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638 results for Oligonucleotides,+Antisense+-+genetics

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Select record 21
ArticlesPeer ReviewedFull Text
Preclinical development of a miR-132 inhibitor for heart failure treatment
Author / Creator:Foinquinos, Ariana ; Batkai, Sandor ; Genschel, Celina ; Viereck, Janika ; Rump, Steffen ; Gyöngyösi, Mariann ; Traxler, Denise ; Riesenhuber, Martin ; Spannbauer, Andreas ; Lukovic, Dominika ; Weber, Natalie ; Zlabinger, Katrin ; Hašimbegović, Ena ; Winkler, Johannes ; Fiedler, Jan ; Dangwal, Seema ; Fischer, Martin ; de la Roche, Jeanne ; Wojciechowski, Daniel ; Kraft, Theresia ; Garamvölgyi, Rita ; Neitzel, Sonja ; Chatterjee, Shambhabi ; Yin, Xiaoke ; Bär, Christian ; Mayr, Manuel ; Xiao, Ke ; Thum, Thomas
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2020-01, Vol.11 (1), p.633-10, Article 633
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RNA-targeting and gene editing therapies for transthyretin amyloidosis
Author / Creator:Aimo, Alberto ; Castiglione, Vincenzo ; Rapezzi, Claudio ; Franzini, Maria ; Panichella, Giorgia ; Vergaro, Giuseppe ; Gillmore, Julian ; Fontana, Marianna ; Passino, Claudio ; Emdin, Michele
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews cardiology, 2022-10, Vol.19 (10), p.655-667
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Therapeutic approaches for Duchenne muscular dystrophy
Author / Creator:Roberts, Thomas C. ; Wood, Matthew J. A. ; Davies, Kay E.
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Drug discovery, 2023-11, Vol.22 (11), p.917-934
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Precise RNA editing by recruiting endogenous ADARs with antisense oligonucleotides
Author / Creator:Merkle, Tobias ; Merz, Sarah ; Reautschnig, Philipp ; Blaha, Andreas ; Li, Qin ; Vogel, Paul ; Wettengel, Jacqueline ; Li, Jin Billy ; Stafforst, Thorsten
Publisher:New York: Nature Publishing Group US
Journal title:Nature biotechnology, 2019-02, Vol.37 (2), p.133-138
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ABCA4-associated disease as a model for missing heritability in autosomal recessive disorders: novel noncoding splice, cis-regulatory, structural, and recurrent hypomorphic variants
Author / Creator:Bauwens, Miriam ; Garanto, Alejandro ; Sangermano, Riccardo ; Naessens, Sarah ; Weisschuh, Nicole ; De Zaeytijd, Julie ; Khan, Mubeen ; Sadler, Françoise ; Balikova, Irina ; Van Cauwenbergh, Caroline ; Rosseel, Toon ; Bauwens, Jim ; De Leeneer, Kim ; De Jaegere, Sarah ; Van Laethem, Thalia ; De Vries, Meindert ; Carss, Keren ; Arno, Gavin ; Fakin, Ana ; Webster, Andrew R. ; de Ravel de l’Argentière, Thomy J. L. ; Sznajer, Yves ; Vuylsteke, Marnik ; Kohl, Susanne ; Wissinger, Bernd ; Cherry, Timothy ; Collin, Rob W. J. ; Cremers, Frans P. M. ; Leroy, Bart P. ; De Baere, Elfride
Publisher:New York: Nature Publishing Group US
Journal title:Genetics in medicine, 2019-08, Vol.21 (8), p.1761-1771
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Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration
Author / Creator:Lagier-Tourenne, Clotilde ; Baughn, Michael ; Rigo, Frank ; Sun, Shuying ; Liu, Patrick ; Li, Hai-Ri ; Jiang, Jie ; Watt, Andrew T ; Chun, Seung ; Katz, Melanie ; Qiu, Jinsong ; Sun, Ying ; Ling, Shuo-Chien ; Zhu, Qiang ; Polymenidou, Magdalini ; Drenner, Kevin ; Artates, Jonathan W ; McAlonis-Downes, Melissa ; Markmiller, Sebastian ; Hutt, Kasey R ; Pizzo, Donald P ; Cady, Janet ; Harms, Matthew B ; Baloh, Robert H ; Vandenberg, Scott R ; Yeo, Gene W ; Fu, Xiang-Dong ; Bennett, C Frank ; Cleveland, Don W ; Ravits, John
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2013-11, Vol.110 (47), p.E4530-E4539
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Select record 27
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Cryo-EM and antisense targeting of the 28-kDa frameshift stimulation element from the SARS-CoV-2 RNA genome
Author / Creator:Zhang, Kaiming ; Zheludev, Ivan N. ; Hagey, Rachel J. ; Haslecker, Raphael ; Hou, Yixuan J. ; Kretsch, Rachael ; Pintilie, Grigore D. ; Rangan, Ramya ; Kladwang, Wipapat ; Li, Shanshan ; Wu, Marie Teng-Pei ; Pham, Edward A. ; Bernardin-Souibgui, Claire ; Baric, Ralph S. ; Sheahan, Timothy P. ; D’Souza, Victoria ; Glenn, Jeffrey S. ; Chiu, Wah ; Das, Rhiju
Publisher:New York: Nature Publishing Group US
Journal title:Nature structural & molecular biology, 2021-09, Vol.28 (9), p.747-754
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Development of microRNA therapeutics is coming of age
Author / Creator:van Rooij, Eva ; Kauppinen, Sakari
Publisher:London: Nature Publishing Group UK
Journal title:EMBO molecular medicine, 2014-07, Vol.6 (7), p.851-864
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RNA-extraction-free nano-amplified colorimetric test for point-of-care clinical diagnosis of COVID-19
Author / Creator:Alafeef, Maha ; Moitra, Parikshit ; Dighe, Ketan ; Pan, Dipanjan
Publisher:London: Nature Publishing Group UK
Journal title:Nature protocols, 2021-06, Vol.16 (6), p.3141-3162
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Select record 30
ArticlesPeer ReviewedFull Text
Damage-induced lncRNAs control the DNA damage response through interaction with DDRNAs at individual double-strand breaks
Author / Creator:Michelini, Flavia ; Pitchiaya, Sethuramasundaram ; Vitelli, Valerio ; Sharma, Sheetal ; Gioia, Ubaldo ; Pessina, Fabio ; Cabrini, Matteo ; Wang, Yejun ; Capozzo, Ilaria ; Iannelli, Fabio ; Matti, Valentina ; Francia, Sofia ; Shivashankar, G. V. ; Walter, Nils G. ; d’Adda di Fagagna, Fabrizio
Publisher:London: Nature Publishing Group UK
Journal title:Nature cell biology, 2017-12, Vol.19 (12), p.1400-1411
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Select record 31
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Interferon-α receptor antisense oligonucleotides reduce neuroinflammation and neuropathology in a mouse model of cerebral interferonopathy
Author / Creator:Viengkhou, Barney ; Hong, Christine ; Mazur, Curt ; Damle, Sagar ; Gallo, Nicholas B ; Fang, Terry C ; Henry, Kate ; Campbell, Iain L ; Kamme, Fredrik ; Hofer, Markus J
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2024-02, Vol.134 (4)
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Select record 32
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A framework for individualized splice-switching oligonucleotide therapy
Author / Creator:Kim, Jinkuk ; Woo, Sijae ; de Gusmao, Claudio M. ; Zhao, Boxun ; Chin, Diana H. ; DiDonato, Renata L. ; Nguyen, Minh A. ; Nakayama, Tojo ; Hu, Chunguang April ; Soucy, Aubrie ; Kuniholm, Ashley ; Thornton, Jennifer Karlin ; Riccardi, Olivia ; Friedman, Danielle A. ; El Achkar, Christelle Moufawad ; Dash, Zane ; Cornelissen, Laura ; Donado, Carolina ; Faour, Kamli N. W. ; Bush, Lynn W. ; Suslovitch, Victoria ; Lentucci, Claudia ; Park, Peter J. ; Lee, Eunjung Alice ; Patterson, Al ; Philippakis, Anthony A. ; Margus, Brad ; Berde, Charles B. ; Yu, Timothy W.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2023-07, Vol.619 (7971), p.828-836
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Select record 33
ArticlesPeer ReviewedFull Text
Towards a therapy for Angelman syndrome by targeting a long non-coding RNA
Author / Creator:Meng, Linyan ; Ward, Amanda J. ; Chun, Seung ; Bennett, C. Frank ; Beaudet, Arthur L. ; Rigo, Frank
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2015-02, Vol.518 (7539), p.409-412
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Select record 34
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Translation efficiency of mRNAs is increased by antisense oligonucleotides targeting upstream open reading frames
Author / Creator:Liang, Xue-hai ; Shen, Wen ; Sun, Hong ; Migawa, Michael T ; Vickers, Timothy A ; Crooke, Stanley T
Publisher:New York: Nature Publishing Group US
Journal title:Nature biotechnology, 2016-08, Vol.34 (8), p.875-880
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Select record 35
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Molecular Mechanisms of Antisense Oligonucleotides
Author / Creator:Crooke, Stanley T.
Publisher:United States: Mary Ann Liebert, Inc
Journal title:Nucleic acid therapeutics, 2017-04, Vol.27 (2), p.7-77
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Select record 36
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Inhibition of miR-25 improves cardiac contractility in the failing heart
Author / Creator:Wahlquist, Christine ; Jeong, Dongtak ; Rojas-Muñoz, Agustin ; Kho, Changwon ; Lee, Ahyoung ; Mitsuyama, Shinichi ; van Mil, Alain ; Jin Park, Woo ; Sluijter, Joost P. G. ; Doevendans, Pieter A. F. ; Hajjar, Roger J. ; Mercola, Mark
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2014-04, Vol.508 (7497), p.531-535
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Select record 37
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Deep transcriptome profiling of mammalian stem cells supports a regulatory role for retrotransposons in pluripotency maintenance
Author / Creator:Fort, Alexandre ; Hashimoto, Kosuke ; Yamada, Daisuke ; Salimullah, Md ; Keya, Chaman A ; Saxena, Alka ; Bonetti, Alessandro ; Voineagu, Irina ; Bertin, Nicolas ; Kratz, Anton ; Noro, Yukihiko ; Wong, Chee-Hong ; de Hoon, Michiel ; Andersson, Robin ; Sandelin, Albin ; Suzuki, Harukazu ; Wei, Chia-Lin ; Koseki, Haruhiko ; Hasegawa, Yuki ; Forrest, Alistair R R ; Carninci, Piero
Publisher:New York: Nature Publishing Group US
Journal title:Nature genetics, 2014-06, Vol.46 (6), p.558-566
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Select record 38
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SMN deficiency in severe models of spinal muscular atrophy causes widespread intron retention and DNA damage
Author / Creator:Jangi, Mohini ; Fleet, Christina ; Cullen, Patrick ; Gupta, Shipra V. ; Mekhoubad, Shila ; Chiao, Eric ; Allaire, Norm ; Bennett, C. Frank ; Rigo, Frank ; Krainer, Adrian R. ; Hurt, Jessica A. ; Carulli, John P. ; Staropoli, John F.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2017-03, Vol.114 (12), p.E2347-E2356
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Select record 39
ArticlesPeer ReviewedFull Text
Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43
Author / Creator:Polymenidou, Magdalini ; Lagier-Tourenne, Clotilde ; Hutt, Kasey R ; Huelga, Stephanie C ; Moran, Jacqueline ; Liang, Tiffany Y ; Ling, Shuo-Chien ; Sun, Eveline ; Wancewicz, Edward ; Mazur, Curt ; Kordasiewicz, Holly ; Sedaghat, Yalda ; Donohue, John Paul ; Shiue, Lily ; Bennett, C Frank ; Yeo, Gene W ; Cleveland, Don W
Publisher:New York: Nature Publishing Group US
Journal title:Nature neuroscience, 2011-04, Vol.14 (4), p.459-468
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Select record 40
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Head-to-head antisense transcription and R-loop formation promotes transcriptional activation
Author / Creator:Boque-Sastre, Raquel ; Soler, Marta ; Oliveira-Mateos, Cristina ; Portela, Anna ; Moutinho, Catia ; Sayols, Sergi ; Villanueva, Alberto ; Esteller, Manel ; Guil, Sonia
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2015-05, Vol.112 (18), p.5785-5790
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Preclinical development of a miR-132 inhibitor for heart failure treatment

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RNA-targeting and gene editing therapies for transthyretin amyloidosis

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Therapeutic approaches for Duchenne muscular dystrophy

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Precise RNA editing by recruiting endogenous ADARs with antisense oligonucleotides

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ABCA4-associated disease as a model for missing heritability in autosomal recessive disorders: novel noncoding splice, cis-regulatory, structural, and recurrent hypomorphic variants

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Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration

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Cryo-EM and antisense targeting of the 28-kDa frameshift stimulation element from the SARS-CoV-2 RNA genome

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Development of microRNA therapeutics is coming of age

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RNA-extraction-free nano-amplified colorimetric test for point-of-care clinical diagnosis of COVID-19

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Damage-induced lncRNAs control the DNA damage response through interaction with DDRNAs at individual double-strand breaks

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Interferon-α receptor antisense oligonucleotides reduce neuroinflammation and neuropathology in a mouse model of cerebral interferonopathy

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A framework for individualized splice-switching oligonucleotide therapy

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Towards a therapy for Angelman syndrome by targeting a long non-coding RNA

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Translation efficiency of mRNAs is increased by antisense oligonucleotides targeting upstream open reading frames

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Molecular Mechanisms of Antisense Oligonucleotides

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Inhibition of miR-25 improves cardiac contractility in the failing heart

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Deep transcriptome profiling of mammalian stem cells supports a regulatory role for retrotransposons in pluripotency maintenance

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SMN deficiency in severe models of spinal muscular atrophy causes widespread intron retention and DNA damage

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Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43

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Head-to-head antisense transcription and R-loop formation promotes transcriptional activation

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