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Select record 21
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Pro-inflammatory cytokines induce cell death, inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells
Author / Creator:Demine, Stéphane ; Schiavo, Andrea Alex ; Marín-Cañas, Sandra ; Marchetti, Piero ; Cnop, Miriam ; Eizirik, Decio L.
Publisher:England: BioMed Central Ltd
Journal title:Stem cell research & therapy, 2020-01, Vol.11 (1), p.7-15, Article 7
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Death Protein 5 and p53-Upregulated Modulator of Apoptosis Mediate the Endoplasmic Reticulum Stress–Mitochondrial Dialog Triggering Lipotoxic Rodent and Human β-Cell Apoptosis
Author / Creator:Cunha, Daniel A. ; Igoillo-Esteve, Mariana ; Gurzov, Esteban N. ; Germano, Carla M. ; Naamane, Najib ; Marhfour, Ihsane ; Fukaya, Makiko ; Vanderwinden, Jean-Marie ; Gysemans, Conny ; Mathieu, Chantal ; Marselli, Lorella ; Marchetti, Piero ; Harding, Heather P. ; Ron, David ; Eizirik, Décio L. ; Cnop, Miriam
Publisher:Alexandria, VA: American Diabetes Association
Journal title:Diabetes (New York, N.Y.), 2012-11, Vol.61 (11), p.2763-2775
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Type 2 diabetes mellitus—an autoimmune disease?
Author / Creator:Velloso, Lício A. ; Eizirik, Decio L. ; Cnop, Miriam
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Endocrinology, 2013-12, Vol.9 (12), p.750-755
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Myo9b mutations are associated with altered dendritic cell functions and increased susceptibility to autoimmune diabetes onset
Author / Creator:Zhang, Jing ; Zou, Yuan ; Chen, Longmin ; Sun, Fei ; Xu, Qianqian ; Zhou, Qing ; Wang, Yi ; Luo, Xi ; Wang, Na ; Li, Yang ; Zhang, Shu ; Xiong, Fei ; Yang, Ping ; Liu, Shiwei ; Yang, Tao ; Weng, Jianping ; Eizirik, Décio L. ; Yan, Jinhua ; Zhou, Zhiguang ; Wang, Cong-Yi
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2023-09, Vol.14 (1), p.5977-17, Article 5977
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PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Interferon-γ–Induced Pancreatic β-Cell Apoptosis
Author / Creator:Moore, Fabrice ; Colli, Maikel L. ; Cnop, Miriam ; Esteve, Mariana Igoillo ; Cardozo, Alessandra K. ; Cunha, Daniel A. ; Bugliani, Marco ; Marchetti, Piero ; Eizirik, Décio L.
Publisher:Alexandria, VA: American Diabetes Association
Journal title:Diabetes (New York, N.Y.), 2009-06, Vol.58 (6), p.1283-1291
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The type 1 diabetes gene TYK2 regulates β-cell development and its responses to interferon-α
Author / Creator:Chandra, Vikash ; Ibrahim, Hazem ; Halliez, Clémentine ; Prasad, Rashmi B. ; Vecchio, Federica ; Dwivedi, Om Prakash ; Kvist, Jouni ; Balboa, Diego ; Saarimäki-Vire, Jonna ; Montaser, Hossam ; Barsby, Tom ; Lithovius, Väinö ; Artner, Isabella ; Gopalakrishnan, Swetha ; Groop, Leif ; Mallone, Roberto ; Eizirik, Decio L. ; Otonkoski, Timo
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2022-10, Vol.13 (1), p.6363-16, Article 6363
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Kdm2a deficiency in macrophages enhances thermogenesis to protect mice against HFD-induced obesity by enhancing H3K36me2 at the Pparg locus
Author / Creator:Chen Longmin ; Zhang, Jing ; Zou Yuan ; Wang Faxi ; Li, Jingyi ; Sun, Fei ; Luo Xi ; Zhang, Meng ; Guo Yanchao ; Yu, Qilin ; Yang, Ping ; Zhou, Qing ; Chen Zhishui ; Zhang, Huilan ; Gong Quan ; Zhao Jiajun ; Eizirik, Decio L ; Zhou, Zhiguang ; Xiong Fei ; Zhang, Shu ; Cong-Yi, Wang
Publisher:Rome: Nature Publishing Group
Journal title:Cell death and differentiation, 2021-06, Vol.28 (6), p.1880-1899
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IL-17A increases the expression of proinflammatory chemokines in human pancreatic islets
Author / Creator:Grieco, Fabio A. ; Moore, Fabrice ; Vigneron, François ; Santin, Izortze ; Villate, Olatz ; Marselli, Lorella ; Rondas, Dieter ; Korf, Hannelie ; Overbergh, Lutgart ; Dotta, Francesco ; Marchetti, Piero ; Mathieu, Chantal ; Eizirik, Décio L.
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Diabetologia, 2014-03, Vol.57 (3), p.502-511
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Transcriptional Regulation of the Endoplasmic Reticulum Stress Gene Chop in Pancreatic Insulin-Producing Cells
Author / Creator:Pirot, Pierre ; Ortis, Fernanda ; Cnop, Miriam ; Ma, Yanjun ; Hendershot, Linda M. ; Eizirik, Décio L. ; Cardozo, Alessandra K.
Publisher:Alexandria, VA: American Diabetes Association
Journal title:Diabetes (New York, N.Y.), 2007-04, Vol.56 (4), p.1069-1077
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Combined transcriptome and proteome profiling of the pancreatic β-cell response to palmitate unveils key pathways of β-cell lipotoxicity
Author / Creator:Lytrivi, Maria ; Ghaddar, Kassem ; Lopes, Miguel ; Rosengren, Victoria ; Piron, Anthony ; Yi, Xiaoyan ; Johansson, Henrik ; Lehtiö, Janne ; Igoillo-Esteve, Mariana ; Cunha, Daniel A. ; Marselli, Lorella ; Marchetti, Piero ; Ortsäter, Henrik ; Eizirik, Decio L. ; Cnop, Miriam
Publisher:England: BioMed Central
Journal title:BMC genomics, 2020-08, Vol.21 (1), p.590-15, Article 590
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GLP-1R agonists demonstrate potential to treat Wolfram syndrome in human preclinical models
Author / Creator:Gorgogietas, Vyron ; Rajaei, Bahareh ; Heeyoung, Chae ; Santacreu, Bruno J ; Marín-Cañas, Sandra ; Salpea, Paraskevi ; Sawatani, Toshiaki ; Musuaya, Anyishai ; Arroyo, María N ; Moreno-Castro, Cristina ; Benabdallah, Khadija ; Demarez, Celine ; Toivonen, Sanna ; Cosentino, Cristina ; Pachera, Nathalie ; Lytrivi, Maria ; Cai, Ying ; Carnel, Lode ; Brown, Cris ; Urano, Fumihiko ; Marchetti, Piero ; Gilon, Patrick ; Eizirik, Decio L ; Cnop, Miriam ; Igoillo-Esteve, Mariana
Publisher:Heidelberg: Springer Nature B.V
Journal title:Diabetologia, 2023-07, Vol.66 (7), p.1306-1321
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Select record 32
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Interferon-α promotes HLA-B-restricted presentation of conventional and alternative antigens in human pancreatic β-cells
Author / Creator:Carré, Alexia ; Samassa, Fatoumata ; Zhou, Zhicheng ; Perez-Hernandez, Javier ; Lekka, Christiana ; Manganaro, Anthony ; Oshima, Masaya ; Liao, Hanqing ; Parker, Robert ; Nicastri, Annalisa ; Brandao, Barbara ; Colli, Maikel L. ; Eizirik, Decio L. ; Aluri, Jahnavi ; Patel, Deep ; Göransson, Marcus ; Burgos Morales, Orlando ; Anderson, Amanda ; Landry, Laurie ; Kobaisi, Farah ; Scharfmann, Raphael ; Marselli, Lorella ; Marchetti, Piero ; You, Sylvaine ; Nakayama, Maki ; Hadrup, Sine R. ; Kent, Sally C. ; Richardson, Sarah J. ; Ternette, Nicola ; Mallone, Roberto
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2025-01, Vol.16 (1), p.765-19, Article 765
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Select record 33
ArticlesPeer ReviewedFull Text
Beta Cell Imaging—From Pre-Clinical Validation to First in Man Testing
Author / Creator:Demine, Stephane ; Schulte, Michael L. ; Territo, Paul R. ; Eizirik, Decio L.
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2020-10, Vol.21 (19), p.7274
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Mast cells infiltrate pancreatic islets in human type 1 diabetes
Author / Creator:Martino, Luisa ; Masini, Matilde ; Bugliani, Marco ; Marselli, Lorella ; Suleiman, Mara ; Boggi, Ugo ; Nogueira, Tatiane C. ; Filipponi, Franco ; Occhipinti, Margherita ; Campani, Daniela ; Dotta, Francesco ; Syed, Farooq ; Eizirik, Decio L. ; Marchetti, Piero ; De Tata, Vincenzo
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Diabetologia, 2015-11, Vol.58 (11), p.2554-2562
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Select record 35
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Cytokines Interleukin-1β and Tumor Necrosis Factor-α Regulate Different Transcriptional and Alternative Splicing Networks in Primary β-Cells
Author / Creator:Ortis, Fernanda ; Naamane, Najib ; Flamez, Daisy ; Ladrière, Laurence ; Moore, Fabrice ; Cunha, Daniel A. ; Colli, Maikel L. ; Thykjaer, Thomas ; Thorsen, Kasper ; Ørntoft, Torben F. ; Eizirik, Decio L.
Publisher:Alexandria, VA: American Diabetes Association
Journal title:Diabetes (New York, N.Y.), 2010-02, Vol.59 (2), p.358-374
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Presumption of innocence for beta cells: why are they vulnerable autoimmune targets in type 1 diabetes?
Author / Creator:Mallone, Roberto ; Eizirik, Decio L
Publisher:Heidelberg: Springer Nature B.V
Journal title:Diabetologia, 2020-10, Vol.63 (10), p.1999-2006
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Select record 37
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In vivo activation of the PI3K–Akt pathway in mouse beta cells by the EGFR mutation L858R protects against diabetes
Author / Creator:Hakonen, Elina ; Ustinov, Jarkko ; Eizirik, Décio L. ; Sariola, Hannu ; Miettinen, Päivi J. ; Otonkoski, Timo
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Diabetologia, 2014-05, Vol.57 (5), p.970-979
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Select record 38
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Why does the immune system destroy pancreatic β-cells but not α-cells in type 1 diabetes?
Author / Creator:Eizirik, Decio L ; Szymczak, Florian ; Mallone, Roberto
Publisher:London: Nature Publishing Group
Journal title:Nature reviews. Endocrinology, 2023-07, Vol.19 (7), p.425-434
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Select record 39
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Detection and quantification of beta cells by PET imaging: why clinical implementation has never been closer
Author / Creator:Gotthardt, Martin ; Eizirik, Decio L ; Henk-Jan Aanstoot ; Korsgren, Olle ; Mul, Dick ; Martin, Frank ; Boss, Marti ; Jansen, Tom J P ; Sanne A M van Lith ; Buitinga, Mijke ; Eriksson, Olof ; Cnop, Miriam ; Brom, Maarten
Publisher:Heidelberg: Springer Nature B.V
Journal title:Diabetologia, 2018-12, Vol.61 (12), p.2516-2519
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Select record 40
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Coxsackievirus B Tailors the Unfolded Protein Response to Favour Viral Amplification in Pancreatic β Cells
Author / Creator:Colli, Maikel L. ; Paula, Flavia M. ; Marselli, Lorella ; Marchetti, Piero ; Roivainen, Merja ; Eizirik, Decio L. ; Op de beeck, Anne
Publisher:Basel, Switzerland: S. Karger AG
Journal title:Journal of innate immunity, 2019-01, Vol.11 (4), p.375-390
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Showing 21 to 40 of 196 results

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Pro-inflammatory cytokines induce cell death, inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells

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Death Protein 5 and p53-Upregulated Modulator of Apoptosis Mediate the Endoplasmic Reticulum Stress–Mitochondrial Dialog Triggering Lipotoxic Rodent and Human β-Cell Apoptosis

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Type 2 diabetes mellitus—an autoimmune disease?

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Myo9b mutations are associated with altered dendritic cell functions and increased susceptibility to autoimmune diabetes onset

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PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Interferon-γ–Induced Pancreatic β-Cell Apoptosis

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The type 1 diabetes gene TYK2 regulates β-cell development and its responses to interferon-α

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Kdm2a deficiency in macrophages enhances thermogenesis to protect mice against HFD-induced obesity by enhancing H3K36me2 at the Pparg locus

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IL-17A increases the expression of proinflammatory chemokines in human pancreatic islets

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Transcriptional Regulation of the Endoplasmic Reticulum Stress Gene Chop in Pancreatic Insulin-Producing Cells

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Combined transcriptome and proteome profiling of the pancreatic β-cell response to palmitate unveils key pathways of β-cell lipotoxicity

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GLP-1R agonists demonstrate potential to treat Wolfram syndrome in human preclinical models

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Interferon-α promotes HLA-B-restricted presentation of conventional and alternative antigens in human pancreatic β-cells

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Beta Cell Imaging—From Pre-Clinical Validation to First in Man Testing

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Mast cells infiltrate pancreatic islets in human type 1 diabetes

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Cytokines Interleukin-1β and Tumor Necrosis Factor-α Regulate Different Transcriptional and Alternative Splicing Networks in Primary β-Cells

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Presumption of innocence for beta cells: why are they vulnerable autoimmune targets in type 1 diabetes?

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In vivo activation of the PI3K–Akt pathway in mouse beta cells by the EGFR mutation L858R protects against diabetes

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Why does the immune system destroy pancreatic β-cells but not α-cells in type 1 diabetes?

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Detection and quantification of beta cells by PET imaging: why clinical implementation has never been closer

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Coxsackievirus B Tailors the Unfolded Protein Response to Favour Viral Amplification in Pancreatic β Cells

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