Mechanisms and optimization of in vivo delivery of lipophilic siRNAs
Mechanisms and optimization of in vivo delivery of lipophilic siRNAs
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Cholesterol-conjugated siRNAs can silence gene expression
in vivo
. Here we synthesize a variety of lipophilic siRNAs and use them to elucidate the requirements for siRNA delivery
in vivo
. We show that conjugation to bile acids and long-chain fatty acids, in addition to cholesterol, mediates siRNA uptake into cells and gene silencing
Alternative Titles
Full title
Mechanisms and optimization of in vivo delivery of lipophilic siRNAs
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TN_cdi_proquest_miscellaneous_68357613
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_68357613
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ISSN
1087-0156
E-ISSN
1546-1696
DOI
10.1038/nbt1339
