Using mitochondrial sirtuins as drug targets: disease implications and available compounds
Using mitochondrial sirtuins as drug targets: disease implications and available compounds
About this item
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Author / Creator
Publisher
Cham: Springer International Publishing
Journal title
Language
English
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Publisher
Cham: Springer International Publishing
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Scope and Contents
Contents
Sirtuins are an evolutionary conserved family of NAD
+
-dependent protein lysine deacylases. Mammals have seven Sirtuin isoforms, Sirt1–7. They contribute to regulation of metabolism, stress responses, and aging processes, and are considered therapeutic targets for metabolic and aging-related diseases. While initial studies were focused on Si...
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Full title
Using mitochondrial sirtuins as drug targets: disease implications and available compounds
Authors, Artists and Contributors
Author / Creator
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11108305
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11108305
Other Identifiers
ISSN
1420-682X
E-ISSN
1420-9071
DOI
10.1007/s00018-016-2180-7
