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ArticlesPeer ReviewedFull Text
A bioorthogonal system reveals antitumour immune function of pyroptosis
Author / Creator:Wang, Qinyang ; Wang, Yupeng ; Ding, Jingjin ; Wang, Chunhong ; Zhou, Xuehan ; Gao, Wenqing ; Huang, Huanwei ; Shao, Feng ; Liu, Zhibo
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2020-03, Vol.579 (7799), p.421-426
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Trastuzumab Deruxtecan: First Approval
Author / Creator:Keam, Susan J.
Publisher:Cham: Springer International Publishing
Journal title:Drugs (New York, N.Y.), 2020-04, Vol.80 (5), p.501-508
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Structures of the HER2–HER3–NRG1β complex reveal a dynamic dimer interface
Author / Creator:Diwanji, Devan ; Trenker, Raphael ; Thaker, Tarjani M. ; Wang, Feng ; Agard, David A. ; Verba, Kliment A. ; Jura, Natalia
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2021-12, Vol.600 (7888), p.339-343
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Optimization of therapeutic antibodies by predicting antigen specificity from antibody sequence via deep learning
Author / Creator:Mason, Derek M. ; Friedensohn, Simon ; Weber, Cédric R. ; Jordi, Christian ; Wagner, Bastian ; Meng, Simon M. ; Ehling, Roy A. ; Bonati, Lucia ; Dahinden, Jan ; Gainza, Pablo ; Correia, Bruno E. ; Reddy, Sai T.
Publisher:London: Nature Publishing Group UK
Journal title:Nature biomedical engineering, 2021-06, Vol.5 (6), p.600-612
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A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy
Author / Creator:Maruani, Antoine ; Smith, Mark E.B. ; Miranda, Enrique ; Chester, Kerry A. ; Chudasama, Vijay ; Caddick, Stephen
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2015-03, Vol.6 (1), p.6645, Article 6645
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Stoichiometric and irreversible cysteine-selective protein modification using carbonylacrylic reagents
Author / Creator:Bernardim, Barbara ; Cal, Pedro M.S.D. ; Matos, Maria J. ; Oliveira, Bruno L. ; Martínez-Sáez, Nuria ; Albuquerque, Inês S. ; Perkins, Elizabeth ; Corzana, Francisco ; Burtoloso, Antonio C.B. ; Jiménez-Osés, Gonzalo ; Bernardes, Gonçalo J. L.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2016-10, Vol.7 (1), p.13128-9, Article 13128
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ArticlesPeer ReviewedFull Text
A common glycan structure on immunoglobulin G for enhancement of effector functions
Author / Creator:Lin, Chin-Wei ; Tsai, Ming-Hung ; Li, Shiou-Ting ; Tsai, Tsung-I ; Chu, Kuo-Ching ; Liu, Ying-Chih ; Lai, Meng-Yu ; Wu, Chia-Yu ; Tseng, Yung-Chieh ; Shivatare, Sachin S. ; Wang, Chia-Hung ; Chao, Ping ; Wang, Shi-Yun ; Shih, Hao-Wei ; Zeng, Yi-Fang ; You, Tsai-Hong ; Liao, Jung-Yu ; Tu, Yu-Chen ; Lin, Yih-Shyan ; Chuang, Hong-Yang ; Chen, Chia-Lin ; Tsai, Charng-Sheng ; Huang, Chiu-Chen ; Lin, Nan-Horng ; Ma, Che ; Wu, Chung-Yi ; Wong, Chi-Huey
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2015-08, Vol.112 (34), p.10611-10616
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ArticlesPeer ReviewedFull Text
Human Epidermal Growth Factor Receptor 2 (HER2) in Advanced Gastric Cancer: Current Knowledge and Future Perspectives
Author / Creator:Palle, Juliette ; Rochand, Adrien ; Pernot, Simon ; Gallois, Claire ; Taïeb, Julien ; Zaanan, Aziz
Publisher:Cham: Springer International Publishing
Journal title:Drugs (New York, N.Y.), 2020-03, Vol.80 (4), p.401-415
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ArticlesPeer ReviewedFull Text
Trastuzumab Charge Variants: a Study on Physicochemical and Pharmacokinetic Properties
Author / Creator:Torkashvand, Fatemeh ; Mehranfar, Mahsa ; Rashidi Gero, Mahsa ; Jafarian, Parisa ; Mirabzadeh, Esmat ; Azarian, Bahareh ; Sardari, Soroush ; Vaziri, Behrouz
Publisher:Iran
Journal title:Iranian biomedical journal, 2023-03, Vol.27 (2 & 3), p.108-116
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ArticlesPeer ReviewedFull Text
Glycoengineered Monoclonal Antibodies with Homogeneous Glycan (M3, G0, G2, and A2) Using a Chemoenzymatic Approach Have Different Affinities for FcγRIIIa and Variable Antibody-Dependent Cellular Cytot...
Author / Creator:Kurogochi, Masaki ; Mori, Masako ; Osumi, Kenji ; Tojino, Mami ; Sugawara, Shu-ichi ; Takashima, Shou ; Hirose, Yuriko ; Tsukimura, Wataru ; Mizuno, Mamoru ; Amano, Junko ; Matsuda, Akio ; Tomita, Masahiro ; Takayanagi, Atsushi ; Shoda, Shin-Ichiro ; Shirai, Takashi
Publisher:United States: Public Library of Science
Journal title:PloS one, 2015-07, Vol.10 (7), p.e0132848-e0132848
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ArticlesPeer ReviewedFull Text
Trastuzumab-grafted PAMAM dendrimers for the selective delivery of anticancer drugs to HER2-positive breast cancer
Author / Creator:Kulhari, Hitesh ; Pooja, Deep ; Shrivastava, Shweta ; Kuncha, Madhusudana ; Naidu, V. G. M. ; Bansal, Vipul ; Sistla, Ramakrishna ; Adams, David J.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2016-04, Vol.6 (1), p.23179, Article 23179
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ArticlesPeer ReviewedFull Text
Removal of Excipients from Drug Product may Impact Antibody Characterization of Monoclonal Antibodies
Author / Creator:Krishna, Kunal ; Sarin, Deepika ; Trivedi, Drashti ; Bhattacharya, Sanghati ; Refaat, Hesham ; Ahmad, Aziz ; Nejadnik, Reza ; Rathore, Anurag S.
Publisher:Cham: Springer International Publishing
Journal title:The AAPS journal, 2025-05, Vol.27 (4), p.88, Article 88
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ArticlesPeer ReviewedFull Text
Impact of Various Forced Oxidative Stress Factors in Rapid Degradation of mAb: Trastuzumab as a Case Study
Author / Creator:Sreenivasan, Shravan ; Rathore, Anurag S.
Publisher:New York: Springer US
Journal title:Pharmaceutical research, 2025-02, Vol.42 (2), p.335-351
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PF-05280014 (a trastuzumab biosimilar) plus paclitaxel compared with reference trastuzumab plus paclitaxel for HER2-positive metastatic breast cancer: a randomised, double-blind study
Author / Creator:Pegram, Mark D. ; Bondarenko, Igor ; Zorzetto, Marina Moreira Costa ; Hingmire, Sachin ; Iwase, Hirotaka ; Krivorotko, Petr V. ; Lee, Keun Seok ; Li, Rubi K. ; Pikiel, Joanna ; Aggarwal, Rajesh ; Ewesuedo, Reginald ; Freyman, Amy ; Li, Ray ; Vana, Alicia ; Yin, Donghua ; Zacharchuk, Charles ; Tan-Chiu, Elizabeth
Publisher:London: Nature Publishing Group UK
Journal title:British journal of cancer, 2019-01, Vol.120 (2), p.172-182
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A proposed production method for astatinated (At-211) Trastuzumab for use in a Phase I clinical trial
Author / Creator:Aneheim, Emma ; Bäck, Tom ; Jensen, Holger ; Palm, Stig ; Lindegren, Sture
Publisher:United States: Public Library of Science
Journal title:PloS one, 2024-09, Vol.19 (9), p.e0307543
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Improved characterization of trastuzumab deruxtecan with PTCR and internal fragments implemented in middle-down MS workflows
Author / Creator:Beaumal, Corentin ; Deslignière, Evolène ; Diemer, Hélène ; Carapito, Christine ; Cianférani, Sarah ; Hernandez-Alba, Oscar
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Analytical and bioanalytical chemistry, 2024-01, Vol.416 (2), p.519-532
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Applying UHPLC-HRAM MS/MS Method to Assess Host Cell Protein Clearance during the Purification Process Development of Therapeutic mAbs
Author / Creator:Kiyonami, Reiko ; Melani, Rafael ; Chen, Ying ; Leon, AI De ; Du, Min
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2024-09, Vol.25 (17), p.9687
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Quantification of an Antibody-Conjugated Drug in Fat Plasma by an Affinity Capture LC-MS/MS Method for a Novel Prenyl Transferase-Mediated Site-Specific Antibody–Drug Conjugate
Author / Creator:Lee, Byeong ill ; Park, Min-Ho ; Byeon, Jin-Ju ; Shin, Seok-Ho ; Choi, Jangmi ; Park, Yuri ; Park, Yun-Hee ; Chae, Jeiwook ; Shin, Young G.
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2020-03, Vol.25 (7), p.1515
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On the use of DNA as a linker in antibody-drug conjugates: synthesis, stability and in vitro potency
Author / Creator:Dovgan, Igor ; Ehkirch, Anthony ; Lehot, Victor ; Kuhn, Isabelle ; Koniev, Oleksandr ; Kolodych, Sergii ; Hentz, Alexandre ; Ripoll, Manon ; Ursuegui, Sylvain ; Nothisen, Marc ; Cianférani, Sarah ; Wagner, Alain
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2020-05, Vol.10 (1), p.7691, Article 7691
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Effectiveness of [67Cu]Cu-trastuzumab as a theranostic against HER2-positive breast cancer
Author / Creator:Pougoue Ketchemen, Jessica ; Njotu, Fabrice Ngoh ; Babeker, Hanan ; Ahenkorah, Stephen ; Tikum, Anjong Florence ; Nwangele, Emmanuel ; Henning, Nikita ; Cleeren, Frederik ; Fonge, Humphrey
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:European journal of nuclear medicine and molecular imaging, 2024-06, Vol.51 (7), p.2070-2084
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Showing 1 to 20 of 81 results

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A bioorthogonal system reveals antitumour immune function of pyroptosis

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Trastuzumab Deruxtecan: First Approval

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Structures of the HER2–HER3–NRG1β complex reveal a dynamic dimer interface

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Optimization of therapeutic antibodies by predicting antigen specificity from antibody sequence via deep learning

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A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy

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Stoichiometric and irreversible cysteine-selective protein modification using carbonylacrylic reagents

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A common glycan structure on immunoglobulin G for enhancement of effector functions

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Human Epidermal Growth Factor Receptor 2 (HER2) in Advanced Gastric Cancer: Current Knowledge and Future Perspectives

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Trastuzumab Charge Variants: a Study on Physicochemical and Pharmacokinetic Properties

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Glycoengineered Monoclonal Antibodies with Homogeneous Glycan (M3, G0, G2, and A2) Using a Chemoenzymatic Approach Have Different Affinities for FcγRIIIa and Variable Antibody-Dependent Cellular Cytot...

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Trastuzumab-grafted PAMAM dendrimers for the selective delivery of anticancer drugs to HER2-positive breast cancer

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Removal of Excipients from Drug Product may Impact Antibody Characterization of Monoclonal Antibodies

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Impact of Various Forced Oxidative Stress Factors in Rapid Degradation of mAb: Trastuzumab as a Case Study

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PF-05280014 (a trastuzumab biosimilar) plus paclitaxel compared with reference trastuzumab plus paclitaxel for HER2-positive metastatic breast cancer: a randomised, double-blind study

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A proposed production method for astatinated (At-211) Trastuzumab for use in a Phase I clinical trial

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Improved characterization of trastuzumab deruxtecan with PTCR and internal fragments implemented in middle-down MS workflows

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Applying UHPLC-HRAM MS/MS Method to Assess Host Cell Protein Clearance during the Purification Process Development of Therapeutic mAbs

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Quantification of an Antibody-Conjugated Drug in Fat Plasma by an Affinity Capture LC-MS/MS Method for a Novel Prenyl Transferase-Mediated Site-Specific Antibody–Drug Conjugate

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On the use of DNA as a linker in antibody-drug conjugates: synthesis, stability and in vitro potency

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Effectiveness of [67Cu]Cu-trastuzumab as a theranostic against HER2-positive breast cancer

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