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54 results for Lactams,+Macrocyclic+-+chemistry

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PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations
Author / Creator:Zou, Helen Y. ; Li, Qiuhua ; Engstrom, Lars D. ; West, Melissa ; Appleman, Vicky ; Wong, Katy A. ; McTigue, Michele ; Deng, Ya-Li ; Liu, Wei ; Brooun, Alexei ; Timofeevski, Sergei ; McDonnell, Scott R. P. ; Jiang, Ping ; Falk, Matthew D. ; Lappin, Patrick B. ; Affolter, Timothy ; Nichols, Tim ; Hu, Wenyue ; Lam, Justine ; Johnson, Ted W. ; Smeal, Tod ; Charest, Al ; Fantin, Valeria R.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2015-03, Vol.112 (11), p.3493-3498
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Activation and characterization of a cryptic polycyclic tetramate macrolactam biosynthetic gene cluster
Author / Creator:Luo, Yunzi ; Huang, Hua ; Liang, Jing ; Wang, Meng ; Lu, Lu ; Shao, Zengyi ; Cobb, Ryan E. ; Zhao, Huimin
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2013-12, Vol.4 (1), p.2894-2894, Article 2894
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Structure and function of the geldanamycin amide synthase from Streptomyces hygroscopicus
Author / Creator:Ewert, Wiebke ; Bartens, Christian ; Ongouta, Jekaterina ; Holmes, Monika ; Heutling, Anja ; Kishore, Anusha ; Urbansky, Tim ; Zeilinger, Carsten ; Preller, Matthias ; Kirschning, Andreas
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2025-03, Vol.16 (1), p.2464-13, Article 2464
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The Odd Couple(s): An Overview of Beta-Lactam Antibiotics Bearing More Than One Pharmacophoric Group
Author / Creator:De Rosa, Margherita ; Verdino, Anna ; Soriente, Annunziata ; Marabotti, Anna
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2021-01, Vol.22 (2), p.617
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Genome Mining of Marine-Derived Streptomyces sp. SCSIO 40010 Leads to Cytotoxic New Polycyclic Tetramate Macrolactams
Author / Creator:Liu, Wei ; Zhang, Wenjun ; Jin, Hongbo ; Zhang, Qingbo ; Chen, Yuchan ; Jiang, Xiaodong ; Zhang, Guangtao ; Zhang, Liping ; Zhang, Weimin ; She, Zhigang ; Zhang, Changsheng
Publisher:Switzerland: MDPI AG
Journal title:Marine drugs, 2019-11, Vol.17 (12), p.663
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Geldanamycins: Potent Hsp90 Inhibitors with Significant Potential in Cancer Therapy
Author / Creator:Abdullah, Omeima ; Omran, Ziad
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2024-10, Vol.25 (20), p.11293
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Common biosynthetic origins for polycyclic tetramate macrolactams from phylogenetically diverse bacteria
Author / Creator:Blodgett, Joshua A. V. ; Oh, Dong-Chan ; Cao, Shugeng ; Currie, Cameron R. ; Kolter, Roberto ; Clardy, Jon ; Meinwald, Jerrold
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2010-06, Vol.107 (26), p.11692-11697
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A Smart Hyperthermia Nanofiber-Platform-Enabled Sustained Release of Doxorubicin and 17AAG for Synergistic Cancer Therapy
Author / Creator:Chen, Lili ; Fujisawa, Nanami ; Takanohashi, Masato ; Najmina, Mazaya ; Uto, Koichiro ; Ebara, Mitsuhiro
Publisher:Switzerland: MDPI
Journal title:International journal of molecular sciences, 2021-03, Vol.22 (5), p.2542
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Structural Characterization of Heat Shock Protein 90β and Molecular Interactions with Geldanamycin and Ritonavir: A Computational Study
Author / Creator:Lima, Carlyle Ribeiro ; Antunes, Deborah ; Caffarena, Ernesto ; Carels, Nicolas
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2024-08, Vol.25 (16), p.8782
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Light-induced rearrangement from macrocyclic to bicyclic lactam: A case study of N-chlorinated laurolactam
Author / Creator:Zubčić, Gabrijel ; Pavić, Kristina ; You, Jiangyang ; Vrček, Valerije ; Portada, Tomislav ; Bešić, Erim ; Šakić, Davor
Publisher:Poland: Sciendo
Journal title:Acta Pharmaceutica, 2024-12, Vol.74 (4), p.725-737
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Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90
Author / Creator:Kang, Byoung Heon ; Plescia, Janet ; Song, Ho Young ; Meli, Massimiliano ; Colombo, Giorgio ; Beebe, Kristin ; Scroggins, Bradley ; Neckers, Len ; Altieri, Dario C
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2009-03, Vol.119 (3), p.454-464
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A docking-based structural analysis of geldanamycin-derived inhibitor binding to human or Leishmania Hsp90
Author / Creator:Palma, Luana Carneiro ; Ferreira, Luiz Felipe Gomes Rebello ; Petersen, Antonio Luis de Oliveira Almeida ; Dias, Beatriz Rocha Simões ; Menezes, Juliana Perrone Bezerra de ; Moreira, Diogo Rodrigo de Magalhães ; Hernandes, Marcelo Zaldini ; Veras, Patricia Sampaio Tavares
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2019-10, Vol.9 (1), p.14756-9, Article 14756
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The Discovery of Weddellamycin, a Tricyclic Polyene Macrolactam Antibiotic from an Antarctic Deep-Sea-Derived Streptomyces sp. DSS69, by Heterologous Expression
Author / Creator:Chen, Lu ; Liu, Kai ; Hong, Jiali ; Cui, Zhanzhao ; He, Weijun ; Wang, Yemin ; Deng, Zixin ; Tao, Meifeng
Publisher:Switzerland: MDPI AG
Journal title:Marine drugs, 2024-04, Vol.22 (4), p.189
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Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90
Author / Creator:Kitson, Russell R. A. ; Chang, Chuan-Hsin ; Xiong, Rui ; Williams, Huw E. L. ; Davis, Adrienne L. ; Lewis, William ; Dehn, Donna L. ; Siegel, David ; Roe, S. Mark ; Prodromou, Chrisostomos ; Ross, David ; Moody, Christopher J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature chemistry, 2013-04, Vol.5 (4), p.307-314
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Development of 17-Allylamino-17-Demethoxygeldanamycin Hydroquinone Hydrochloride (IPI-504), an Anti-Cancer Agent Directed against Hsp90
Author / Creator:Sydor, Jens R. ; Normant, Emmanuel ; Pien, Christine S. ; Porter, James R. ; Ge, Jie ; Grenier, Louis ; Pak, Roger H. ; Ali, Janid A. ; Dembski, Marlene S. ; Hudak, Jebecka ; Patterson, Jon ; Penders, Courtney ; Pink, Melissa ; Read, Margaret A. ; Sang, Jim ; Woodward, Caroline ; Zhang, Yilong ; Grayzel, David S. ; Wright, Jim ; Barrett, John A. ; Palombella, Vito J. ; Adams, Julian ; Tong, Jeffrey K.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2006-11, Vol.103 (46), p.17408-17413
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Diversity-Oriented Synthesis Probe Targets Plasmodium falciparum Cytochrome b Ubiquinone Reduction Site and Synergizes With Oxidation Site Inhibitors
Author / Creator:Lukens, Amanda K. ; Heidebrecht, Richard W. ; Mulrooney, Carol ; Beaudoin, Jennifer A. ; Comer, Eamon ; Duvall, Jeremy R. ; Fitzgerald, Mark E. ; Masi, Daniela ; Galinsky, Kevin ; Scherer, Christina A. ; Palmer, Michelle ; Munoz, Benito ; Foley, Michael ; Schreiber, Stuart L. ; Wiegand, Roger C. ; Wirth, Dyann F.
Publisher:United States: Oxford University Press
Journal title:The Journal of infectious diseases, 2015-04, Vol.211 (7), p.1097-1103
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Combined delivery of paclitaxel and tanespimycin via micellar nanocarriers: pharmacokinetics, efficacy and metabolomic analysis
Author / Creator:Katragadda, Usha ; Fan, Wei ; Wang, Yingzhe ; Teng, Quincy ; Tan, Chalet
Publisher:United States: Public Library of Science
Journal title:PloS one, 2013-03, Vol.8 (3), p.e58619
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Anti-trypanosomal compound, sagamilactam, a new polyene macrocyclic lactam from Actinomadura sp. K13-0306
Author / Creator:Kimura, Tōru ; Iwatsuki, Masato ; Asami, Yukihiro ; Ishiyama, Aki ; Hokari, Rei ; Otoguro, Kazuhiko ; Matsumoto, Atsuko ; Sato, Noriko ; Shiomi, Kazuro ; Takahashi, Yōko ; Ōmura, Satoshi ; Nakashima, Takuji
Publisher:London: Nature Publishing Group UK
Journal title:Journal of antibiotics, 2016-11, Vol.69 (11), p.818-824
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Butremycin, the 3-hydroxyl derivative of ikarugamycin and a protonated aromatic tautomer of 5'-methylthioinosine from a Ghanaian Micromonospora sp. K310
Author / Creator:Kyeremeh, Kwaku ; Acquah, Kojo Sekyi ; Sazak, Anil ; Houssen, Wael ; Tabudravu, Jioji ; Deng, Hai ; Jaspars, Marcel
Publisher:Switzerland: MDPI AG
Journal title:Marine drugs, 2014-02, Vol.12 (2), p.999-1012
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Design, Synthesis and In Vitro Investigation of Novel Basic Celastrol Carboxamides as Bio-Inspired Leishmanicidal Agents Endowed with Inhibitory Activity against Leishmania Hsp90
Author / Creator:Bassanini, Ivan ; Parapini, Silvia ; Ferrandi, Erica E ; Gabriele, Elena ; Basilico, Nicoletta ; Taramelli, Donatella ; Sparatore, Anna
Publisher:Switzerland: MDPI AG
Journal title:Biomolecules (Basel, Switzerland), 2021-01, Vol.11 (1), p.56
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Showing 1 to 20 of 54 results

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PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations

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Activation and characterization of a cryptic polycyclic tetramate macrolactam biosynthetic gene cluster

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Structure and function of the geldanamycin amide synthase from Streptomyces hygroscopicus

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The Odd Couple(s): An Overview of Beta-Lactam Antibiotics Bearing More Than One Pharmacophoric Group

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Genome Mining of Marine-Derived Streptomyces sp. SCSIO 40010 Leads to Cytotoxic New Polycyclic Tetramate Macrolactams

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Geldanamycins: Potent Hsp90 Inhibitors with Significant Potential in Cancer Therapy

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Common biosynthetic origins for polycyclic tetramate macrolactams from phylogenetically diverse bacteria

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A Smart Hyperthermia Nanofiber-Platform-Enabled Sustained Release of Doxorubicin and 17AAG for Synergistic Cancer Therapy

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Structural Characterization of Heat Shock Protein 90β and Molecular Interactions with Geldanamycin and Ritonavir: A Computational Study

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Light-induced rearrangement from macrocyclic to bicyclic lactam: A case study of N-chlorinated laurolactam

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Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90

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A docking-based structural analysis of geldanamycin-derived inhibitor binding to human or Leishmania Hsp90

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The Discovery of Weddellamycin, a Tricyclic Polyene Macrolactam Antibiotic from an Antarctic Deep-Sea-Derived Streptomyces sp. DSS69, by Heterologous Expression

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Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90

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Development of 17-Allylamino-17-Demethoxygeldanamycin Hydroquinone Hydrochloride (IPI-504), an Anti-Cancer Agent Directed against Hsp90

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Diversity-Oriented Synthesis Probe Targets Plasmodium falciparum Cytochrome b Ubiquinone Reduction Site and Synergizes With Oxidation Site Inhibitors

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Combined delivery of paclitaxel and tanespimycin via micellar nanocarriers: pharmacokinetics, efficacy and metabolomic analysis

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Anti-trypanosomal compound, sagamilactam, a new polyene macrocyclic lactam from Actinomadura sp. K13-0306

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Butremycin, the 3-hydroxyl derivative of ikarugamycin and a protonated aromatic tautomer of 5'-methylthioinosine from a Ghanaian Micromonospora sp. K310

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Design, Synthesis and In Vitro Investigation of Novel Basic Celastrol Carboxamides as Bio-Inspired Leishmanicidal Agents Endowed with Inhibitory Activity against Leishmania Hsp90

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