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A framework for advancing our understanding of cancer-associated fibroblasts
Author / Creator:Sahai, Erik ; Astsaturov, Igor ; Cukierman, Edna ; DeNardo, David G. ; Egeblad, Mikala ; Evans, Ronald M. ; Fearon, Douglas ; Greten, Florian R. ; Hingorani, Sunil R. ; Hunter, Tony ; Hynes, Richard O. ; Jain, Rakesh K. ; Janowitz, Tobias ; Jorgensen, Claus ; Kimmelman, Alec C. ; Kolonin, Mikhail G. ; Maki, Robert G. ; Powers, R. Scott ; Puré, Ellen ; Ramirez, Daniel C. ; Scherz-Shouval, Ruth ; Sherman, Mara H. ; Stewart, Sheila ; Tlsty, Thea D. ; Tuveson, David A. ; Watt, Fiona M. ; Weaver, Valerie ; Weeraratna, Ashani T. ; Werb, Zena
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Cancer, 2020-03, Vol.20 (3), p.174-186
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Inhibition of interferon-signalling halts cancer-associated fibroblast-dependent protection of breast cancer cells from chemotherapy
Author / Creator:Broad, Robyn V. ; Jones, Stacey J. ; Teske, Melina C. ; Wastall, Laura M. ; Hanby, Andrew M. ; Thorne, James L. ; Hughes, Thomas A.
Publisher:London: Nature Publishing Group UK
Journal title:British journal of cancer, 2021-03, Vol.124 (6), p.1110-1120
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CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistance in gastric cancer
Author / Creator:Zhang, Haiyang ; Deng, Ting ; Liu, Rui ; Ning, Tao ; Yang, Haiou ; Liu, Dongying ; Zhang, Qiumo ; Lin, Dan ; Ge, Shaohua ; Bai, Ming ; Wang, Xinyi ; Zhang, Le ; Li, Hongli ; Yang, Yuchong ; Ji, Zhi ; Wang, Hailong ; Ying, Guoguang ; Ba, Yi
Publisher:England: BioMed Central Ltd
Journal title:Molecular cancer, 2020-02, Vol.19 (1), p.43-17, Article 43
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Cancer-associated fibroblasts as abettors of tumor progression at the crossroads of EMT and therapy resistance
Author / Creator:Fiori, Micol Eleonora ; Di Franco, Simone ; Villanova, Lidia ; Bianca, Paola ; Stassi, Giorgio ; De Maria, Ruggero
Publisher:England: BioMed Central Ltd
Journal title:Molecular cancer, 2019-03, Vol.18 (1), p.70-70, Article 70
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Identification and characterization of Cardiac Glycosides as senolytic compounds
Author / Creator:Triana-Martínez, Francisco ; Picallos-Rabina, Pilar ; Da Silva-Álvarez, Sabela ; Pietrocola, Federico ; Llanos, Susana ; Rodilla, Verónica ; Soprano, Enrica ; Pedrosa, Pablo ; Ferreirós, Alba ; Barradas, Marta ; Hernández-González, Fernanda ; Lalinde, Marta ; Prats, Neus ; Bernadó, Cristina ; González, Patricia ; Gómez, María ; Ikonomopoulou, Maria P. ; Fernández-Marcos, Pablo J. ; García-Caballero, Tomás ; del Pino, Pablo ; Arribas, Joaquín ; Vidal, Anxo ; González-Barcia, Miguel ; Serrano, Manuel ; Loza, María I. ; Domínguez, Eduardo ; Collado, Manuel
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2019-10, Vol.10 (1), p.4731-4731, Article 4731
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Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice
Author / Creator:Cai, Yusheng ; Zhou, Huanhuan ; Zhu, Yinhua ; Sun, Qi ; Ji, Yin ; Xue, Anqi ; Wang, Yuting ; Chen, Wenhan ; Yu, Xiaojie ; Wang, Longteng ; Chen, Han ; Li, Cheng ; Luo, Tuoping ; Deng, Hongkui
Publisher:Singapore: Springer Singapore
Journal title:Cell research, 2020-07, Vol.30 (7), p.574-589
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Cancer-associated fibroblasts—heroes or villains?
Author / Creator:Gieniec, Krystyna A. ; Butler, Lisa M. ; Worthley, Daniel L. ; Woods, Susan L.
Publisher:London: Nature Publishing Group UK
Journal title:British journal of cancer, 2019-08, Vol.121 (4), p.293-302
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Influence of tumour micro-environment heterogeneity on therapeutic response
Author / Creator:Junttila, Melissa R. ; de Sauvage, Frederic J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2013-09, Vol.501 (7467), p.346-354
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Single-cell mapping of lineage and identity in direct reprogramming
Author / Creator:Biddy, Brent A. ; Kong, Wenjun ; Kamimoto, Kenji ; Guo, Chuner ; Waye, Sarah E. ; Sun, Tao ; Morris, Samantha A.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2018-12, Vol.564 (7735), p.219-224
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ArticlesPeer ReviewedFull Text
Cancer-associated fibroblast exosomes regulate survival and proliferation of pancreatic cancer cells
Author / Creator:Richards, K E ; Zeleniak, A E ; Fishel, M L ; Wu, J ; Littlepage, L E ; Hill, R
Publisher:London: Nature Publishing Group UK
Journal title:Oncogene, 2017-03, Vol.36 (13), p.1770-1778
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Novel therapeutic strategies targeting fibroblasts and fibrosis in heart disease
Author / Creator:Gourdie, Robert G. ; Dimmeler, Stefanie ; Kohl, Peter
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Drug discovery, 2016-09, Vol.15 (9), p.620-638
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Mechanical forces regulate the interactions of fibronectin and collagen I in extracellular matrix
Author / Creator:Kubow, Kristopher E. ; Vukmirovic, Radmila ; Zhe, Lin ; Klotzsch, Enrico ; Smith, Michael L. ; Gourdon, Delphine ; Luna, Sheila ; Vogel, Viola
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2015-08, Vol.6 (1), p.8026, Article 8026
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Identification of HSP90 inhibitors as a novel class of senolytics
Author / Creator:Fuhrmann-Stroissnigg, Heike ; Ling, Yuan Yuan ; Zhao, Jing ; McGowan, Sara J. ; Zhu, Yi ; Brooks, Robert W. ; Grassi, Diego ; Gregg, Siobhan Q. ; Stripay, Jennifer L. ; Dorronsoro, Akaitz ; Corbo, Lana ; Tang, Priscilla ; Bukata, Christina ; Ring, Nadja ; Giacca, Mauro ; Li, Xuesen ; Tchkonia, Tamara ; Kirkland, James L. ; Niedernhofer, Laura J. ; Robbins, Paul D.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2017-09, Vol.8 (1), p.422-14, Article 422
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Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL
Author / Creator:Yosef, Reut ; Pilpel, Noam ; Tokarsky-Amiel, Ronit ; Biran, Anat ; Ovadya, Yossi ; Cohen, Snir ; Vadai, Ezra ; Dassa, Liat ; Shahar, Elisheva ; Condiotti, Reba ; Ben-Porath, Ittai ; Krizhanovsky, Valery
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2016-04, Vol.7 (1), p.11190-11190, Article 11190
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ArticlesPeer ReviewedFull Text
Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds
Author / Creator:Hou, Pingping ; Li, Yanqin ; Zhang, Xu ; Liu, Chun ; Guan, Jingyang ; Li, Honggang ; Zhao, Ting ; Ye, Junqing ; Yang, Weifeng ; Liu, Kang ; Ge, Jian ; Xu, Jun ; Zhang, Qiang ; Zhao, Yang ; Deng, Hongkui
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2013-08, Vol.341 (6146), p.651-654
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ArticlesPeer ReviewedFull Text
Exosomal transfer of stroma-derived miR21 confers paclitaxel resistance in ovarian cancer cells through targeting APAF1
Author / Creator:Au Yeung, Chi Lam ; Co, Ngai-Na ; Tsuruga, Tetsushi ; Yeung, Tsz-Lun ; Kwan, Suet-Ying ; Leung, Cecilia S. ; Li, Yong ; Lu, Edward S. ; Kwan, Kenny ; Wong, Kwong-Kwok ; Schmandt, Rosemarie ; Lu, Karen H. ; Mok, Samuel C.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2016-03, Vol.7 (1), p.11150-11150, Article 11150
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Reduced Graphene Oxide Incorporated GelMA Hydrogel Promotes Angiogenesis For Wound Healing Applications
Author / Creator:Rehman, Syed Raza Ur ; Augustine, Robin ; Zahid, Alap Ali ; Ahmed, Rashid ; Tariq, Muhammad ; Hasan, Anwarul
Publisher:New Zealand: Dove Medical Press Limited
Journal title:International journal of nanomedicine, 2019-12, Vol.14, p.9603-9617
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Conversion of human fibroblasts into functional cardiomyocytes by small molecules
Author / Creator:Cao, Nan ; Huang, Yu ; Zheng, Jiashun ; Spencer, C. Ian ; Zhang, Yu ; Fu, Ji-Dong ; Nie, Baoming ; Xie, Min ; Zhang, Mingliang ; Wang, Haixia ; Ma, Tianhua ; Xu, Tao ; Shi, Guilai ; Srivastava, Deepak ; Ding, Sheng
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2016-06, Vol.352 (6290), p.1216-1220
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Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors
Author / Creator:Zhu, Yi ; Tchkonia, Tamara ; Fuhrmann‐Stroissnigg, Heike ; Dai, Haiming M. ; Ling, Yuanyuan Y. ; Stout, Michael B. ; Pirtskhalava, Tamar ; Giorgadze, Nino ; Johnson, Kurt O. ; Giles, Cory B. ; Wren, Jonathan D. ; Niedernhofer, Laura J. ; Robbins, Paul D. ; Kirkland, James L.
Publisher:England: John Wiley & Sons, Inc
Journal title:Aging cell, 2016-06, Vol.15 (3), p.428-435
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IL-11 is a crucial determinant of cardiovascular fibrosis
Author / Creator:Schafer, Sebastian ; Viswanathan, Sivakumar ; Widjaja, Anissa A. ; Lim, Wei-Wen ; Moreno-Moral, Aida ; DeLaughter, Daniel M. ; Ng, Benjamin ; Patone, Giannino ; Chow, Kingsley ; Khin, Ester ; Tan, Jessie ; Chothani, Sonia P. ; Ye, Lei ; Rackham, Owen J. L. ; Ko, Nicole S. J. ; Sahib, Norliza E. ; Pua, Chee Jian ; Zhen, Nicole T. G. ; Xie, Chen ; Wang, Mao ; Maatz, Henrike ; Lim, Shiqi ; Saar, Kathrin ; Blachut, Susanne ; Petretto, Enrico ; Schmidt, Sabine ; Putoczki, Tracy ; Guimarães-Camboa, Nuno ; Wakimoto, Hiroko ; van Heesch, Sebastiaan ; Sigmundsson, Kristmundur ; Lim, See L. ; Soon, Jia L. ; Chao, Victor T. T. ; Chua, Yeow L. ; Tan, Teing E. ; Evans, Sylvia M. ; Loh, Yee J. ; Jamal, Muhammad H. ; Ong, Kim K. ; Chua, Kim C. ; Ong, Boon-Hean ; Chakaramakkil, Mathew J. ; Seidman, Jonathan G. ; Seidman, Christine E. ; Hubner, Norbert ; Sin, Kenny Y. K. ; Cook, Stuart A.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2017-12, Vol.552 (7683), p.110-115
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A framework for advancing our understanding of cancer-associated fibroblasts

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Inhibition of interferon-signalling halts cancer-associated fibroblast-dependent protection of breast cancer cells from chemotherapy

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CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistance in gastric cancer

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Cancer-associated fibroblasts as abettors of tumor progression at the crossroads of EMT and therapy resistance

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Identification and characterization of Cardiac Glycosides as senolytic compounds

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Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice

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Cancer-associated fibroblasts—heroes or villains?

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Influence of tumour micro-environment heterogeneity on therapeutic response

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Single-cell mapping of lineage and identity in direct reprogramming

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Cancer-associated fibroblast exosomes regulate survival and proliferation of pancreatic cancer cells

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Novel therapeutic strategies targeting fibroblasts and fibrosis in heart disease

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Mechanical forces regulate the interactions of fibronectin and collagen I in extracellular matrix

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Identification of HSP90 inhibitors as a novel class of senolytics

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Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL

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Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds

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Exosomal transfer of stroma-derived miR21 confers paclitaxel resistance in ovarian cancer cells through targeting APAF1

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Reduced Graphene Oxide Incorporated GelMA Hydrogel Promotes Angiogenesis For Wound Healing Applications

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Conversion of human fibroblasts into functional cardiomyocytes by small molecules

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Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors

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IL-11 is a crucial determinant of cardiovascular fibrosis

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