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Newsletter articlesFull Text
Researchers discover "Achilles' heel" for lymphoid leukemia
Publisher:Ottawa: PR Newswire Association LLC
Journal title:Canada NewsWire, 2013
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ArticlesPeer ReviewedFull Text
Single-cell analysis of mixed-lineage states leading to a binary cell fate choice
Author / Creator:Olsson, Andre ; Venkatasubramanian, Meenakshi ; Chaudhri, Viren K. ; Aronow, Bruce J. ; Salomonis, Nathan ; Singh, Harinder ; Grimes, H. Leighton
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2016-09, Vol.537 (7622), p.698-702
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ArticlesPeer ReviewedFull Text
Unraveling bone marrow architecture
Author / Creator:Lucas, Daniel ; Salomonis, Nathan ; Grimes, H. Leighton
Publisher:London: Nature Publishing Group UK
Journal title:Nature cell biology, 2020-01, Vol.22 (1), p.5-6
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ArticlesPeer ReviewedFull Text
Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma
Author / Creator:Lee, Catherine ; Rudneva, Vasilisa A. ; Erkek, Serap ; Zapatka, Marc ; Chau, Lianne Q. ; Tacheva-Grigorova, Silvia K. ; Garancher, Alexandra ; Rusert, Jessica M. ; Aksoy, Ozlem ; Lea, Robin ; Mohammad, Helai P. ; Wang, Jianxun ; Weiss, William A. ; Grimes, H. Leighton ; Pfister, Stefan M. ; Northcott, Paul A. ; Wechsler-Reya, Robert J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2019-01, Vol.10 (1), p.332-332, Article 332
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ArticlesPeer ReviewedFull Text
Decision level integration of unimodal and multimodal single cell data with scTriangulate
Author / Creator:Li, Guangyuan ; Song, Baobao ; Singh, Harinder ; Surya Prasath, V. B. ; Leighton Grimes, H. ; Salomonis, Nathan
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2023-01, Vol.14 (1), p.406-16, Article 406
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ArticlesPeer ReviewedFull Text
MAPK-negative feedback regulation confers dependence to JAK2V617F signaling
Author / Creator:Kesarwani, Meenu ; Kincaid, Zachary ; Azhar, Mohammad ; Menke, Jacob ; Schwieterman, Joshua ; Ansari, Sekhu ; Reaves, Angela ; Deininger, Michael E. ; Levine, Ross ; Grimes, H. Leighton ; Azam, Mohammad
Publisher:London: Nature Publishing Group UK
Journal title:Leukemia, 2023-08, Vol.37 (8), p.1686-1697
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ArticlesPeer ReviewedFull Text
Targeting c-FOS and DUSP1 abrogates intrinsic resistance to tyrosine-kinase inhibitor therapy in BCR-ABL-induced leukemia
Author / Creator:Kesarwani, Meenu ; Kincaid, Zachary ; Gomaa, Ahmed ; Huber, Erika ; Rohrabaugh, Sara ; Siddiqui, Zain ; Bouso, Muhammad F ; Latif, Tahir ; Xu, Ming ; Komurov, Kakajan ; Mulloy, James C ; Cancelas, Jose A ; Grimes, H Leighton ; Azam, Mohammad
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2017-04, Vol.23 (4), p.472-482
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ArticlesPeer ReviewedFull Text
Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells
Author / Creator:Goyama, Susumu ; Schibler, Janet ; Cunningham, Lea ; Zhang, Yue ; Rao, Yalan ; Nishimoto, Nahoko ; Nakagawa, Masahiro ; Olsson, Andre ; Wunderlich, Mark ; Link, Kevin A. ; Mizukawa, Benjamin ; Grimes, H. Leighton ; Kurokawa, Mineo ; Liu, P. Paul ; Huang, Gang ; Mulloy, James C.
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2013-09, Vol.123 (9), p.3876-3888
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ArticlesPeer ReviewedFull Text
A calcium- and calpain-dependent pathway determines the response to lenalidomide in myelodysplastic syndromes
Author / Creator:Fang, Jing ; Liu, Xiaona ; Bolanos, Lyndsey ; Barker, Brenden ; Rigolino, Carmela ; Cortelezzi, Agostino ; Oliva, Esther N ; Cuzzola, Maria ; Grimes, H Leighton ; Fontanillo, Celia ; Komurov, Kakajan ; MacBeth, Kyle ; Starczynowski, Daniel T
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2016-07, Vol.22 (7), p.727-734
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ArticlesPeer ReviewedFull Text
The miR-23a~27a~24-2 microRNA cluster buffers transcription and signaling pathways during hematopoiesis
Author / Creator:Kurkewich, Jeffrey L. ; Hansen, Justin ; Klopfenstein, Nathan ; Zhang, Helen ; Wood, Christian ; Boucher, Austin ; Hickman, Joseph ; Muench, David E. ; Grimes, H. Leighton ; Dahl, Richard
Publisher:United States: Public Library of Science
Journal title:PLoS genetics, 2017-07, Vol.13 (7), p.e1006887-e1006887
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ArticlesPeer ReviewedFull Text
Essential role of a ThPOK autoregulatory loop in the maintenance of mature CD4+ T cell identity and function
Author / Creator:Basu, Jayati ; Reis, Bernardo S. ; Peri, Suraj ; Zha, Jikun ; Hua, Xiang ; Ge, Lu ; Ferchen, Kyle ; Nicolas, Emmanuelle ; Czyzewicz, Philip ; Cai, Kathy Q. ; Tan, Yinfei ; Fuxman Bass, Juan I. ; Walhout, Albertha J. M. ; Grimes, H. Leighton ; Grivennikov, Sergei I. ; Mucida, Daniel ; Kappes, Dietmar J.
Publisher:New York: Nature Publishing Group US
Journal title:Nature immunology, 2021-08, Vol.22 (8), p.969-982
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ArticlesPeer ReviewedFull Text
Pathogenesis of ELANE-mutant severe neutropenia revealed by induced pluripotent stem cells
Author / Creator:Nayak, Ramesh C. ; Trump, Lisa R. ; Aronow, Bruce J. ; Myers, Kasiani ; Mehta, Parinda ; Kalfa, Theodosia ; Wellendorf, Ashley M. ; Valencia, C. Alexander ; Paddison, Patrick J. ; Horwitz, Marshall S. ; Grimes, H. Leighton ; Lutzko, Carolyn ; Cancelas, Jose A.
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2015-08, Vol.125 (8), p.3103-3116
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ArticlesPeer ReviewedFull Text
Phospho serine and threonine analysis of normal and mutated granulocyte colony stimulating factor receptors
Author / Creator:Dwivedi, Pankaj ; Muench, David E. ; Wagner, Michael ; Azam, Mohammad ; Grimes, H. Leighton ; Greis, Kenneth D.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific data, 2019-04, Vol.6 (1), p.21, Article 21
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ArticlesPeer ReviewedFull Text
Time resolved quantitative phospho-tyrosine analysis reveals Bruton’s Tyrosine kinase mediated signaling downstream of the mutated granulocyte-colony stimulating factor receptors
Author / Creator:Dwivedi, Pankaj ; Muench, David E. ; Wagner, Michael ; Azam, Mohammad ; Grimes, H. Leighton ; Greis, Kenneth D.
Publisher:London: Nature Publishing Group UK
Journal title:Leukemia, 2019-01, Vol.33 (1), p.75-87
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ArticlesPeer ReviewedFull Text
Therapeutic antagonists of microRNAs deplete leukemia-initiating cell activity
Author / Creator:Velu, Chinavenmeni S. ; Chaubey, Aditya ; Phelan, James D. ; Horman, Shane R. ; Wunderlich, Mark ; Guzman, Monica L. ; Jegga, Anil G. ; Zeleznik-Le, Nancy J. ; Chen, Jianjun ; Mulloy, James C. ; Cancelas, Jose A. ; Jordan, Craig T. ; Aronow, Bruce J. ; Marcucci, Guido ; Bhat, Balkrishen ; Gebelein, Brian ; Grimes, H. Leighton
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2014-01, Vol.124 (1), p.222-236
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ArticlesPeer ReviewedFull Text
Inflammation rapidly recruits mammalian GMP and MDP from bone marrow into regional lymphatics
Author / Creator:Serrano-Lopez, Juana ; Hegde, Shailaja ; Kumar, Sachin ; Serrano, Josefina ; Fang, Jing ; Wellendorf, Ashley M ; Roche, Paul A ; Rangel, Yamileth ; Carrington, Leolene J ; Geiger, Hartmut ; Grimes, H Leighton ; Luther, Sanjiv ; Maillard, Ivan ; Sanchez-Garcia, Joaquin ; Starczynowski, Daniel T ; Cancelas, Jose A
Publisher:England: eLife Science Publications, Ltd
Journal title:eLife, 2021-04, Vol.10
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ArticlesPeer ReviewedFull Text
Clonal hematopoiesis of indeterminate potential and its impact on patient trajectories after stem cell transplantation
Author / Creator:Park, Derek S. ; Akuffo, Afua A. ; Muench, David E. ; Grimes, H. Leighton ; Epling-Burnette, Pearlie K. ; Maini, Philip K. ; Anderson, Alexander R. A. ; Bonsall, Michael B.
Publisher:United States: Public Library of Science
Journal title:PLoS computational biology, 2019-04, Vol.15 (4), p.e1006913-e1006913
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ArticlesPeer ReviewedFull Text
Akt phosphorylates the Y-box binding protein 1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast cancer cells
Author / Creator:Sutherland, Brent W ; Kucab, Jill ; Wu, Joyce ; Lee, Cathy ; Cheang, Maggie C U ; Yorida, Erika ; Turbin, Dmitry ; Dedhar, Shoukat ; Nelson, Colleen ; Pollak, Michael ; Leighton Grimes, H ; Miller, Kathy ; Badve, Sunil ; Huntsman, David ; Blake-Gilks, C ; Chen, Min ; Pallen, Catherine J ; Dunn, Sandra E
Publisher:London: Nature Publishing Group UK
Journal title:Oncogene, 2005-06, Vol.24 (26), p.4281-4292
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ArticlesPeer ReviewedFull Text
Identification of IFRD1 as a modifier gene for cystic fibrosis lung disease
Author / Creator:Gu, YuanYuan ; Harley, Isaac T. W. ; Henderson, Lindsay B. ; Aronow, Bruce J. ; Vietor, Ilja ; Huber, Lukas A. ; Harley, John B. ; Kilpatrick, Jeffrey R. ; Langefeld, Carl D. ; Williams, Adrienne H. ; Jegga, Anil G. ; Chen, Jing ; Wills-Karp, Marsha ; Arshad, S. Hasan ; Ewart, Susan L. ; Thio, Chloe L. ; Flick, Leah M. ; Filippi, Marie-Dominique ; Grimes, H. Leighton ; Drumm, Mitchell L. ; Cutting, Garry R. ; Knowles, Michael R. ; Karp, Christopher L.
Publisher:London: Nature Publishing Group UK
Journal title:Nature, 2009-04, Vol.458 (7241), p.1039-1042
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ArticlesPeer ReviewedFull Text
The 3′ Region of the Chicken Hypersensitive Site-4 Insulator Has Properties Similar to Its Core and Is Required for Full Insulator Activity
Author / Creator:Arumugam, Paritha I. ; Urbinati, Fabrizia ; Velu, Chinavenmeni S. ; Higashimoto, Tomoyasu ; Grimes, H. Leighton ; Malik, Punam
Publisher:United States: Public Library of Science
Journal title:PloS one, 2009-09, Vol.4 (9), p.e6995-e6995
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Showing 1 to 20 of 57 results

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Researchers discover "Achilles' heel" for lymphoid leukemia

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Single-cell analysis of mixed-lineage states leading to a binary cell fate choice

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Unraveling bone marrow architecture

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Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma

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Decision level integration of unimodal and multimodal single cell data with scTriangulate

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MAPK-negative feedback regulation confers dependence to JAK2V617F signaling

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Targeting c-FOS and DUSP1 abrogates intrinsic resistance to tyrosine-kinase inhibitor therapy in BCR-ABL-induced leukemia

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Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells

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A calcium- and calpain-dependent pathway determines the response to lenalidomide in myelodysplastic syndromes

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The miR-23a~27a~24-2 microRNA cluster buffers transcription and signaling pathways during hematopoiesis

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Essential role of a ThPOK autoregulatory loop in the maintenance of mature CD4+ T cell identity and function

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Pathogenesis of ELANE-mutant severe neutropenia revealed by induced pluripotent stem cells

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Phospho serine and threonine analysis of normal and mutated granulocyte colony stimulating factor receptors

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Time resolved quantitative phospho-tyrosine analysis reveals Bruton’s Tyrosine kinase mediated signaling downstream of the mutated granulocyte-colony stimulating factor receptors

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Therapeutic antagonists of microRNAs deplete leukemia-initiating cell activity

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Inflammation rapidly recruits mammalian GMP and MDP from bone marrow into regional lymphatics

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Clonal hematopoiesis of indeterminate potential and its impact on patient trajectories after stem cell transplantation

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Akt phosphorylates the Y-box binding protein 1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast cancer cells

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Identification of IFRD1 as a modifier gene for cystic fibrosis lung disease

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The 3′ Region of the Chicken Hypersensitive Site-4 Insulator Has Properties Similar to Its Core and Is Required for Full Insulator Activity

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