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91 results for Ingelman-Sundberg,+Magnus

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Select record 21
ArticlesPeer ReviewedFull Text
Human hepatic 3D spheroids as a model for steatosis and insulin resistance
Author / Creator:Kozyra, Mikael ; Johansson, Inger ; Nordling, Åsa ; Ullah, Shahid ; Lauschke, Volker M. ; Ingelman-Sundberg, Magnus
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2018-09, Vol.8 (1), p.14297-12, Article 14297
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Allele-specific expression and gene methylation in the control of CYP1A2 mRNA level in human livers
Author / Creator:Ghotbi, Roza ; Gomez, Alvin ; Milani, Lili ; Tybring, Gunnel ; Syvänen, Ann-Christine ; Bertilsson, Leif ; Ingelman-Sundberg, Magnus ; Aklillu, Eleni
Publisher:London: Nature Publishing Group UK
Journal title:The pharmacogenomics journal, 2009-06, Vol.9 (3), p.208-217
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Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models
Author / Creator:Weaver, Richard J. ; Blomme, Eric A. ; Chadwick, Amy E. ; Copple, Ian M. ; Gerets, Helga H. J. ; Goldring, Christopher E. ; Guillouzo, Andre ; Hewitt, Philip G. ; Ingelman-Sundberg, Magnus ; Jensen, Klaus Gjervig ; Juhila, Satu ; Klingmüller, Ursula ; Labbe, Gilles ; Liguori, Michael J. ; Lovatt, Cerys A. ; Morgan, Paul ; Naisbitt, Dean J. ; Pieters, Raymond H. H. ; Snoeys, Jan ; van de Water, Bob ; Williams, Dominic P. ; Park, B. Kevin
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Drug discovery, 2020-02, Vol.19 (2), p.131-148
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The Importance of Patient-Specific Factors for Hepatic Drug Response and Toxicity
Author / Creator:Lauschke, Volker ; Ingelman-Sundberg, Magnus
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2016-10, Vol.17 (10), p.1714-1714
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Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease
Author / Creator:Bell, Catherine C. ; Hendriks, Delilah F. G. ; Moro, Sabrina M. L. ; Ellis, Ewa ; Walsh, Joanne ; Renblom, Anna ; Fredriksson Puigvert, Lisa ; Dankers, Anita C. A. ; Jacobs, Frank ; Snoeys, Jan ; Sison-Young, Rowena L. ; Jenkins, Rosalind E. ; Nordling, Åsa ; Mkrtchian, Souren ; Park, B. Kevin ; Kitteringham, Neil R. ; Goldring, Christopher E. P. ; Lauschke, Volker M. ; Ingelman-Sundberg, Magnus
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2016-05, Vol.6 (1), p.25187, Article 25187
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Pharmacogenomic Biomarkers for Prediction of Severe Adverse Drug Reactions
Author / Creator:Ingelman-Sundberg, Magnus
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2008-02, Vol.358 (6), p.637-639
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Novel copy-number variations in pharmacogenes contribute to interindividual differences in drug pharmacokinetics
Author / Creator:Santos, María ; Niemi, Mikko ; Hiratsuka, Masahiro ; Kumondai, Masaki ; Ingelman-Sundberg, Magnus ; Lauschke, Volker M ; Rodríguez-Antona, Cristina
Publisher:New York: Nature Publishing Group US
Journal title:Genetics in medicine, 2018-06, Vol.20 (6), p.622-629
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The TM6SF2 E167K genetic variant induces lipid biosynthesis and reduces apolipoprotein B secretion in human hepatic 3D spheroids
Author / Creator:Prill, Sebastian ; Caddeo, Andrea ; Baselli, Guido ; Jamialahmadi, Oveis ; Dongiovanni, Paola ; Rametta, Raffaela ; Kanebratt, Kajsa P. ; Pujia, Arturo ; Pingitore, Piero ; Mancina, Rosellina Margherita ; Lindén, Daniel ; Whatling, Carl ; Janefeldt, Annika ; Kozyra, Mikael ; Ingelman-Sundberg, Magnus ; Valenti, Luca ; Andersson, Tommy B. ; Romeo, Stefano
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2019-08, Vol.9 (1), p.11585-11585, Article 11585
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Mechanisms of 5-HT receptor antagonists in the regulation of fibrosis in a 3D human liver spheroid model
Author / Creator:Redenšek Trampuž, Sara ; van Riet, Sander ; Nordling, Åsa ; Ingelman-Sundberg, Magnus
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2024-01, Vol.14 (1), p.1396-1396, Article 1396
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Select record 30
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AMP-activated protein kinase activation and NADPH oxidase inhibition by inorganic nitrate and nitrite prevent liver steatosis
Author / Creator:Cordero-Herrera, Isabel ; Kozyra, Mikael ; Zhuge, Zhengbing ; Haworth, Sarah McCann ; Moretti, Chiara ; Peleli, Maria ; Caldeira-Dias, Mayara ; Jahandideh, Arghavan ; Huirong, Han ; de Campos Cruz, Josiane ; Kleschyov, Andrei L. ; Montenegro, Marcelo F. ; Ingelman-Sundberg, Magnus ; Weitzberg, Eddie ; Lundberg, Jon O. ; Carlstrom, Mattias
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2019-01, Vol.116 (1), p.217-226
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Impact of CYP2C19 genotype on sertraline exposure in 1200 Scandinavian patients
Author / Creator:Bråten, Line S ; Haslemo Tore ; Jukic, Marin M ; Ingelman-Sundberg Magnus ; Molden Espen ; Kringen, Marianne K
Publisher:New York: Nature Publishing Group
Journal title:Neuropsychopharmacology (New York, N.Y.), 2020-02, Vol.45 (3), p.570-576
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Select record 32
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Emerging strategies to bridge the gap between pharmacogenomic research and its clinical implementation
Author / Creator:Lauschke, Volker M ; Ingelman-Sundberg Magnus
Publisher:London: Nature Publishing Group
Journal title:Npj genomic medicine, 2020, Vol.5 (1)
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Select record 33
ArticlesPeer ReviewedFull Text
The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model
Author / Creator:Dusek, Jan ; Mejdrová, Ivana ; Dohnalová, Klára ; Smutny, Tomas ; Chalupsky, Karel ; Krutakova, Maria ; Skoda, Josef ; Rashidian, Azam ; Pavkova, Ivona ; Škach, Kryštof ; Hricová, Jana ; Chocholouskova, Michaela ; Smutna, Lucie ; Kamaraj, Rajamanikkam ; Hroch, Miloš ; Leníček, Martin ; Mičuda, Stanislav ; Pijnenburg, Dirk ; van Beuningen, Rinie ; Holčapek, Michal ; Vítek, Libor ; Ingelman-Sundberg, Magnus ; Burk, Oliver ; Kronenberger, Thales ; Nencka, Radim ; Pavek, Petr
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2025-02, Vol.16 (1), p.1418-21, Article 1418
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Select record 34
ArticlesPeer ReviewedFull Text
Genetic and epigenetic regulation of gene expression in fetal and adult human livers
Author / Creator:Bonder, Marc Jan ; Kasela, Silva ; Kals, Mart ; Tamm, Riin ; Lokk, Kaie ; Barragan, Isabel ; Buurman, Wim A ; Deelen, Patrick ; Greve, Jan-Willem ; Ivanov, Maxim ; Rensen, Sander S ; van Vliet-Ostaptchouk, Jana V ; Wolfs, Marcel G ; Fu, Jingyuan ; Hofker, Marten H ; Wijmenga, Cisca ; Zhernakova, Alexandra ; Ingelman-Sundberg, Magnus ; Franke, Lude ; Milani, Lili
Publisher:England: BioMed Central Ltd
Journal title:BMC genomics, 2014-10, Vol.15 (1), p.860-860, Article 860
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Select record 35
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Emerging trends in pharmacogenomics: from common variant associations toward comprehensive genomic profiling
Author / Creator:Ingelman-Sundberg, Magnus ; Nebert, Daniel W. ; Lauschke, Volker M.
Publisher:England: BioMed Central
Journal title:Human genomics, 2023-11, Vol.17 (1), p.105-5, Article 105
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Proof of principle concept for the analysis and functional prediction of rare genetic variants in the CYP2C19 and CYP2D6 genes
Author / Creator:Johansson, Inger ; Lu, Yuchen ; Zhou, Yitian ; Krebs, Kristi ; Akcan, Martina ; Milani, Lili ; Ingelman-Sundberg, Magnus
Publisher:England: BioMed Central
Journal title:HUMAN GENOMICS, 2025-05, Vol.19 (1), p.62-11, Article 62
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Select record 37
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The Role of CTGF in Liver Fibrosis Induced in 3D Human Liver Spheroids
Author / Creator:Trampuž, Sara Redenšek ; van Riet, Sander ; Nordling, Åsa ; Ingelman-Sundberg, Magnus
Publisher:Switzerland: MDPI AG
Journal title:Cells (Basel, Switzerland), 2023-01, Vol.12 (2), p.302
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Select record 38
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The Human Cytochrome P450 (CYP) Allele Nomenclature website: a peer-reviewed database of CYP variants and their associated effects
Author / Creator:Sim, Sarah C ; Ingelman-Sundberg, Magnus
Publisher:England: BioMed Central
Journal title:Human genomics, 2010-04, Vol.4 (4), p.278-281
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Select record 39
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Human liver spheroids in chemically defined conditions for studies of gene-drug, drug-drug and disease-drug interactions
Author / Creator:Ingelman-Sundberg, Magnus ; Lauschke, Volker M
Publisher:England: Future Medicine Ltd
Journal title:Pharmacogenomics, 2018-09, Vol.19 (14), p.1133-1138
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Select record 40
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Human Liver Spheroids as a Model to Study Aetiology and Treatment of Hepatic Fibrosis
Author / Creator:Hurrell, Tracey ; Kastrinou-Lampou, Vlasia ; Fardellas, Achilleas ; Hendriks, Delilah F. G. ; Nordling, Åsa ; Johansson, Inger ; Baze, Audrey ; Parmentier, Céline ; Richert, Lysiane ; Ingelman-Sundberg, Magnus
Publisher:Switzerland: MDPI AG
Journal title:Cells (Basel, Switzerland), 2020-04, Vol.9 (4), p.964
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Showing 21 to 40 of 91 results

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Human hepatic 3D spheroids as a model for steatosis and insulin resistance

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Allele-specific expression and gene methylation in the control of CYP1A2 mRNA level in human livers

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Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models

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The Importance of Patient-Specific Factors for Hepatic Drug Response and Toxicity

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Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease

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Pharmacogenomic Biomarkers for Prediction of Severe Adverse Drug Reactions

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Novel copy-number variations in pharmacogenes contribute to interindividual differences in drug pharmacokinetics

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The TM6SF2 E167K genetic variant induces lipid biosynthesis and reduces apolipoprotein B secretion in human hepatic 3D spheroids

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Mechanisms of 5-HT receptor antagonists in the regulation of fibrosis in a 3D human liver spheroid model

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AMP-activated protein kinase activation and NADPH oxidase inhibition by inorganic nitrate and nitrite prevent liver steatosis

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Impact of CYP2C19 genotype on sertraline exposure in 1200 Scandinavian patients

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Emerging strategies to bridge the gap between pharmacogenomic research and its clinical implementation

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The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model

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Genetic and epigenetic regulation of gene expression in fetal and adult human livers

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Emerging trends in pharmacogenomics: from common variant associations toward comprehensive genomic profiling

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Proof of principle concept for the analysis and functional prediction of rare genetic variants in the CYP2C19 and CYP2D6 genes

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The Role of CTGF in Liver Fibrosis Induced in 3D Human Liver Spheroids

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The Human Cytochrome P450 (CYP) Allele Nomenclature website: a peer-reviewed database of CYP variants and their associated effects

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Human liver spheroids in chemically defined conditions for studies of gene-drug, drug-drug and disease-drug interactions

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Human Liver Spheroids as a Model to Study Aetiology and Treatment of Hepatic Fibrosis

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