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Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington’s disease patients
Author / Creator:Wild, Edward J. ; Boggio, Roberto ; Langbehn, Douglas ; Robertson, Nicola ; Haider, Salman ; Miller, James R.C. ; Zetterberg, Henrik ; Leavitt, Blair R. ; Kuhn, Rainer ; Tabrizi, Sarah J. ; Macdonald, Douglas ; Weiss, Andreas
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2015-05, Vol.125 (5), p.1979-1986
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Lowering mutant huntingtin protein
Author / Creator:Crunkhorn, Sarah
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Drug discovery, 2020-01, Vol.19 (1), p.22-22
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Human-to-mouse prion-like propagation of mutant huntingtin protein
Author / Creator:Jeon, Iksoo ; Cicchetti, Francesca ; Cisbani, Giulia ; Lee, Suji ; Li, Endan ; Bae, Jiwoo ; Lee, Nayeon ; Li, Ling ; Im, Wooseok ; Kim, Manho ; Kim, Hyun Sook ; Oh, Seung-Hun ; Kim, Tae-Aug ; Ko, Jung Jae ; Aubé, Benoit ; Oueslati, Abid ; Kim, Yun Joong ; Song, Jihwan
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Acta neuropathologica, 2016-10, Vol.132 (4), p.577-592
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Potential function for the Huntingtin protein as a scaffold for selective autophagy
Author / Creator:Ochaba, Joseph ; Lukacsovich, Tamás ; Csikos, George ; Zheng, Shuqiu ; Margulis, Julia ; Salazar, Lisa ; Mao, Kai ; Lau, Alice L. ; Yeung, Sylvia Y. ; Humbert, Sandrine ; Saudou, Frédéric ; Klionsky, Daniel J. ; Finkbeiner, Steven ; Zeitlin, Scott O. ; Marsh, J. Lawrence ; Housman, David E. ; Thompson, Leslie M. ; Steffan, Joan S.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2014-11, Vol.111 (47), p.16889-16894
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Salivary Huntingtin protein is uniquely associated with clinical features of Huntington’s disease
Author / Creator:Parkin, Georgia M. ; Corey-Bloom, Jody ; Snell, Chase ; Smith, Haileigh ; Laurenza, Angela ; Daldin, Manuel ; Bresciani, Alberto ; Thomas, Elizabeth A.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2023-01, Vol.13 (1), p.1034-9, Article 1034
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Detection of antibodies against the huntingtin protein in human plasma
Author / Creator:Denis, Hélèna L. ; Alpaugh, Melanie ; Alvarez, Claudia P. ; Fenyi, Alexis ; Barker, Roger A. ; Chouinard, Sylvain ; Arrowsmith, Cheryl H. ; Melki, Ronald ; Labib, Richard ; Harding, Rachel J. ; Cicchetti, Francesca
Publisher:Cham: Springer International Publishing
Journal title:Cellular and molecular life sciences : CMLS, 2023-02, Vol.80 (2), p.45, Article 45
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Phosphorylation of huntingtin at residue T3 is decreased in Huntington’s disease and modulates mutant huntingtin protein conformation
Author / Creator:Cariulo, Cristina ; Azzollini, Lucia ; Verani, Margherita ; Martufi, Paola ; Boggio, Roberto ; Chiki, Anass ; Deguire, Sean M. ; Cherubini, Marta ; Gines, Silvia ; Marsh, J. Lawrence ; Conforti, Paola ; Cattaneo, Elena ; Santimone, Iolanda ; Squitieri, Ferdinando ; Lashuel, Hilal A. ; Petricca, Lara ; Caricasole, Andrea
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2017-12, Vol.114 (50), p.E10809-E10818
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Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein
Author / Creator:Al-Ramahi, Ismael ; Giridharan, Sai Srinivas Panapakkam ; Chen, Yu-Chi ; Patnaik, Samarjit ; Safren, Nathaniel ; Hasegawa, Junya ; de Haro, Maria ; Wagner Gee, Amanda K ; Titus, Steven A ; Jeong, Hyunkyung ; Clarke, Jonathan ; Krainc, Dimitri ; Zheng, Wei ; Irvine, Robin F ; Barmada, Sami ; Ferrer, Marc ; Southall, Noel ; Weisman, Lois S ; Botas, Juan ; Marugan, Juan Jose
Publisher:England: eLife Sciences Publications Ltd
Journal title:eLife, 2017-12, Vol.6
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Glyceraldehyde-3-Phosphate Dehydrogenase Facilitates Macroautophagic Degradation of Mutant Huntingtin Protein Aggregates
Author / Creator:Chaudhary, Surbhi ; Dhiman, Asmita ; Dilawari, Rahul ; Chaubey, Gaurav Kumar ; Talukdar, Sharmila ; Modanwal, Radheshyam ; Patidar, Anil ; Malhotra, Himanshu ; Raje, Chaaya Iyengar ; Raje, Manoj
Publisher:New York: Springer US
Journal title:Molecular neurobiology, 2021-11, Vol.58 (11), p.5790-5798
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Selective clearance of mutant huntingtin protein
Author / Creator:Zoghbi, Huda Y
Publisher:London: Nature Publishing Group
Journal title:Nature (London), 2019-11, Vol.575 (7781), p.1-2
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Quantification of huntingtin protein species in Huntington’s disease patient leukocytes using optimised electrochemiluminescence immunoassays
Author / Creator:Hensman Moss, Davina J. ; Robertson, Nicola ; Farmer, Ruth ; Scahill, Rachael I. ; Haider, Salman ; Tessari, Michela A. ; Flynn, Geraldine ; Fischer, David F. ; Wild, Edward J. ; Macdonald, Douglas ; Tabrizi, Sarah J.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2017-12, Vol.12 (12), p.e0189891-e0189891
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Harnessing chaperone-mediated autophagy for the selective degradation of mutant huntingtin protein
Author / Creator:Bauer, Peter O ; Goswami, Anand ; Wong, Hon Kit ; Okuno, Misako ; Kurosawa, Masaru ; Yamada, Mizuki ; Miyazaki, Haruko ; Matsumoto, Gen ; Kino, Yoshihiro ; Nagai, Yoshitaka ; Nukina, Nobuyuki
Publisher:New York: Nature Publishing Group US
Journal title:Nature biotechnology, 2010-03, Vol.28 (3), p.256-263
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Prion-like properties of the mutant huntingtin protein in living organisms: the evidence and the relevance
Author / Creator:Alpaugh, Melanie ; Denis, Hélèna L. ; Cicchetti, Francesca
Publisher:London: Nature Publishing Group UK
Journal title:Molecular psychiatry, 2022-01, Vol.27 (1), p.269-280
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Suppression of toxicity of the mutant huntingtin protein by its interacting compound, desonide
Author / Creator:Song, Haikun ; Wang, Cen ; Zhu, Chenggang ; Wang, Ziying ; Yang, Huiya ; Wu, Peng ; Cui, Xiaotian ; Botas, Juan ; Dang, Yongjun ; Ding, Yu ; Fei, Yiyan ; Lu, Boxun
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2022-03, Vol.119 (10), p.1-12
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Regulation of Blos1 by IRE1 prevents the accumulation of Huntingtin protein aggregates
Author / Creator:Bae, Donghwi ; Jones, Rachel Elizabeth ; Piscopo, Katherine M. ; Tyagi, Mitali ; Shepherd, Jason D. ; Hollien, Julie
Publisher:United States: American Society for Cell Biology
Journal title:Molecular biology of the cell, 2022-11, Vol.33 (13), p.ar125
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Quantifying mutant huntingtin protein in human cerebrospinal fluid to support the development of huntingtin-lowering therapies
Author / Creator:Vauleon, Stephanie ; Schutz, Katharina ; Massonnet, Benoit ; Gruben, Nanda ; Manchester, Marianne ; Buehler, Alessandra ; Schick, Eginhard ; Boak, Lauren ; Hawellek, David J.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2023-04, Vol.13 (1), p.5332-5332, Article 5332
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A role of cellular translation regulation associated with toxic Huntingtin protein
Author / Creator:Joag, Hiranmay ; Ghatpande, Vighnesh ; Desai, Meghal ; Sarkar, Maitheli ; Raina, Anshu ; Shinde, Mrunalini ; Chitale, Ruta ; Deo, Ankita ; Bose, Tania ; Majumdar, Amitabha
Publisher:Cham: Springer International Publishing
Journal title:Cellular and molecular life sciences : CMLS, 2020-09, Vol.77 (18), p.3657-3670
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Fighting the Huntington’s Disease with a G-Quadruplex-Forming Aptamer Specifically Binding to Mutant Huntingtin Protein: Biophysical Characterization, In Vitro and In Vivo Studies
Author / Creator:Riccardi, Claudia ; D’Aria, Federica ; Digilio, Filomena Anna ; Carillo, Maria Rosaria ; Amato, Jussara ; Fasano, Dominga ; De Rosa, Laura ; Paladino, Simona ; Melone, Mariarosa Anna Beatrice ; Montesarchio, Daniela ; Giancola, Concetta
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2022-04, Vol.23 (9), p.4804
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Siah-1-interacting protein regulates mutated huntingtin protein aggregation in Huntington’s disease models
Author / Creator:Latoszek, Ewelina ; Wiweger, Małgorzata ; Ludwiczak, Jan ; Dunin-Horkawicz, Stanisław ; Kuznicki, Jacek ; Czeredys, Magdalena
Publisher:England: BioMed Central Ltd
Journal title:Cell & bioscience, 2022-03, Vol.12 (1), p.34-34, Article 34
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Ultrasensitive measurement of huntingtin protein in cerebrospinal fluid demonstrates increase with Huntington disease stage and decrease following brain huntingtin suppression
Author / Creator:Southwell, Amber L. ; Smith, Stephen E.P. ; Davis, Tessa R. ; Caron, Nicholas S. ; Villanueva, Erika B. ; Xie, Yuanyun ; Collins, Jennifer A. ; Li Ye, Min ; Sturrock, Aaron ; Leavitt, Blair R. ; Schrum, Adam G. ; Hayden, Michael R.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2015-07, Vol.5 (1), p.12166-12166, Article 12166
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Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington’s disease patients

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Lowering mutant huntingtin protein

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Human-to-mouse prion-like propagation of mutant huntingtin protein

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Potential function for the Huntingtin protein as a scaffold for selective autophagy

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Salivary Huntingtin protein is uniquely associated with clinical features of Huntington’s disease

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Detection of antibodies against the huntingtin protein in human plasma

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Phosphorylation of huntingtin at residue T3 is decreased in Huntington’s disease and modulates mutant huntingtin protein conformation

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Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein

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Glyceraldehyde-3-Phosphate Dehydrogenase Facilitates Macroautophagic Degradation of Mutant Huntingtin Protein Aggregates

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Selective clearance of mutant huntingtin protein

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Quantification of huntingtin protein species in Huntington’s disease patient leukocytes using optimised electrochemiluminescence immunoassays

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Harnessing chaperone-mediated autophagy for the selective degradation of mutant huntingtin protein

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Prion-like properties of the mutant huntingtin protein in living organisms: the evidence and the relevance

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Suppression of toxicity of the mutant huntingtin protein by its interacting compound, desonide

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Regulation of Blos1 by IRE1 prevents the accumulation of Huntingtin protein aggregates

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Quantifying mutant huntingtin protein in human cerebrospinal fluid to support the development of huntingtin-lowering therapies

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A role of cellular translation regulation associated with toxic Huntingtin protein

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Fighting the Huntington’s Disease with a G-Quadruplex-Forming Aptamer Specifically Binding to Mutant Huntingtin Protein: Biophysical Characterization, In Vitro and In Vivo Studies

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Siah-1-interacting protein regulates mutated huntingtin protein aggregation in Huntington’s disease models

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Ultrasensitive measurement of huntingtin protein in cerebrospinal fluid demonstrates increase with Huntington disease stage and decrease following brain huntingtin suppression

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