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238 results for Skin+Neoplasms+-+enzymology

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ArticlesPeer ReviewedFull Text
Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond
Author / Creator:Holderfield, Matthew ; Deuker, Marian M. ; McCormick, Frank ; McMahon, Martin
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Cancer, 2014-07, Vol.14 (7), p.455-467
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Lactate dehydrogenase as a selection criterion for ipilimumab treatment in metastatic melanoma
Author / Creator:Kelderman, Sander ; Heemskerk, Bianca ; van Tinteren, Harm ; van den Brom, Rob R. H. ; Hospers, Geke A. P. ; van den Eertwegh, Alfonsus J. M. ; Kapiteijn, Ellen W. ; de Groot, Jan Willem B. ; Soetekouw, Patricia ; Jansen, Rob L. ; Fiets, Edward ; Furness, Andrew J. S. ; Renn, Alexandra ; Krzystanek, Marcin ; Szallasi, Zoltan ; Lorigan, Paul ; Gore, Martin E. ; Schumacher, Ton N. M. ; Haanen, John B. A. G. ; Larkin, James M. G. ; Blank, Christian U.
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Cancer Immunology, Immunotherapy, 2014-05, Vol.63 (5), p.449-458
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Vemurafenib in patients with BRAF(V600) mutated metastatic melanoma: an open-label, multicentre, safety study
Author / Creator:Larkin, James ; Del Vecchio, Michele ; Ascierto, Paolo A ; Krajsova, Ivana ; Schachter, Jacob ; Neyns, Bart ; Espinosa, Enrique ; Garbe, Claus ; Sileni, Vanna Chiarion ; Gogas, Helen ; Miller, Jr, Wilson H ; Mandalà, Mario ; Hospers, Geke A P ; Arance, Ana ; Queirolo, Paola ; Hauschild, Axel ; Brown, Michael P ; Mitchell, Lada ; Veronese, Luisa ; Blank, Christian U
Publisher:England
Journal title:The lancet oncology, 2014-04, Vol.15 (4), p.436
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Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: a phase 1 dose-escalation trial
Author / Creator:Falchook, Gerald S, Dr ; Lewis, Karl D, MD ; Infante, Jeffrey R, MD ; Gordon, Michael S, MD ; Vogelzang, Nicholas J, MD ; DeMarini, Douglas J, PhD ; Sun, Peng, PhD ; Moy, Christopher, MS ; Szabo, Stephen A, BA ; Roadcap, Lori T, MS ; Peddareddigari, Vijay GR, MD ; Lebowitz, Peter F, MD ; Le, Ngocdiep T, MD ; Burris, Howard A, MD ; Messersmith, Wells A, MD ; O'Dwyer, Peter J, Prof ; Kim, Kevin B, MD ; Flaherty, Keith, MD ; Bendell, Johanna C, MD ; Gonzalez, Rene, Prof ; Kurzrock, Razelle, Prof ; Fecher, Leslie A, MD
Publisher:England: Elsevier Ltd
Journal title:The lancet oncology, 2012-08, Vol.13 (8), p.782-789
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Fumarate hydratase inactivation in hereditary leiomyomatosis and renal cell cancer is synthetic lethal with ferroptosis induction
Author / Creator:Kerins, Michael J. ; Milligan, John ; Wohlschlegel, James A. ; Ooi, Aikseng
Publisher:England: John Wiley & Sons, Inc
Journal title:Cancer science, 2018-09, Vol.109 (9), p.2757-2766
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Comparison of high resolution melting analysis, pyrosequencing, next generation sequencing and immunohistochemistry to conventional Sanger sequencing for the detection of p.V600E and non-p.V600E BRAF...
Author / Creator:Ihle, Michaela Angelika ; Fassunke, Jana ; König, Katharina ; Grünewald, Inga ; Schlaak, Max ; Kreuzberg, Nicole ; Tietze, Lothar ; Schildhaus, Hans-Ulrich ; Büttner, Reinhard ; Merkelbach-Bruse, Sabine
Publisher:England: BioMed Central
Journal title:BMC cancer, 2014-01, Vol.14 (1), p.13-13
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Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi
Author / Creator:Van Raamsdonk, Catherine D. ; Bezrookove, Vladimir ; Green, Gary ; Bauer, Jürgen ; Gaugler, Lona ; O’Brien, Joan M. ; Simpson, Elizabeth M. ; Barsh, Gregory S. ; Bastian, Boris C.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2009-01, Vol.457 (7229), p.599-602
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The deacylase SIRT5 supports melanoma viability by influencing chromatin dynamics
Author / Creator:Giblin, William ; Bringman-Rodenbarger, Lauren ; Guo, Angela H. ; Kumar, Surinder ; Monovich, Alexander C. ; Mostafa, Ahmed M. ; Skinner, Mary E. ; Azar, Michelle ; Mady, Ahmed S.A. ; Chung, Carolina H. ; Kadambi, Namrata ; Melong, Keith-Allen ; Lee, Ho-Joon ; Zhang, Li ; Sajjakulnukit, Peter ; Trefely, Sophie ; Varner, Erika L. ; Iyer, Sowmya ; Wang, Min ; Wilmott, James S. ; Soyer, H. Peter ; Sturm, Richard A. ; Pritchard, Antonia L. ; Andea, Aleodor A. ; Scolyer, Richard A. ; Stark, Mitchell S. ; Scott, David A. ; Fullen, Douglas R. ; Bosenberg, Marcus W. ; Chandrasekaran, Sriram ; Nikolovska-Coleska, Zaneta ; Verhaegen, Monique E. ; Snyder, Nathaniel W. ; Rivera, Miguel N. ; Osterman, Andrei L. ; Lyssiotis, Costas A. ; Lombard, David B.
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2021-06, Vol.131 (12), p.1-18
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MNK1/2 inhibition limits oncogenicity and metastasis of KIT-mutant melanoma
Author / Creator:Zhan, Yao ; Guo, Jun ; Yang, William ; Goncalves, Christophe ; Rzymski, Tomasz ; Dreas, Agnieszka ; Żyłkiewicz, Eliza ; Mikulski, Maciej ; Brzózka, Krzysztof ; Golas, Aniela ; Kong, Yan ; Ma, Meng ; Huang, Fan ; Huor, Bonnie ; Guo, Qianyu ; da Silva, Sabrina Daniela ; Torres, Jose ; Cai, Yutian ; Topisirovic, Ivan ; Su, Jie ; Bijian, Krikor ; Alaoui-Jamali, Moulay A. ; Huang, Sidong ; Journe, Fabrice ; Ghanem, Ghanem E. ; Miller, Wilson H. ; del Rincón, Sonia V.
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2017-11, Vol.127 (11), p.4179-4192
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Melanoma with in-frame deletion of MAP2K1: a distinct molecular subtype of cutaneous melanoma mutually exclusive from BRAF, NRAS, and NF1 mutations
Author / Creator:Williams, Erik A. ; Montesion, Meagan ; Shah, Nikunj ; Sharaf, Radwa ; Pavlick, Dean C. ; Sokol, Ethan S. ; Alexander, Brian ; Venstrom, Jeff ; Elvin, Julia A. ; Ross, Jeffrey S. ; Williams, Kevin Jon ; Tse, Julie Y. ; Mochel, Mark C.
Publisher:New York: Elsevier Inc
Journal title:Modern pathology, 2020-12, Vol.33 (12), p.2397-2406
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Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4
Author / Creator:Prickett, Todd D ; Agrawal, Neena S ; Wei, Xiaomu ; Yates, Kristin E ; Lin, Jimmy C ; Wunderlich, John R ; Cronin, Julia C ; Cruz, Pedro ; Rosenberg, Steven A ; Samuels, Yardena
Publisher:New York: Nature Publishing Group US
Journal title:Nature genetics, 2009-10, Vol.41 (10), p.1127-1132
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Fusion partners of NTRK3 affect subcellular localization of the fusion kinase and cytomorphology of melanocytes
Author / Creator:de la Fouchardière, Arnaud ; Tee, Meng Kian ; Peternel, Sandra ; Valdebran, Manuel ; Pissaloux, Daniel ; Tirode, Franck ; Busam, Klaus J. ; LeBoit, Philip E. ; McCalmont, Timothy H. ; Bastian, Boris C. ; Yeh, Iwei
Publisher:New York: Elsevier Inc
Journal title:Modern pathology, 2021-04, Vol.34 (4), p.735-747
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Comprehensive investigation of matrix metalloproteinases in skin cutaneous melanoma: diagnostic, prognostic, and therapeutic insights
Author / Creator:Wu, Lingxia ; Liu, Chenxiaoxiao ; Hu, Weicai
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2025-01, Vol.15 (1), p.2152-19, Article 2152
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Incidence of the V600K mutation among melanoma patients with BRAF mutations, and potential therapeutic response to the specific BRAF inhibitor PLX4032
Author / Creator:Rubinstein, Jill C ; Sznol, Mario ; Pavlick, Anna C ; Ariyan, Stephan ; Cheng, Elaine ; Bacchiocchi, Antonella ; Kluger, Harriet M ; Narayan, Deepak ; Halaban, Ruth
Publisher:England: BioMed Central Ltd
Journal title:Journal of translational medicine, 2010-07, Vol.8 (1), p.67-67, Article 67
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Selumetinib plus dacarbazine versus placebo plus dacarbazine as first-line treatment for BRAF-mutant metastatic melanoma: a phase 2 double-blind randomised study
Author / Creator:Robert, Caroline, Dr ; Dummer, Reinhard, Prof ; Gutzmer, Ralf, Prof ; Lorigan, Paul, MB ; Kim, Kevin B, MD ; Nyakas, Marta, MD ; Arance, Ana, MD ; Liszkay, Gabriella, Prof ; Schadendorf, Dirk, Prof ; Cantarini, Mireille, MBChB ; Spencer, Stuart, MSc ; Middleton, Mark R, Prof
Publisher:England: Elsevier Ltd
Journal title:The lancet oncology, 2013-07, Vol.14 (8), p.733-740
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Correlation of BRAF and NRAS mutation status with outcome, site of distant metastasis and response to chemotherapy in metastatic melanoma
Author / Creator:Carlino, M S ; Haydu, L E ; Kakavand, H ; Menzies, A M ; Hamilton, A L ; Yu, B ; Ng, C C ; Cooper, W A ; Thompson, J F ; Kefford, R F ; O'Toole, S A ; Scolyer, R A ; Long, G V
Publisher:London: Nature Publishing Group UK
Journal title:British journal of cancer, 2014-07, Vol.111 (2), p.292-299
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TERT promoter mutations are frequent in atypical fibroxanthomas and pleomorphic dermal sarcomas
Author / Creator:Griewank, Klaus G ; Schilling, Bastian ; Murali, Rajmohan ; Bielefeld, Nicola ; Schwamborn, Marion ; Sucker, Antje ; Zimmer, Lisa ; Hillen, Uwe ; Schaller, Jörg ; Brenn, Thomas ; Schadendorf, Dirk ; Mentzel, Thomas
Publisher:New York: Elsevier Inc
Journal title:Modern pathology, 2014-04, Vol.27 (4), p.502-508
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Mutations of the TERT promoter are common in basal cell carcinoma and squamous cell carcinoma
Author / Creator:Scott, Glynis A ; Laughlin, Todd S ; Rothberg, Paul G
Publisher:New York: Elsevier Inc
Journal title:Modern pathology, 2014-04, Vol.27 (4), p.516-523
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Both HDAC5 and HDAC6 are required for the proliferation and metastasis of melanoma cells
Author / Creator:Liu, Jiaqi ; Gu, Jianying ; Feng, Zihao ; Yang, Yanhong ; Zhu, Ningwen ; Lu, Weiyue ; Qi, Fazhi
Publisher:England: BioMed Central Ltd
Journal title:Journal of translational medicine, 2016-01, Vol.14 (1), p.7, Article 7
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Senescence-associated secretory factors induced by cisplatin in melanoma cells promote non-senescent melanoma cell growth through activation of the ERK1/2-RSK1 pathway
Author / Creator:Sun, Xuerong ; Shi, Benyan ; Zheng, Huiling ; Ling, Min ; Yang, Jie ; Li, Xiaoyi ; Liao, Xiaoxin ; Huang, Weixing ; Zhang, Mingmeng ; Xu, Shun ; Zhu, Zhe ; Cui, Hongjing ; Liu, Xinguang
Publisher:London: Springer Nature B.V
Journal title:Cell death & disease, 2018-02, Vol.9, p.1-15
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Showing 1 to 20 of 238 results

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Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond

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Lactate dehydrogenase as a selection criterion for ipilimumab treatment in metastatic melanoma

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Vemurafenib in patients with BRAF(V600) mutated metastatic melanoma: an open-label, multicentre, safety study

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Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: a phase 1 dose-escalation trial

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Fumarate hydratase inactivation in hereditary leiomyomatosis and renal cell cancer is synthetic lethal with ferroptosis induction

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Comparison of high resolution melting analysis, pyrosequencing, next generation sequencing and immunohistochemistry to conventional Sanger sequencing for the detection of p.V600E and non-p.V600E BRAF...

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Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi

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The deacylase SIRT5 supports melanoma viability by influencing chromatin dynamics

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MNK1/2 inhibition limits oncogenicity and metastasis of KIT-mutant melanoma

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Melanoma with in-frame deletion of MAP2K1: a distinct molecular subtype of cutaneous melanoma mutually exclusive from BRAF, NRAS, and NF1 mutations

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Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4

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Fusion partners of NTRK3 affect subcellular localization of the fusion kinase and cytomorphology of melanocytes

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Comprehensive investigation of matrix metalloproteinases in skin cutaneous melanoma: diagnostic, prognostic, and therapeutic insights

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Incidence of the V600K mutation among melanoma patients with BRAF mutations, and potential therapeutic response to the specific BRAF inhibitor PLX4032

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Selumetinib plus dacarbazine versus placebo plus dacarbazine as first-line treatment for BRAF-mutant metastatic melanoma: a phase 2 double-blind randomised study

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Correlation of BRAF and NRAS mutation status with outcome, site of distant metastasis and response to chemotherapy in metastatic melanoma

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TERT promoter mutations are frequent in atypical fibroxanthomas and pleomorphic dermal sarcomas

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Mutations of the TERT promoter are common in basal cell carcinoma and squamous cell carcinoma

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Both HDAC5 and HDAC6 are required for the proliferation and metastasis of melanoma cells

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Senescence-associated secretory factors induced by cisplatin in melanoma cells promote non-senescent melanoma cell growth through activation of the ERK1/2-RSK1 pathway

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