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ArticlesPeer ReviewedFull Text
Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism
Author / Creator:Cohen, Samuel I. A. ; Linse, Sara ; Luheshi, Leila M. ; Hellstrand, Erik ; White, Duncan A. ; Rajah, Luke ; Otzen, Daniel E. ; Vendruscolo, Michele ; Dobson, Christopher M. ; Knowles, Tuomas P. J.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2013-06, Vol.110 (24), p.9758-9763
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Protein drug stability: a formulation challenge
Author / Creator:Frokjaer, Sven ; Otzen, Daniel E.
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Drug discovery, 2005-04, Vol.4 (4), p.298-306
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The hydrophobic effect characterises the thermodynamic signature of amyloid fibril growth
Author / Creator:van Gils, Juami Hermine Mariama ; van Dijk, Erik ; Peduzzo, Alessia ; Hofmann, Alexander ; Vettore, Nicola ; Schützmann, Marie P ; Groth, Georg ; Mouhib, Halima ; Otzen, Daniel E ; Buell, Alexander K ; Abeln, Sanne
Publisher:United States: Public Library of Science
Journal title:PLoS computational biology, 2020-05, Vol.16 (5), p.e1007767-e1007767
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ArticlesPeer ReviewedFull Text
Low-resolution structure of a vesicle disrupting α-synuclein oligomer that accumulates during fibrillation
Author / Creator:Giehm, Lise ; Svergun, Dmitri I ; Otzen, Daniel E ; Vestergaard, Bente
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2011-02, Vol.108 (8), p.3246-3251
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Elevated concentrations cause upright alpha-synuclein conformation at lipid interfaces
Author / Creator:Roeters, Steven J. ; Strunge, Kris ; Pedersen, Kasper B. ; Golbek, Thaddeus W. ; Bregnhøj, Mikkel ; Zhang, Yuge ; Wang, Yin ; Dong, Mingdong ; Nielsen, Janni ; Otzen, Daniel E. ; Schiøtt, Birgit ; Weidner, Tobias
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2023-09, Vol.14 (1), p.5731-5731, Article 5731
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Overexpression of human alpha-Synuclein leads to dysregulated microbiome/metabolites with ageing in a rat model of Parkinson disease
Author / Creator:Singh, Yogesh ; Trautwein, Christoph ; Romani, Joan ; Salker, Madhuri S ; Neckel, Peter H ; Fraccaroli, Isabel ; Abeditashi, Mahkameh ; Woerner, Nils ; Admard, Jakob ; Dhariwal, Achal ; Dueholm, Morten K D ; Schäfer, Karl-Herbert ; Lang, Florian ; Otzen, Daniel E ; Lashuel, Hilal A ; Riess, Olaf ; Casadei, Nicolas
Publisher:England: BioMed Central Ltd
Journal title:Molecular neurodegeneration, 2023-07, Vol.18 (1), p.44-44, Article 44
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Multiple system atrophy-associated oligodendroglial protein p25α stimulates formation of novel α-synuclein strain with enhanced neurodegenerative potential
Author / Creator:Ferreira, Nelson ; Gram, Hjalte ; Sorrentino, Zachary A. ; Gregersen, Emil ; Schmidt, Sissel Ida ; Reimer, Lasse ; Betzer, Cristine ; Perez-Gozalbo, Clara ; Beltoja, Marjo ; Nagaraj, Madhu ; Wang, Jie ; Nowak, Jan S. ; Dong, Mingdong ; Willén, Katarina ; Cholak, Ersoy ; Bjerregaard-Andersen, Kaare ; Mendez, Nicolas ; Rabadia, Prakruti ; Shahnawaz, Mohammad ; Soto, Claudio ; Otzen, Daniel E. ; Akbey, Ümit ; Meyer, Morten ; Giasson, Benoit I. ; Romero-Ramos, Marina ; Jensen, Poul Henning
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Acta neuropathologica, 2021-07, Vol.142 (1), p.87-115
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Accelerated Amyloid Beta Pathogenesis by Bacterial Amyloid FapC
Author / Creator:Javed, Ibrahim ; Zhang, Zhenzhen ; Adamcik, Jozef ; Andrikopoulos, Nicholas ; Li, Yuhuan ; Otzen, Daniel E. ; Lin, Sijie ; Mezzenga, Raffaele ; Davis, Thomas P. ; Ding, Feng ; Ke, Pu Chun
Publisher:Germany: John Wiley & Sons, Inc
Journal title:Advanced science, 2020-09, Vol.7 (18), p.2001299-n/a
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ArticlesPeer ReviewedFull Text
Protein Unfolding in Detergents: Effect of Micelle Structure, Ionic Strength, pH, and Temperature
Author / Creator:Otzen, Daniel E.
Publisher:United States: Elsevier Inc
Journal title:Biophysical journal, 2002-10, Vol.83 (4), p.2219-2230
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ArticlesPeer ReviewedFull Text
Curli functional amyloid systems are phylogenetically widespread and display large diversity in operon and protein structure
Author / Creator:Dueholm, Morten S ; Albertsen, Mads ; Otzen, Daniel ; Nielsen, Per Halkjær
Publisher:United States: Public Library of Science
Journal title:PloS one, 2012-12, Vol.7 (12), p.e51274-e51274
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ArticlesPeer ReviewedFull Text
The Use of Surfactants to Solubilise a Glucagon Analogue
Author / Creator:Madsen, Jens Kvist ; Giehm, Lise ; Otzen, Daniel E.
Publisher:New York: Springer US
Journal title:Pharmaceutical research, 2018-12, Vol.35 (12), p.235-13, Article 235
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Alzheimer's Progenitor Amyloid‐β Targets and Dissolves Microbial Amyloids and Impairs Biofilm Function
Author / Creator:Ali, Syed Aoun ; Chung, Ka Hang Karen ; Forgham, Helen ; Olsen, William P. ; Kakinen, Aleksandr ; Balaji, Arunpandian ; Otzen, Daniel E. ; Davis, Thomas Paul ; Javed, Ibrahim
Publisher:Weinheim: John Wiley & Sons, Inc
Journal title:Advanced science, 2023-10, Vol.10 (29), p.e2301423-n/a
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ArticlesPeer ReviewedFull Text
Cooperative folding of a polytopic α-helical membrane protein involves a compact N-terminal nucleus and nonnative loops
Author / Creator:Paslawski, Wojciech ; Lillelund, Ove K. ; Kristensen, Julie Veje ; Schafer, Nicholas P. ; Baker, Rosanna P. ; Urban, Sinisa ; Otzen, Daniel E.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2015-06, Vol.112 (26), p.7978-7983
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The effect of osmolytes on protein fibrillation
Author / Creator:Macchi, Francesca ; Eisenkolb, Maike ; Kiefer, Hans ; Otzen, Daniel E
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2012-03, Vol.13 (3), p.3801-3819
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Sequential pH-driven dimerization and stabilization of the N-terminal domain enables rapid spider silk formation
Author / Creator:Kronqvist, Nina ; Otikovs, Martins ; Chmyrov, Volodymyr ; Chen, Gefei ; Andersson, Marlene ; Nordling, Kerstin ; Landreh, Michael ; Sarr, Médoune ; Jörnvall, Hans ; Wennmalm, Stefan ; Widengren, Jerker ; Meng, Qing ; Rising, Anna ; Otzen, Daniel ; Knight, Stefan D. ; Jaudzems, Kristaps ; Johansson, Jan
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2014, Vol.5 (1), p.3254-3254, Article 3254
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ArticlesPeer ReviewedFull Text
A Triple Role for a Bilayer: Using Nanoliposomes to Cross and Protect Cellular Membranes
Author / Creator:Otzen, Daniel E. ; Morshedi, Dina ; Mohammad-Beigi, Hossein ; Aliakbari, Farhang
Publisher:New York: Springer US
Journal title:The Journal of membrane biology, 2021-02, Vol.254 (1), p.29-39
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Anastellin impacts on the processing of extracellular matrix fibronectin and stimulates release of cytokines from coronary artery smooth muscle cells
Author / Creator:He, Jianfei ; Steffen, Jonas Hyld ; Thulstrup, Peter Waaben ; Pedersen, Jannik Nedergaard ; Sauerland, Max B. ; Otzen, Daniel E. ; Hawkins, Clare L. ; Gourdon, Pontus ; Davies, Michael J. ; Hägglund, Per
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2022-12, Vol.12 (1), p.22051-22051, Article 22051
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The Bacterial Amyloids Phenol Soluble Modulins from Staphylococcus aureus Catalyze Alpha-Synuclein Aggregation
Author / Creator:Haikal, Caroline ; Ortigosa-Pascual, Lei ; Najarzadeh, Zahra ; Bernfur, Katja ; Svanbergsson, Alexander ; Otzen, Daniel E ; Linse, Sara ; Li, Jia-Yi
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2021-11, Vol.22 (21), p.11594
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The neural chaperone proSAAS blocks α-synuclein fibrillation and neurotoxicity
Author / Creator:Jarvela, Timothy S. ; Lam, Hoa A. ; Helwig, Michael ; Lorenzen, Nikolai ; Otzen, Daniel E. ; McLean, Pamela J. ; Maidment, Nigel T. ; Lindberg, Iris
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2016-08, Vol.113 (32), p.E4708-E4715
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Evolutionary insight into the functional amyloids of the pseudomonads
Author / Creator:Dueholm, Morten S ; Otzen, Daniel ; Nielsen, Per Halkjær
Publisher:United States: Public Library of Science
Journal title:PloS one, 2013-10, Vol.8 (10), p.e76630-e76630
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Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism

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Protein drug stability: a formulation challenge

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The hydrophobic effect characterises the thermodynamic signature of amyloid fibril growth

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Low-resolution structure of a vesicle disrupting α-synuclein oligomer that accumulates during fibrillation

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Elevated concentrations cause upright alpha-synuclein conformation at lipid interfaces

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Overexpression of human alpha-Synuclein leads to dysregulated microbiome/metabolites with ageing in a rat model of Parkinson disease

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Multiple system atrophy-associated oligodendroglial protein p25α stimulates formation of novel α-synuclein strain with enhanced neurodegenerative potential

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Accelerated Amyloid Beta Pathogenesis by Bacterial Amyloid FapC

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Protein Unfolding in Detergents: Effect of Micelle Structure, Ionic Strength, pH, and Temperature

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Curli functional amyloid systems are phylogenetically widespread and display large diversity in operon and protein structure

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The Use of Surfactants to Solubilise a Glucagon Analogue

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Alzheimer's Progenitor Amyloid‐β Targets and Dissolves Microbial Amyloids and Impairs Biofilm Function

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Cooperative folding of a polytopic α-helical membrane protein involves a compact N-terminal nucleus and nonnative loops

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The effect of osmolytes on protein fibrillation

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Sequential pH-driven dimerization and stabilization of the N-terminal domain enables rapid spider silk formation

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A Triple Role for a Bilayer: Using Nanoliposomes to Cross and Protect Cellular Membranes

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Anastellin impacts on the processing of extracellular matrix fibronectin and stimulates release of cytokines from coronary artery smooth muscle cells

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The Bacterial Amyloids Phenol Soluble Modulins from Staphylococcus aureus Catalyze Alpha-Synuclein Aggregation

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The neural chaperone proSAAS blocks α-synuclein fibrillation and neurotoxicity

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Evolutionary insight into the functional amyloids of the pseudomonads

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