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ArticlesPeer ReviewedFull Text
2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer
Author / Creator:Blomme, Arnaud ; Ford, Catriona A. ; Mui, Ernest ; Patel, Rachana ; Ntala, Chara ; Jamieson, Lauren E. ; Planque, Mélanie ; McGregor, Grace H. ; Peixoto, Paul ; Hervouet, Eric ; Nixon, Colin ; Salji, Mark ; Gaughan, Luke ; Markert, Elke ; Repiscak, Peter ; Sumpton, David ; Blanco, Giovanny Rodriguez ; Lilla, Sergio ; Kamphorst, Jurre J. ; Graham, Duncan ; Faulds, Karen ; MacKay, Gillian M. ; Fendt, Sarah-Maria ; Zanivan, Sara ; Leung, Hing Y.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2020-05, Vol.11 (1), p.2508-17, Article 2508
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PPAR-gamma induced AKT3 expression increases levels of mitochondrial biogenesis driving prostate cancer
Author / Creator:Galbraith, Laura C. A. ; Mui, Ernest ; Nixon, Colin ; Hedley, Ann ; Strachan, David ; MacKay, Gillian ; Sumpton, David ; Sansom, Owen J. ; Leung, Hing Y. ; Ahmad, Imran
Publisher:London: Nature Publishing Group UK
Journal title:Oncogene, 2021-04, Vol.40 (13), p.2355-2366
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Traject3d allows label-free identification of distinct co-occurring phenotypes within 3D culture by live imaging
Author / Creator:Freckmann, Eva C. ; Sandilands, Emma ; Cumming, Erin ; Neilson, Matthew ; Román-Fernández, Alvaro ; Nikolatou, Konstantina ; Nacke, Marisa ; Lannagan, Tamsin R. M. ; Hedley, Ann ; Strachan, David ; Salji, Mark ; Morton, Jennifer P. ; McGarry, Lynn ; Leung, Hing Y. ; Sansom, Owen J. ; Miller, Crispin J. ; Bryant, David M.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2022-09, Vol.13 (1), p.5317-5317, Article 5317
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Application of Holistic Liquid Chromatography-High Resolution Mass Spectrometry Based Urinary Metabolomics for Prostate Cancer Detection and Biomarker Discovery
Author / Creator:Zhang, Tong ; Watson, David G ; Wang, Lijie ; Abbas, Muhammad ; Murdoch, Laura ; Bashford, Lisa ; Ahmad, Imran ; Lam, Nga-Yee ; Ng, Anthony C F ; Leung, Hing Y
Publisher:United States: Public Library of Science
Journal title:PloS one, 2013-06, Vol.8 (6), p.e65880
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RUNX1 marks a luminal castration-resistant lineage established at the onset of prostate development
Author / Creator:Mevel, Renaud ; Steiner, Ivana ; Mason, Susan ; Galbraith, Laura Ca ; Patel, Rahima ; Fadlullah, Muhammad Zh ; Ahmad, Imran ; Leung, Hing Y ; Oliveira, Pedro ; Blyth, Karen ; Baena, Esther ; Lacaud, Georges
Publisher:England: eLife Science Publications, Ltd
Journal title:eLife, 2020-10, Vol.9
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A contemporary analysis of disease upstaging of Gleason 3 + 3 prostate cancer patients after robot‐assisted laparoscopic prostatectomy
Author / Creator:Taggart, Ruairidh ; Dutto, Lorenzo ; Leung, Hing Y. ; Salji, Mark ; Ahmad, Imran
Publisher:United States: John Wiley & Sons, Inc
Journal title:Cancer medicine (Malden, MA), 2023-11, Vol.12 (22), p.20830-20837
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Impact of Centralisation of Radical Prostatectomy Driven by the Introduction of Robotic Systems on Positive Surgical Margin and Biochemical Recurrence in pT2 Prostate Cancer
Author / Creator:Ibrahim, Ibrahim ; Kouli, Omar ; Ilangovan, Sanjana ; Sneddon, Melanie ; Nalagatla, Sarika ; Marshall, Carol ; Dutto, Lorenzo ; Leung, Hing Y. ; Ahmad, Imran
Publisher:United States: John Wiley & Sons, Inc
Journal title:Cancer medicine (Malden, MA), 2025-01, Vol.14 (2), p.e70514-n/a
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An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism
Author / Creator:Nacke, Marisa ; Sandilands, Emma ; Nikolatou, Konstantina ; Román-Fernández, Álvaro ; Mason, Susan ; Patel, Rachana ; Lilla, Sergio ; Yelland, Tamas ; Galbraith, Laura C. A. ; Freckmann, Eva C. ; McGarry, Lynn ; Morton, Jennifer P. ; Shanks, Emma ; Leung, Hing Y. ; Markert, Elke ; Ismail, Shehab ; Zanivan, Sara ; Blyth, Karen ; Bryant, David M.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-03, Vol.12 (1), p.1623-22, Article 1623
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Sprouty2, PTEN, and PP2A interact to regulate prostate cancer progression
Author / Creator:Patel, Rachana ; Gao, Meiling ; Ahmad, Imran ; Fleming, Janis ; Singh, Lukram B ; Rai, Taranjit Singh ; McKie, Arthur B ; Seywright, Morag ; Barnetson, Robert J ; Edwards, Joanne ; Sansom, Owen J ; Leung, Hing Y
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2013-03, Vol.123 (3), p.1157-1175
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ArticlesPeer ReviewedFull Text
Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments
Author / Creator:Peck, Barrie ; Schug, Zachary T ; Zhang, Qifeng ; Dankworth, Beatrice ; Jones, Dylan T ; Smethurst, Elizabeth ; Patel, Rachana ; Mason, Susan ; Jiang, Ming ; Saunders, Rebecca ; Howell, Michael ; Mitter, Richard ; Spencer-Dene, Bradley ; Stamp, Gordon ; McGarry, Lynn ; James, Daniel ; Shanks, Emma ; Aboagye, Eric O ; Critchlow, Susan E ; Leung, Hing Y ; Harris, Adrian L ; Wakelam, Michael J O ; Gottlieb, Eyal ; Schulze, Almut
Publisher:England: BioMed Central Ltd
Journal title:Cancer & metabolism, 2016-04, Vol.4 (5), p.6-6, Article 6
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The RNA-binding protein Sam68 regulates expression and transcription function of the androgen receptor splice variant AR-V7
Author / Creator:Stockley, Jacqueline ; Markert, Elke ; Zhou, Yan ; Robson, Craig N. ; Elliott, David J. ; Lindberg, Johan ; Leung, Hing Y. ; Rajan, Prabhakar
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2015-08, Vol.5 (1), p.13426-13426, Article 13426
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ArticlesPeer ReviewedFull Text
The cancer-associated cell migration protein TSPAN1 is under control of androgens and its upregulation increases prostate cancer cell migration
Author / Creator:Munkley, Jennifer ; McClurg, Urszula L. ; Livermore, Karen E. ; Ehrmann, Ingrid ; Knight, Bridget ; Mccullagh, Paul ; Mcgrath, John ; Crundwell, Malcolm ; Harries, Lorna W. ; Leung, Hing Y. ; Mills, Ian G. ; Robson, Craig N. ; Rajan, Prabhakar ; Elliott, David J.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2017-07, Vol.7 (1), p.5249-11, Article 5249
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Regression of prostate tumors after intravenous administration of lactoferrin-bearing polypropylenimine dendriplexes encoding TNF-α, TRAIL, and interleukin-12
Author / Creator:Altwaijry, Najla ; Somani, Sukrut ; Parkinson, John A. ; Tate, Rothwelle J. ; Keating, Patricia ; Warzecha, Monika ; Mackenzie, Graeme R. ; Leung, Hing Y. ; Dufès, Christine
Publisher:England: Taylor & Francis
Journal title:Drug delivery, 2018-11, Vol.25 (1), p.679-689
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ArticlesPeer ReviewedFull Text
BRF1 accelerates prostate tumourigenesis and perturbs immune infiltration
Author / Creator:Loveridge, Carolyn J. ; Slater, Sarah ; Campbell, Kirsteen J. ; Nam, Noor A. ; Knight, John ; Ahmad, Imran ; Hedley, Ann ; Lilla, Sergio ; Repiscak, Peter ; Patel, Rachana ; Salji, Mark ; Fleming, Janis ; Mitchell, Louise ; Nixon, Colin ; Strathdee, Douglas ; Neilson, Matthew ; Ntala, Chara ; Bryson, Sheila ; Zanivan, Sara ; Edwards, Joanne ; Robson, Craig N. ; Goodyear, Carl S. ; Blyth, Karen ; Leung, Hing Y.
Publisher:London: Nature Publishing Group UK
Journal title:Oncogene, 2020-02, Vol.39 (8), p.1797-1806
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THEM6‐mediated reprogramming of lipid metabolism supports treatment resistance in prostate cancer
Author / Creator:Blomme, Arnaud ; Peter, Coralie ; Mui, Ernest ; Rodriguez Blanco, Giovanny ; An, Ning ; Mason, Louise M ; Jamieson, Lauren E ; McGregor, Grace H ; Lilla, Sergio ; Ntala, Chara ; Patel, Rachana ; Thiry, Marc ; Kung, Sonia H Y ; Leclercq, Marine ; Ford, Catriona A ; Rushworth, Linda K ; McGarry, David J ; Mason, Susan ; Repiscak, Peter ; Nixon, Colin ; Salji, Mark J ; Markert, Elke ; MacKay, Gillian M ; Kamphorst, Jurre J ; Graham, Duncan ; Faulds, Karen ; Fazli, Ladan ; Gleave, Martin E ; Avezov, Edward ; Edwards, Joanne ; Yin, Huabing ; Sumpton, David ; Blyth, Karen ; Close, Pierre ; Murphy, Daniel J ; Zanivan, Sara ; Leung, Hing Y
Publisher:London: Nature Publishing Group UK
Journal title:EMBO molecular medicine, 2022-03, Vol.14 (3), p.e14764-n/a
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A Comparative Evaluation of Mediastinal Nodal SUVmax and Derived Ratios from 18F-FDG PET/CT Imaging to Predict Nodal Metastases in Non-Small Cell Lung Cancer
Author / Creator:AlRasheedi, Maha ; Han, Sai ; Thygesen, Helene ; Neilson, Matt ; Hendry, Fraser ; Alkarn, Ahmed ; Maclay, John D. ; Leung, Hing Y.
Publisher:Basel: MDPI AG
Journal title:Diagnostics (Basel), 2023-03, Vol.13 (7), p.1209
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Developing a coordinate-based strategy to support cognitive targeted prostate biopsies and correlative spatial-histopathological outcome analysis
Author / Creator:Clement, Keiran ; Day, Lizzy ; Rooney, Helen ; Neilson, Matt ; Birrell, Fiona ; Salji, Mark ; Norman, Elizabeth ; Clark, Ross ; Patel, Amit ; Morrison, John ; Leung, Hing
Publisher:China: Wolters Kluwer India Pvt. Ltd
Journal title:Asian journal of andrology, 2021-05, Vol.23 (3), p.231-235
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Sprouty2 loss‐induced IL6 drives castration‐resistant prostate cancer through scavenger receptor B1
Author / Creator:Patel, Rachana ; Fleming, Janis ; Mui, Ernest ; Loveridge, Carolyn ; Repiscak, Peter ; Blomme, Arnaud ; Harle, Victoria ; Salji, Mark ; Ahmad, Imran ; Teo, Katy ; Hamdy, Freddie C ; Hedley, Ann ; van den Broek, Niels ; Mackay, Gillian ; Edwards, Joanne ; Sansom, Owen J ; Leung, Hing Y
Publisher:London: Nature Publishing Group UK
Journal title:EMBO molecular medicine, 2018-04, Vol.10 (4), p.1-n/a
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Targeting the DNA double strand break repair machinery in prostate cancer
Author / Creator:Shaheen, Fadhel S ; Znojek, Pawel ; Fisher, Ann ; Webster, Martin ; Plummer, Ruth ; Gaughan, Luke ; Smith, Graeme C M ; Leung, Hing Y ; Curtin, Nicola J ; Robson, Craig N
Publisher:United States: Public Library of Science
Journal title:PloS one, 2011-05, Vol.6 (5), p.e20311
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HER2 overcomes PTEN (loss)-induced senescence to cause aggressive prostate cancer
Author / Creator:Ahmad, Imran ; Patel, Rachana ; Singh, Lukram Babloo ; Nixon, Colin ; Seywright, Morag ; Barnetson, Robert J ; Brunton, Valerie G ; Muller, William J ; Edwards, Joanne ; Sansom, Owen J ; Leung, Hing Y
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2011-09, Vol.108 (39), p.16392-16397
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2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer

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PPAR-gamma induced AKT3 expression increases levels of mitochondrial biogenesis driving prostate cancer

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Traject3d allows label-free identification of distinct co-occurring phenotypes within 3D culture by live imaging

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Application of Holistic Liquid Chromatography-High Resolution Mass Spectrometry Based Urinary Metabolomics for Prostate Cancer Detection and Biomarker Discovery

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RUNX1 marks a luminal castration-resistant lineage established at the onset of prostate development

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A contemporary analysis of disease upstaging of Gleason 3 + 3 prostate cancer patients after robot‐assisted laparoscopic prostatectomy

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Impact of Centralisation of Radical Prostatectomy Driven by the Introduction of Robotic Systems on Positive Surgical Margin and Biochemical Recurrence in pT2 Prostate Cancer

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An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism

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Sprouty2, PTEN, and PP2A interact to regulate prostate cancer progression

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Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments

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The RNA-binding protein Sam68 regulates expression and transcription function of the androgen receptor splice variant AR-V7

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The cancer-associated cell migration protein TSPAN1 is under control of androgens and its upregulation increases prostate cancer cell migration

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Regression of prostate tumors after intravenous administration of lactoferrin-bearing polypropylenimine dendriplexes encoding TNF-α, TRAIL, and interleukin-12

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BRF1 accelerates prostate tumourigenesis and perturbs immune infiltration

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THEM6‐mediated reprogramming of lipid metabolism supports treatment resistance in prostate cancer

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A Comparative Evaluation of Mediastinal Nodal SUVmax and Derived Ratios from 18F-FDG PET/CT Imaging to Predict Nodal Metastases in Non-Small Cell Lung Cancer

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Developing a coordinate-based strategy to support cognitive targeted prostate biopsies and correlative spatial-histopathological outcome analysis

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Sprouty2 loss‐induced IL6 drives castration‐resistant prostate cancer through scavenger receptor B1

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Targeting the DNA double strand break repair machinery in prostate cancer

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HER2 overcomes PTEN (loss)-induced senescence to cause aggressive prostate cancer

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