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ArticlesPeer ReviewedFull Text
Lorlatinib in a Child with ALK-Fusion–Positive High-Grade Glioma
Author / Creator:Bagchi, Aditi ; Orr, Brent A ; Campagne, Olivia ; Dhanda, Sandeep ; Nair, Sreenath ; Tran, Quynh ; Christensen, Anthony M ; Gajjar, Amar ; Furtado, Larissa V ; Vasilyeva, Aksana ; Boop, Frederick ; Stewart, Clinton ; Robinson, Giles W
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2021-08, Vol.385 (8), p.761-763
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Lorlatinib: First Global Approval
Author / Creator:Syed, Yahiya Y.
Publisher:Cham: Springer International Publishing
Journal title:Drugs (New York, N.Y.), 2019-01, Vol.79 (1), p.93-98
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First-Line Lorlatinib or Crizotinib in Advanced ALK-Positive Lung Cancer
Author / Creator:Shaw, Alice T ; Bauer, Todd M ; de Marinis, Filippo ; Felip, Enriqueta ; Goto, Yasushi ; Liu, Geoffrey ; Mazieres, Julien ; Kim, Dong-Wan ; Mok, Tony ; Polli, Anna ; Thurm, Holger ; Calella, Anna M ; Peltz, Gerson ; Solomon, Benjamin J
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2020-11, Vol.383 (21), p.2018-2029
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Lorlatinib in advanced ROS1-positive non-small-cell lung cancer: a multicentre, open-label, single-arm, phase 1–2 trial
Author / Creator:Shaw, Alice T, Prof ; Solomon, Benjamin J, Prof ; Chiari, Rita, MD ; Riely, Gregory J, MD ; Besse, Benjamin, Prof ; Soo, Ross A, MD ; Kao, Steven, MBChB ; Lin, Chia-Chi, MD ; Bauer, Todd M, MD ; Clancy, Jill S, BS ; Thurm, Holger, MD ; Martini, Jean-Francois, PhD ; Peltz, Gerson, MD ; Abbattista, Antonello, BSc ; Li, Sherry, MS ; Ou, Sai-Hong Ignatius, Prof
Publisher:England: Elsevier Ltd
Journal title:The lancet oncology, 2019-12, Vol.20 (12), p.1691-1701
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Lorlatinib CROWNed
Author / Creator:Romero, Diana
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Clinical oncology, 2021-01, Vol.18 (1), p.6-6
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Lorlatinib in patients with ALK-positive non-small-cell lung cancer: results from a global phase 2 study
Author / Creator:Solomon, Benjamin J, Prof ; Besse, Benjamin, Prof ; Bauer, Todd M, MD ; Felip, Enriqueta, MD ; Soo, Ross A, MD ; Camidge, D Ross, Prof ; Chiari, Rita, MD ; Bearz, Alessandra, MD ; Lin, Chia-Chi, MD ; Gadgeel, Shirish M, Prof ; Riely, Gregory J, MD ; Tan, Eng Huat, MBBS ; Seto, Takashi, Prof ; James, Leonard P, MD ; Clancy, Jill S, BS ; Abbattista, Antonello, BSc ; Martini, Jean-François, PhD ; Chen, Joseph, PharmD ; Peltz, Gerson, MD ; Thurm, Holger, MD ; Ou, Sai-Hong Ignatius, Prof ; Shaw, Alice T, Prof
Publisher:England: Elsevier Ltd
Journal title:The lancet oncology, 2018-12, Vol.19 (12), p.1654-1667
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The underlying mechanisms of lorlatinib penetration across the blood‐brain barrier and the distribution characteristics of lorlatinib in the brain
Author / Creator:Chen, Wei ; Jin, Dujia ; Shi, Yafei ; Zhang, Yujun ; Zhou, Haiyan ; Li, Guohui
Publisher:United States: John Wiley & Sons, Inc
Journal title:Cancer medicine (Malden, MA), 2020-06, Vol.9 (12), p.4350-4359
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Pan‐HER inhibitors overcome lorlatinib resistance caused by NRG1/HER3 activation in ALK‐rearranged lung cancer
Author / Creator:Taniguchi, Hirokazu ; Akagi, Kazumasa ; Dotsu, Yosuke ; Yamada, Tadaaki ; Ono, Sawana ; Imamura, Erika ; Gyotoku, Hiroshi ; Takemoto, Shinnosuke ; Yamaguchi, Hiroyuki ; Sen, Triparna ; Yano, Seiji ; Mukae, Hiroshi
Publisher:England: John Wiley & Sons, Inc
Journal title:Cancer science, 2023-01, Vol.114 (1), p.164-173
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Resensitization to Crizotinib by the Lorlatinib ALK Resistance Mutation L1198F
Author / Creator:Shaw, Alice T ; Friboulet, Luc ; Leshchiner, Ignaty ; Gainor, Justin F ; Bergqvist, Simon ; Brooun, Alexei ; Burke, Benjamin J ; Deng, Ya-Li ; Liu, Wei ; Dardaei, Leila ; Frias, Rosa L ; Schultz, Kate R ; Logan, Jennifer ; James, Leonard P ; Smeal, Tod ; Timofeevski, Sergei ; Katayama, Ryohei ; Iafrate, A. John ; Le, Long ; McTigue, Michele ; Getz, Gad ; Johnson, Ted W ; Engelman, Jeffrey A
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2016-01, Vol.374 (1), p.54-61
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ArticlesPeer ReviewedFull Text
Gilteritinib overcomes lorlatinib resistance in ALK-rearranged cancer
Author / Creator:Mizuta, Hayato ; Okada, Koutaroh ; Araki, Mitsugu ; Adachi, Jun ; Takemoto, Ai ; Kutkowska, Justyna ; Maruyama, Kohei ; Yanagitani, Noriko ; Oh-hara, Tomoko ; Watanabe, Kana ; Tamai, Keiichi ; Friboulet, Luc ; Katayama, Kazuhiro ; Ma, Biao ; Sasakura, Yoko ; Sagae, Yukari ; Kukimoto-Niino, Mutsuko ; Shirouzu, Mikako ; Takagi, Satoshi ; Simizu, Siro ; Nishio, Makoto ; Okuno, Yasushi ; Fujita, Naoya ; Katayama, Ryohei
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-02, Vol.12 (1), p.1261-1261, Article 1261
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Real‐world therapeutic effectiveness of lorlatinib after alectinib in Japanese patients with ALK‐positive non‐small‐cell lung cancer
Author / Creator:Goto, Yasushi ; Shukuya, Takehito ; Murata, Ai ; Kikkawa, Hironori ; Emir, Birol ; Wiltshire, Robin ; Miura, Satoru
Publisher:England: John Wiley & Sons, Inc
Journal title:Cancer science, 2023-06, Vol.114 (6), p.2560-2568
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Lorlatinib in ROS1-positive NSCLC
Author / Creator:Killock, David
Publisher:England: Nature Publishing Group
Journal title:Nature reviews. Clinical oncology, 2020-01, Vol.17 (1), p.7-7
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Lorlatinib in ROS1-positive NSCLC: LUNG CANCER
Author / Creator:Killock, David
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Clinical oncology, 2020-01, Vol.17 (1), p.7-7
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Lorlatinib with or without chemotherapy in ALK-driven refractory/relapsed neuroblastoma: phase 1 trial results
Author / Creator:Goldsmith, Kelly C. ; Park, Julie R. ; Kayser, Kimberly ; Malvar, Jemily ; Chi, Yueh-Yun ; Groshen, Susan G. ; Villablanca, Judith G. ; Krytska, Kateryna ; Lai, Lillian M. ; Acharya, Patricia T. ; Goodarzian, Fariba ; Pawel, Bruce ; Shimada, Hiroyuki ; Ghazarian, Susan ; States, Lisa ; Marshall, Lynley ; Chesler, Louis ; Granger, Meaghan ; Desai, Ami V. ; Mody, Rajen ; Morgenstern, Daniel A. ; Shusterman, Suzanne ; Macy, Margaret E. ; Pinto, Navin ; Schleiermacher, Gudrun ; Vo, Kieuhoa ; Thurm, Holger C. ; Chen, Joseph ; Liyanage, Marlon ; Peltz, Gerson ; Matthay, Katherine K. ; Berko, Esther R. ; Maris, John M. ; Marachelian, Araz ; Mossé, Yael P.
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2023-05, Vol.29 (5), p.1092-1102
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Brain Penetration of Lorlatinib: Cumulative Incidences of CNS and Non-CNS Progression with Lorlatinib in Patients with Previously Treated ALK-Positive Non-Small-Cell Lung Cancer
Author / Creator:Bauer, Todd M. ; Shaw, Alice T. ; Johnson, Melissa L. ; Navarro, Alejandro ; Gainor, Justin F. ; Thurm, Holger ; Pithavala, Yazdi K. ; Abbattista, Antonello ; Peltz, Gerson ; Felip, Enriqueta
Publisher:Cham: Springer International Publishing
Journal title:Targeted oncology, 2020-02, Vol.15 (1), p.55-65
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Lorlatinib: Hyperglycaemia: case report
Publisher:Cham: Springer International Publishing
Journal title:Reactions weekly, 2022-03, Vol.1896 (1), p.276-276
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Lorlatinib: Minimal change disease and hyperlipidaemia: case report
Publisher:Cham: Springer International Publishing
Journal title:Reactions weekly, 2022-03, Vol.1896 (1), p.277-277
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Lorlatinib in non-small-cell lung cancer with ALK or ROS1 rearrangement: an international, multicentre, open-label, single-arm first-in-man phase 1 trial
Author / Creator:Shaw, Alice T ; Felip, Enriqueta ; Bauer, Todd M ; Besse, Benjamin ; Navarro, Alejandro ; Postel-Vinay, Sophie ; Gainor, Justin F ; Johnson, Melissa ; Dietrich, Jorg ; James, Leonard P ; Clancy, Jill S ; Chen, Joseph ; Martini, Jean-François ; Abbattista, Antonello ; Solomon, Benjamin J
Publisher:England: Elsevier Ltd
Journal title:The lancet oncology, 2017-12, Vol.18 (12), p.1590-1599
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Yes‐associated protein 1 mediates initial cell survival during lorlatinib treatment through AKT signaling in ROS1‐rearranged lung cancer
Author / Creator:Yamazoe, Masatoshi ; Ozasa, Hiroaki ; Tsuji, Takahiro ; Funazo, Tomoko ; Yoshida, Hiroshi ; Hashimoto, Kentaro ; Hosoya, Kazutaka ; Ogimoto, Tatsuya ; Ajimizu, Hitomi ; Yoshida, Hironori ; Itotani, Ryo ; Sakamori, Yuichi ; Kuninaga, Kiyomitsu ; Aoki, Wataru ; Hirai, Toyohiro
Publisher:England: John Wiley & Sons, Inc
Journal title:Cancer science, 2023-02, Vol.114 (2), p.546-560
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Lorlatinib in previously treated anaplastic lymphoma kinase‐rearranged non–small cell lung cancer: Japanese subgroup analysis of a global study
Author / Creator:Seto, Takashi ; Hayashi, Hidetoshi ; Satouchi, Miyako ; Goto, Yasushi ; Niho, Seiji ; Nogami, Naoyuki ; Hida, Toyoaki ; Takahashi, Toshiaki ; Sakakibara‐Konishi, Jun ; Morise, Masahiro ; Nagasawa, Takashi ; Suzuki, Mie ; Ohkura, Masayuki ; Fukuhara, Kei ; Thurm, Holger ; Peltz, Gerson ; Nishio, Makoto
Publisher:England: John Wiley & Sons, Inc
Journal title:Cancer science, 2020-10, Vol.111 (10), p.3726-3738
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Showing 1 to 20 of 931 results

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Lorlatinib in a Child with ALK-Fusion–Positive High-Grade Glioma

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Lorlatinib: First Global Approval

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First-Line Lorlatinib or Crizotinib in Advanced ALK-Positive Lung Cancer

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Lorlatinib in advanced ROS1-positive non-small-cell lung cancer: a multicentre, open-label, single-arm, phase 1–2 trial

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Lorlatinib CROWNed

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Lorlatinib in patients with ALK-positive non-small-cell lung cancer: results from a global phase 2 study

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The underlying mechanisms of lorlatinib penetration across the blood‐brain barrier and the distribution characteristics of lorlatinib in the brain

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Pan‐HER inhibitors overcome lorlatinib resistance caused by NRG1/HER3 activation in ALK‐rearranged lung cancer

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Resensitization to Crizotinib by the Lorlatinib ALK Resistance Mutation L1198F

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Gilteritinib overcomes lorlatinib resistance in ALK-rearranged cancer

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Real‐world therapeutic effectiveness of lorlatinib after alectinib in Japanese patients with ALK‐positive non‐small‐cell lung cancer

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Lorlatinib in ROS1-positive NSCLC

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Lorlatinib in ROS1-positive NSCLC: LUNG CANCER

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Lorlatinib with or without chemotherapy in ALK-driven refractory/relapsed neuroblastoma: phase 1 trial results

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Brain Penetration of Lorlatinib: Cumulative Incidences of CNS and Non-CNS Progression with Lorlatinib in Patients with Previously Treated ALK-Positive Non-Small-Cell Lung Cancer

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Lorlatinib: Hyperglycaemia: case report

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Lorlatinib: Minimal change disease and hyperlipidaemia: case report

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Lorlatinib in non-small-cell lung cancer with ALK or ROS1 rearrangement: an international, multicentre, open-label, single-arm first-in-man phase 1 trial

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Yes‐associated protein 1 mediates initial cell survival during lorlatinib treatment through AKT signaling in ROS1‐rearranged lung cancer

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Lorlatinib in previously treated anaplastic lymphoma kinase‐rearranged non–small cell lung cancer: Japanese subgroup analysis of a global study

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