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ArticlesPeer ReviewedFull Text
The Genetic Evolution of Melanoma from Precursor Lesions
Author / Creator:Shain, A. Hunter ; Yeh, Iwei ; Kovalyshyn, Ivanka ; Sriharan, Aravindhan ; Talevich, Eric ; Gagnon, Alexander ; Dummer, Reinhard ; North, Jeffrey ; Pincus, Laura ; Ruben, Beth ; Rickaby, William ; D’Arrigo, Corrado ; Robson, Alistair ; Bastian, Boris C
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2015-11, Vol.373 (20), p.1926-1936
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High-dimensional single-cell analysis predicts response to anti-PD-1 immunotherapy
Author / Creator:Krieg, Carsten ; Nowicka, Malgorzata ; Guglietta, Silvia ; Schindler, Sabrina ; Hartmann, Felix J ; Weber, Lukas M ; Dummer, Reinhard ; Robinson, Mark D ; Levesque, Mitchell P ; Becher, Burkhard
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2018-02, Vol.24 (2), p.144-153
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Nivolumab plus ipilimumab or nivolumab alone versus ipilimumab alone in advanced melanoma (CheckMate 067): 4-year outcomes of a multicentre, randomised, phase 3 trial
Author / Creator:Hodi, Frank Stephen, MD ; Chiarion-Sileni, Vanna, MD ; Gonzalez, Rene, Prof ; Grob, Jean-Jacques, Prof ; Rutkowski, Piotr, Prof ; Cowey, Charles Lance, MD ; Lao, Christopher D, MD ; Schadendorf, Dirk, Prof ; Wagstaff, John, Prof ; Dummer, Reinhard, MD ; Ferrucci, Pier Francesco, MD ; Smylie, Michael, MD ; Hill, Andrew, MD ; Hogg, David, MD ; Marquez-Rodas, Ivan, Prof ; Jiang, Joel, PhD ; Rizzo, Jasmine, MD ; Larkin, James, FRCP ; Wolchok, Jedd D, Prof
Publisher:England: Elsevier Ltd
Journal title:The lancet oncology, 2018-11, Vol.19 (11), p.1480-1492
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Epacadostat plus pembrolizumab versus placebo plus pembrolizumab in patients with unresectable or metastatic melanoma (ECHO-301/KEYNOTE-252): a phase 3, randomised, double-blind study
Author / Creator:Long, Georgina V, Prof ; Dummer, Reinhard, Prof ; Hamid, Omid, MD ; Gajewski, Thomas F, Prof ; Caglevic, Christian, MD ; Dalle, Stephane, Prof ; Arance, Ana, MD ; Carlino, Matteo S, PhD ; Grob, Jean-Jacques, Prof ; Kim, Tae Min, Prof ; Demidov, Lev, Prof ; Robert, Caroline, Prof ; Larkin, James, Prof ; Anderson, James R, PhD ; Maleski, Janet, BSN ; Jones, Mark, MD ; Diede, Scott J, MD ; Mitchell, Tara C, MD
Publisher:England: Elsevier Ltd
Journal title:The lancet oncology, 2019-08, Vol.20 (8), p.1083-1097
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Ultraviolet A and Photosensitivity during Vemurafenib Therapy
Author / Creator:Dummer, Reinhard ; Rinderknecht, Jeannine ; Goldinger, Simone M
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2012-02, Vol.366 (5), p.480-481
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Adjuvant Dabrafenib plus Trametinib in Stage III BRAF-Mutated Melanoma
Author / Creator:Long, Georgina V ; Hauschild, Axel ; Santinami, Mario ; Atkinson, Victoria ; Mandalà, Mario ; Chiarion-Sileni, Vanna ; Larkin, James ; Nyakas, Marta ; Dutriaux, Caroline ; Haydon, Andrew ; Robert, Caroline ; Mortier, Laurent ; Schachter, Jacob ; Schadendorf, Dirk ; Lesimple, Thierry ; Plummer, Ruth ; Ji, Ran ; Zhang, Pingkuan ; Mookerjee, Bijoyesh ; Legos, Jeff ; Kefford, Richard ; Dummer, Reinhard ; Kirkwood, John M
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2017-11, Vol.377 (19), p.1813-1823
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Improved Overall Survival in Melanoma with Combined Dabrafenib and Trametinib
Author / Creator:Robert, Caroline ; Karaszewska, Boguslawa ; Schachter, Jacob ; Rutkowski, Piotr ; Mackiewicz, Andrzej ; Stroiakovski, Daniil ; Lichinitser, Michael ; Dummer, Reinhard ; Grange, Florent ; Mortier, Laurent ; Chiarion-Sileni, Vanna ; Drucis, Kamil ; Krajsova, Ivana ; Hauschild, Axel ; Lorigan, Paul ; Wolter, Pascal ; Long, Georgina V ; Flaherty, Keith ; Nathan, Paul ; Ribas, Antoni ; Martin, Anne-Marie ; Sun, Peng ; Crist, Wendy ; Legos, Jeff ; Rubin, Stephen D ; Little, Shonda M ; Schadendorf, Dirk
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2015-01, Vol.372 (1), p.30-39
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Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma
Author / Creator:Larkin, James ; Chiarion-Sileni, Vanna ; Gonzalez, Rene ; Grob, Jean Jacques ; Cowey, C. Lance ; Lao, Christopher D ; Schadendorf, Dirk ; Dummer, Reinhard ; Smylie, Michael ; Rutkowski, Piotr ; Ferrucci, Pier F ; Hill, Andrew ; Wagstaff, John ; Carlino, Matteo S ; Haanen, John B ; Maio, Michele ; Marquez-Rodas, Ivan ; McArthur, Grant A ; Ascierto, Paolo A ; Long, Georgina V ; Callahan, Margaret K ; Postow, Michael A ; Grossmann, Kenneth ; Sznol, Mario ; Dreno, Brigitte ; Bastholt, Lars ; Yang, Arvin ; Rollin, Linda M ; Horak, Christine ; Hodi, F. Stephen ; Wolchok, Jedd D
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2015-07, Vol.373 (1), p.23-34
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Genomic correlates of response to CTLA-4 blockade in metastatic melanoma
Author / Creator:Van Allen, Eliezer M. ; Miao, Diana ; Schilling, Bastian ; Shukla, Sachet A. ; Blank, Christian ; Zimmer, Lisa ; Sucker, Antje ; Hillen, Uwe ; Foppen, Marnix H. Geukes ; Goldinger, Simone M. ; Utikal, Jochen ; Hassel, Jessica C. ; Weide, Benjamin ; Kaehler, Katharina C. ; Loquai, Carmen ; Mohr, Peter ; Gutzmer, Ralf ; Dummer, Reinhard ; Gabriel, Stacey ; Wu, Catherine J. ; Schadendorf, Dirk ; Garraway, Levi A.
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2015-10, Vol.350 (6257), p.207-211
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The role of triple therapy and therapy sequence in treatment of BRAF-mutant metastatic melanoma. Response to overall survival with first-line atezolizumab in combination with vemurafenib and cobimetin...
Author / Creator:Dummer, Reinhard ; Welti, Michèle ; Ramelyte, Egle
Publisher:England: BioMed Central Ltd
Journal title:Journal of translational medicine, 2023-08, Vol.21 (1), p.529-529, Article 529
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Improved Survival with MEK Inhibition in BRAF-Mutated Melanoma
Author / Creator:Flaherty, Keith T ; Robert, Caroline ; Hersey, Peter ; Nathan, Paul ; Garbe, Claus ; Milhem, Mohammed ; Demidov, Lev V ; Hassel, Jessica C ; Rutkowski, Piotr ; Mohr, Peter ; Dummer, Reinhard ; Trefzer, Uwe ; Larkin, James M.G ; Utikal, Jochen ; Dreno, Brigitte ; Nyakas, Marta ; Middleton, Mark R ; Becker, Jürgen C ; Casey, Michelle ; Sherman, Laurie J ; Wu, Frank S ; Ouellet, Daniele ; Martin, Anne-Marie ; Patel, Kiran ; Schadendorf, Dirk
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2012-07, Vol.367 (2), p.107-114
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The World of Melanoma: Epidemiologic, Genetic, and Anatomic Differences of Melanoma Across the Globe
Author / Creator:Dimitriou, Florentia ; Krattinger, Regina ; Ramelyte, Egle ; Barysch, Marjam J. ; Micaletto, Sara ; Dummer, Reinhard ; Goldinger, Simone M.
Publisher:New York: Springer US
Journal title:Current oncology reports, 2018-11, Vol.20 (11), p.87-9, Article 87
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Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): a randomised, controlled, phase 2 trial
Author / Creator:Ribas, Antoni, Prof ; Puzanov, Igor, MD ; Dummer, Reinhard, Prof ; Schadendorf, Dirk, Prof ; Hamid, Omid, MD ; Robert, Caroline, Prof ; Hodi, F Stephen, MD ; Schachter, Jacob, Prof ; Pavlick, Anna C, MD ; Lewis, Karl D, MD ; Cranmer, Lee D, MD ; Blank, Christian U, MD ; O'Day, Steven J, MD ; Ascierto, Paolo A, Prof ; Salama, April K S, MD ; Margolin, Kim A, Prof ; Loquai, Carmen, MD ; Eigentler, Thomas K, MD ; Gangadhar, Tara C, MD ; Carlino, Matteo S, MBBS ; Agarwala, Sanjiv S, Prof ; Moschos, Stergios J, MD ; Sosman, Jeffrey A, Prof ; Goldinger, Simone M, MD ; Shapira-Frommer, Ronnie, MD ; Gonzalez, Rene, Prof ; Kirkwood, John M, Prof ; Wolchok, Jedd D, Prof ; Eggermont, Alexander, Prof ; Li, Xiaoyun Nicole, PhD ; Zhou, Wei, PhD ; Zernhelt, Adriane M, BS ; Lis, Joy, BSN ; Ebbinghaus, Scot, MD ; Kang, S Peter, MD ; Daud, Adil, Prof
Publisher:England: Elsevier Ltd
Journal title:The lancet oncology, 2015-08, Vol.16 (8), p.908-918
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Cemiplimab in locally advanced basal cell carcinoma after hedgehog inhibitor therapy: an open-label, multi-centre, single-arm, phase 2 trial
Author / Creator:Stratigos, Alexander J, Prof ; Sekulic, Aleksandar, Prof ; Peris, Ketty, Prof ; Bechter, Oliver, Prof ; Prey, Sorilla, MD ; Kaatz, Martin, MD ; Lewis, Karl D, Prof ; Basset-Seguin, Nicole, Prof ; Chang, Anne Lynn S, Prof ; Dalle, Stèphane, Prof ; Orland, Almudena Fernandez, MD ; Licitra, Lisa, MD ; Robert, Caroline, MD ; Ulrich, Claas, MD ; Hauschild, Axel, Prof ; Migden, Michael R, Prof ; Dummer, Reinhard, Prof ; Li, Siyu, PhD ; Yoo, Suk-Young, PhD ; Mohan, Kosalai, PhD ; Coates, Ebony, MHA ; Jankovic, Vladimir, MD ; Fiaschi, Nathalie, PhD ; Okoye, Emmanuel, MBBS ; Bassukas, Ioannis D, Prof ; Loquai, Carmen, MD ; De Giorgi, Vincenzo, MD ; Eroglu, Zeynep, MD ; Gutzmer, Ralf, Prof ; Ulrich, Jens, Prof ; Puig, Susana, MD ; Seebach, Frank, MD ; Thurston, Gavin, PhD ; Weinreich, David M, MD ; Yancopoulos, George D, MD ; Lowy, Israel, MD ; Bowler, Timothy, MD ; Fury, Matthew G, MD
Publisher:England: Elsevier Ltd
Journal title:The lancet oncology, 2021-06, Vol.22 (6), p.848-857
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Adjuvant ipilimumab versus placebo after complete resection of high-risk stage III melanoma (EORTC 18071): a randomised, double-blind, phase 3 trial
Author / Creator:Eggermont, Alexander M M, Prof ; Chiarion-Sileni, Vanna, MD ; Grob, Jean-Jacques, Prof ; Dummer, Reinhard, Prof ; Wolchok, Jedd D, MD ; Schmidt, Henrik, MD ; Hamid, Omid, MD ; Robert, Caroline, Prof ; Ascierto, Paolo A, Prof ; Richards, Jon M, MD ; Lebbé, Céleste, Prof ; Ferraresi, Virginia, MD ; Smylie, Michael, MD ; Weber, Jeffrey S, MD ; Maio, Michele, MD ; Konto, Cyril, MD ; Hoos, Axel, MD ; de Pril, Veerle, MSc ; Gurunath, Ravichandra Karra, MD ; de Schaetzen, Gaetan, PhD ; Suciu, Stefan, PhD ; Testori, Alessandro, MD
Publisher:England: Elsevier Ltd
Journal title:The lancet oncology, 2015-05, Vol.16 (5), p.522-530
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Binimetinib versus dacarbazine in patients with advanced NRAS-mutant melanoma (NEMO): a multicentre, open-label, randomised, phase 3 trial
Author / Creator:Dummer, Reinhard, Prof ; Schadendorf, Dirk, Prof ; Ascierto, Paolo A, MD ; Arance, Ana, MD ; Dutriaux, Caroline, MD ; Di Giacomo, Anna Maria, MD ; Rutkowski, Piotr, Prof ; Del Vecchio, Michele, MD ; Gutzmer, Ralf, Prof ; Mandala, Mario, MD ; Thomas, Luc, Prof ; Demidov, Lev, Prof ; Garbe, Claus, Prof ; Hogg, David, MD ; Liszkay, Gabriella, Prof ; Queirolo, Paola, MD ; Wasserman, Ernesto, MD ; Ford, James, MS ; Weill, Marine, MSc ; Sirulnik, L Andres, MD ; Jehl, Valentine, MSc ; Bozón, Viviana, MD ; Long, Georgina V, Prof ; Flaherty, Keith, MD
Publisher:England: Elsevier Ltd
Journal title:The lancet oncology, 2017-04, Vol.18 (4), p.435-445
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Pembrolizumab versus placebo as adjuvant therapy in resected stage IIB or IIC melanoma (KEYNOTE-716): distant metastasis-free survival results of a multicentre, double-blind, randomised, phase 3 trial
Author / Creator:Long, Georgina V, Prof ; Luke, Jason J, MD ; Khattak, Muhammad A, Prof ; de la Cruz Merino, Luis, MD ; Del Vecchio, Michele, MD ; Rutkowski, Piotr, Prof ; Spagnolo, Francesco, MD ; Mackiewicz, Jacek, Prof ; Chiarion-Sileni, Vanna, MD ; Kirkwood, John M, MD ; Robert, Caroline, MD ; Grob, Jean-Jacques, Prof ; de Galitiis, Federica, MD ; Schadendorf, Dirk, Prof ; Carlino, Matteo S, MD ; Mohr, Peter, MD ; Dummer, Reinhard, MD ; Gershenwald, Jeffrey E, MD ; Yoon, Charles H, MD ; Wu, Xi Lawrence, DrPH ; Fukunaga-Kalabis, Mizuho, MD ; Krepler, Clemens, MD ; Eggermont, Alexander M M, Prof ; Ascierto, Paolo A, MD
Publisher:England: Elsevier Ltd
Journal title:The lancet oncology, 2022-11, Vol.23 (11), p.1378-1388
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Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation
Author / Creator:Chapman, Paul B ; Hauschild, Axel ; Robert, Caroline ; Haanen, John B ; Ascierto, Paolo ; Larkin, James ; Dummer, Reinhard ; Garbe, Claus ; Testori, Alessandro ; Maio, Michele ; Hogg, David ; Lorigan, Paul ; Lebbe, Celeste ; Jouary, Thomas ; Schadendorf, Dirk ; Ribas, Antoni ; O'Day, Steven J ; Sosman, Jeffrey A ; Kirkwood, John M ; Eggermont, Alexander M.M ; Dreno, Brigitte ; Nolop, Keith ; Li, Jiang ; Nelson, Betty ; Hou, Jeannie ; Lee, Richard J ; Flaherty, Keith T ; McArthur, and Grant A
Publisher:Waltham, MA: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2011-06, Vol.364 (26), p.2507-2516
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Safety and efficacy of vemurafenib in BRAFV600E and BRAFV600K mutation-positive melanoma (BRIM-3): extended follow-up of a phase 3, randomised, open-label study
Author / Creator:McArthur, Grant A, Prof ; Chapman, Paul B, Prof ; Robert, Caroline, MD ; Larkin, James, MD ; Haanen, John B, MD ; Dummer, Reinhard, Prof ; Ribas, Antoni, Prof ; Hogg, David, Prof ; Hamid, Omid, MD ; Ascierto, Paolo A, MD ; Garbe, Claus, Prof ; Testori, Alessandro, MD ; Maio, Michele, MD ; Lorigan, Paul, MD ; Lebbé, Celeste, Prof ; Jouary, Thomas, MD ; Schadendorf, Dirk, Prof ; O'Day, Stephen J, MD ; Kirkwood, John M., Prof ; Eggermont, Alexander M, Prof ; Dréno, Brigitte, Prof ; Sosman, Jeffrey A, Prof ; Flaherty, Keith T, MD ; Yin, Ming, PhD ; Caro, Ivor, MD ; Cheng, Suzanne, PhD ; Trunzer, Kerstin, PhD ; Hauschild, Axel, Prof
Publisher:London: Elsevier Ltd
Journal title:The lancet oncology, 2014-03, Vol.15 (3), p.323-332
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Epigenetic control of melanoma cell invasiveness by the stem cell factor SALL4
Author / Creator:Diener, Johanna ; Baggiolini, Arianna ; Pernebrink, Mattias ; Dalcher, Damian ; Lerra, Luigi ; Cheng, Phil F. ; Varum, Sandra ; Häusel, Jessica ; Stierli, Salome ; Treier, Mathias ; Studer, Lorenz ; Basler, Konrad ; Levesque, Mitchell P. ; Dummer, Reinhard ; Santoro, Raffaella ; Cantù, Claudio ; Sommer, Lukas
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-08, Vol.12 (1), p.5056-18, Article 5056
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Showing 1 to 20 of 308 results

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The Genetic Evolution of Melanoma from Precursor Lesions

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High-dimensional single-cell analysis predicts response to anti-PD-1 immunotherapy

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Nivolumab plus ipilimumab or nivolumab alone versus ipilimumab alone in advanced melanoma (CheckMate 067): 4-year outcomes of a multicentre, randomised, phase 3 trial

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Epacadostat plus pembrolizumab versus placebo plus pembrolizumab in patients with unresectable or metastatic melanoma (ECHO-301/KEYNOTE-252): a phase 3, randomised, double-blind study

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Ultraviolet A and Photosensitivity during Vemurafenib Therapy

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Adjuvant Dabrafenib plus Trametinib in Stage III BRAF-Mutated Melanoma

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Improved Overall Survival in Melanoma with Combined Dabrafenib and Trametinib

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Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma

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Genomic correlates of response to CTLA-4 blockade in metastatic melanoma

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The role of triple therapy and therapy sequence in treatment of BRAF-mutant metastatic melanoma. Response to overall survival with first-line atezolizumab in combination with vemurafenib and cobimetin...

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Improved Survival with MEK Inhibition in BRAF-Mutated Melanoma

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The World of Melanoma: Epidemiologic, Genetic, and Anatomic Differences of Melanoma Across the Globe

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Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): a randomised, controlled, phase 2 trial

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Cemiplimab in locally advanced basal cell carcinoma after hedgehog inhibitor therapy: an open-label, multi-centre, single-arm, phase 2 trial

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Adjuvant ipilimumab versus placebo after complete resection of high-risk stage III melanoma (EORTC 18071): a randomised, double-blind, phase 3 trial

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Binimetinib versus dacarbazine in patients with advanced NRAS-mutant melanoma (NEMO): a multicentre, open-label, randomised, phase 3 trial

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Pembrolizumab versus placebo as adjuvant therapy in resected stage IIB or IIC melanoma (KEYNOTE-716): distant metastasis-free survival results of a multicentre, double-blind, randomised, phase 3 trial

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Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation

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Safety and efficacy of vemurafenib in BRAFV600E and BRAFV600K mutation-positive melanoma (BRIM-3): extended follow-up of a phase 3, randomised, open-label study

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Epigenetic control of melanoma cell invasiveness by the stem cell factor SALL4

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