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ArticlesPeer ReviewedFull Text
Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474
Author / Creator:van Esbroeck, Annelot C. M. ; Janssen, Antonius P. A. ; Cognetta, Armand B. ; Ogasawara, Daisuke ; Shpak, Guy ; van der Kroeg, Mark ; Kantae, Vasudev ; Baggelaar, Marc P. ; de Vrij, Femke M. S. ; Deng, Hui ; Allarà, Marco ; Fezza, Filomena ; Lin, Zhanmin ; van der Wel, Tom ; Soethoudt, Marjolein ; Mock, Elliot D. ; den Dulk, Hans ; Baak, Ilse L. ; Florea, Bogdan I. ; Hendriks, Giel ; De Petrocellis, Luciano ; Overkleeft, Herman S. ; Hankemeier, Thomas ; De Zeeuw, Chris I. ; Di Marzo, Vincenzo ; Maccarrone, Mauro ; Cravatt, Benjamin F. ; Kushner, Steven A. ; van der Stelt, Mario
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2017-06, Vol.356 (6342), p.1084-1087
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Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity
Author / Creator:Li, Fei ; Jiang, Changtao ; Krausz, Kristopher W. ; Li, Yunfei ; Albert, Istvan ; Hao, Haiping ; Fabre, Kristin M. ; Mitchell, James B. ; Patterson, Andrew D. ; Gonzalez, Frank J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2013-09, Vol.4 (1), p.2384-2384, Article 2384
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FAAH inhibitors in the limelight, but regrettably
Author / Creator:Mallet, Christophe ; Dubray, Claude ; Dualé, Christian
Publisher:Germany: Dustri - Verlag Dr. Karl Feistle GmbH & Co. KG
Journal title:International journal of clinical pharmacology and therapeutics, 2016-07, Vol.54 (7), p.498-501
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Protective effects of elevated anandamide on stress and fear-related behaviors: translational evidence from humans and mice
Author / Creator:Mayo, Leah M. ; Asratian, Anna ; Lindé, Johan ; Holm, Lovisa ; Nätt, Daniel ; Augier, Gaëlle ; Stensson, Niclas ; Vecchiarelli, Haley A. ; Balsevich, Georgia ; Aukema, Robert J. ; Ghafouri, Bijar ; Spagnolo, Primavera A. ; Lee, Francis S. ; Hill, Matthew N. ; Heilig, Markus
Publisher:London: Nature Publishing Group UK
Journal title:Molecular psychiatry, 2020-05, Vol.25 (5), p.993-1005
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Development of a covalent inhibitor of gut bacterial bile salt hydrolases
Author / Creator:Adhikari, Arijit A. ; Seegar, Tom C. M. ; Ficarro, Scott B. ; McCurry, Megan D. ; Ramachandran, Deepti ; Yao, Lina ; Chaudhari, Snehal N. ; Ndousse-Fetter, Sula ; Banks, Alexander S. ; Marto, Jarrod A. ; Blacklow, Stephen C. ; Devlin, A. Sloan
Publisher:New York: Nature Publishing Group US
Journal title:Nature chemical biology, 2020-03, Vol.16 (3), p.318-326
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Acute Neurologic Disorder from an Inhibitor of Fatty Acid Amide Hydrolase
Author / Creator:Kerbrat, Anne ; Ferré, Jean-Christophe ; Fillatre, Pierre ; Ronzière, Thomas ; Vannier, Stéphane ; Carsin-Nicol, Béatrice ; Lavoué, Sylvain ; Vérin, Marc ; Gauvrit, Jean-Yves ; Le Tulzo, Yves ; Edan, Gilles
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2016-11, Vol.375 (18), p.1717-1725
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Quorum quenching enzymes and their application in degrading signal molecules to block quorum sensing-dependent infection
Author / Creator:Chen, Fang ; Gao, Yuxin ; Chen, Xiaoyi ; Yu, Zhimin ; Li, Xianzhen
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2013-08, Vol.14 (9), p.17477-17500
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Endogenous cannabinoid release within prefrontal-limbic pathways affects memory consolidation of emotional training
Author / Creator:Morena, Maria ; Roozendaal, Benno ; Trezza, Viviana ; Ratano, Patrizia ; Peloso, Andrea ; Hauer, Daniela ; Atsak, Piray ; Trabace, Luigia ; Cuomo, Vincenzo ; McGaugh, James L ; Schelling, Gustav ; Campolongo, Patrizia
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2014-12, Vol.111 (51), p.18333-18338
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Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects
Author / Creator:Long, Jonathan Z ; Li, Weiwei ; Booker, Lamont ; Burston, James J ; Kinsey, Steven G ; Schlosburg, Joel E ; Pavón, Franciso J ; Serrano, Antonia M ; Selley, Dana E ; Parsons, Loren H ; Lichtman, Aron H ; Cravatt, Benjamin F
Publisher:New York: Nature Publishing Group US
Journal title:Nature chemical biology, 2009-01, Vol.5 (1), p.37-44
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Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system
Author / Creator:Schlosburg, Joel E ; Blankman, Jacqueline L ; Long, Jonathan Z ; Nomura, Daniel K ; Pan, Bin ; Kinsey, Steven G ; Nguyen, Peter T ; Ramesh, Divya ; Booker, Lamont ; Burston, James J ; Thomas, Elizabeth A ; Selley, Dana E ; Sim-Selley, Laura J ; Liu, Qing-song ; Lichtman, Aron H ; Cravatt, Benjamin F
Publisher:New York: Nature Publishing Group US
Journal title:Nature neuroscience, 2010-09, Vol.13 (9), p.1113-1119
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Translating slow-binding inhibition kinetics into cellular and in vivo effects
Author / Creator:Walkup, Grant K ; You, Zhiping ; Ross, Philip L ; Allen, Eleanor K H ; Daryaee, Fereidoon ; Hale, Michael R ; O'Donnell, John ; Ehmann, David E ; Schuck, Virna J A ; Buurman, Ed T ; Choy, Allison L ; Hajec, Laurel ; Murphy-Benenato, Kerry ; Marone, Valerie ; Patey, Sara A ; Grosser, Lena A ; Johnstone, Michele ; Walker, Stephen G ; Tonge, Peter J ; Fisher, Stewart L
Publisher:New York: Nature Publishing Group US
Journal title:Nature chemical biology, 2015-06, Vol.11 (6), p.416-423
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Deficient endocannabinoid signaling in the central amygdala contributes to alcohol dependence-related anxiety-like behavior and excessive alcohol intake
Author / Creator:Serrano, Antonia ; Pavon, Francisco J ; Buczynski, Matthew W ; Schlosburg, Joel ; Natividad, Luis A ; Polis, Ilham Y ; Stouffer, David G ; Zorrilla, Eric P ; Roberto, Marisa ; Cravatt, Benjamin F ; Martin-Fardon, Rémi ; Rodriguez de Fonseca, Fernando ; Parsons, Loren H
Publisher:England: Nature Publishing Group
Journal title:Neuropsychopharmacology (New York, N.Y.), 2018-08, Vol.43 (9), p.1840-1850
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Stress-induced modulation of endocannabinoid signaling leads to delayed strengthening of synaptic connectivity in the amygdala
Author / Creator:Yasmin, Farhana ; Colangeli, Roberto ; Morena, Maria ; Filipski, Sarah ; van der Stelt, Mario ; Pittman, Quentin J. ; Hillard, Cecilia J. ; Teskey, G. Campbell ; McEwen, Bruce S. ; Hill, Matthew N. ; Chattarji, Sumantra
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2020-01, Vol.117 (1), p.650-655
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Therapeutic potential of inhibitors of endocannabinoid degradation for the treatment of stress-related hyperalgesia in an animal model of chronic pain
Author / Creator:Lomazzo, Ermelinda ; Bindila, Laura ; Remmers, Floor ; Lerner, Raissa ; Schwitter, Claudia ; Hoheisel, Ulrich ; Lutz, Beat
Publisher:England: Nature Publishing Group
Journal title:Neuropsychopharmacology (New York, N.Y.), 2015-01, Vol.40 (2), p.488-501
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Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity
Author / Creator:Gunduz-Cinar, O ; MacPherson, K P ; Cinar, R ; Gamble-George, J ; Sugden, K ; Williams, B ; Godlewski, G ; Ramikie, T S ; Gorka, A X ; Alapafuja, S O ; Nikas, S P ; Makriyannis, A ; Poulton, R ; Patel, S ; Hariri, A R ; Caspi, A ; Moffitt, T E ; Kunos, G ; Holmes, A
Publisher:London: Nature Publishing Group UK
Journal title:Molecular psychiatry, 2013-07, Vol.18 (7), p.813-823
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Enhancing Endocannabinoid Neurotransmission Augments The Efficacy of Extinction Training and Ameliorates Traumatic Stress-Induced Behavioral Alterations in Rats
Author / Creator:Morena, Maria ; Berardi, Andrea ; Colucci, Paola ; Palmery, Maura ; Trezza, Viviana ; Hill, Matthew N ; Campolongo, Patrizia
Publisher:England: Nature Publishing Group
Journal title:Neuropsychopharmacology (New York, N.Y.), 2018-05, Vol.43 (6), p.1284-1296
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Regulation of Hfq by the RNA CrcZ in Pseudomonas aeruginosa carbon catabolite repression
Author / Creator:Sonnleitner, Elisabeth ; Bläsi, Udo
Publisher:United States: Public Library of Science
Journal title:PLoS genetics, 2014-06, Vol.10 (6), p.e1004440-e1004440
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Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo
Author / Creator:Long, Jonathan Z ; Nomura, Daniel K ; Vann, Robert E ; Walentiny, D. Matthew ; Booker, Lamont ; Jin, Xin ; Burston, James J ; Sim-Selley, Laura J ; Lichtman, Aron H ; Wiley, Jenny L ; Cravatt, Benjamin F
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2009-12, Vol.106 (48), p.20270-20275
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Disruption of fatty acid amide hydrolase activity prevents the effects of chronic stress on anxiety and amygdalar microstructure
Author / Creator:Hill, M N ; Kumar, S A ; Filipski, S B ; Iverson, M ; Stuhr, K L ; Keith, J M ; Cravatt, B F ; Hillard, C J ; Chattarji, S ; McEwen, B S
Publisher:London: Nature Publishing Group UK
Journal title:Molecular psychiatry, 2013-10, Vol.18 (10), p.1125-1135
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Anticonvulsant Effects of Synthetic N -(3-Methoxybenzyl)oleamide and N -(3-Methoxybenzyl)linoleamide Macamides: An In Silico and In Vivo Study
Author / Creator:Vera-López, Karin Jannet ; Aguilar-Pineda, Jorge Alberto ; Moscoso-Palacios, Rodrigo Martín ; Davila-Del-Carpio, Gonzalo ; Manrique-Murillo, José Luis ; Gómez, Badhin ; González-Melchor, Minerva ; Nieto-Montesinos, Rita
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2025-01, Vol.30 (2), p.333
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Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474

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Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity

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FAAH inhibitors in the limelight, but regrettably

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Protective effects of elevated anandamide on stress and fear-related behaviors: translational evidence from humans and mice

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Development of a covalent inhibitor of gut bacterial bile salt hydrolases

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Acute Neurologic Disorder from an Inhibitor of Fatty Acid Amide Hydrolase

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Quorum quenching enzymes and their application in degrading signal molecules to block quorum sensing-dependent infection

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Endogenous cannabinoid release within prefrontal-limbic pathways affects memory consolidation of emotional training

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Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects

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Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system

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Translating slow-binding inhibition kinetics into cellular and in vivo effects

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Deficient endocannabinoid signaling in the central amygdala contributes to alcohol dependence-related anxiety-like behavior and excessive alcohol intake

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Stress-induced modulation of endocannabinoid signaling leads to delayed strengthening of synaptic connectivity in the amygdala

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Therapeutic potential of inhibitors of endocannabinoid degradation for the treatment of stress-related hyperalgesia in an animal model of chronic pain

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Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity

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Enhancing Endocannabinoid Neurotransmission Augments The Efficacy of Extinction Training and Ameliorates Traumatic Stress-Induced Behavioral Alterations in Rats

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Regulation of Hfq by the RNA CrcZ in Pseudomonas aeruginosa carbon catabolite repression

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Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo

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Disruption of fatty acid amide hydrolase activity prevents the effects of chronic stress on anxiety and amygdalar microstructure

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Anticonvulsant Effects of Synthetic N -(3-Methoxybenzyl)oleamide and N -(3-Methoxybenzyl)linoleamide Macamides: An In Silico and In Vivo Study

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