Spike residue 403 affects binding of coronavirus spikes to human ACE2
Spike residue 403 affects binding of coronavirus spikes to human ACE2
About this item
Full title
Author / Creator
Zech, Fabian , Schniertshauer, Daniel , Jung, Christoph , Herrmann, Alexandra , Cordsmeier, Arne , Xie, Qinya , Nchioua, Rayhane , Prelli Bozzo, Caterina , Volcic, Meta , Koepke, Lennart , Müller, Janis A. , Krüger, Jana , Heller, Sandra , Stenger, Steffen , Hoffmann, Markus , Pöhlmann, Stefan , Kleger, Alexander , Jacob, Timo , Conzelmann, Karl-Klaus , Ensser, Armin , Sparrer, Konstantin M. J. and Kirchhoff, Frank
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
The bat sarbecovirus RaTG13 is a close relative of SARS-CoV-2, the cause of the COVID-19 pandemic. However, this bat virus was most likely unable to directly infect humans since its Spike (S) protein does not interact efficiently with the human ACE2 receptor. Here, we show that a single T403R mutation increases binding of RaTG13 S to human ACE2 and...
Alternative Titles
Full title
Spike residue 403 affects binding of coronavirus spikes to human ACE2
Authors, Artists and Contributors
Author / Creator
Schniertshauer, Daniel
Jung, Christoph
Herrmann, Alexandra
Cordsmeier, Arne
Xie, Qinya
Nchioua, Rayhane
Prelli Bozzo, Caterina
Volcic, Meta
Koepke, Lennart
Müller, Janis A.
Krüger, Jana
Heller, Sandra
Stenger, Steffen
Hoffmann, Markus
Pöhlmann, Stefan
Kleger, Alexander
Jacob, Timo
Conzelmann, Karl-Klaus
Ensser, Armin
Sparrer, Konstantin M. J.
Kirchhoff, Frank
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_91810263eb144d8ba565afe0bc95450d
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_91810263eb144d8ba565afe0bc95450d
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-27180-0
