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Intestinal Permeability and Drug Absorption: Predictive Experimental, Computational and In Vivo Approaches
Author / Creator:Dahlgren, David ; Lennernäs, Hans
Publisher:Switzerland: MDPI AG
Journal title:Pharmaceutics, 2019-08, Vol.11 (8), p.411
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Antibody-Drug Conjugates and Targeted Treatment Strategies for Hepatocellular Carcinoma: A Drug-Delivery Perspective
Author / Creator:Dahlgren, David ; Lennernäs, Hans
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2020-06, Vol.25 (12), p.2861
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Influence of extracellular matrix composition on tumour cell behaviour in a biomimetic in vitro model for hepatocellular carcinoma
Author / Creator:Calitz, Carlemi ; Rosenquist, Jenny ; Degerstedt, Oliver ; Khaled, Jaafar ; Kopsida, Maria ; Fryknäs, Mårten ; Lennernäs, Hans ; Samanta, Ayan ; Heindryckx, Femke
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2023-01, Vol.13 (1), p.748-748, Article 748
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Melatonin mitigates chemotherapy-induced small intestinal atrophy in rats and reduces cytotoxicity in murine intestinal organoids
Author / Creator:Peters, Karsten ; Lerma Clavero, Ada ; Kullenberg, Fredrik ; Kopsida, Maria ; Dahlgren, David ; Heindryckx, Femke ; Lennernäs, Hans ; Sjöblom, Markus
Publisher:United States: Public Library of Science
Journal title:PloS one, 2024-09, Vol.19 (9), p.e0307414
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Drug Resistance and Endoplasmic Reticulum Stress in Hepatocellular Carcinoma
Author / Creator:Khaled, Jaafar ; Kopsida, Maria ; Lennernäs, Hans ; Heindryckx, Femke
Publisher:Switzerland: MDPI AG
Journal title:Cells (Basel, Switzerland), 2022-02, Vol.11 (4), p.632
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Drug Absorption Parameters Obtained Using the Isolated Perfused Rat Lung Model Are Predictive of Rat In Vivo Lung Absorption
Author / Creator:Eriksson, Johanna ; Sjögren, Erik ; Lennernäs, Hans ; Thörn, Helena
Publisher:Cham: Springer International Publishing
Journal title:The AAPS journal, 2020-05, Vol.22 (3), p.71-71, Article 71
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Melatonin-Activated Receptor Signaling Pathways Mediate Protective Effects on Surfactant-Induced Increase in Jejunal Mucosal Permeability in Rats
Author / Creator:Peters, Karsten ; Dahlgren, David ; Lennernäs, Hans ; Sjöblom, Markus
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2021-10, Vol.22 (19), p.10762
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Liver Cancer Cell Lines Treated with Doxorubicin under Normoxia and Hypoxia: Cell Viability and Oncologic Protein Profile
Author / Creator:Dubbelboer, Ilse R. ; Pavlovic, Natasa ; Heindryckx, Femke ; Sjögren, Erik ; Lennernäs, Hans
Publisher:Switzerland: MDPI AG
Journal title:Cancers, 2019-07, Vol.11 (7), p.1024
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Predicting Intestinal Precipitation—A Case Example for a Basic BCS Class II Drug
Author / Creator:Carlert, Sara ; Pålsson, Anna ; Hanisch, Gunilla ; von Corswant, Christian ; Nilsson, Catarina ; Lindfors, Lennart ; Lennernäs, Hans ; Abrahamsson, Bertil
Publisher:Boston: Boston : Springer US
Journal title:Pharmaceutical research, 2010-10, Vol.27 (10), p.2119-2130
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The In Vivo Effect of Transcellular Permeation Enhancers on the Intestinal Permeability of Two Peptide Drugs Enalaprilat and Hexarelin
Author / Creator:Dahlgren, David ; Sjöblom, Markus ; Hedeland, Mikael ; Lennernäs, Hans
Publisher:Switzerland: MDPI
Journal title:Pharmaceutics, 2020-01, Vol.12 (2), p.99
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In Vitro Cell Toxicity and Intracellular Uptake of Doxorubicin Exposed as a Solution or Liposomes: Implications for Treatment of Hepatocellular Carcinoma
Author / Creator:Kullenberg, Fredrik ; Degerstedt, Oliver ; Calitz, Carlemi ; Pavlović, Nataša ; Balgoma, David ; Gråsjö, Johan ; Sjögren, Erik ; Hedeland, Mikael ; Heindryckx, Femke ; Lennernäs, Hans
Publisher:Basel: MDPI AG
Journal title:Cells (Basel, Switzerland), 2021-07, Vol.10 (7), p.1717
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Protective Effects of Melatonin and Misoprostol against Experimentally Induced Increases in Intestinal Permeability in Rats
Author / Creator:Peters, Karsten ; Dahlgren, David ; Egerszegi, Péter Pál ; Lennernäs, Hans ; Sjöblom, Markus
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2022-03, Vol.23 (6), p.2912
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Does the choice of applied physiologically‐based pharmacokinetics platform matter? A case study on simvastatin disposition and drug–drug interaction
Author / Creator:Prieto Garcia, Luna ; Lundahl, Anna ; Ahlström, Christine ; Vildhede, Anna ; Lennernäs, Hans ; Sjögren, Erik
Publisher:Hoboken: John Wiley & Sons, Inc
Journal title:CPT: pharmacometrics and systems pharmacology, 2022-09, Vol.11 (9), p.1194-1209
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Chemotherapeutics Combined with Luminal Irritants: Effects on Small-Intestinal Mannitol Permeability and Villus Length in Rats
Author / Creator:Cano-Cebrián, Maria-José ; Dahlgren, David ; Kullenberg, Fredrik ; Peters, Karsten ; Olander, Tobias ; Sjöblom, Markus ; Lennernäs, Hans
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2022-01, Vol.23 (3), p.1021
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ArticlesPeer ReviewedFull Text
Carbon Dioxide-Mediated Generation of Hybrid Nanoparticles for Improved Bioavailability of Protein Kinase Inhibitors
Author / Creator:Jesson, Gérald ; Brisander, Magnus ; Andersson, Per ; Demirbüker, Mustafa ; Derand, Helene ; Lennernäs, Hans ; Malmsten, Martin
Publisher:Boston: Springer US
Journal title:Pharmaceutical research, 2014-03, Vol.31 (3), p.694-705
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Physiologically based pharmacokinetics modeling and transporter proteomics to predict systemic and local liver and muscle disposition of statins
Author / Creator:Prieto Garcia, Luna ; Vildhede, Anna ; Nordell, Pär ; Ahlström, Christine ; Montaser, Ahmed B. ; Terasaki, Tetsuya ; Lennernäs, Hans ; Sjögren, Erik
Publisher:United States: John Wiley & Sons, Inc
Journal title:CPT: pharmacometrics and systems pharmacology, 2024-06, Vol.13 (6), p.1029-1043
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Anthracyclins Increase PUFAs: Potential Implications in ER Stress and Cell Death
Author / Creator:Balgoma, David ; Kullenberg, Fredrik ; Calitz, Carlemi ; Kopsida, Maria ; Heindryckx, Femke ; Lennernäs, Hans ; Hedeland, Mikael
Publisher:Switzerland: MDPI AG
Journal title:Cells (Basel, Switzerland), 2021-05, Vol.10 (5), p.1163
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ArticlesPeer ReviewedFull Text
Regional Intestinal Drug Permeability and Effects of Permeation Enhancers in Rat
Author / Creator:Dahlgren, David ; Cano-Cebrián, Maria-Jose ; Olander, Tobias ; Hedeland, Mikael ; Sjöblom, Markus ; Lennernäs, Hans
Publisher:Switzerland: MDPI AG
Journal title:Pharmaceutics, 2020-03, Vol.12 (3), p.242
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Orthogonality in Principal Component Analysis Allows the Discovery of Lipids in the Jejunum That Are Independent of Ad Libitum Feeding
Author / Creator:Balgoma, David ; Kullenberg, Fredrik ; Peters, Karsten ; Dahlgren, David ; Heindryckx, Femke ; Lennernäs, Hans ; Hedeland, Mikael
Publisher:Basel: MDPI AG
Journal title:Metabolites, 2022-09, Vol.12 (9), p.866
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Prevention of Rat Intestinal Injury with a Drug Combination of Melatonin and Misoprostol
Author / Creator:Dahlgren, David ; Cano-Cebrián, Maria-José ; Hellström, Per M. ; Wanders, Alkwin ; Sjöblom, Markus ; Lennernäs, Hans
Publisher:Switzerland: MDPI
Journal title:International journal of molecular sciences, 2020-09, Vol.21 (18), p.6771
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Showing 1 to 20 of 57 results

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Intestinal Permeability and Drug Absorption: Predictive Experimental, Computational and In Vivo Approaches

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Antibody-Drug Conjugates and Targeted Treatment Strategies for Hepatocellular Carcinoma: A Drug-Delivery Perspective

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Influence of extracellular matrix composition on tumour cell behaviour in a biomimetic in vitro model for hepatocellular carcinoma

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Melatonin mitigates chemotherapy-induced small intestinal atrophy in rats and reduces cytotoxicity in murine intestinal organoids

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Drug Resistance and Endoplasmic Reticulum Stress in Hepatocellular Carcinoma

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Drug Absorption Parameters Obtained Using the Isolated Perfused Rat Lung Model Are Predictive of Rat In Vivo Lung Absorption

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Melatonin-Activated Receptor Signaling Pathways Mediate Protective Effects on Surfactant-Induced Increase in Jejunal Mucosal Permeability in Rats

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Liver Cancer Cell Lines Treated with Doxorubicin under Normoxia and Hypoxia: Cell Viability and Oncologic Protein Profile

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Predicting Intestinal Precipitation—A Case Example for a Basic BCS Class II Drug

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The In Vivo Effect of Transcellular Permeation Enhancers on the Intestinal Permeability of Two Peptide Drugs Enalaprilat and Hexarelin

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In Vitro Cell Toxicity and Intracellular Uptake of Doxorubicin Exposed as a Solution or Liposomes: Implications for Treatment of Hepatocellular Carcinoma

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Protective Effects of Melatonin and Misoprostol against Experimentally Induced Increases in Intestinal Permeability in Rats

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Does the choice of applied physiologically‐based pharmacokinetics platform matter? A case study on simvastatin disposition and drug–drug interaction

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Chemotherapeutics Combined with Luminal Irritants: Effects on Small-Intestinal Mannitol Permeability and Villus Length in Rats

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Carbon Dioxide-Mediated Generation of Hybrid Nanoparticles for Improved Bioavailability of Protein Kinase Inhibitors

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Physiologically based pharmacokinetics modeling and transporter proteomics to predict systemic and local liver and muscle disposition of statins

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Anthracyclins Increase PUFAs: Potential Implications in ER Stress and Cell Death

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Regional Intestinal Drug Permeability and Effects of Permeation Enhancers in Rat

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Orthogonality in Principal Component Analysis Allows the Discovery of Lipids in the Jejunum That Are Independent of Ad Libitum Feeding

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Prevention of Rat Intestinal Injury with a Drug Combination of Melatonin and Misoprostol

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