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Mutation in the TRPC6 Cation Channel Causes Familial Focal Segmental Glomerulosclerosis
Author / Creator:Winn, Michelle P ; Conlon, Peter J ; Lynn, Kelvin L ; Farrington, Merry Kay ; Creazzo, Tony ; Hawkins, April F ; Daskalakis, Nikki ; Kwan, Shu Ying ; Ebersviller, Seth ; Burchette, James L ; Pericak-Vance, Margaret A ; Howell, David N ; Vance, Jeffery M ; Rosenberg, Paul B
Publisher:Washington, DC: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2005-06, Vol.308 (5729), p.1801-1804
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Structural basis for pharmacological modulation of the TRPC6 channel
Author / Creator:Bai, Yonghong ; Yu, Xinchao ; Chen, Hao ; Horne, Daniel ; White, Ryan ; Wu, Xiaosu ; Lee, Paul ; Gu, Yan ; Ghimire-Rijal, Sudipa ; Lin, Daniel C-H ; Huang, Xin
Publisher:England: eLife Sciences Publications Ltd
Journal title:eLife, 2020-03, Vol.9
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Reduced TRPC6 mRNA levels in the blood cells of patients with Alzheimer’s disease and mild cognitive impairment
Author / Creator:Lu, R ; Wang, J ; Tao, R ; Wang, J ; Zhu, T ; Guo, W ; Sun, Y ; Li, H ; Gao, Y ; Zhang, W ; Fowler, C J ; Li, Q ; Chen, S ; Wu, Z ; Masters, C L ; Zhong, C ; Jing, N ; Wang, Y ; Wang, Y
Publisher:London: Nature Publishing Group UK
Journal title:Molecular psychiatry, 2018-03, Vol.23 (3), p.767-776
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Novel Mechanistic Insights and Potential Therapeutic Impact of TRPC6 in Neurovascular Coupling and Ischemic Stroke
Author / Creator:Shekhar, Shashank ; Liu, Yedan ; Wang, Shaoxun ; Zhang, Huawei ; Fang, Xing ; Zhang, Jin ; Fan, Letao ; Zheng, Baoying ; Roman, Richard J. ; Wang, Zhen ; Fan, Fan ; Booz, George W.
Publisher:Switzerland: MDPI
Journal title:International journal of molecular sciences, 2021-02, Vol.22 (4), p.2074
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Analysis of hyperforin (St. John’s wort) action at TRPC6 channel leads to the development of a new class of antidepressant drugs
Author / Creator:El Hamdaoui, Yamina ; Zheng, Fang ; Fritz, Nikolas ; Ye, Lian ; Tran, Mai Anh ; Schwickert, Kevin ; Schirmeister, Tanja ; Braeuning, Albert ; Lichtenstein, Dajana ; Hellmich, Ute A. ; Weikert, Dorothee ; Heinrich, Markus ; Treccani, Giulia ; Schäfer, Michael K. E. ; Nowak, Gabriel ; Nürnberg, Bernd ; Alzheimer, Christian ; Müller, Christian P. ; Friedland, Kristina
Publisher:London: Nature Publishing Group UK
Journal title:Molecular psychiatry, 2022-12, Vol.27 (12), p.5070-5085
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The TRPC6-AMPK Pathway is Involved in Insulin-Dependent Cytoskeleton Reorganization and Glucose Uptake in Cultured Rat Podocytes
Author / Creator:Rachubik, Patrycja ; Szrejder, Maria ; Rogacka, Dorota ; Audzeyenka, Irena ; Rychłowski, Michał ; Angielski, Stefan ; Piwkowska, Agnieszka
Publisher:Basel, Switzerland: S. Karger AG
Journal title:Cellular physiology and biochemistry, 2018-01, Vol.51 (1), p.393-410
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Cystic fibrosis transmembrane conductance regulator dysfunction in platelets drives lung hyperinflammation
Author / Creator:Ortiz-Muñoz, Guadalupe ; Yu, Michelle A. ; Lefrançais, Emma ; Mallavia, Beñat ; Valet, Colin ; Tian, Jennifer J. ; Ranucci, Serena ; Wang, Kristin M. ; Liu, Zhe ; Kwaan, Nicholas ; Dawson, Diana ; Kleinhenz, Mary Ellen ; Khasawneh, Fadi T. ; Haggie, Peter M. ; Verkman, Alan S. ; Looney, Mark R.
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2020-04, Vol.130 (4), p.2041-2053
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The cation channel mechanisms of subthreshold inward depolarizing currents in the mice VTA dopaminergic neurons and their roles in the chronic-stress-induced depression-like behavior
Author / Creator:Wang, Jing ; Su, Min ; Zhang, Dongmei ; Zhang, Ludi ; Niu, Chenxu ; Li, Chaoyi ; You, Shuangzhu ; Sang, Yuqi ; Zhang, Yongxue ; Du, Xiaona ; Zhang, Hailin
Publisher:England: eLife Science Publications, Ltd
Journal title:eLife, 2024-12, Vol.12
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Long-term spironolactone treatment reduces coronary TRPC expression, vasoconstriction, and atherosclerosis in metabolic syndrome pigs
Author / Creator:Li, Wennan ; Chen, Xingjuan ; Riley, Ashley M. ; Hiett, S. Christopher ; Temm, Constance J. ; Beli, Eleni ; Long, Xin ; Chakraborty, Saikat ; Alloosh, Mouhamad ; White, Fletcher A. ; Grant, Maria B. ; Sturek, Michael ; Obukhov, Alexander G.
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Basic research in cardiology, 2017-09, Vol.112 (5), p.54-54, Article 54
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Nicotine-Induced Airway Smooth Muscle Cell Proliferation Involves TRPC6-Dependent Calcium Influx Via α7 nAChR
Author / Creator:Hong, Wei ; Peng, Gongyong ; Hao, Binwei ; Liao, Baoling ; Zhao, Zhuxiang ; Zhou, Yumin ; Peng, Fang ; Ye, Xiuqin ; Huang, Lingmei ; Zheng, Mengning ; Pu, Jinding ; Liang, Chunxiao ; Yi, Erkang ; Peng, Huanhuan ; Li, Bing ; Ran, Pixin
Publisher:Basel, Switzerland: S. Karger AG
Journal title:Cellular physiology and biochemistry, 2017, Vol.43 (3), p.986-1002
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Role of TRPC6 in kidney damage after acute ischemic kidney injury
Author / Creator:Zheng, Zhihuang ; Tsvetkov, Dmitry ; Bartolomaeus, Theda Ulrike Patricia ; Erdogan, Cem ; Krügel, Ute ; Schleifenbaum, Johanna ; Schaefer, Michael ; Nürnberg, Bernd ; Chai, Xiaoning ; Ludwig, Friedrich-Alexander ; N’diaye, Gabriele ; Köhler, May-Britt ; Wu, Kaiyin ; Gollasch, Maik ; Markó, Lajos
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2022-02, Vol.12 (1), p.3038-3038, Article 3038
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Genetic determinants of daytime napping and effects on cardiometabolic health
Author / Creator:Dashti, Hassan S. ; Daghlas, Iyas ; Lane, Jacqueline M. ; Huang, Yunru ; Udler, Miriam S. ; Wang, Heming ; Ollila, Hanna M. ; Jones, Samuel E. ; Kim, Jaegil ; Wood, Andrew R. ; Weedon, Michael N. ; Aslibekyan, Stella ; Garaulet, Marta ; Saxena, Richa
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-02, Vol.12 (1), p.900-900, Article 900
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TRPC3 Is Downregulated in Primary Hyperparathyroidism
Author / Creator:Kirstein, Emilie ; Schaudien, Dirk ; Wagner, Mathias ; Diebolt, Coline M. ; Bozzato, Alessandro ; Tschernig, Thomas ; Englisch, Colya N.
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2024-04, Vol.25 (8), p.4392
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The Role of TRPC6 in the Neuroprotection of Calycosin Against Cerebral Ischemic Injury
Author / Creator:Guo, Chao ; Ma, Yongyuan ; Ma, Shanbo ; Mu, Fei ; Deng, Jiao ; Duan, Jialin ; Xiong, Lize ; Yin, Ying ; Wang, Yanhua ; Xi, Miaomaio ; Wen, Aidong
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2017-06, Vol.7 (1), p.3039-13, Article 3039
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Tetrandrine Suppresses Transient Receptor Potential Cation Channel Protein 6 Overexpression- Induced Podocyte Damage via Blockage of RhoA/ROCK1 Signaling
Author / Creator:Yu, Jin ; Zhu, Caifeng ; Yin, Jiazhen ; Yu, Dongrong ; Wan, Feng ; Tang, Xuanli ; Jiang, Xue
Publisher:New Zealand: Dove Medical Press Limited
Journal title:Drug design, development and therapy, 2020-01, Vol.14, p.361-370
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Trpc6 gain-of-function disease mutation enhances phosphatidylserine exposure in murine platelets
Author / Creator:Boekell, Kimber L. ; Brown, Brittney J. ; Talbot, Brianna E. ; Schlondorff, Johannes S.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2022-06, Vol.17 (6), p.e0270431-e0270431
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Pharmacological Activation of TRPC6 Channel Prevents Colitis Progression
Author / Creator:Nishiyama, Kazuhiro ; Kato, Yuri ; Nishimura, Akiyuki ; Mi, Xinya ; Nagata, Ryu ; Mori, Yasuo ; Azuma, Yasu-Taka ; Nishida, Motohiro
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2024-02, Vol.25 (4), p.2401
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Inflammaging in cervical and lumbar degenerated intervertebral discs: analysis of proinflammatory cytokine and TRP channel expression
Author / Creator:Sadowska, Aleksandra ; Touli, Ermioni ; Hitzl, Wolfgang ; Greutert, Helen ; Ferguson, Stephen J. ; Wuertz-Kozak, Karin ; Hausmann, Oliver N.
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:European spine journal, 2018-03, Vol.27 (3), p.564-577
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Computer-Based Drug Design of Positive Modulators of Store-Operated Calcium Channels to Prevent Synaptic Dysfunction in Alzheimer’s Disease
Author / Creator:Hunanyan, Lernik ; Ghamaryan, Viktor ; Makichyan, Ani ; Popugaeva, Elena
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2021-12, Vol.22 (24), p.13618
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In vivo selective inhibition of TRPC6 by antagonist BI 749327 ameliorates fibrosis and dysfunction in cardiac and renal disease
Author / Creator:Lin, Brian Leei ; Matera, Damian ; Doerner, Julia F. ; Zheng, Nan ; del Camino, Donato ; Mishra, Sumita ; Bian, Hong ; Zeveleva, Svetlana ; Zhen, Xiaoguang ; Blair, Nathaniel T. ; Chong, Jayhong A. ; Hessler, David P. ; Bedja, Djahida ; Zhu, Guangshuo ; Muller, Grace K. ; Ranek, Mark J. ; Pantages, Lynn ; McFarland, Mary ; Netherton, Matthew R. ; Berry, Angela ; Wong, Diane ; Rast, Georg ; Qian, Hu Sheng ; Weldon, Steven M. ; Kuo, Jay J. ; Sauer, Achim ; Sarko, Chris ; Moran, Magdalene M. ; Kass, David A. ; Pullen, Steven S.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2019-05, Vol.116 (20), p.10156-10161
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Showing 1 to 20 of 156 results

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Mutation in the TRPC6 Cation Channel Causes Familial Focal Segmental Glomerulosclerosis

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Structural basis for pharmacological modulation of the TRPC6 channel

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Reduced TRPC6 mRNA levels in the blood cells of patients with Alzheimer’s disease and mild cognitive impairment

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Novel Mechanistic Insights and Potential Therapeutic Impact of TRPC6 in Neurovascular Coupling and Ischemic Stroke

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Analysis of hyperforin (St. John’s wort) action at TRPC6 channel leads to the development of a new class of antidepressant drugs

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The TRPC6-AMPK Pathway is Involved in Insulin-Dependent Cytoskeleton Reorganization and Glucose Uptake in Cultured Rat Podocytes

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Cystic fibrosis transmembrane conductance regulator dysfunction in platelets drives lung hyperinflammation

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The cation channel mechanisms of subthreshold inward depolarizing currents in the mice VTA dopaminergic neurons and their roles in the chronic-stress-induced depression-like behavior

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Long-term spironolactone treatment reduces coronary TRPC expression, vasoconstriction, and atherosclerosis in metabolic syndrome pigs

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Nicotine-Induced Airway Smooth Muscle Cell Proliferation Involves TRPC6-Dependent Calcium Influx Via α7 nAChR

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Role of TRPC6 in kidney damage after acute ischemic kidney injury

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Genetic determinants of daytime napping and effects on cardiometabolic health

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TRPC3 Is Downregulated in Primary Hyperparathyroidism

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The Role of TRPC6 in the Neuroprotection of Calycosin Against Cerebral Ischemic Injury

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Tetrandrine Suppresses Transient Receptor Potential Cation Channel Protein 6 Overexpression- Induced Podocyte Damage via Blockage of RhoA/ROCK1 Signaling

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Trpc6 gain-of-function disease mutation enhances phosphatidylserine exposure in murine platelets

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Pharmacological Activation of TRPC6 Channel Prevents Colitis Progression

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Inflammaging in cervical and lumbar degenerated intervertebral discs: analysis of proinflammatory cytokine and TRP channel expression

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Computer-Based Drug Design of Positive Modulators of Store-Operated Calcium Channels to Prevent Synaptic Dysfunction in Alzheimer’s Disease

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In vivo selective inhibition of TRPC6 by antagonist BI 749327 ameliorates fibrosis and dysfunction in cardiac and renal disease

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