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EZH2 inhibitor tazemetostat in patients with relapsed or refractory, BAP1-inactivated malignant pleural mesothelioma: a multicentre, open-label, phase 2 study
Author / Creator:Zauderer, Marjorie G, MD ; Szlosarek, Peter W, Prof ; Le Moulec, Sylvestre, MD ; Popat, Sanjay, Prof ; Taylor, Paul, MBChB ; Planchard, David, MD ; Scherpereel, Arnaud, Prof ; Koczywas, Marianna, MD ; Forster, Martin, MD ; Cameron, Robert B, Prof ; Peikert, Tobias, MD ; Argon, Evren Kocabaş, DVM ; Michaud, Neil R, PhD ; Szanto, Attila, MD ; Yang, Jay, PhD ; Chen, Yingxue, PhD ; Kansra, Vikram, PhD ; Agarwal, Shefali, MD ; Fennell, Dean A, Prof
Publisher:England: Elsevier Ltd
Journal title:The lancet oncology, 2022-06, Vol.23 (6), p.758-767
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Tazemetostat, an EZH2 inhibitor, in relapsed or refractory B-cell non-Hodgkin lymphoma and advanced solid tumours: a first-in-human, open-label, phase 1 study
Author / Creator:Italiano, Antoine ; Soria, Jean-Charles ; Toulmonde, Maud ; Michot, Jean-Marie ; Lucchesi, Carlo ; Varga, Andrea ; Coindre, Jean-Michel ; Blakemore, Stephen J ; Clawson, Alicia ; Suttle, Benjamin ; McDonald, Alice A ; Woodruff, Mark ; Ribich, Scott ; Hedrick, Eric ; Keilhack, Heike ; Thomson, Blythe ; Owa, Takashi ; Copeland, Robert A ; Ho, Peter T C ; Ribrag, Vincent
Publisher:England: Elsevier Ltd
Journal title:The lancet oncology, 2018-05, Vol.19 (5), p.649-659
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The EZH2 inhibitor tazemetostat upregulates the expression of CCL17/TARC in B‐cell lymphoma and enhances T‐cell recruitment
Author / Creator:Yuan, Hepei ; Nishikori, Momoko ; Otsuka, Yasuyuki ; Arima, Hiroshi ; Kitawaki, Toshio ; Takaori‐Kondo, Akifumi
Publisher:Tokyo: John Wiley & Sons, Inc
Journal title:Cancer science, 2021-11, Vol.112 (11), p.4604-4616
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PRC2-mediated repression of SMARCA2 predicts EZH2 inhibitor activity in SWI/SNF mutant tumors
Author / Creator:Januario, Thomas ; Ye, Xiaofen ; Bainer, Russell ; Alicke, Bruno ; Smith, Tunde ; Haley, Benjamin ; Modrusan, Zora ; Gould, Stephen ; Yauch, Robert L.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2017-11, Vol.114 (46), p.12249-12254
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(−)‐Epigallocatechin‐3‐gallate and EZH2 inhibitor GSK343 have similar inhibitory effects and mechanisms of action on colorectal cancer cells
Author / Creator:Ying, Le ; Yan, Feng ; Williams, Bryan RG ; Xu, Ping ; Li, Xin ; Zhao, Yueling ; Hu, Yiqun ; Wang, Yuefei ; Xu, Dakang ; Dai, Jing
Publisher:Australia: Wiley Subscription Services, Inc
Journal title:Clinical and experimental pharmacology & physiology, 2018-01, Vol.45 (1), p.58-67
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EZH2 inhibitor GSK343 inhibits sepsis‑induced intestinal disorders
Author / Creator:Yue, Dongyou ; Wang, Zhiying ; Yang, Yongan ; Hu, Zhenjun ; Luo, Ganping ; Wang, Fu
Publisher:Greece: Spandidos Publications
Journal title:Experimental and therapeutic medicine, 2021-05, Vol.21 (5), p.437-437, Article 437
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The Role of EZH2 Inhibitor, GSK-126, in Seizure Susceptibility
Author / Creator:Wang, Zhongcheng ; Su, Yaxin ; Zhuang, Dezheng ; Lan, Ting
Publisher:New York: Springer US
Journal title:Journal of molecular neuroscience, 2021-03, Vol.71 (3), p.556-564
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Study on the Effect of EZH2 Inhibitor Combined with TIGIT Monoclonal Antibody against Multiple Myeloma Cells
Author / Creator:Liu, Zhaoyun ; Jia, Yue ; Yang, Chun ; Liu, Hui ; Shen, Hongli ; Wang, Hao ; Fu, Rong
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2023-05, Vol.24 (10), p.8603
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Tanshinone I, a new EZH2 inhibitor restricts normal and malignant hematopoiesis through upregulation of MMP9 and ABCG2
Author / Creator:Huang, Ying ; Yu, Shan-He ; Zhen, Wen-Xuan ; Cheng, Tao ; Wang, Dan ; Lin, Jie-Bo ; Wu, Yu-Han ; Wang, Yi-Fan ; Chen, Yi ; Shu, Li-Ping ; Wang, Yi ; Sun, Xiao-Jian ; Zhou, Yi ; Yang, Fan ; Hsu, Chih-Hung ; Xu, Peng-Fei
Publisher:Wyoming: Ivyspring International Publisher Pty Ltd
Journal title:Theranostics, 2021-01, Vol.11 (14), p.6891-6904
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The novel EZH2 inhibitor, GSK126, suppresses cell migration and angiogenesis via down-regulating VEGF-A
Author / Creator:Chen, Ya-Tian ; Zhu, Feng ; Lin, Wei-Ren ; Ying, Rong-Biao ; Yang, You-Ping ; Zeng, Ling-Hui
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Cancer chemotherapy and pharmacology, 2016-04, Vol.77 (4), p.757-765
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Overcoming EZH2 Inhibitor Resistance by Taxane in PTEN-Mutated Cancer
Author / Creator:Ma, Linlin ; Yan, Yuqian ; Bai, Yang ; Yang, Yinhui ; Pan, Yunqian ; Gang, Xiaokun ; Karnes, R. Jeffrey ; Zhang, Jun ; Lv, Qiubo ; Wu, Qiang ; Huang, Haojie
Publisher:Australia: Ivyspring International Publisher Pty Ltd
Journal title:Theranostics, 2019-01, Vol.9 (17), p.5020-5034
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Hypoxia makes EZH2 inhibitor not easy—advances of crosstalk between HIF and EZH2
Author / Creator:Huang, Zhanya ; Tang, Yuanjun ; Zhang, Jianlin ; Huang, Jiaqi ; Cheng, Rui ; Guo, Yunyun ; Kleer, Celina G ; Wang, Yuqing ; Xue, Lixiang
Publisher:UK: Oxford University Press
Journal title:Life metabolism, 2024-08, Vol.3 (4)
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Evaluation of an EZH2 inhibitor in patient-derived orthotopic xenograft models of pediatric brain tumors alone and in combination with chemo- and radiation therapies
Author / Creator:Qi, Lin ; Lindsay, Holly ; Kogiso, Mari ; Du, Yuchen ; Braun, Frank K. ; Zhang, Huiyuan ; Guo, Lei ; Zhao, Sibo ; Injac, Sarah G. ; Baxter, Patricia A. ; Su, Jack MF ; Xiao, Sophie ; Erickson, Stephen W. ; Earley, Eric J. ; Teicher, Beverly ; Smith, Malcolm A. ; Li, Xiao-Nan
Publisher:New York: Elsevier Inc
Journal title:Laboratory investigation, 2022-02, Vol.102 (2), p.185-193
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EZH2 inhibitor Tazemetostat synergizes with JQ-1 in esophageal cancer by inhibiting c-Myc signaling pathway
Author / Creator:Ding, Nan ; You, Abin ; Zhao, Senxia ; Yang, Hu ; Lai, Chunping ; Ye, Feng
Publisher:New York: Springer US
Journal title:Medical oncology (Northwood, London, England), 2023-08, Vol.40 (10), p.281-281, Article 281
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Selective EZH2 inhibitor zld1039 alleviates inflammation in cisplatin-induced acute kidney injury partially by enhancing RKIP and suppressing NF-κB p65 pathway
Author / Creator:Wen, Li ; Tao, Shao-hua ; Guo, Fan ; Li, Ling-zhi ; Yang, Hong-liu ; Liang, Yan ; Zhang, Li-dan ; Ma, Liang ; Fu, Ping
Publisher:Singapore: Springer Nature Singapore
Journal title:Acta pharmacologica Sinica, 2022-08, Vol.43 (8), p.2067-2080
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Convection-Enhanced Delivery of Enhancer of Zeste Homolog-2 (EZH2) Inhibitor for the Treatment of Diffuse Intrinsic Pontine Glioma
Author / Creator:Sasaki, Takahiro ; Katagi, Hiroaki ; Goldman, Stewart ; Becher, Oren J ; Hashizume, Rintaro
Publisher:United States: Oxford University Press
Journal title:Neurosurgery, 2020-12, Vol.87 (6), p.E680-E688
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Combination of EZH2 inhibitor and BET inhibitor for treatment of diffuse intrinsic pontine glioma
Author / Creator:Zhang, Yaqin ; Dong, Weijie ; Zhu, Junying ; Wang, Lizhu ; Wu, Xinjian ; Shan, Hong
Publisher:England: BioMed Central Ltd
Journal title:Cell & bioscience, 2017-10, Vol.7 (1), p.56-10, Article 56
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HOTAIR‐EZH2 inhibitor AC1Q3QWB upregulates CWF19L1 and enhances cell cycle inhibition of CDK4/6 inhibitor palbociclib in glioma
Author / Creator:Shi, Jin ; Lv, Shigang ; Wu, Miaojing ; Wang, Xianggan ; Deng, Yan ; Li, Yansheng ; Li, Kuanxun ; Zhao, Hongyu ; Zhu, Xingen ; Ye, Minhua
Publisher:United States: John Wiley and Sons Inc
Journal title:Clinical and translational medicine, 2020-03, Vol.10 (1), p.182-198
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Discovery of IHMT-337 as a potent irreversible EZH2 inhibitor targeting CDK4 transcription for malignancies
Author / Creator:Mei, Husheng ; Wu, Hong ; Yang, Jing ; Zhou, Bin ; Wang, Aoli ; Hu, Chen ; Qi, Shuang ; Jiang, Zongru ; Zou, Fengming ; Wang, Beilei ; Liu, Feiyang ; Chen, Yongfei ; Wang, Wenchao ; Liu, Jing ; Liu, Qingsong
Publisher:London: Nature Publishing Group UK
Journal title:Signal transduction and targeted therapy, 2023-01, Vol.8 (1), p.18-18, Article 18
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Fuse-binding protein 1 is a target of the EZH2 inhibitor GSK343, in osteosarcoma cells
Author / Creator:Xiong, Xifeng ; Zhang, Jinli ; Liang, Weiguo ; Cao, Wenjuan ; Qin, Shengnan ; Dai, Libing ; Ye, Dongping ; Liu, Zhihe
Publisher:Athens: D.A. Spandidos
Journal title:International journal of oncology, 2016-08, Vol.49 (2), p.623-628
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EZH2 inhibitor tazemetostat in patients with relapsed or refractory, BAP1-inactivated malignant pleural mesothelioma: a multicentre, open-label, phase 2 study

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Tazemetostat, an EZH2 inhibitor, in relapsed or refractory B-cell non-Hodgkin lymphoma and advanced solid tumours: a first-in-human, open-label, phase 1 study

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The EZH2 inhibitor tazemetostat upregulates the expression of CCL17/TARC in B‐cell lymphoma and enhances T‐cell recruitment

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PRC2-mediated repression of SMARCA2 predicts EZH2 inhibitor activity in SWI/SNF mutant tumors

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(−)‐Epigallocatechin‐3‐gallate and EZH2 inhibitor GSK343 have similar inhibitory effects and mechanisms of action on colorectal cancer cells

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EZH2 inhibitor GSK343 inhibits sepsis‑induced intestinal disorders

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The Role of EZH2 Inhibitor, GSK-126, in Seizure Susceptibility

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Study on the Effect of EZH2 Inhibitor Combined with TIGIT Monoclonal Antibody against Multiple Myeloma Cells

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Tanshinone I, a new EZH2 inhibitor restricts normal and malignant hematopoiesis through upregulation of MMP9 and ABCG2

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The novel EZH2 inhibitor, GSK126, suppresses cell migration and angiogenesis via down-regulating VEGF-A

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Overcoming EZH2 Inhibitor Resistance by Taxane in PTEN-Mutated Cancer

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Hypoxia makes EZH2 inhibitor not easy—advances of crosstalk between HIF and EZH2

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Evaluation of an EZH2 inhibitor in patient-derived orthotopic xenograft models of pediatric brain tumors alone and in combination with chemo- and radiation therapies

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EZH2 inhibitor Tazemetostat synergizes with JQ-1 in esophageal cancer by inhibiting c-Myc signaling pathway

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Selective EZH2 inhibitor zld1039 alleviates inflammation in cisplatin-induced acute kidney injury partially by enhancing RKIP and suppressing NF-κB p65 pathway

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Convection-Enhanced Delivery of Enhancer of Zeste Homolog-2 (EZH2) Inhibitor for the Treatment of Diffuse Intrinsic Pontine Glioma

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Combination of EZH2 inhibitor and BET inhibitor for treatment of diffuse intrinsic pontine glioma

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HOTAIR‐EZH2 inhibitor AC1Q3QWB upregulates CWF19L1 and enhances cell cycle inhibition of CDK4/6 inhibitor palbociclib in glioma

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Discovery of IHMT-337 as a potent irreversible EZH2 inhibitor targeting CDK4 transcription for malignancies

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Fuse-binding protein 1 is a target of the EZH2 inhibitor GSK343, in osteosarcoma cells

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