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ArticlesPeer ReviewedFull Text
Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway
Author / Creator:Boussiotis, Vassiliki A
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2016-11, Vol.375 (18), p.1767-1778
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Identification of CMTM6 and CMTM4 as PD-L1 protein regulators
Author / Creator:Mezzadra, Riccardo ; Sun, Chong ; Jae, Lucas T. ; Gomez-Eerland, Raquel ; de Vries, Evert ; Wu, Wei ; Logtenberg, Meike E. W. ; Slagter, Maarten ; Rozeman, Elisa A. ; Hofland, Ingrid ; Broeks, Annegien ; Horlings, Hugo M. ; Wessels, Lodewyk F. A. ; Blank, Christian U. ; Xiao, Yanling ; Heck, Albert J. R. ; Borst, Jannie ; Brummelkamp, Thijn R. ; Schumacher, Ton N. M.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2017-09, Vol.549 (7670), p.106-110
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Synergistic and low adverse effect cancer immunotherapy by immunogenic chemotherapy and locally expressed PD-L1 trap
Author / Creator:Song, Wantong ; Shen, Limei ; Wang, Ying ; Liu, Qi ; Goodwin, Tyler J. ; Li, Jingjing ; Dorosheva, Olekasandra ; Liu, Tianzhou ; Liu, Rihe ; Huang, Leaf
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2018-06, Vol.9 (1), p.2237-11, Article 2237
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CA-170 – A Potent Small-Molecule PD-L1 Inhibitor or Not?
Author / Creator:Musielak, Bogdan ; Kocik, Justyna ; Skalniak, Lukasz ; Magiera-Mularz, Katarzyna ; Sala, Dominik ; Czub, Miroslawa ; Stec, Malgorzata ; Siedlar, Maciej ; Holak, Tad A. ; Plewka, Jacek
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2019-08, Vol.24 (15), p.2804
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ARIH1 signaling promotes anti-tumor immunity by targeting PD-L1 for proteasomal degradation
Author / Creator:Wu, Youqian ; Zhang, Chao ; Liu, Xiaolan ; He, Zhengfu ; Shan, Bing ; Zeng, Qingxin ; Zhao, Qingwei ; Zhu, Huaying ; Liao, Hongwei ; Cen, Xufeng ; Xu, Xiaoyan ; Zhang, Mengmeng ; Hou, Tingjun ; Wang, Zhe ; Yan, Huanhuan ; Yang, Shuying ; Sun, Yaqin ; Chen, Yanying ; Wu, Ronghai ; Xie, Tingxue ; Chen, Wei ; Najafov, Ayaz ; Ying, Songmin ; Xia, Hongguang
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-04, Vol.12 (1), p.2346-14, Article 2346
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Comprehensive in vitro characterization of PD-L1 small molecule inhibitors
Author / Creator:Ganesan, Aravindhan ; Ahmed, Marawan ; Okoye, Isobel ; Arutyunova, Elena ; Babu, Dinesh ; Turnbull, William L. ; Kundu, Joydeb Kumar ; Shields, Justin ; Agopsowicz, Katharine Cheryl ; Xu, Lai ; Tabana, Yasser ; Srivastava, Nutan ; Zhang, Guangzhi ; Moon, Tae Chul ; Belovodskiy, Alexandr ; Hena, Mostofa ; Kandadai, Appan Srinivas ; Hosseini, Seyedeh Nargess ; Hitt, Mary ; Walker, John ; Smylie, Michael ; West, Frederick G. ; Siraki, Arno G. ; Lemieux, M. Joanne ; Elahi, Shokrollah ; Nieman, James A. ; Tyrrell, D. Lorne ; Houghton, Michael ; Barakat, Khaled
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2019-08, Vol.9 (1), p.12392-19, Article 12392
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PD-L1 degradation is regulated by electrostatic membrane association of its cytoplasmic domain
Author / Creator:Wen, Maorong ; Cao, Yunlei ; Wu, Bin ; Xiao, Taoran ; Cao, Ruiyu ; Wang, Qian ; Liu, Xiwei ; Xue, Hongjuan ; Yu, Yang ; Lin, Jialing ; Xu, Chenqi ; Xu, Jie ; OuYang, Bo
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-08, Vol.12 (1), p.5106-13, Article 5106
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A secreted PD-L1 splice variant that covalently dimerizes and mediates immunosuppression
Author / Creator:Mahoney, Kathleen M. ; Shukla, Sachet A. ; Patsoukis, Nikolaos ; Chaudhri, Apoorvi ; Browne, Edward P. ; Arazi, Arnon ; Eisenhaure, Thomas M. ; Pendergraft, William F. ; Hua, Ping ; Pham, Hung C. ; Bu, Xia ; Zhu, Baogong ; Hacohen, Nir ; Fritsch, Edward F. ; Boussiotis, Vassiliki A. ; Wu, Catherine J. ; Freeman, Gordon J.
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Cancer Immunology, Immunotherapy, 2019-03, Vol.68 (3), p.421-432
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Intrapleural nano-immunotherapy promotes innate and adaptive immune responses to enhance anti-PD-L1 therapy for malignant pleural effusion
Author / Creator:Liu, Yang ; Wang, Lulu ; Song, Qianqian ; Ali, Muhammad ; Crowe, William N. ; Kucera, Gregory L. ; Hawkins, Gregory A. ; Soker, Shay ; Thomas, Karl W. ; Miller, Lance D. ; Lu, Yong ; Bellinger, Christina R. ; Zhang, Wei ; Habib, Amyn A. ; Petty, W. Jeffrey ; Zhao, Dawen
Publisher:London: Nature Publishing Group UK
Journal title:Nature nanotechnology, 2022-02, Vol.17 (2), p.206-216
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Computational design of a synthetic PD-1 agonist
Author / Creator:Bryan, Cassie M. ; Rocklin, Gabriel J. ; Bick, Matthew J. ; Ford, Alex ; Majri-Morrison, Sonia ; Kroll, Ashley V. ; Miller, Chad J. ; Carter, Lauren ; Goreshnik, Inna ; Kang, Alex ; DiMaio, Frank ; Tarbell, Kristin V. ; Baker, David
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2021-07, Vol.118 (29), p.1-9
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PD-L1 lncRNA splice isoform promotes lung adenocarcinoma progression via enhancing c-Myc activity
Author / Creator:Qu, Shuang ; Jiao, Zichen ; Lu, Geng ; Yao, Bing ; Wang, Ting ; Rong, Weiwei ; Xu, Jiahan ; Fan, Ting ; Sun, Xinlei ; Yang, Rong ; Wang, Jun ; Yao, Yongzhong ; Xu, Guifang ; Yan, Xin ; Wang, Tao ; Liang, Hongwei ; Zen, Ke
Publisher:England: BioMed Central Ltd
Journal title:Genome Biology, 2021-04, Vol.22 (1), p.104-104, Article 104
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A high-affinity human PD-1/PD-L2 complex informs avenues for small-molecule immune checkpoint drug discovery
Author / Creator:Tang, Shaogeng ; Kim, Peter S.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2019-12, Vol.116 (49), p.24500-24506
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A mating mechanism to generate diversity for the Darwinian selection of DNA-encoded synthetic molecules
Author / Creator:Vummidi, Balayeshwanth R. ; Farrera-Soler, Lluc ; Daguer, Jean-Pierre ; Dockerill, Millicent ; Barluenga, Sofia ; Winssinger, Nicolas
Publisher:London: Nature Publishing Group UK
Journal title:Nature chemistry, 2022-02, Vol.14 (2), p.141-152
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ArticlesPeer ReviewedFull Text
Distinct PD-L1 binding characteristics of therapeutic monoclonal antibody durvalumab
Author / Creator:Tan, Shuguang ; Liu, Kefang ; Chai, Yan ; Zhang, Catherine W.-H. ; Gao, Shan ; Gao, George F. ; Qi, Jianxun
Publisher:Beijing: Higher Education Press
Journal title:Protein & cell, 2018-01, Vol.9 (1), p.135-139
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In silico exploration of PD-L1 binding compounds: Structure-based virtual screening, molecular docking, and MD simulation
Author / Creator:Alanzi, Abdullah ; Moussa, Ashaimaa Y. ; Mothana, Ramzi A. ; Abbas, Munawar ; Ali, Ijaz
Publisher:United States: Public Library of Science
Journal title:PloS one, 2024-08, Vol.19 (8), p.e0306804
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Molecular Dynamics-Guided Repositioning of FDA-Approved Drugs for PD-L1 Inhibition with In Vitro Anticancer Potential
Author / Creator:Jiang, Dejun ; Yoou, Myoung-Schook ; Cho, Sungjoon ; Choi, Youngjin
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2025-05, Vol.26 (10), p.4497
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Serum assisted PD-L1 aptamer screening for improving its stability
Author / Creator:Zhou, Yu ; Zhang, Haozhe ; Ding, Yujing ; Yu, Changyuan ; Li, Hao
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2025-01, Vol.15 (1), p.1848-8, Article 1848
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Investigation of protein-protein interactions and hot spot region between PD-1 and PD-L1 by fragment molecular orbital method
Author / Creator:Lim, Hocheol ; Chun, Jungho ; Jin, Xuemei ; Kim, Jongwan ; Yoon, JeongHyeok ; No, Kyoung Tai
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2019-11, Vol.9 (1), p.16727-11, Article 16727
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Spatial and stoichiometric in situ analysis of biomolecular oligomerization at single-protein resolution
Author / Creator:Masullo, Luciano A. ; Kowalewski, Rafal ; Honsa, Monique ; Heinze, Larissa ; Xu, Shuhan ; Steen, Philipp R. ; Grabmayr, Heinrich ; Pachmayr, Isabelle ; Reinhardt, Susanne C. M. ; Perovic, Ana ; Kwon, Jisoo ; Oxley, Ethan P. ; Dickins, Ross A. ; Bastings, Maartje M. C. ; Parish, Ian A. ; Jungmann, Ralf
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2025-05, Vol.16 (1), p.4202-11, Article 4202
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Unraveling the Specific Recognition Between PD-L1 and Engineered CLP002 Functionalized Gold Nanostructures: MD Simulation Studies
Author / Creator:Giannetti, Micaela ; Gobbo, Marina ; Litti, Lucio ; Caligiuri, Isabella ; Rizzolio, Flavio ; Meneghetti, Moreno ; Mazzuca, Claudia ; Palleschi, Antonio
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2025-05, Vol.30 (9), p.2045
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Showing 1 to 20 of 48 results

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Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway

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Identification of CMTM6 and CMTM4 as PD-L1 protein regulators

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Synergistic and low adverse effect cancer immunotherapy by immunogenic chemotherapy and locally expressed PD-L1 trap

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CA-170 – A Potent Small-Molecule PD-L1 Inhibitor or Not?

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ARIH1 signaling promotes anti-tumor immunity by targeting PD-L1 for proteasomal degradation

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Comprehensive in vitro characterization of PD-L1 small molecule inhibitors

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PD-L1 degradation is regulated by electrostatic membrane association of its cytoplasmic domain

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A secreted PD-L1 splice variant that covalently dimerizes and mediates immunosuppression

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Intrapleural nano-immunotherapy promotes innate and adaptive immune responses to enhance anti-PD-L1 therapy for malignant pleural effusion

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Computational design of a synthetic PD-1 agonist

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PD-L1 lncRNA splice isoform promotes lung adenocarcinoma progression via enhancing c-Myc activity

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A high-affinity human PD-1/PD-L2 complex informs avenues for small-molecule immune checkpoint drug discovery

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A mating mechanism to generate diversity for the Darwinian selection of DNA-encoded synthetic molecules

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Distinct PD-L1 binding characteristics of therapeutic monoclonal antibody durvalumab

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In silico exploration of PD-L1 binding compounds: Structure-based virtual screening, molecular docking, and MD simulation

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Molecular Dynamics-Guided Repositioning of FDA-Approved Drugs for PD-L1 Inhibition with In Vitro Anticancer Potential

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Serum assisted PD-L1 aptamer screening for improving its stability

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Investigation of protein-protein interactions and hot spot region between PD-1 and PD-L1 by fragment molecular orbital method

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Spatial and stoichiometric in situ analysis of biomolecular oligomerization at single-protein resolution

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Unraveling the Specific Recognition Between PD-L1 and Engineered CLP002 Functionalized Gold Nanostructures: MD Simulation Studies

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