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783 results for Lactams,+Macrocyclic

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Activation and characterization of a cryptic polycyclic tetramate macrolactam biosynthetic gene cluster
Author / Creator:Luo, Yunzi ; Huang, Hua ; Liang, Jing ; Wang, Meng ; Lu, Lu ; Shao, Zengyi ; Cobb, Ryan E. ; Zhao, Huimin
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2013-12, Vol.4 (1), p.2894-2894, Article 2894
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First-Line Lorlatinib or Crizotinib in Advanced ALK-Positive Lung Cancer
Author / Creator:Shaw, Alice T ; Bauer, Todd M ; de Marinis, Filippo ; Felip, Enriqueta ; Goto, Yasushi ; Liu, Geoffrey ; Mazieres, Julien ; Kim, Dong-Wan ; Mok, Tony ; Polli, Anna ; Thurm, Holger ; Calella, Anna M ; Peltz, Gerson ; Solomon, Benjamin J
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2020-11, Vol.383 (21), p.2018-2029
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Lorlatinib in patients with ALK-positive non-small-cell lung cancer: results from a global phase 2 study
Author / Creator:Solomon, Benjamin J, Prof ; Besse, Benjamin, Prof ; Bauer, Todd M, MD ; Felip, Enriqueta, MD ; Soo, Ross A, MD ; Camidge, D Ross, Prof ; Chiari, Rita, MD ; Bearz, Alessandra, MD ; Lin, Chia-Chi, MD ; Gadgeel, Shirish M, Prof ; Riely, Gregory J, MD ; Tan, Eng Huat, MBBS ; Seto, Takashi, Prof ; James, Leonard P, MD ; Clancy, Jill S, BS ; Abbattista, Antonello, BSc ; Martini, Jean-François, PhD ; Chen, Joseph, PharmD ; Peltz, Gerson, MD ; Thurm, Holger, MD ; Ou, Sai-Hong Ignatius, Prof ; Shaw, Alice T, Prof
Publisher:England: Elsevier Ltd
Journal title:The lancet oncology, 2018-12, Vol.19 (12), p.1654-1667
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Lorlatinib in non-small-cell lung cancer with ALK or ROS1 rearrangement: an international, multicentre, open-label, single-arm first-in-man phase 1 trial
Author / Creator:Shaw, Alice T ; Felip, Enriqueta ; Bauer, Todd M ; Besse, Benjamin ; Navarro, Alejandro ; Postel-Vinay, Sophie ; Gainor, Justin F ; Johnson, Melissa ; Dietrich, Jorg ; James, Leonard P ; Clancy, Jill S ; Chen, Joseph ; Martini, Jean-François ; Abbattista, Antonello ; Solomon, Benjamin J
Publisher:England: Elsevier Ltd
Journal title:The lancet oncology, 2017-12, Vol.18 (12), p.1590-1599
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PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations
Author / Creator:Zou, Helen Y. ; Li, Qiuhua ; Engstrom, Lars D. ; West, Melissa ; Appleman, Vicky ; Wong, Katy A. ; McTigue, Michele ; Deng, Ya-Li ; Liu, Wei ; Brooun, Alexei ; Timofeevski, Sergei ; McDonnell, Scott R. P. ; Jiang, Ping ; Falk, Matthew D. ; Lappin, Patrick B. ; Affolter, Timothy ; Nichols, Tim ; Hu, Wenyue ; Lam, Justine ; Johnson, Ted W. ; Smeal, Tod ; Charest, Al ; Fantin, Valeria R.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2015-03, Vol.112 (11), p.3493-3498
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A class of extracellular vesicles from breast cancer cells activates VEGF receptors and tumour angiogenesis
Author / Creator:Feng, Qiyu ; Zhang, Chengliang ; Lum, David ; Druso, Joseph E. ; Blank, Bryant ; Wilson, Kristin F. ; Welm, Alana ; Antonyak, Marc A. ; Cerione, Richard A.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2017-02, Vol.8 (1), p.14450-14450, Article 14450
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Common biosynthetic origins for polycyclic tetramate macrolactams from phylogenetically diverse bacteria
Author / Creator:Blodgett, Joshua A. V. ; Oh, Dong-Chan ; Cao, Shugeng ; Currie, Cameron R. ; Kolter, Roberto ; Clardy, Jon ; Meinwald, Jerrold
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2010-06, Vol.107 (26), p.11692-11697
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Enhanced Efficacy of Gastric Cancer Treatment through Targeted Exosome Delivery of 17-DMAG Anticancer Agent
Author / Creator:Park, Jung Hyun ; Kim, Say-June ; Kim, Ok-Hee ; Kim, Dong Jin
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2024-08, Vol.25 (16), p.8762
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Geldanamycins: Potent Hsp90 Inhibitors with Significant Potential in Cancer Therapy
Author / Creator:Abdullah, Omeima ; Omran, Ziad
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2024-10, Vol.25 (20), p.11293
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A Smart Hyperthermia Nanofiber-Platform-Enabled Sustained Release of Doxorubicin and 17AAG for Synergistic Cancer Therapy
Author / Creator:Chen, Lili ; Fujisawa, Nanami ; Takanohashi, Masato ; Najmina, Mazaya ; Uto, Koichiro ; Ebara, Mitsuhiro
Publisher:Switzerland: MDPI
Journal title:International journal of molecular sciences, 2021-03, Vol.22 (5), p.2542
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A Phase II trial of 17-allylamino, 17-demethoxygeldanamycin (17-AAG, tanespimycin) in patients with metastatic melanoma
Author / Creator:Pacey, Simon ; Gore, Martin ; Chao, David ; Banerji, Udai ; Larkin, James ; Sarker, Sarah ; Owen, Karen ; Asad, Yasmin ; Raynaud, Florence ; Walton, Mike ; Judson, Ian ; Workman, Paul ; Eisen, Tim
Publisher:Boston: Springer US
Journal title:Investigational new drugs, 2012-02, Vol.30 (1), p.341-349
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Suppression of tumor-associated neutrophils by lorlatinib attenuates pancreatic cancer growth and improves treatment with immune checkpoint blockade
Author / Creator:Nielsen, Sebastian R. ; Strøbech, Jan E. ; Horton, Edward R. ; Jackstadt, Rene ; Laitala, Anu ; Bravo, Marina C. ; Maltese, Giorgia ; Jensen, Adina R. D. ; Reuten, Raphael ; Rafaeva, Maria ; Karim, Saadia A. ; Hwang, Chang-Il ; Arnes, Luis ; Tuveson, David A. ; Sansom, Owen J. ; Morton, Jennifer P. ; Erler, Janine T.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-06, Vol.12 (1), p.3414-15, Article 3414
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A new polycyclic tetramate macrolactam from Allostreptomyces RD068384: stereochemistry and antifungal potential
Author / Creator:Elsbaey, Marwa ; Samaru, Yuki ; Elekhnawy, Engy ; Oku, Naoya ; Igarashi, Yasuhiro
Publisher:Tokyo: Springer Japan
Journal title:Journal of antibiotics, 2024-06, Vol.77 (6), p.393-396
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New polycyclic tetramate macrolactams with antimycobacterial activity produced by marine-derived Streptomyces sp. KKMA-0239
Author / Creator:Shigeno, Satoru ; Kadowaki, Miyu ; Nagai, Kenichiro ; Hosoda, Kanji ; Terahara, Takeshi ; Nishimura, Tomoyasu ; Hasegawa, Naoki ; Tomoda, Hiroshi ; Ohshiro, Taichi
Publisher:Tokyo: Springer Japan
Journal title:Journal of antibiotics, 2024-05, Vol.77 (5), p.265-271
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Gilteritinib overcomes lorlatinib resistance in ALK-rearranged cancer
Author / Creator:Mizuta, Hayato ; Okada, Koutaroh ; Araki, Mitsugu ; Adachi, Jun ; Takemoto, Ai ; Kutkowska, Justyna ; Maruyama, Kohei ; Yanagitani, Noriko ; Oh-hara, Tomoko ; Watanabe, Kana ; Tamai, Keiichi ; Friboulet, Luc ; Katayama, Kazuhiro ; Ma, Biao ; Sasakura, Yoko ; Sagae, Yukari ; Kukimoto-Niino, Mutsuko ; Shirouzu, Mikako ; Takagi, Satoshi ; Simizu, Siro ; Nishio, Makoto ; Okuno, Yasushi ; Fujita, Naoya ; Katayama, Ryohei
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-02, Vol.12 (1), p.1261-1261, Article 1261
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The Discovery of Weddellamycin, a Tricyclic Polyene Macrolactam Antibiotic from an Antarctic Deep-Sea-Derived Streptomyces sp. DSS69, by Heterologous Expression
Author / Creator:Chen, Lu ; Liu, Kai ; Hong, Jiali ; Cui, Zhanzhao ; He, Weijun ; Wang, Yemin ; Deng, Zixin ; Tao, Meifeng
Publisher:Switzerland: MDPI AG
Journal title:Marine drugs, 2024-04, Vol.22 (4), p.189
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Chronic Treatment with 17-DMAG Improves Balance and Coordination in A New Mouse Model of Machado-Joseph Disease
Author / Creator:Silva-Fernandes, Anabela ; Duarte-Silva, Sara ; Neves-Carvalho, Andreia ; Amorim, Marina ; Soares-Cunha, Carina ; Oliveira, Pedro ; Thirstrup, Kenneth ; Teixeira-Castro, Andreia ; Maciel, Patrícia
Publisher:Boston: Springer US
Journal title:Neurotherapeutics, 2014-04, Vol.11 (2), p.433-449
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Inhibition of heat shock protein 90 destabilizes receptor tyrosine kinase ROR1 in lung adenocarcinoma
Author / Creator:Khaledian, Behnoush ; Taguchi, Ayumu ; Shin‐ya, Kazuo ; Kondo‐Ida, Lisa ; Kagaya, Noritaka ; Suzuki, Motoshi ; Kajino, Taisuke ; Yamaguchi, Tomoya ; Shimada, Yukako ; Takahashi, Takashi
Publisher:England: John Wiley & Sons, Inc
Journal title:Cancer science, 2021-03, Vol.112 (3), p.1225-1234
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Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90
Author / Creator:Kitson, Russell R. A. ; Chang, Chuan-Hsin ; Xiong, Rui ; Williams, Huw E. L. ; Davis, Adrienne L. ; Lewis, William ; Dehn, Donna L. ; Siegel, David ; Roe, S. Mark ; Prodromou, Chrisostomos ; Ross, David ; Moody, Christopher J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature chemistry, 2013-04, Vol.5 (4), p.307-314
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HSP90 inhibitor geldanamycin reverts IL-13– and IL-17–induced airway goblet cell metaplasia
Author / Creator:Pezzulo, Alejandro A. ; Tudas, Rosarie A. ; Stewart, Carley G. ; Buonfiglio, Luis G. Vargas ; Lindsay, Brian D. ; Taft, Peter J. ; Gansemer, Nicholas D. ; Zabner, Joseph
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2019-02, Vol.129 (2), p.744-758
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Showing 1 to 20 of 783 results

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Activation and characterization of a cryptic polycyclic tetramate macrolactam biosynthetic gene cluster

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First-Line Lorlatinib or Crizotinib in Advanced ALK-Positive Lung Cancer

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Lorlatinib in patients with ALK-positive non-small-cell lung cancer: results from a global phase 2 study

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Lorlatinib in non-small-cell lung cancer with ALK or ROS1 rearrangement: an international, multicentre, open-label, single-arm first-in-man phase 1 trial

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PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations

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A class of extracellular vesicles from breast cancer cells activates VEGF receptors and tumour angiogenesis

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Common biosynthetic origins for polycyclic tetramate macrolactams from phylogenetically diverse bacteria

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Enhanced Efficacy of Gastric Cancer Treatment through Targeted Exosome Delivery of 17-DMAG Anticancer Agent

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Geldanamycins: Potent Hsp90 Inhibitors with Significant Potential in Cancer Therapy

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A Smart Hyperthermia Nanofiber-Platform-Enabled Sustained Release of Doxorubicin and 17AAG for Synergistic Cancer Therapy

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A Phase II trial of 17-allylamino, 17-demethoxygeldanamycin (17-AAG, tanespimycin) in patients with metastatic melanoma

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Suppression of tumor-associated neutrophils by lorlatinib attenuates pancreatic cancer growth and improves treatment with immune checkpoint blockade

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A new polycyclic tetramate macrolactam from Allostreptomyces RD068384: stereochemistry and antifungal potential

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New polycyclic tetramate macrolactams with antimycobacterial activity produced by marine-derived Streptomyces sp. KKMA-0239

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Gilteritinib overcomes lorlatinib resistance in ALK-rearranged cancer

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The Discovery of Weddellamycin, a Tricyclic Polyene Macrolactam Antibiotic from an Antarctic Deep-Sea-Derived Streptomyces sp. DSS69, by Heterologous Expression

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Chronic Treatment with 17-DMAG Improves Balance and Coordination in A New Mouse Model of Machado-Joseph Disease

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Inhibition of heat shock protein 90 destabilizes receptor tyrosine kinase ROR1 in lung adenocarcinoma

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Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90

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HSP90 inhibitor geldanamycin reverts IL-13– and IL-17–induced airway goblet cell metaplasia

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