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ArticlesPeer ReviewedFull Text
Targeting the differential addiction to anti-apoptotic BCL-2 family for cancer therapy
Author / Creator:Inoue-Yamauchi, Akane ; Jeng, Paul S. ; Kim, Kwanghee ; Chen, Hui-Chen ; Han, Song ; Ganesan, Yogesh Tengarai ; Ishizawa, Kota ; Jebiwott, Sylvia ; Dong, Yiyu ; Pietanza, Maria C. ; Hellmann, Matthew D. ; Kris, Mark G. ; Hsieh, James J. ; Cheng, Emily H.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2017-07, Vol.8 (1), p.16078-16078, Article 16078
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PTPσ inhibitors promote hematopoietic stem cell regeneration
Author / Creator:Zhang, Yurun ; Roos, Martina ; Himburg, Heather ; Termini, Christina M. ; Quarmyne, Mamle ; Li, Michelle ; Zhao, Liman ; Kan, Jenny ; Fang, Tiancheng ; Yan, Xiao ; Pohl, Katherine ; Diers, Emelyne ; Jin Gim, Hyo ; Damoiseaux, Robert ; Whitelegge, Julian ; McBride, William ; Jung, Michael E. ; Chute, John P.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2019-08, Vol.10 (1), p.3667-15, Article 3667
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Identification of BCL-XL as highly active survival factor and promising therapeutic target in colorectal cancer
Author / Creator:Scherr, Anna-Lena ; Mock, Andreas ; Gdynia, Georg ; Schmitt, Nathalie ; Heilig, Christoph E. ; Korell, Felix ; Rhadakrishnan, Praveen ; Hoffmeister, Paula ; Metzeler, Klaus H. ; Schulze-Osthoff, Klaus ; Illert, Anna L. ; Boerries, Melanie ; Trojan, Jörg ; Waidmann, Oliver ; Falkenhorst, Johanna ; Siveke, Jens ; Jost, Philipp J. ; Bitzer, Michael ; Malek, Nisar P. ; Vecchione, Loredana ; Jelas, Ivan ; Brors, Benedikt ; Glimm, Hanno ; Stenzinger, Albrecht ; Grekova, Svetlana P. ; Gehrig, Tobias ; Schulze-Bergkamen, Henning ; Jäger, Dirk ; Schirmacher, Peter ; Heikenwalder, Mathias ; Goeppert, Benjamin ; Schneider, Martin ; Fröhling, Stefan ; Köhler, Bruno C.
Publisher:London: Nature Publishing Group UK
Journal title:Cell death & disease, 2020-10, Vol.11 (10), p.875-875, Article 875
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Bim, Puma and Noxa upregulation by Naftopidil sensitizes ovarian cancer to the BH3-mimetic ABT-737 and the MEK inhibitor Trametinib
Author / Creator:Florent, Romane ; Weiswald, Louis-Bastien ; Lambert, Bernard ; Brotin, Emilie ; Abeilard, Edwige ; Louis, Marie-Hélène ; Babin, Guillaume ; Poulain, Laurent ; N’Diaye, Monique
Publisher:London: Nature Publishing Group UK
Journal title:Cell death & disease, 2020-05, Vol.11 (5), p.380, Article 380
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Sequential combinations of chemotherapeutic agents with BH3 mimetics to treat rhabdomyosarcoma and avoid resistance
Author / Creator:Alcon, Clara ; Manzano-Muñoz, Albert ; Prada, Estela ; Mora, Jaume ; Soriano, Aroa ; Guillén, Gabriela ; Gallego, Soledad ; Roma, Josep ; Samitier, Josep ; Villanueva, Alberto ; Montero, Joan
Publisher:London: Nature Publishing Group UK
Journal title:Cell death & disease, 2020-08, Vol.11 (8), p.634, Article 634
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Stat3 activation in human endometrial and cervical cancers
Author / Creator:Chen, C-L ; Hsieh, F-C ; Lieblein, J C ; Brown, J ; Chan, C ; Wallace, J A ; Cheng, G ; Hall, B M ; Lin, J
Publisher:London: Nature Publishing Group UK
Journal title:British journal of cancer, 2007-02, Vol.96 (4), p.591-599
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(–)‐Epigallocatechin gallate suppresses the growth of human hepatocellular carcinoma cells by inhibiting activation of the vascular endothelial growth factor–vascular endothelial growth factor recepto...
Author / Creator:Shirakami, Yohei ; Shimizu, Masahito ; Adachi, Seiji ; Sakai, Hiroyasu ; Nakagawa, Takayuki ; Yasuda, Yoichi ; Tsurumi, Hisashi ; Hara, Yukihiko ; Moriwaki, Hisataka
Publisher:Melbourne, Australia: Blackwell Publishing Asia
Journal title:Cancer science, 2009-10, Vol.100 (10), p.1957-1962
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Berberine induces apoptosis in SW620 human colonic carcinoma cells through generation of reactive oxygen species and activation of JNK/p38 MAPK and FasL
Author / Creator:HSU, Wen-Hsiu ; HSIEH, Yih-Shou ; KUO, Hsing-Chun ; TENG, Chun-Yuh ; HUANG, Hai-I ; WANG, Chau-Jong ; YANG, Shun-Fa ; LIOU, Yi-Sheng ; KUO, Wu-Hsien
Publisher:Berlin: Springer
Journal title:Archives of toxicology, 2007-10, Vol.81 (10), p.719-728
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DHT Inhibits the Aβ25–35-Induced Apoptosis by Regulation of Seladin-1, Survivin, XIAP, bax, and bcl-xl Expression Through a Rapid PI3-K/Akt Signaling in C6 Glial Cell Lines
Author / Creator:Bing, Lelin ; Wu, Junfeng ; Zhang, Jianfeng ; Chen, Yinghui ; Hong, Zhen ; Zu, Hengbing
Publisher:Boston: Springer US
Journal title:Neurochemical research, 2015-01, Vol.40 (1), p.41-48
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MCL1 inhibition is effective against a subset of small-cell lung cancer with high MCL1 and low BCL-X L expression
Author / Creator:Yasuda, Yuto ; Ozasa, Hiroaki ; Kim, Young Hak ; Yamazoe, Masatoshi ; Ajimizu, Hitomi ; Yamamoto Funazo, Tomoko ; Nomizo, Takashi ; Tsuji, Takahiro ; Yoshida, Hironori ; Sakamori, Yuichi ; Nakajima, Naoki ; Menju, Toshi ; Yoshizawa, Akihiko ; Date, Hiroshi ; Hirai, Toyohiro
Publisher:England
Journal title:Cell death & disease, 2020-03, Vol.11 (3), p.177
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ArticlesPeer ReviewedFull Text
Safety and efficacy of intravitreal injection of recombinant erythropoietin for protection of photoreceptor cells in a rat model of retinal detachment
Author / Creator:Xie, Z ; Chen, F ; Wu, X ; Zhuang, C ; Zhu, J ; Wang, J ; Ji, H ; Wang, Y ; Hua, X
Publisher:London: Nature Publishing Group UK
Journal title:Eye (London), 2012-01, Vol.26 (1), p.144-152
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Erucylphospho-N,N,N-trimethylpropylammonium (erufosine) is a potential antimyeloma drug devoid of myelotoxicity
Author / Creator:Yosifov, Deyan Y ; Todorov, Plamen T ; Zaharieva, Maya M ; Georgiev, Kaloyan D ; Pilicheva, Bissera A ; Konstantinov, Spiro M ; Berger, Martin R
Publisher:Berlin/Heidelberg: Berlin/Heidelberg : Springer-Verlag
Journal title:Cancer chemotherapy and pharmacology, 2011-01, Vol.67 (1), p.13-25
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ArticlesPeer ReviewedFull Text
Zinc at pharmacologic concentrations affects cytokine expression and induces apoptosis of human peripheral blood mononuclear cells
Author / Creator:Chang, Kee-Lung ; Hung, Thu-Ching ; Hsieh, Bau-Shan ; Chen, Yen-Hui ; Chen, Te-Fu ; Cheng, Hsiao-Ling
Publisher:New York, NY: Elsevier Inc
Journal title:Nutrition (Burbank, Los Angeles County, Calif.), 2006-05, Vol.22 (5), p.465-474
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ArticlesPeer ReviewedFull Text
Butyric Acid Induces Apoptosis via Oxidative Stress in Jurkat T-cells
Author / Creator:Kurita-Ochiai, T. ; Ochiai, K.
Publisher:Los Angeles, CA: SAGE Publications
Journal title:Journal of dental research, 2010-07, Vol.89 (7), p.689-694
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Role of protein flexibility in the design of Bcl-X(L) targeting agents: insight from molecular dynamics
Author / Creator:Novak, William ; Wang, Hongming ; Krilov, Goran
Publisher:Netherlands
Journal title:Journal of computer-aided molecular design, 2009-01, Vol.23 (1), p.49-61
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Vincristine and lomustine induce apoptosis and p21(WAF1) up-regulation in medulloblastoma and normal human epithelial and fibroblast cells
Author / Creator:Shinwari, Zakia ; Manogaran, Pulicat S ; Alrokayan, Salman A ; Al-Hussein, Khaled A ; Aboussekhra, Abdelilah
Publisher:United States
Journal title:Journal of neuro-oncology, 2008-04, Vol.87 (2), p.123
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Ginkgo biloba and Angelica archangelica bring back an impartial hepatic apoptotic to anti-apoptotic protein ratio after exposure to technetium 99mTc
Author / Creator:Raafat, Bassem M ; Saleh, Ahmed ; Shafaa, Medhat W ; Khedr, Mahmoud ; Ghafaar, Amany A
Publisher:London, England: SAGE Publications
Journal title:Toxicology and industrial health, 2013-02, Vol.29 (1), p.14-22
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Transferrin fails to provide protection against Fas-induced hepatic injury in mice with deletion of functional transferrin-receptor type 2
Author / Creator:Lesnikov, Vladimir ; Gorden, Nicholas ; Fausto, Nelson ; Spaulding, Emily ; Campbell, Jean ; Shulman, Howard ; Fleming, Robert E ; Deeg, H. Joachim
Publisher:Boston: Boston : Springer US
Journal title:Apoptosis (London), 2008-08, Vol.13 (8), p.1005-1012
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ArticlesPeer ReviewedFull Text
Extrinsic nitric oxide donor partially reverses arginine deiminase induced cell growth inhibition through NFkappaB and Bcl-X L
Author / Creator:Seo, Jae Hong ; Sung, Hwa Jung ; Choi, Chul Won ; Kim, Byung Soo ; Shin, Sang Won ; Kim, Yeul Hong ; Min, Bon Hong ; Kim, Jun Suk
Publisher:United States
Journal title:Investigational new drugs, 2008-06, Vol.26 (3), p.277-282
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Inhibition of p38alpha MAPK enhances proteasome inhibitor-induced apoptosis of myeloma cells by modulating Hsp27, Bcl-X(L), Mcl-1 and p53 levels in vitro and inhibits tumor growth in vivo
Author / Creator:Navas, T A ; Nguyen, A N ; Hideshima, T ; Reddy, M ; Ma, J Y ; Haghnazari, E ; Henson, M ; Stebbins, E G ; Kerr, I ; O'Young, G ; Kapoun, A M ; Chakravarty, S ; Mavunkel, B ; Perumattam, J ; Luedtke, G ; Dugar, S ; Medicherla, S ; Protter, A A ; Schreiner, G F ; Anderson, K C ; Higgins, L S
Publisher:England
Journal title:Leukemia, 2006-06, Vol.20 (6), p.1017-1027
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Targeting the differential addiction to anti-apoptotic BCL-2 family for cancer therapy

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PTPσ inhibitors promote hematopoietic stem cell regeneration

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Identification of BCL-XL as highly active survival factor and promising therapeutic target in colorectal cancer

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Bim, Puma and Noxa upregulation by Naftopidil sensitizes ovarian cancer to the BH3-mimetic ABT-737 and the MEK inhibitor Trametinib

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Sequential combinations of chemotherapeutic agents with BH3 mimetics to treat rhabdomyosarcoma and avoid resistance

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Stat3 activation in human endometrial and cervical cancers

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(–)‐Epigallocatechin gallate suppresses the growth of human hepatocellular carcinoma cells by inhibiting activation of the vascular endothelial growth factor–vascular endothelial growth factor recepto...

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Berberine induces apoptosis in SW620 human colonic carcinoma cells through generation of reactive oxygen species and activation of JNK/p38 MAPK and FasL

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DHT Inhibits the Aβ25–35-Induced Apoptosis by Regulation of Seladin-1, Survivin, XIAP, bax, and bcl-xl Expression Through a Rapid PI3-K/Akt Signaling in C6 Glial Cell Lines

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MCL1 inhibition is effective against a subset of small-cell lung cancer with high MCL1 and low BCL-X L expression

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Safety and efficacy of intravitreal injection of recombinant erythropoietin for protection of photoreceptor cells in a rat model of retinal detachment

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Erucylphospho-N,N,N-trimethylpropylammonium (erufosine) is a potential antimyeloma drug devoid of myelotoxicity

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Zinc at pharmacologic concentrations affects cytokine expression and induces apoptosis of human peripheral blood mononuclear cells

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Butyric Acid Induces Apoptosis via Oxidative Stress in Jurkat T-cells

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Role of protein flexibility in the design of Bcl-X(L) targeting agents: insight from molecular dynamics

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Vincristine and lomustine induce apoptosis and p21(WAF1) up-regulation in medulloblastoma and normal human epithelial and fibroblast cells

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Ginkgo biloba and Angelica archangelica bring back an impartial hepatic apoptotic to anti-apoptotic protein ratio after exposure to technetium 99mTc

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Transferrin fails to provide protection against Fas-induced hepatic injury in mice with deletion of functional transferrin-receptor type 2

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Extrinsic nitric oxide donor partially reverses arginine deiminase induced cell growth inhibition through NFkappaB and Bcl-X L

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Inhibition of p38alpha MAPK enhances proteasome inhibitor-induced apoptosis of myeloma cells by modulating Hsp27, Bcl-X(L), Mcl-1 and p53 levels in vitro and inhibits tumor growth in vivo

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