EWS-WT1 fusion isoforms establish oncogenic programs and therapeutic vulnerabilities in desmoplastic...
EWS-WT1 fusion isoforms establish oncogenic programs and therapeutic vulnerabilities in desmoplastic small round cell tumors
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Full title
Author / Creator
Boulay, Gaylor , Broye, Liliane C. , Dong, Rui , Iyer, Sowmya , Sanalkumar, Rajendran , Xing, Yu-Hang , Buisson, Rémi , Rengarajan, Shruthi , Naigles, Beverly , Duc, Benoît , Volorio, Angela , Awad, Mary E. , Renella, Raffaele , Chebib, Ivan , Nielsen, G. Petur , Choy, Edwin , Cote, Gregory M. , Zou, Lee , Letovanec, Igor , Stamenkovic, Ivan , Rivera, Miguel N. and Riggi, Nicolò
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
EWS fusion oncoproteins underlie several human malignancies including Desmoplastic Small Round Cell Tumor (DSRCT), an aggressive cancer driven by EWS-WT1 fusion proteins. Here we combine chromatin occupancy and 3D profiles to identify EWS-WT1-dependent gene regulation networks and target genes. We show that EWS-WT1 is a powerful chromatin activator...
Alternative Titles
Full title
EWS-WT1 fusion isoforms establish oncogenic programs and therapeutic vulnerabilities in desmoplastic small round cell tumors
Authors, Artists and Contributors
Author / Creator
Broye, Liliane C.
Dong, Rui
Iyer, Sowmya
Sanalkumar, Rajendran
Xing, Yu-Hang
Buisson, Rémi
Rengarajan, Shruthi
Naigles, Beverly
Duc, Benoît
Volorio, Angela
Awad, Mary E.
Renella, Raffaele
Chebib, Ivan
Nielsen, G. Petur
Choy, Edwin
Cote, Gregory M.
Zou, Lee
Letovanec, Igor
Stamenkovic, Ivan
Rivera, Miguel N.
Riggi, Nicolò
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_fd00253648764577aeb52739a580a6a3
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_fd00253648764577aeb52739a580a6a3
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-51851-3
