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An interbacterial toxin inhibits target cell growth by synthesizing (p)ppApp
Author / Creator:Ahmad, Shehryar ; Wang, Boyuan ; Walker, Matthew D. ; Tran, Hiu-Ki R. ; Stogios, Peter J. ; Savchenko, Alexei ; Grant, Robert A. ; McArthur, Andrew G. ; Laub, Michael T. ; Whitney, John C.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2019-11, Vol.575 (7784), p.674-678
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Molecular mechanism of plasmid-borne resistance to sulfonamide antibiotics
Author / Creator:Venkatesan, Meenakshi ; Fruci, Michael ; Verellen, Lou Ann ; Skarina, Tatiana ; Mesa, Nathalie ; Flick, Robert ; Pham, Chester ; Mahadevan, Radhakrishnan ; Stogios, Peter J. ; Savchenko, Alexei
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2023-07, Vol.14 (1), p.4031-4031, Article 4031
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A small molecule produced by Lactobacillus species blocks Candida albicans filamentation by inhibiting a DYRK1-family kinase
Author / Creator:MacAlpine, Jessie ; Daniel-Ivad, Martin ; Liu, Zhongle ; Yano, Junko ; Revie, Nicole M. ; Todd, Robert T. ; Stogios, Peter J. ; Sanchez, Hiram ; O’Meara, Teresa R. ; Tompkins, Thomas A. ; Savchenko, Alexei ; Selmecki, Anna ; Veri, Amanda O. ; Andes, David R. ; Fidel, Paul L. ; Robbins, Nicole ; Nodwell, Justin ; Whitesell, Luke ; Cowen, Leah E.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-10, Vol.12 (1), p.6151-16, Article 6151
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The evolution of substrate discrimination in macrolide antibiotic resistance enzymes
Author / Creator:Pawlowski, Andrew C. ; Stogios, Peter J. ; Koteva, Kalinka ; Skarina, Tatiana ; Evdokimova, Elena ; Savchenko, Alexei ; Wright, Gerard D.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2018-01, Vol.9 (1), p.112-12, Article 112
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Diverse mechanisms of metaeffector activity in an intracellular bacterial pathogen, Legionella pneumophila
Author / Creator:Urbanus, Malene L ; Quaile, Andrew T ; Stogios, Peter J ; Morar, Mariya ; Rao, Chitong ; Di Leo, Rosa ; Evdokimova, Elena ; Lam, Mandy ; Oatway, Christina ; Cuff, Marianne E ; Osipiuk, Jerzy ; Michalska, Karolina ; Nocek, Boguslaw P ; Taipale, Mikko ; Savchenko, Alexei ; Ensminger, Alexander W
Publisher:London: Nature Publishing Group UK
Journal title:Molecular systems biology, 2016-12, Vol.12 (12), p.893-n/a
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Legionella pneumophila S1P-lyase targets host sphingolipid metabolism and restrains autophagy
Author / Creator:Rolando, Monica ; Escoll, Pedro ; Nora, Tamara ; Botti, Joëlle ; Boitez, Valérie ; Bedia, Carmen ; Daniels, Craig ; Abraham, Gilu ; Stogios, Peter J. ; Skarina, Tatiana ; Christophe, Charlotte ; Dervins-Ravault, Delphine ; Cazalet, Christel ; Hilbi, Hubert ; Rupasinghe, Thusitha W. T. ; Tull, Dedreia ; McConville, Malcolm J. ; Ong, Sze Ying ; Hartland, Elizabeth L. ; Codogno, Patrice ; Levade, Thierry ; Naderer, Thomas ; Savchenko, Alexei ; Buchrieser, Carmen
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2016-02, Vol.113 (7), p.1901-1906
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Structural and functional analysis of EntV reveals a 12 amino acid fragment protective against fungal infections
Author / Creator:Cruz, Melissa R. ; Cristy, Shane ; Guha, Shantanu ; De Cesare, Giuseppe Buda ; Evdokimova, Elena ; Sanchez, Hiram ; Borek, Dominika ; Miramón, Pedro ; Yano, Junko ; Fidel, Paul L. ; Savchenko, Alexei ; Andes, David R. ; Stogios, Peter J. ; Lorenz, Michael C. ; Garsin, Danielle A.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2022-10, Vol.13 (1), p.6047-6047, Article 6047
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Three mutations repurpose a plant karrikin receptor to a strigolactone receptor
Author / Creator:Arellano-Saab, Amir ; Bunsick, Michael ; Galib, Hasan Al ; Zhao, Wenda ; Schuetz, Stefan ; Bradley, James Michael ; Xu, Zhenhua ; Adityani, Claresta ; Subha, Asrinus ; McKay, Hayley ; de Saint Germain, Alexandre ; Boyer, François-Didier ; McErlean, Christopher S. P. ; Toh, Shigeo ; McCourt, Peter ; Stogios, Peter J. ; Lumba, Shelley
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2021-07, Vol.118 (30), p.1-8
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Structure-guided optimization of small molecules targeting Yck2 as a strategy to combat Candida albicans
Author / Creator:Puumala, Emily ; Nandakumar, Meganathan ; Yiu, Bonnie ; Stogios, Peter J. ; Strickland, Benjamin G. ; Zarnowski, Robert ; Wang, Xiaoyu ; Williams, Noelle S. ; Savchenko, Alexei ; Andes, David R. ; Robbins, Nicole ; Whitesell, Luke ; Willson, Timothy M. ; Cowen, Leah E.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2025-03, Vol.16 (1), p.2156-16, Article 2156
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Global atlas of predicted functional domains in Legionella pneumophila Dot/Icm translocated effectors
Author / Creator:Patel, Deepak T ; Stogios, Peter J ; Jaroszewski, Lukasz ; Urbanus, Malene L ; Sedova, Mayya ; Semper, Cameron ; Le, Cathy ; Takkouche, Abraham ; Ichii, Keita ; Innabi, Julie ; Patel, Dhruvin H ; Ensminger, Alexander W ; Godzik, Adam ; Savchenko, Alexei
Publisher:London: Nature Publishing Group UK
Journal title:Molecular systems biology, 2025-01, Vol.21 (1), p.59-89
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Addendum: A small molecule produced by Lactobacillus species blocks Candida albicans filamentation by inhibiting a DYRK1-family kinase
Author / Creator:MacAlpine, Jessie ; Daniel-Ivad, Martin ; Liu, Zhongle ; Yano, Junko ; Revie, Nicole M. ; Todd, Robert T. ; Stogios, Peter J. ; Sanchez, Hiram ; O’Meara, Teresa R. ; Tompkins, Thomas A. ; Savchenko, Alexei ; Selmecki, Anna ; Veri, Amanda O. ; Andes, David R. ; Fidel, Paul L. ; Robbins, Nicole ; Nodwell, Justin ; Whitesell, Luke ; Cowen, Leah E.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2024-08, Vol.15 (1), p.6440-1, Article 6440
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Rifampin phosphotransferase is an unusual antibiotic resistance kinase
Author / Creator:Stogios, Peter J. ; Cox, Georgina ; Spanogiannopoulos, Peter ; Pillon, Monica C. ; Waglechner, Nicholas ; Skarina, Tatiana ; Koteva, Kalinka ; Guarné, Alba ; Savchenko, Alexei ; Wright, Gerard D.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2016-04, Vol.7 (1), p.11343-12, Article 11343
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Structural basis for the evolution of vancomycin resistance D,D-peptidases
Author / Creator:Meziane-Cherif, Djalal ; Stogios, Peter J. ; Evdokimova, Elena ; Savchenko, Alexei ; Courvalin, Patrice
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2014-04, Vol.111 (16), p.5872-5877
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Identification and characterization of a large family of superbinding bacterial SH2 domains
Author / Creator:Kaneko, Tomonori ; Stogios, Peter J. ; Ruan, Xiang ; Voss, Courtney ; Evdokimova, Elena ; Skarina, Tatiana ; Chung, Amy ; Liu, Xiaoling ; Li, Lei ; Savchenko, Alexei ; Ensminger, Alexander W. ; Li, Shawn S.-C.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2018-10, Vol.9 (1), p.4549-15, Article 4549
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Structural analysis of a hormone-bound Striga strigolactone receptor
Author / Creator:Arellano-Saab, Amir ; Skarina, Tatiana ; Xu, Zhenhua ; McErlean, Christopher S. P. ; Savchenko, Alexei ; Lumba, Shelley ; Stogios, Peter J. ; McCourt, Peter
Publisher:London: Nature Publishing Group UK
Journal title:Nature plants, 2023-06, Vol.9 (6), p.883-888
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Structural analysis of extracellular ATP-independent chaperones of streptococcal species and protein substrate interactions
Author / Creator:Agbavor, Charles ; Torres, Madeline ; Inniss, Nicole L. ; Latimer, Sarah ; Minasov, George ; Shuvalova, Ludmilla ; Wawrzak, Zdzislaw ; Borek, Dominika ; Otwinowski, Zbyszek ; Stogios, Peter J. ; Savchenko, Alexei ; Anderson, Wayne F. ; Satchell, Karla J. F. ; Cahoon, Laty A.
Publisher:United States: American Society for Microbiology
Journal title:mSphere, 2025-02, Vol.10 (2), p.e0107824
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An Inserted α/β Subdomain Shapes the Catalytic Pocket of Lactobacillus johnsonii Cinnamoyl Esterase
Author / Creator:Lai, Kin-Kwan ; Stogios, Peter J. ; Vu, Clara ; Xu, Xiaohui ; Cui, Hong ; Molloy, Sara ; Savchenko, Alexei ; Yakunin, Alexander ; Gonzalez, Claudio F.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2011, Vol.6 (8), p.e23269
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Structural and molecular rationale for the diversification of resistance mediated by the Antibiotic_NAT family
Author / Creator:Stogios, Peter J. ; Bordeleau, Emily ; Xu, Zhiyu ; Skarina, Tatiana ; Evdokimova, Elena ; Chou, Sommer ; Diorio-Toth, Luke ; D’Souza, Alaric W. ; Patel, Sanket ; Dantas, Gautam ; Wright, Gerard D. ; Savchenko, Alexei
Publisher:London: Nature Publishing Group UK
Journal title:Communications biology, 2022-03, Vol.5 (1), p.263-263, Article 263
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Structure-function analysis identifies highly sensitive strigolactone receptors in Striga
Author / Creator:Toh, Shigeo ; Holbrook-Smith, Duncan ; Stogios, Peter J. ; Onopriyenko, Olena ; Lumba, Shelley ; Tsuchiya, Yuichiro ; Savchenko, Alexei ; McCourt, Peter
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2015-10, Vol.350 (6257), p.203-207
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Mechanistic plasticity in ApmA enables aminoglycoside promiscuity for resistance
Author / Creator:Bordeleau, Emily ; Stogios, Peter J. ; Evdokimova, Elena ; Koteva, Kalinka ; Savchenko, Alexei ; Wright, Gerard D.
Publisher:New York: Nature Publishing Group US
Journal title:Nature chemical biology, 2024-02, Vol.20 (2), p.234-242
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Showing 1 to 20 of 32 results

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An interbacterial toxin inhibits target cell growth by synthesizing (p)ppApp

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Molecular mechanism of plasmid-borne resistance to sulfonamide antibiotics

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A small molecule produced by Lactobacillus species blocks Candida albicans filamentation by inhibiting a DYRK1-family kinase

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The evolution of substrate discrimination in macrolide antibiotic resistance enzymes

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Diverse mechanisms of metaeffector activity in an intracellular bacterial pathogen, Legionella pneumophila

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Legionella pneumophila S1P-lyase targets host sphingolipid metabolism and restrains autophagy

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Structural and functional analysis of EntV reveals a 12 amino acid fragment protective against fungal infections

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Three mutations repurpose a plant karrikin receptor to a strigolactone receptor

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Structure-guided optimization of small molecules targeting Yck2 as a strategy to combat Candida albicans

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Global atlas of predicted functional domains in Legionella pneumophila Dot/Icm translocated effectors

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Addendum: A small molecule produced by Lactobacillus species blocks Candida albicans filamentation by inhibiting a DYRK1-family kinase

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Rifampin phosphotransferase is an unusual antibiotic resistance kinase

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Structural basis for the evolution of vancomycin resistance D,D-peptidases

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Identification and characterization of a large family of superbinding bacterial SH2 domains

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Structural analysis of a hormone-bound Striga strigolactone receptor

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Structural analysis of extracellular ATP-independent chaperones of streptococcal species and protein substrate interactions

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An Inserted α/β Subdomain Shapes the Catalytic Pocket of Lactobacillus johnsonii Cinnamoyl Esterase

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Structural and molecular rationale for the diversification of resistance mediated by the Antibiotic_NAT family

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Structure-function analysis identifies highly sensitive strigolactone receptors in Striga

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Mechanistic plasticity in ApmA enables aminoglycoside promiscuity for resistance

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