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ArticlesPeer ReviewedFull Text
Developing TRAIL/TRAIL death receptor-based cancer therapies
Author / Creator:Yuan, Xun ; Gajan, Ambikai ; Chu, Qian ; Xiong, Hua ; Wu, Kongming ; Wu, Gen Sheng
Publisher:New York: Springer US
Journal title:Cancer and metastasis reviews, 2018-12, Vol.37 (4), p.733-748
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Shikonin sensitizes A549 cells to TRAIL-induced apoptosis through the JNK, STAT3 and AKT pathways
Author / Creator:Guo, Zhi Lan ; Li, Jing Zhe ; Ma, Yan Yan ; Qian, Dan ; Zhong, Ju Ying ; Jin, Meng Meng ; Huang, Peng ; Che, Lu Yang ; Pan, Bing ; Wang, Yi ; Sun, Zhen Xiao ; Liu, Chang Zhen
Publisher:England: BioMed Central Ltd
Journal title:BMC cell biology, 2018-12, Vol.19 (1), p.29-29, Article 29
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Harnessing TRAIL-induced cell death for cancer therapy: a long walk with thrilling discoveries
Author / Creator:Montinaro, Antonella ; Walczak, Henning
Publisher:London: Nature Publishing Group UK
Journal title:Cell death and differentiation, 2023-02, Vol.30 (2), p.237-249
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Reversal of pancreatic desmoplasia by a tumour stroma-targeted nitric oxide nanogel overcomes TRAIL resistance in pancreatic tumours
Author / Creator:Huang, Hsi-Chien ; Sung, Yun-Chieh ; Li, Chung-Pin ; Wan, Dehui ; Chao, Po-Han ; Tseng, Yu-Ting ; Liao, Bo-Wen ; Cheng, Hui-Teng ; Hsu, Fu-Fei ; Huang, Chieh-Cheng ; Chen, Yi-Ting ; Liao, Yu-Hui ; Hsieh, Hsin Tzu ; Shih, Yu-Chuan ; Liu, I-Ju ; Wu, Han-Chung ; Lu, Tsai-Te ; Wang, Jane ; Chen, Yunching
Publisher:England: BMJ Publishing Group Ltd and British Society of Gastroenterology
Journal title:Gut, 2022-09, Vol.71 (9), p.1843-1855
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Mitochondrial levels determine variability in cell death by modulating apoptotic gene expression
Author / Creator:Márquez-Jurado, Silvia ; Díaz-Colunga, Juan ; das Neves, Ricardo Pires ; Martinez-Lorente, Antonio ; Almazán, Fernando ; Guantes, Raúl ; Iborra, Francisco J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2018-01, Vol.9 (1), p.389-11, Article 389
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A time to kill: targeting apoptosis in cancer
Author / Creator:Koff, Jean L ; Ramachandiran, Sampath ; Bernal-Mizrachi, Leon
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2015-01, Vol.16 (2), p.2942-2955
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Fundamental trade-offs between information flow in single cells and cellular populations
Author / Creator:Suderman, Ryan ; Bachman, John A. ; Smith, Adam ; Sorger, Peter K. ; Deeds, Eric J.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2017-05, Vol.114 (22), p.5755-5760
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Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome acti...
Author / Creator:Arlt, A ; Sebens, S ; Krebs, S ; Geismann, C ; Grossmann, M ; Kruse, M-L ; Schreiber, S ; Schäfer, H
Publisher:London: Nature Publishing Group UK
Journal title:Oncogene, 2013-10, Vol.32 (40), p.4825-4835
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LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L
Author / Creator:Taraborrelli, Lucia ; Peltzer, Nieves ; Montinaro, Antonella ; Kupka, Sebastian ; Rieser, Eva ; Hartwig, Torsten ; Sarr, Aida ; Darding, Maurice ; Draber, Peter ; Haas, Tobias L. ; Akarca, Ayse ; Marafioti, Teresa ; Pasparakis, Manolis ; Bertin, John ; Gough, Peter J. ; Bouillet, Philippe ; Strasser, Andreas ; Leverkus, Martin ; Silke, John ; Walczak, Henning
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2018-09, Vol.9 (1), p.3910-12, Article 3910
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TRAIL induces necroptosis involving RIPK1/RIPK3-dependent PARP-1 activation
Author / Creator:Jouan-Lanhouet, S ; Arshad, M I ; Piquet-Pellorce, C ; Martin-Chouly, C ; Le Moigne-Muller, G ; Van Herreweghe, F ; Takahashi, N ; Sergent, O ; Lagadic-Gossmann, D ; Vandenabeele, P ; Samson, M ; Dimanche-Boitrel, M-T
Publisher:London: Nature Publishing Group UK
Journal title:Cell death and differentiation, 2012-12, Vol.19 (12), p.2003-2014
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ArticlesPeer ReviewedFull Text
Chemotherapy-induced release of circulating-tumor cells into the bloodstream in collective migration units with cancer-associated fibroblasts in metastatic cancer patients
Author / Creator:Ortiz-Otero, Nerymar ; Marshall, Jocelyn R ; Lash, Bradley ; King, Michael R
Publisher:England: BioMed Central Ltd
Journal title:BMC cancer, 2020-09, Vol.20 (1), p.873-873, Article 873
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ArticlesPeer ReviewedFull Text
Phosphatidylserine exposure during apoptosis reflects bidirectional trafficking between plasma membrane and cytoplasm
Author / Creator:Lee, S-H ; Meng, X W ; Flatten, K S ; Loegering, D A ; Kaufmann, S H
Publisher:London: Nature Publishing Group UK
Journal title:Cell death and differentiation, 2013-01, Vol.20 (1), p.64-76
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ArticlesPeer ReviewedFull Text
Hexokinases inhibit death receptor–dependent apoptosis on the mitochondria
Author / Creator:Lauterwasser, Joachim ; Fimm-Todt, Franziska ; Oelgeklaus, Aline ; Schreiner, Annabell ; Funk, Kathrin ; Falquez-Medina, Hugo ; Klesse, Ramona ; Jahreis, Günther ; Zerbes, Ralf M. ; O’Neill, Katelyn ; van der Laan, Martin ; Luo, Xu ; Edlich, Frank
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2021-08, Vol.118 (33), p.1-10
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ArticlesPeer ReviewedFull Text
Assessment of therapeutic efficacy and fate of engineered human mesenchymal stem cells for cancer therapy
Author / Creator:Sasportas, Laura S ; Kasmieh, Randa ; Wakimoto, Hiroaki ; Hingtgen, Shawn ; van de Water, Jeroen A.J.M ; Mohapatra, Gayatry ; Figueiredo, Jose Luiz ; Martuza, Robert L ; Weissleder, Ralph ; Shah, Khalid
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2009-03, Vol.106 (12), p.4822-4827
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Potent pro-apoptotic combination therapy is highly effective in a broad range of cancers
Author / Creator:Montinaro, Antonella ; Areso Zubiaur, Itziar ; Saggau, Julia ; Kretz, Anna-Laura ; Ferreira, Rute M. M. ; Hassan, Omar ; Kitzig, Ella ; Müller, Ines ; El-Bahrawy, Mona A. ; von Karstedt, Silvia ; Kulms, Dagmar ; Liccardi, Gianmaria ; Lemke, Johannes ; Walczak, Henning
Publisher:London: Nature Publishing Group UK
Journal title:Cell death and differentiation, 2022-03, Vol.29 (3), p.492-503
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ArticlesPeer ReviewedFull Text
Fractional killing arises from cell‐to‐cell variability in overcoming a caspase activity threshold
Author / Creator:Roux, Jérémie ; Hafner, Marc ; Bandara, Samuel ; Sims, Joshua J ; Hudson, Hannah ; Chai, Diana ; Sorger, Peter K
Publisher:London: Nature Publishing Group UK
Journal title:Molecular systems biology, 2015-05, Vol.11 (5), p.803-n/a
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ArticlesPeer ReviewedFull Text
TAK1 activates AMPK‐dependent cytoprotective autophagy in TRAIL‐treated epithelial cells
Author / Creator:Herrero‐Martín, Griselda ; Høyer‐Hansen, Maria ; García‐García, Celina ; Fumarola, Claudia ; Farkas, Thomas ; López‐Rivas, Abelardo ; Jäättelä, Marja
Publisher:London: Nature Publishing Group UK
Journal title:The EMBO journal, 2009-03, Vol.28 (6), p.677-685
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A set of NF-κB–regulated microRNAs induces acquired TRAIL resistance in Lung cancer
Author / Creator:Jeon, Young-Jun ; Middleton, Justin ; Kim, Taewan ; Laganà, Alessandro ; Piovan, Claudia ; Secchiero, Paola ; Nuovo, Gerard J. ; Cui, Ri ; Joshi, Pooja ; Romano, Giulia ; Di Leva, Gianpiero ; Lee, Bum-Kyu ; Sun, Hui-Lung ; Kim, Yonghwan ; Fadda, Paolo ; Alder, Hansjuerg ; Garofalo, Michela ; Croce, Carlo M.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2015-06, Vol.112 (26), p.E3355-E3364
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ArticlesPeer ReviewedFull Text
Apigenin potentiates TRAIL therapy of non-small cell lung cancer via upregulating DR4/DR5 expression in a p53-dependent manner
Author / Creator:Chen, Minghui ; Wang, Xueshi ; Zha, Daolong ; Cai, Fangfang ; Zhang, Wenjing ; He, Yan ; Huang, Qilai ; Zhuang, Hongqin ; Hua, Zi-Chun
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2016-10, Vol.6 (1), p.35468-35468, Article 35468
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Housing temperature-induced stress drives therapeutic resistance in murine tumour models through β2-adrenergic receptor activation
Author / Creator:Eng, Jason W.-L. ; Reed, Chelsey B. ; Kokolus, Kathleen M. ; Pitoniak, Rosemarie ; Utley, Adam ; Bucsek, Mark J. ; Ma, Wen Wee ; Repasky, Elizabeth A. ; Hylander, Bonnie L.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2015-03, Vol.6 (1), p.6426-6426, Article 6426
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Developing TRAIL/TRAIL death receptor-based cancer therapies

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Shikonin sensitizes A549 cells to TRAIL-induced apoptosis through the JNK, STAT3 and AKT pathways

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Harnessing TRAIL-induced cell death for cancer therapy: a long walk with thrilling discoveries

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Reversal of pancreatic desmoplasia by a tumour stroma-targeted nitric oxide nanogel overcomes TRAIL resistance in pancreatic tumours

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Mitochondrial levels determine variability in cell death by modulating apoptotic gene expression

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A time to kill: targeting apoptosis in cancer

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Fundamental trade-offs between information flow in single cells and cellular populations

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Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome acti...

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LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L

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TRAIL induces necroptosis involving RIPK1/RIPK3-dependent PARP-1 activation

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Chemotherapy-induced release of circulating-tumor cells into the bloodstream in collective migration units with cancer-associated fibroblasts in metastatic cancer patients

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Phosphatidylserine exposure during apoptosis reflects bidirectional trafficking between plasma membrane and cytoplasm

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Hexokinases inhibit death receptor–dependent apoptosis on the mitochondria

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Assessment of therapeutic efficacy and fate of engineered human mesenchymal stem cells for cancer therapy

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Potent pro-apoptotic combination therapy is highly effective in a broad range of cancers

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Fractional killing arises from cell‐to‐cell variability in overcoming a caspase activity threshold

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TAK1 activates AMPK‐dependent cytoprotective autophagy in TRAIL‐treated epithelial cells

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A set of NF-κB–regulated microRNAs induces acquired TRAIL resistance in Lung cancer

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Apigenin potentiates TRAIL therapy of non-small cell lung cancer via upregulating DR4/DR5 expression in a p53-dependent manner

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Housing temperature-induced stress drives therapeutic resistance in murine tumour models through β2-adrenergic receptor activation

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