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21 results for Singh,+Karun+K.

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ArticlesPeer ReviewedFull Text
Altered TAOK2 activity causes autism-related neurodevelopmental and cognitive abnormalities through RhoA signaling
Author / Creator:Richter, Melanie ; Murtaza, Nadeem ; Scharrenberg, Robin ; White, Sean H. ; Johanns, Ole ; Walker, Susan ; Yuen, Ryan K. C. ; Schwanke, Birgit ; Bedürftig, Bianca ; Henis, Melad ; Scharf, Sarah ; Kraus, Vanessa ; Dörk, Ronja ; Hellmann, Jakob ; Lindenmaier, Zsuzsa ; Ellegood, Jacob ; Hartung, Henrike ; Kwan, Vickie ; Sedlacik, Jan ; Fiehler, Jens ; Schweizer, Michaela ; Lerch, Jason P. ; Hanganu-Opatz, Ileana L. ; Morellini, Fabio ; Scherer, Stephen W. ; Singh, Karun K. ; Calderon de Anda, Froylan
Publisher:London: Nature Publishing Group UK
Journal title:Molecular psychiatry, 2019-09, Vol.24 (9), p.1329-1350
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ArticlesPeer ReviewedFull Text
Human pluripotent stem cell (hPSC) and organoid models of autism: opportunities and limitations
Author / Creator:Kilpatrick, Savannah ; Irwin, Courtney ; Singh, Karun K.
Publisher:London: Nature Publishing Group UK
Journal title:Translational psychiatry, 2023-06, Vol.13 (1), p.217-217, Article 217
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ArticlesPeer ReviewedFull Text
Wnt signaling networks in autism spectrum disorder and intellectual disability
Author / Creator:Kwan, Vickie ; Unda, Brianna K. ; Singh, Karun K.
Publisher:England: BioMed Central Ltd
Journal title:Journal of neurodevelopmental disorders, 2016-12, Vol.8 (1), p.45-45, Article 45
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ArticlesPeer ReviewedFull Text
Emerging proteomic approaches to identify the underlying pathophysiology of neurodevelopmental and neurodegenerative disorders
Author / Creator:Murtaza, Nadeem ; Uy, Jarryll ; Singh, Karun K.
Publisher:England: BioMed Central Ltd
Journal title:Molecular autism, 2020-04, Vol.11 (1), p.27-27, Article 27
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CNTN5-/+or EHMT2-/+human iPSC-derived neurons from individuals with autism develop hyperactive neuronal networks
Author / Creator:Deneault, Eric ; Faheem, Muhammad ; White, Sean H ; Rodrigues, Deivid C ; Sun, Song ; Wei, Wei ; Piekna, Alina ; Thompson, Tadeo ; Howe, Jennifer L ; Chalil, Leon ; Kwan, Vickie ; Walker, Susan ; Pasceri, Peter ; Roth, Frederick P ; Yuen, Ryan KC ; Singh, Karun K ; Ellis, James ; Scherer, Stephen W
Publisher:England: eLife Sciences Publications Ltd
Journal title:eLife, 2019-02, Vol.8
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ArticlesPeer ReviewedFull Text
Disruption of the autism-associated gene SCN2A alters synaptic development and neuronal signaling in patient iPSC-glutamatergic neurons
Author / Creator:Brown, Chad O. ; Uy, Jarryll A. ; Murtaza, Nadeem ; Rosa, Elyse ; Alfonso, Alexandria ; Dave, Biren M. ; Kilpatrick, Savannah ; Cheng, Annie A. ; White, Sean H. ; Scherer, Stephen W. ; Singh, Karun K.
Publisher:Switzerland: Frontiers Research Foundation
Journal title:Frontiers in cellular neuroscience, 2024-01, Vol.17, p.1239069-1239069
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ArticlesPeer ReviewedFull Text
Neuregulin-1 Regulates Cortical Inhibitory Neuron Dendrite and Synapse Growth through DISC1
Author / Creator:Unda, Brianna K. ; Singh, Karun K. ; Kwan, Vickie
Publisher:Cairo, Egypt: Hindawi Publishing Corporation
Journal title:Neural plasticity, 2016-01, Vol.2016 (2016), p.1-15
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ArticlesPeer ReviewedFull Text
Origin of Sex-Biased Mental Disorders: An Evolutionary Perspective
Author / Creator:Singh, Rama S. ; Singh, Karun K. ; Singh, Shiva M.
Publisher:New York: Springer US
Journal title:Journal of molecular evolution, 2021-06, Vol.89 (4-5), p.195-213
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TAOK2 rescues autism-linked developmental deficits in a 16p11.2 microdeletion mouse model
Author / Creator:Scharrenberg, Robin ; Richter, Melanie ; Johanns, Ole ; Meka, Durga Praveen ; Rücker, Tabitha ; Murtaza, Nadeem ; Lindenmaier, Zsuzsa ; Ellegood, Jacob ; Naumann, Anne ; Zhao, Bing ; Schwanke, Birgit ; Sedlacik, Jan ; Fiehler, Jens ; Hanganu-Opatz, Ileana L. ; Lerch, Jason P. ; Singh, Karun K. ; de Anda, Froylan Calderon
Publisher:London: Nature Publishing Group UK
Journal title:Molecular psychiatry, 2022-11, Vol.27 (11), p.4707-4721
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Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome
Author / Creator:Unda, Brianna K. ; Chalil, Leon ; Yoon, Sehyoun ; Kilpatrick, Savannah ; Irwin, Courtney ; Xing, Sansi ; Murtaza, Nadeem ; Cheng, Anran ; Brown, Chad ; Afonso, Alexandria ; McCready, Elizabeth ; Ronen, Gabriel M. ; Howe, Jennifer ; Caye-Eude, Aurélie ; Verloes, Alain ; Doble, Brad W. ; Faivre, Laurence ; Vitobello, Antonio ; Scherer, Stephen W. ; Lu, Yu ; Penzes, Peter ; Singh, Karun K.
Publisher:London: Nature Publishing Group UK
Journal title:Molecular psychiatry, 2023-04, Vol.28 (4), p.1747-1769
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ArticlesPeer ReviewedFull Text
Developmental axon pruning mediated by BDNF-p75NTR–dependent axon degeneration
Author / Creator:Singh, Karun K ; Park, Katya J ; Hong, Elizabeth J ; Kramer, Bianca M ; Greenberg, Michael E ; Kaplan, David R ; Miller, Freda D
Publisher:New York: Nature Publishing Group US
Journal title:Nature neuroscience, 2008-06, Vol.11 (6), p.649-658
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ReviewsPeer ReviewedFull Text
A mini-review: Bridging the gap between autism spectrum disorder and pain comorbidities
Author / Creator:Brown, Chad O. ; Uy, Jarryll ; Singh, Karun K.
Publisher:United States: Taylor & Francis
Journal title:Canadian journal of pain, 2020, Vol.4 (4), p.37-44
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ArticlesFull Text
Direct control of translational elongation by TAOK2β highlights altered protein synthesis as a fundamental underlying component of autism
Author / Creator:Henis, Melad ; Rucker, Tabitha ; Scharrenberg, Robin ; Richter, Melanie ; Baltussen, Lucas ; Durga Praveen Meka ; Schwanke, Birgit ; Neelagandan, Nagammal ; Daaboul, Danie ; Murtaza, Nadeem ; Krisp, Christoph ; Harder, Sonke ; Schluter, Hartmut ; Kneussel, Matthias ; Hermans-Borgmeyer, Irm ; De Wit, Joris ; Singh, Karun K ; Duncan, Kent E ; Froylan Calderon De Anda
Publisher:Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title:bioRxiv, 2022-09
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ArticlesPeer ReviewedFull Text
Ankyrin-G regulates neurogenesis and Wnt signaling by altering the subcellular localization of β-catenin
Author / Creator:Durak, O ; de Anda, F C ; Singh, K K ; Leussis, M P ; Petryshen, T L ; Sklar, P ; Tsai, L-H
Publisher:London: Nature Publishing Group UK
Journal title:Molecular psychiatry, 2015-03, Vol.20 (3), p.388-397
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ArticlesFull Text
Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome
Author / Creator:Unda, Brianna K ; Chalil, Leon ; Yoon, Sehyoun ; Kilpatrick, Savannah ; Sansi Xing ; Murtaza, Nadeem ; Cheng, Anran ; Afonso, Alexandria ; Mccready, Elizabeth ; Ronen, Gabriel ; Howe, Jennifer ; Caye-Eude, Aurelie ; Verloes, Alain ; Doble, Brad W ; Faivre, Laurence ; Vitobello, Antonio ; Lu, Yu ; Penzes, Peter ; Scherer, Stephen W ; Singh, Karun K
Publisher:Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title:bioRxiv, 2022-01
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ArticlesFull Text
Disruption of the autism-associated gene SCN2A alters synaptic development and neuronal signaling in patient iPSC-glutamatergic neurons
Author / Creator:Brown, Chad O ; Uy, Jarryll ; Murtaza, Nadeem ; Rosa, Elyse ; Afonso, Alexandria ; Sansi Xing ; Dave, Biren M ; Kilpatrick, Savannah ; Cheng, Annie A ; White, Sean H ; Howe, Jennifer ; Scherer, Stephen W ; Lu, Yu ; Singh, Karun K
Publisher:Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title:bioRxiv, 2021-09
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ArticlesPeer ReviewedFull Text
CNTN5.sup.-.sup./+or EHMT2.sup.-.sup./+human iPSC-derived neurons from individuals with autism develop hyperactive neuronal networks
Author / Creator:Deneault, Eric ; Faheem, Muhammad ; White, Sean H ; Rodrigues, Deivid C ; Sun, Song ; Wei, Wei ; Piekna, Alina ; Thompson, Tadeo ; Howe, Jennifer L ; Chalil, Leon ; Kwan, Vickie ; Walker, Susan ; Pasceri, Peter ; Roth, Frederick P ; Yuen, Ryan KC ; Singh, Karun K ; Ellis, James ; Scherer, Stephen W
Publisher:eLife Science Publications, Ltd
Journal title:eLife, 2019-02, Vol.8
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ArticlesFull Text
CNTN5-/+ or EHMT2-/+ iPSC-Derived Neurons from Individuals with Autism Develop Hyperactive Neuronal Networks
Author / Creator:Deneault, Eric ; Faheem, Muhammad ; White, Sean H ; Rodrigues, Deivid C ; Sun, Song ; Wei, Wei ; Piekna, Alina ; Thompson, Tadeo ; Howe, Jennifer L ; Chalil, Leon ; Kwan, Vickie ; Walker, Susan ; Pasceri, Peter ; Roth, Frederick P ; Ryan Kc Yuen ; Singh, Karun K ; Ellis, James ; Scherer, Stephen W
Publisher:Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title:bioRxiv, 2018-07
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Complete Disruption of Autism-Susceptibility Genes by Gene-Editing Predominantly Reduces Functional Connectivity of Isogenic Human Neurons
Author / Creator:Deneault, Eric ; White, Sean H ; Rodrigues, Deivid C ; Ross, Joel ; Faheem, Muhammad ; Zaslavsky, Kirill ; Wang, Zhuozhi ; Alexandrova, Roumiana ; Pellecchia, Giovanna ; Wei, Wei ; Piekna, Alina ; Kaur, Gaganjot ; Howe, Jennifer L ; Kwan, Vickie ; Thiruvahindrapuram, Bhooma ; Walker, Susan ; Pasceri, Peter ; Merico, Daniele ; Ryan Kc Yuen ; Singh, Karun K ; Ellis, James ; Scherer, Stephen W
Publisher:Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title:bioRxiv, 2018-06
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Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease relevant pathologies
Author / Creator:Murtaza, Nadeem ; Cheng, Annie A ; Brown, Chad O ; Durga Praveen Meka ; Hong, Shuai ; Uy, Jarryll A ; El-Hajjar, Joelle ; Pipko, Neta ; Unda, Brianna K ; Schwanke, Birgit ; Sansi Xing ; Thiruvahindrapuram, Bhooma ; Worrawat, Engchuan ; Trost, Brett ; Deneault, Eric ; Froylan Calderon De Anda ; Doble, Bradley W ; Ellis, James ; Anagnostou, Evdokia ; Bader, Gary D ; Scherer, Stephen W ; Lu, Yu ; Karun Kar Singh
Publisher:Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title:bioRxiv, 2022-10
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Altered TAOK2 activity causes autism-related neurodevelopmental and cognitive abnormalities through RhoA signaling

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Human pluripotent stem cell (hPSC) and organoid models of autism: opportunities and limitations

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Wnt signaling networks in autism spectrum disorder and intellectual disability

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Emerging proteomic approaches to identify the underlying pathophysiology of neurodevelopmental and neurodegenerative disorders

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CNTN5-/+or EHMT2-/+human iPSC-derived neurons from individuals with autism develop hyperactive neuronal networks

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Disruption of the autism-associated gene SCN2A alters synaptic development and neuronal signaling in patient iPSC-glutamatergic neurons

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Neuregulin-1 Regulates Cortical Inhibitory Neuron Dendrite and Synapse Growth through DISC1

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Origin of Sex-Biased Mental Disorders: An Evolutionary Perspective

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TAOK2 rescues autism-linked developmental deficits in a 16p11.2 microdeletion mouse model

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Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome

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Developmental axon pruning mediated by BDNF-p75NTR–dependent axon degeneration

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A mini-review: Bridging the gap between autism spectrum disorder and pain comorbidities

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Direct control of translational elongation by TAOK2β highlights altered protein synthesis as a fundamental underlying component of autism

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Ankyrin-G regulates neurogenesis and Wnt signaling by altering the subcellular localization of β-catenin

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Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome

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Disruption of the autism-associated gene SCN2A alters synaptic development and neuronal signaling in patient iPSC-glutamatergic neurons

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CNTN5.sup.-.sup./+or EHMT2.sup.-.sup./+human iPSC-derived neurons from individuals with autism develop hyperactive neuronal networks

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CNTN5-/+ or EHMT2-/+ iPSC-Derived Neurons from Individuals with Autism Develop Hyperactive Neuronal Networks

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Complete Disruption of Autism-Susceptibility Genes by Gene-Editing Predominantly Reduces Functional Connectivity of Isogenic Human Neurons

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Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease relevant pathologies

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