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ArticlesPeer ReviewedFull Text
Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease
Author / Creator:Chu, Hiutung ; Khosravi, Arya ; Kusumawardhani, Indah P. ; Kwon, Alice H. K. ; Vasconcelos, Anilton C. ; Cunha, Larissa D. ; Mayer, Anne E. ; Shen, Yue ; Wu, Wei-Li ; Kambal, Amal ; Targan, Stephan R. ; Xavier, Ramnik J. ; Ernst, Peter B. ; Green, Douglas R. ; McGovern, Dermot P. B. ; Virgin, Herbert W. ; Mazmanian, Sarkis K.
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2016-05, Vol.352 (6289), p.1116-1120
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Ustekinumab Induction and Maintenance Therapy in Refractory Crohn's Disease
Author / Creator:Sandborn, William J ; Gasink, Christopher ; Gao, Long-Long ; Blank, Marion A ; Johanns, Jewel ; Guzzo, Cynthia ; Sands, Bruce E ; Hanauer, Stephen B ; Targan, Stephan ; Rutgeerts, Paul ; Ghosh, Subrata ; de Villiers, Willem J.S ; Panaccione, Remo ; Greenberg, Gordon ; Schreiber, Stefan ; Lichtiger, Simon ; Feagan, Brian G
Publisher:Waltham, MA: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2012-10, Vol.367 (16), p.1519-1528
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Ustekinumab as Induction and Maintenance Therapy for Ulcerative Colitis
Author / Creator:Sands, Bruce E ; Sandborn, William J ; Panaccione, Remo ; O’Brien, Christopher D ; Zhang, Hongyan ; Johanns, Jewel ; Adedokun, Omoniyi J ; Li, Katherine ; Peyrin-Biroulet, Laurent ; Van Assche, Gert ; Danese, Silvio ; Targan, Stephan ; Abreu, Maria T ; Hisamatsu, Tadakazu ; Szapary, Philippe ; Marano, Colleen
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2019-09, Vol.381 (13), p.1201-1214
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A Randomized, Double-Blind, Placebo-Controlled Phase 2 Study of Brodalumab in Patients With Moderate-to-Severe Crohn’s Disease
Author / Creator:Targan, Stephan R ; Feagan, Brian ; Vermeire, Severine ; Panaccione, Remo ; Melmed, Gil Y ; Landers, Carol ; Li, Dalin ; Russell, Chris ; Newmark, Richard ; Zhang, Nan ; Chon, Yun ; Hsu, Yi-Hsiang ; Lin, Shao-Lee ; Klekotka, Paul
Publisher:United States: Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins
Journal title:The American journal of gastroenterology, 2016-11, Vol.111 (11), p.1599-1607
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Constitutive TL1A (TNFSF15) Expression on Lymphoid or Myeloid Cells Leads to Mild Intestinal Inflammation and Fibrosis
Author / Creator:Shih, David Q. ; Barrett, Robert ; Zhang, Xiaolan ; Yeager, Nicole ; Koon, Hon Wai ; Phaosawasdi, Piangwarin ; Song, Yahui ; Ko, Brian ; Wong, Michelle H. ; Michelsen, Kathrin S. ; Martins, Gislaine ; Pothoulakis, Charalabos ; Targan, Stephan R.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2011-01, Vol.6 (1), p.e16090-e16090
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Hypoalbuminemia and Bandemia Predict Failure of Infliximab Rescue Therapy in Acute Severe Ulcerative Colitis
Author / Creator:Syal, Gaurav ; Robbins, Lori ; Kashani, Amir ; Bonthala, Nirupama ; Feldman, Edward ; Fleshner, Phillip ; Vasiliauskas, Eric ; McGovern, Dermot ; Ha, Christina ; Targan, Stephan ; Melmed, Gil Y.
Publisher:New York: Springer US
Journal title:Digestive diseases and sciences, 2021-01, Vol.66 (1), p.199-205
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Development of a Personalized Intestinal Fibrosis Model Using Human Intestinal Organoids Derived From Induced Pluripotent Stem Cells
Author / Creator:Estrada, Hannah Q ; Patel, Shachi ; Rabizadeh, Shervin ; Casero, David ; Targan, Stephan R ; Barrett, Robert J
Publisher:US: Oxford University Press
Journal title:Inflammatory bowel diseases, 2022-05, Vol.28 (5), p.667-679
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Andrographis paniculata Extract (HMPL-004) for Active Ulcerative Colitis
Author / Creator:Sandborn, William J ; Targan, Stephan R ; Byers, Vera S ; Rutty, Dean A ; Mu, Hua ; Zhang, Xun ; Tang, Tom
Publisher:United States: Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins
Journal title:The American journal of gastroenterology, 2013-01, Vol.108 (1), p.90-98
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Effect and Mechanism of TL1A Expression on Epithelial-Mesenchymal Transition during Chronic Colitis-Related Intestinal Fibrosis
Author / Creator:Wenxiu, Jia ; Mingyue, Yang ; Fei, Han ; Yuxin, Luo ; Mengyao, Wu ; Chenyang, Li ; Jia, Song ; Hong, Zhang ; Shih, David Q. ; Targan, Stephan R. ; Xiaolan, Zhang
Publisher:United States: Hindawi
Journal title:Mediators of inflammation, 2021-06, Vol.2021, p.1-21
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Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
Author / Creator:Rioux, John D ; Xavier, Ramnik J ; Taylor, Kent D ; Silverberg, Mark S ; Goyette, Philippe ; Huett, Alan ; Green, Todd ; Kuballa, Petric ; Barmada, M Michael ; Datta, Lisa Wu ; Shugart, Yin Yao ; Griffiths, Anne M ; Targan, Stephan R ; Ippoliti, Andrew F ; Bernard, Edmond-Jean ; Mei, Ling ; Nicolae, Dan L ; Regueiro, Miguel ; Schumm, L Philip ; Steinhart, A Hillary ; Rotter, Jerome I ; Duerr, Richard H ; Cho, Judy H ; Daly, Mark J ; Brant, Steven R
Publisher:New York: Nature Publishing Group US
Journal title:Nature genetics, 2007-05, Vol.39 (5), p.596-604
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Modeling Intestinal Epithelial Response to Interferon-γ in Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids
Author / Creator:Workman, Michael J. ; Troisi, Elissa ; Targan, Stephan R. ; Svendsen, Clive N. ; Barrett, Robert J.
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2020-12, Vol.22 (1), p.288
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Inflammation-independent TL1A-mediated intestinal fibrosis is dependent on the gut microbiome
Author / Creator:Jacob, Noam ; Jacobs, Jonathan P. ; Kumagai, Kotaro ; Ha, Connie W. Y. ; Kanazawa, Yoshitake ; Lagishetty, Venu ; Altmayer, Katherine ; Hamill, Ariel M. ; Von Arx, Aimee ; Sartor, R. Balfour ; Devkota, Suzanne ; Braun, Jonathan ; Michelsen, Kathrin S. ; Targan, Stephan R. ; Shih, David Q.
Publisher:New York: Nature Publishing Group US
Journal title:Mucosal immunology, 2018-09, Vol.11 (5), p.1466-1476
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DEVELOPMENT OF A PERSONALIZED MODEL OF INTESTINAL FIBROSIS USING HUMAN INTESTINAL ORGANOIDS DERIVED FROM INDUCED PLURIPOTENT STEM CELLS
Author / Creator:Estrada, Hannah ; Patel, Shachi ; Rabizadeh, Shervin ; Targan, Stephan ; Barrett, Robert
Publisher:US: Oxford University Press
Journal title:Inflammatory bowel diseases, 2021-01, Vol.27 (Supplement_1), p.S35-S35
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Development of Physiologically Responsive Human iPSC-Derived Intestinal Epithelium to Study Barrier Dysfunction in IBD
Author / Creator:Gleeson, John P. ; Estrada, Hannah Q. ; Yamashita, Michifumi ; Svendsen, Clive N. ; Targan, Stephan R. ; Barrett, Robert J.
Publisher:Switzerland: MDPI
Journal title:International journal of molecular sciences, 2020-02, Vol.21 (4), p.1438
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Differential Levels of Tl1a Affect the Expansion and Function of Regulatory T Cells in Modulating Murine Colitis
Author / Creator:Sidhu-Varma, Maninder ; Shih, David Q. ; Targan, Stephan R.
Publisher:Oxford, UK: Oxford University Press
Journal title:Inflammatory bowel diseases, 2016-03, Vol.22 (3), p.548-559
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Direct signaling of TL1A-DR3 on fibroblasts induces intestinal fibrosis in vivo
Author / Creator:Jacob, Noam ; Kumagai, Kotaro ; Abraham, Jay P ; Shimodaira, Yosuke ; Ye, Yuefang ; Luu, Justin ; Blackwood, Anna Y ; Castanon, Sofi L ; Stamps, Dalton T ; Thomas, Lisa S ; Gonsky, Rivkah ; Shih, David Q ; Michelsen, Kathrin S ; Targan, Stephan R
Publisher:London: Nature Publishing Group
Journal title:Scientific reports, 2020-10, Vol.10 (1)
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Epithelial endoplasmic reticulum stress orchestrates a protective IgA response
Author / Creator:Grootjans, Joep ; Krupka, Niklas ; Hosomi, Shuhei ; Matute, Juan D. ; Hanley, Thomas ; Saveljeva, Svetlana ; Gensollen, Thomas ; Heijmans, Jarom ; Li, Hai ; Limenitakis, Julien P. ; Ganal-Vonarburg, Stephanie C. ; Suo, Shengbao ; Luoma, Adrienne M. ; Shimodaira, Yosuke ; Duan, Jinzhi ; Shih, David Q. ; Conner, Margaret E. ; Glickman, Jonathan N. ; Fuhler, Gwenny M. ; Palm, Noah W. ; de Zoete, Marcel R. ; van der Woude, C. Janneke ; Yuan, Guo-Cheng ; Wucherpfennig, Kai W. ; Targan, Stephan R. ; Rosenstiel, Philip ; Flavell, Richard A. ; McCoy, Kathy D. ; Macpherson, Andrew J. ; Kaser, Arthur ; Blumberg, Richard S.
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2019-03, Vol.363 (6430), p.993-998
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Bacterial flagellin is a dominant antigen in Crohn disease
Author / Creator:Lodes, Michael J. ; Cong, Yingzi ; Elson, Charles O. ; Mohamath, Raodoh ; Landers, Carol J. ; Targan, Stephan R. ; Fort, Madeline ; Hershberg, Robert M.
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2004-05, Vol.113 (9), p.1296-1306
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The antimicrobial peptide cathelicidin modulates Clostridium difficile-associated colitis and toxin A-mediated enteritis in mice
Author / Creator:Hing, Tressia C ; Ho, Samantha ; Shih, David Q ; Ichikawa, Ryan ; Cheng, Michelle ; Chen, Jeremy ; Chen, Xinhua ; Law, Ivy ; Najarian, Robert ; Kelly, Ciaran P ; Gallo, Richard L ; Targan, Stephan R ; Pothoulakis, Charalabos ; Koon, Hon Wai
Publisher:England: BMJ Publishing Group Ltd and British Society of Gastroenterology
Journal title:Gut, 2013-09, Vol.62 (9), p.1295-1305
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ArticlesPeer ReviewedFull Text
IBD-Associated TL1A Gene (TNFSF15) Haplotypes Determine Increased Expression of TL1A Protein
Author / Creator:Michelsen, Kathrin S. ; Thomas, Lisa S. ; Taylor, Kent D. ; Yu, Qi T. ; Mei, Ling ; Landers, Carol J. ; Derkowski, Carrie ; McGovern, Dermot P. B. ; Rotter, Jerome I. ; Targan, Stephan R.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2009-03, Vol.4 (3), p.e4719-e4719
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Showing 1 to 20 of 240 results

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Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease

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Ustekinumab Induction and Maintenance Therapy in Refractory Crohn's Disease

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Ustekinumab as Induction and Maintenance Therapy for Ulcerative Colitis

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A Randomized, Double-Blind, Placebo-Controlled Phase 2 Study of Brodalumab in Patients With Moderate-to-Severe Crohn’s Disease

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Constitutive TL1A (TNFSF15) Expression on Lymphoid or Myeloid Cells Leads to Mild Intestinal Inflammation and Fibrosis

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Hypoalbuminemia and Bandemia Predict Failure of Infliximab Rescue Therapy in Acute Severe Ulcerative Colitis

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Development of a Personalized Intestinal Fibrosis Model Using Human Intestinal Organoids Derived From Induced Pluripotent Stem Cells

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Andrographis paniculata Extract (HMPL-004) for Active Ulcerative Colitis

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Effect and Mechanism of TL1A Expression on Epithelial-Mesenchymal Transition during Chronic Colitis-Related Intestinal Fibrosis

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Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis

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Modeling Intestinal Epithelial Response to Interferon-γ in Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids

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Inflammation-independent TL1A-mediated intestinal fibrosis is dependent on the gut microbiome

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DEVELOPMENT OF A PERSONALIZED MODEL OF INTESTINAL FIBROSIS USING HUMAN INTESTINAL ORGANOIDS DERIVED FROM INDUCED PLURIPOTENT STEM CELLS

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Development of Physiologically Responsive Human iPSC-Derived Intestinal Epithelium to Study Barrier Dysfunction in IBD

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Differential Levels of Tl1a Affect the Expansion and Function of Regulatory T Cells in Modulating Murine Colitis

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Direct signaling of TL1A-DR3 on fibroblasts induces intestinal fibrosis in vivo

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Epithelial endoplasmic reticulum stress orchestrates a protective IgA response

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Bacterial flagellin is a dominant antigen in Crohn disease

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The antimicrobial peptide cathelicidin modulates Clostridium difficile-associated colitis and toxin A-mediated enteritis in mice

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IBD-Associated TL1A Gene (TNFSF15) Haplotypes Determine Increased Expression of TL1A Protein

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