Hou, Jian, Prof ; Chng, Wee Joo, Prof ; Mellqvist, Ulf-Henrik, MD ; Dytfeld, Dominik, MD ; Harousseau, Jean-Luc, Prof ; Goldschmidt, Hartmut, Prof ; Laubach, Jacob, MD ; Munshi, Nikhil C, Prof ; Gay, Francesca, Prof ; Beksac, Meral, Prof ; Costa, Luciano J, MD ; Kaiser, Martin, MD ; Hari, Parameswaran, Prof ; Boccadoro, Mario, Prof ; Usmani, Saad Z, Prof ; Zweegman, Sonja, Prof ; Holstein, Sarah, MD ; Sezer, Orhan, Prof ; Harrison, Simon, Prof ; Nahi, Hareth, MD ; Cook, Gordon, Prof ; Mateos, Maria-Victoria, MD ; Rajkumar, S Vincent, Prof ; Dimopoulos, Meletios A, MD ; Richardson, Paul G, Prof
Publisher:England: Elsevier Ltd
Journal title:The lancet oncology, 2021-03, Vol.22 (3), p.e105-e118
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ArticlesPeer ReviewedFull Text
HER2-targeted therapies — a role beyond breast cancer
Author / Creator:Oh, Do-Youn ; Bang, Yung-Jue
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Clinical oncology, 2020-01, Vol.17 (1), p.33-48
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Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition
Author / Creator:Hangauer, Matthew J. ; Viswanathan, Vasanthi S. ; Ryan, Matthew J. ; Bole, Dhruv ; Eaton, John K. ; Matov, Alexandre ; Galeas, Jacqueline ; Dhruv, Harshil D. ; Berens, Michael E. ; Schreiber, Stuart L. ; McCormick, Frank ; McManus, Michael T.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2017-11, Vol.551 (7679), p.247-250
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ArticlesPeer ReviewedFull Text
Understanding and overcoming resistance to PARP inhibitors in cancer therapy
Author / Creator:Dias, Mariana Paes ; Moser, Sarah C. ; Ganesan, Shridar ; Jonkers, Jos
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Clinical oncology, 2021-12, Vol.18 (12), p.773-791
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ArticlesPeer ReviewedFull Text
Biologically informed deep neural network for prostate cancer discovery
Author / Creator:Elmarakeby, Haitham A. ; Hwang, Justin ; Arafeh, Rand ; Crowdis, Jett ; Gang, Sydney ; Liu, David ; AlDubayan, Saud H. ; Salari, Keyan ; Kregel, Steven ; Richter, Camden ; Arnoff, Taylor E. ; Park, Jihye ; Hahn, William C. ; Van Allen, Eliezer M.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2021-10, Vol.598 (7880), p.348-352
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Mechanisms of Multidrug Resistance in Cancer Chemotherapy
Author / Creator:Bukowski, Karol ; Kciuk, Mateusz ; Kontek, Renata
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2020-05, Vol.21 (9), p.3233
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Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells
Author / Creator:De Henau, Olivier ; Rausch, Matthew ; Winkler, David ; Campesato, Luis Felipe ; Liu, Cailian ; Cymerman, Daniel Hirschhorn ; Budhu, Sadna ; Ghosh, Arnab ; Pink, Melissa ; Tchaicha, Jeremy ; Douglas, Mark ; Tibbitts, Thomas ; Sharma, Sujata ; Proctor, Jennifer ; Kosmider, Nicole ; White, Kerry ; Stern, Howard ; Soglia, John ; Adams, Julian ; Palombella, Vito J. ; McGovern, Karen ; Kutok, Jeffery L. ; Wolchok, Jedd D. ; Merghoub, Taha
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2016-11, Vol.539 (7629), p.443-447
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ArticlesPeer ReviewedFull Text
Chemoresistance in Pancreatic Cancer
Author / Creator:Zeng, Siyuan ; Pöttler, Marina ; Lan, Bin ; Grützmann, Robert ; Pilarsky, Christian ; Yang, Hai
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2019-09, Vol.20 (18), p.4504
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Dual-targeted therapy with trastuzumab and lapatinib in treatment-refractory, KRAS codon 12/13 wild-type, HER2-positive metastatic colorectal cancer (HERACLES): a proof-of-concept, multicentre, open-l...
Author / Creator:Sartore-Bianchi, Andrea, MD ; Trusolino, Livio, MD ; Martino, Cosimo, PhD ; Bencardino, Katia, MD ; Lonardi, Sara, MD ; Bergamo, Francesca, MD ; Zagonel, Vittorina, MD ; Leone, Francesco, MD ; Depetris, Ilaria, MD ; Martinelli, Erika, MD ; Troiani, Teresa, MD ; Ciardiello, Fortunato, Prof ; Racca, Patrizia, MD ; Bertotti, Andrea, MD ; Siravegna, Giulia, MSc ; Torri, Valter, MD ; Amatu, Alessio, MD ; Ghezzi, Silvia, MSc ; Marrapese, Giovanna, PhD ; Palmeri, Laura, MD ; Valtorta, Emanuele, PhD ; Cassingena, Andrea, MSc ; Lauricella, Calogero, PhD ; Vanzulli, Angelo, MD ; Regge, Daniele, MD ; Veronese, Silvio, MSc ; Comoglio, Paolo M, Prof ; Bardelli, Alberto, PhD ; Marsoni, Silvia, Dr ; Siena, Salvatore, Prof
Publisher:England: Elsevier Ltd
Journal title:The lancet oncology, 2016-06, Vol.17 (6), p.738-746
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Resistance to Anti-Angiogenic Therapy in Cancer-Alterations to Anti-VEGF Pathway
Author / Creator:Itatani, Yoshiro ; Kawada, Kenji ; Yamamoto, Takamasa ; Sakai, Yoshiharu
Publisher:Switzerland: MDPI
Journal title:International journal of molecular sciences, 2018-04, Vol.19 (4), p.1232
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ArticlesPeer ReviewedFull Text
Targeting Molecular Mechanisms Underlying Treatment Efficacy and Resistance in Osteosarcoma: A Review of Current and Future Strategies
Author / Creator:Lilienthal, Ingrid ; Herold, Nikolas
Publisher:Switzerland: MDPI
Journal title:International journal of molecular sciences, 2020-09, Vol.21 (18), p.6885
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State-of-the-art strategies for targeting the DNA damage response in cancer
Author / Creator:Pilié, Patrick G. ; Tang, Chad ; Mills, Gordon B. ; Yap, Timothy A.
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Clinical oncology, 2019-02, Vol.16 (2), p.81-104
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Showing 1 to 20 of 4,454 results

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Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation

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COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

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SBI0206965, a novel inhibitor of Ulk1, suppresses non-small cell lung cancer cell growth by modulating both autophagy and apoptosis pathways

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Vemurafenib resistance reprograms melanoma cells towards glutamine dependence

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Dopamine D2 receptor antagonist sulpiride enhances dexamethasone responses in the treatment of drug- resistant and metastatic breast cancer

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Metformin reverses stem cell‑like HepG2 sphere formation and resistance to sorafenib by attenuating epithelial‑mesenchymal transformation

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Metformin reverses multidrug resistance in human hepatocellular carcinoma Bel-7402/5-fluorouracil cells

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Unlocking the potential of antibody–drug conjugates for cancer therapy

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Treatment of relapsed and refractory multiple myeloma: recommendations from the International Myeloma Working Group

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HER2-targeted therapies — a role beyond breast cancer

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Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

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Understanding and overcoming resistance to PARP inhibitors in cancer therapy

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Biologically informed deep neural network for prostate cancer discovery

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Mechanisms of Multidrug Resistance in Cancer Chemotherapy

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Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells

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Chemoresistance in Pancreatic Cancer

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Dual-targeted therapy with trastuzumab and lapatinib in treatment-refractory, KRAS codon 12/13 wild-type, HER2-positive metastatic colorectal cancer (HERACLES): a proof-of-concept, multicentre, open-l...

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Resistance to Anti-Angiogenic Therapy in Cancer-Alterations to Anti-VEGF Pathway

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Targeting Molecular Mechanisms Underlying Treatment Efficacy and Resistance in Osteosarcoma: A Review of Current and Future Strategies

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State-of-the-art strategies for targeting the DNA damage response in cancer

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