Lorlatinib in advanced ROS1-positive non-small-cell lung cancer: a multicentre, open-label, single-a...
Lorlatinib in advanced ROS1-positive non-small-cell lung cancer: a multicentre, open-label, single-arm, phase 1–2 trial
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Author / Creator
Shaw, Alice T, Prof , Solomon, Benjamin J, Prof , Chiari, Rita, MD , Riely, Gregory J, MD , Besse, Benjamin, Prof , Soo, Ross A, MD , Kao, Steven, MBChB , Lin, Chia-Chi, MD , Bauer, Todd M, MD , Clancy, Jill S, BS , Thurm, Holger, MD , Martini, Jean-Francois, PhD , Peltz, Gerson, MD , Abbattista, Antonello, BSc , Li, Sherry, MS and Ou, Sai-Hong Ignatius, Prof
Publisher
England: Elsevier Ltd
Journal title
Language
English
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Publisher
England: Elsevier Ltd
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Scope and Contents
Contents
SummaryBackgroundLorlatinib is a potent, brain-penetrant, third-generation tyrosine kinase inhibitor (TKI) that targets ALK and ROS1 with preclinical activity against most known resistance mutations in ALK and ROS1. We investigated the antitumour activity and safety of lorlatinib in advanced, ROS1-positive non-small-cell lung cancer (NSCLC). Method...
Alternative Titles
Full title
Lorlatinib in advanced ROS1-positive non-small-cell lung cancer: a multicentre, open-label, single-arm, phase 1–2 trial
Authors, Artists and Contributors
Author / Creator
Solomon, Benjamin J, Prof
Chiari, Rita, MD
Riely, Gregory J, MD
Besse, Benjamin, Prof
Soo, Ross A, MD
Kao, Steven, MBChB
Lin, Chia-Chi, MD
Bauer, Todd M, MD
Clancy, Jill S, BS
Thurm, Holger, MD
Martini, Jean-Francois, PhD
Peltz, Gerson, MD
Abbattista, Antonello, BSc
Li, Sherry, MS
Ou, Sai-Hong Ignatius, Prof
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Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_2310721694
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2310721694
Other Identifiers
ISSN
1470-2045
E-ISSN
1474-5488
DOI
10.1016/S1470-2045(19)30655-2
