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135 results for Mitogen-Activated+Protein+Kinases+-+chemistry

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ArticlesPeer ReviewedFull Text
Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase
Author / Creator:Smith, Blake E. ; Wang, Stephen L. ; Jaime-Figueroa, Saul ; Harbin, Alicia ; Wang, Jing ; Hamman, Brian D. ; Crews, Craig M.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2019-01, Vol.10 (1), p.131-131, Article 131
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A structure-based mechanism of cisplatin resistance mediated by glutathione transferase P1-1
Author / Creator:De Luca, Anastasia ; Parker, Lorien J. ; Ang, Wee Han ; Rodolfo, Carlo ; Gabbarini, Valentina ; Hancock, Nancy C. ; Palone, Francesca ; Mazzetti, Anna P. ; Menin, Laure ; Morton, Craig J. ; Parker, Michael W. ; Lo Bello, Mario ; Dyson, Paul J.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2019-07, Vol.116 (28), p.13943-13951
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PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas
Author / Creator:Lu, Hezhe ; Liu, Shujing ; Zhang, Gao ; Bin Wu ; Zhu, Yueyao ; Frederick, Dennie T. ; Hu, Yi ; Zhong, Wenqun ; Randell, Sergio ; Sadek, Norah ; Zhang, Wei ; Chen, Gang ; Cheng, Chaoran ; Zeng, Jingwen ; Wu, Lawrence W. ; Zhang, Jie ; Liu, Xiaoming ; Xu, Wei ; Krepler, Clemens ; Sproesser, Katrin ; Xiao, Min ; Miao, Benchun ; Liu, Jianglan ; Song, Claire D. ; Liu, Jephrey Y. ; Karakousis, Giorgos C. ; Schuchter, Lynn M. ; Lu, Yiling ; Mills, Gordon ; Cong, Yusheng ; Chernoff, Jonathan ; Guo, Jun ; Boland, Genevieve M. ; Sullivan, Ryan J. ; Wei, Zhi ; Field, Jeffrey ; Amaravadi, Ravi K. ; Flaherty, Keith T. ; Herlyn, Meenhard ; Xu, Xiaowei ; Guo, Wei
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2017-10, Vol.550 (7674), p.133-136
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Mitogen-Activated Protein Kinase Cascade MKK7-MPK6 Plays Important Roles in Plant Development and Regulates Shoot Branching by Phosphorylating PIN1 in Arabidopsis
Author / Creator:Jia, Weiyan ; Li, Baohua ; Li, Shujia ; Liang, Yan ; Wu, Xiaowei ; Ma, Mei ; Wang, Jiyao ; Gao, Jin ; Cai, Yueyue ; Zhang, Yuanya ; Wang, Yingchun ; Li, Jiayang ; Wang, Yonghong
Publisher:United States: Public Library of Science
Journal title:PLoS biology, 2016-09, Vol.14 (9), p.e1002550-e1002550
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Dynamic activation and regulation of the mitogen-activated protein kinase p38
Author / Creator:Kumar, Ganesan Senthil ; Clarkson, Michael W. ; Kunze, Micha B. A. ; Granata, Daniele ; Wand, A. Joshua ; Lindorff-Larsen, Kresten ; Page, Rebecca ; Peti, Wolfgang
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2018-05, Vol.115 (18), p.4655-4660
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Differential regulation and properties of MAPKs
Author / Creator:Raman, M ; Chen, W ; Cobb, M H
Publisher:London: Nature Publishing Group UK
Journal title:Oncogene, 2007-05, Vol.26 (22), p.3100-3112
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Genome-wide identification of MAPK, MAPKK, and MAPKKK gene families and transcriptional profiling analysis during development and stress response in cucumber
Author / Creator:Wang, Jie ; Pan, Changtian ; Wang, Yan ; Ye, Lei ; Wu, Jian ; Chen, Lifei ; Zou, Tao ; Lu, Gang
Publisher:England: BioMed Central Ltd
Journal title:BMC genomics, 2015-05, Vol.16 (1), p.386-386, Article 386
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A consistent description of HYdrogen bond and DEhydration energies in protein–ligand complexes: methods behind the HYDE scoring function
Author / Creator:Schneider, Nadine ; Lange, Gudrun ; Hindle, Sally ; Klein, Robert ; Rarey, Matthias
Publisher:Dordrecht: Springer Netherlands
Journal title:Journal of computer-aided molecular design, 2013-01, Vol.27 (1), p.15-29
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Spatio-Temporal Correlations Can Drastically Change the Response of a MAPK Pathway
Author / Creator:Takahashi, Koichi ; Tănase-Nicola, Sorin ; ten Wolde, Pieter Rein ; Austin, Robert H.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2010-02, Vol.107 (6), p.2473-2478
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Phosphorylation of Trihelix Transcriptional Repressor ASR3 by MAP KINASE4 Negatively Regulates Arabidopsis Immunity
Author / Creator:Li, Bo ; Jiang, Shan ; Yu, Xiao ; Cheng, Cheng ; Chen, Sixue ; Cheng, Yanbing ; Yuan, Joshua S. ; Jiang, Daohong ; He, Ping ; Shan, Libo
Publisher:United States: American Society of Plant Biologists
Journal title:The Plant cell, 2015-03, Vol.27 (3), p.839-856
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Targeting the mitogen-activated protein kinase cascade to treat cancer
Author / Creator:Sebolt-Leopold, Judith S. ; Herrera, Roman
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Cancer, 2004-12, Vol.4 (12), p.937-947
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MicroRNAs as Key Players in Melanoma Cell Resistance to MAPK and Immune Checkpoint Inhibitors
Author / Creator:Motti, Maria Letizia ; Minopoli, Michele ; Di Carluccio, Gioconda ; Ascierto, Paolo Antonio ; Carriero, Maria Vincenza
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2020-06, Vol.21 (12), p.4544
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Genome-wide identification and molecular characterization of the MAPK family members in sand pear (Pyrus pyrifolia)
Author / Creator:Xu, Yue ; Wang, Huiying ; Shi, Haiyan
Publisher:England: BioMed Central Ltd
Journal title:BMC genomics, 2025-05, Vol.26 (1), p.485-19, Article 485
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Genome-Wide Identification, Phylogeny and Expressional Profiles of Mitogen Activated Protein Kinase Gene Family in Blakeslea trispora
Author / Creator:Ge, Xin ; Cui, Yue ; Zhang, Yanan ; Li, Jianlin ; Wang, Ping ; Zheng, Yan ; Xin, Qi
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2025-05, Vol.26 (10), p.4789
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Changes in the free-energy landscape of p38α MAP kinase through its canonical activation and binding events as studied by enhanced molecular dynamics simulations
Author / Creator:Kuzmanic, Antonija ; Sutto, Ludovico ; Saladino, Giorgio ; Nebreda, Angel R ; Gervasio, Francesco L ; Orozco, Modesto
Publisher:England: eLife Sciences Publications Ltd
Journal title:eLife, 2017-04, Vol.6
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p38 siRNA-encapsulated PLGA nanoparticles alleviate neuropathic pain behavior in rats by inhibiting microglia activation
Author / Creator:Shin, Juhee ; Yin, Yuhua ; Park, Hyewon ; Park, Seungjo ; Triantafillu, Ursula L ; Kim, Yonghyun ; Kim, Sang Ryong ; Lee, Sun Yeul ; Kim, Do Kyung ; Hong, Jinpyo ; Kim, Dong Woon
Publisher:England: Future Medicine Ltd
Journal title:Nanomedicine (London, England), 2018-07, Vol.13 (13), p.1607-1621
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p38γ and p38δ kinases regulate the Toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation
Author / Creator:Risco, Ana ; del Fresno, Carlos ; Mambol, Agnes ; Alsina-Beauchamp, Dayanira ; MacKenzie, Kirsty F ; Yang, Huei-Ting ; Barber, Domingo F ; Morcelle, Carmen ; Arthur, J. Simon C ; Ley, Steven C ; Ardavin, Carlos ; Cuenda, Ana
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2012-07, Vol.109 (28), p.11200-11205
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intrinsic dynamics of enzymes plays a dominant role in determining the structural changes induced upon inhibitor binding
Author / Creator:Bakan, Ahmet ; Bahar, Ivet
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2009-08, Vol.106 (34), p.14349-14354
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Mapping low-affinity/high-specificity peptide–protein interactions using ligand-footprinting mass spectrometry
Author / Creator:Parker, Benjamin W. ; Goncz, Edward J. ; Krist, David T. ; Statsyuk, Alexander V. ; Nesvizhskii, Alexey I. ; Weiss, Eric L.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2019-10, Vol.116 (42), p.21001-21011
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Droplet-based screening of phosphate transfer catalysis reveals how epistasis shapes MAP kinase interactions with substrates
Author / Creator:Scheele, Remkes A. ; Lindenburg, Laurens H. ; Petek, Maya ; Schober, Markus ; Dalby, Kevin N. ; Hollfelder, Florian
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2022-02, Vol.13 (1), p.844-844, Article 844
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Showing 1 to 20 of 135 results

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Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase

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A structure-based mechanism of cisplatin resistance mediated by glutathione transferase P1-1

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PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas

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Mitogen-Activated Protein Kinase Cascade MKK7-MPK6 Plays Important Roles in Plant Development and Regulates Shoot Branching by Phosphorylating PIN1 in Arabidopsis

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Dynamic activation and regulation of the mitogen-activated protein kinase p38

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Differential regulation and properties of MAPKs

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Genome-wide identification of MAPK, MAPKK, and MAPKKK gene families and transcriptional profiling analysis during development and stress response in cucumber

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A consistent description of HYdrogen bond and DEhydration energies in protein–ligand complexes: methods behind the HYDE scoring function

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Spatio-Temporal Correlations Can Drastically Change the Response of a MAPK Pathway

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Phosphorylation of Trihelix Transcriptional Repressor ASR3 by MAP KINASE4 Negatively Regulates Arabidopsis Immunity

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Targeting the mitogen-activated protein kinase cascade to treat cancer

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MicroRNAs as Key Players in Melanoma Cell Resistance to MAPK and Immune Checkpoint Inhibitors

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Genome-wide identification and molecular characterization of the MAPK family members in sand pear (Pyrus pyrifolia)

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Genome-Wide Identification, Phylogeny and Expressional Profiles of Mitogen Activated Protein Kinase Gene Family in Blakeslea trispora

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Changes in the free-energy landscape of p38α MAP kinase through its canonical activation and binding events as studied by enhanced molecular dynamics simulations

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p38 siRNA-encapsulated PLGA nanoparticles alleviate neuropathic pain behavior in rats by inhibiting microglia activation

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p38γ and p38δ kinases regulate the Toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation

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intrinsic dynamics of enzymes plays a dominant role in determining the structural changes induced upon inhibitor binding

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Mapping low-affinity/high-specificity peptide–protein interactions using ligand-footprinting mass spectrometry

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Droplet-based screening of phosphate transfer catalysis reveals how epistasis shapes MAP kinase interactions with substrates

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