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308 results for BRCA2+Protein+-+metabolism

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ArticlesPeer ReviewedFull Text
DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells
Author / Creator:Sato, Hiro ; Niimi, Atsuko ; Yasuhara, Takaaki ; Permata, Tiara Bunga Mayang ; Hagiwara, Yoshihiko ; Isono, Mayu ; Nuryadi, Endang ; Sekine, Ryota ; Oike, Takahiro ; Kakoti, Sangeeta ; Yoshimoto, Yuya ; Held, Kathryn D. ; Suzuki, Yoshiyuki ; Kono, Koji ; Miyagawa, Kiyoshi ; Nakano, Takashi ; Shibata, Atsushi
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2017-11, Vol.8 (1), p.1751-11, Article 1751
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MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells
Author / Creator:Lemaçon, Delphine ; Jackson, Jessica ; Quinet, Annabel ; Brickner, Joshua R. ; Li, Shan ; Yazinski, Stephanie ; You, Zhongsheng ; Ira, Grzegorz ; Zou, Lee ; Mosammaparast, Nima ; Vindigni, Alessandro
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2017-10, Vol.8 (1), p.860-12, Article 860
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BRCAness revisited
Author / Creator:Lord, Christopher J. ; Ashworth, Alan
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Cancer, 2016-02, Vol.16 (2), p.110-120
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Replication fork reversal triggers fork degradation in BRCA2-defective cells
Author / Creator:Mijic, Sofija ; Zellweger, Ralph ; Chappidi, Nagaraja ; Berti, Matteo ; Jacobs, Kurt ; Mutreja, Karun ; Ursich, Sebastian ; Ray Chaudhuri, Arnab ; Nussenzweig, Andre ; Janscak, Pavel ; Lopes, Massimo
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2017-10, Vol.8 (1), p.859-11, Article 859
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Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance
Author / Creator:Zatreanu, Diana ; Robinson, Helen M. R. ; Alkhatib, Omar ; Boursier, Marie ; Finch, Harry ; Geo, Lerin ; Grande, Diego ; Grinkevich, Vera ; Heald, Robert A. ; Langdon, Sophie ; Majithiya, Jayesh ; McWhirter, Claire ; Martin, Niall M. B. ; Moore, Shaun ; Neves, Joana ; Rajendra, Eeson ; Ranzani, Marco ; Schaedler, Theresia ; Stockley, Martin ; Wiggins, Kimberley ; Brough, Rachel ; Sridhar, Sandhya ; Gulati, Aditi ; Shao, Nan ; Badder, Luned M. ; Novo, Daniela ; Knight, Eleanor G. ; Marlow, Rebecca ; Haider, Syed ; Callen, Elsa ; Hewitt, Graeme ; Schimmel, Joost ; Prevo, Remko ; Alli, Christina ; Ferdinand, Amanda ; Bell, Cameron ; Blencowe, Peter ; Bot, Chris ; Calder, Mathew ; Charles, Mark ; Curry, Jayne ; Ekwuru, Tennyson ; Ewings, Katherine ; Krajewski, Wojciech ; MacDonald, Ellen ; McCarron, Hollie ; Pang, Leon ; Pedder, Chris ; Rigoreau, Laurent ; Swarbrick, Martin ; Wheatley, Ed ; Willis, Simon ; Wong, Ai Ching ; Nussenzweig, Andre ; Tijsterman, Marcel ; Tutt, Andrew ; Boulton, Simon J. ; Higgins, Geoff S. ; Pettitt, Stephen J. ; Smith, Graeme C. M. ; Lord, Christopher J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-06, Vol.12 (1), p.3636-15, Article 3636
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Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models
Author / Creator:Kim, Hyoung ; Xu, Haineng ; George, Erin ; Hallberg, Dorothy ; Kumar, Sushil ; Jagannathan, Veena ; Medvedev, Sergey ; Kinose, Yasuto ; Devins, Kyle ; Verma, Priyanka ; Ly, Kevin ; Wang, Yifan ; Greenberg, Roger A. ; Schwartz, Lauren ; Johnson, Neil ; Scharpf, Robert B. ; Mills, Gordon B. ; Zhang, Rugang ; Velculescu, Victor E. ; Brown, Eric J. ; Simpkins, Fiona
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2020-07, Vol.11 (1), p.3726-3726, Article 3726
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EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation
Author / Creator:Rondinelli, Beatrice ; Gogola, Ewa ; Yücel, Hatice ; Duarte, Alexandra A. ; van de Ven, Marieke ; van der Sluijs, Roxanne ; Konstantinopoulos, Panagiotis A. ; Jonkers, Jos ; Ceccaldi, Raphaël ; Rottenberg, Sven ; D’Andrea, Alan D.
Publisher:London: Nature Publishing Group UK
Journal title:Nature cell biology, 2017-11, Vol.19 (11), p.1371-1378
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BRCA1–BARD1 promotes RAD51-mediated homologous DNA pairing
Author / Creator:Zhao, Weixing ; Steinfeld, Justin B. ; Liang, Fengshan ; Chen, Xiaoyong ; Maranon, David G. ; Jian Ma, Chu ; Kwon, Youngho ; Rao, Timsi ; Wang, Weibin ; Sheng, Chen ; Song, Xuemei ; Deng, Yanhong ; Jimenez-Sainz, Judit ; Lu, Lucy ; Jensen, Ryan B. ; Xiong, Yong ; Kupfer, Gary M. ; Wiese, Claudia ; Greene, Eric C. ; Sung, Patrick
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2017-10, Vol.550 (7676), p.360-365
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Molecular correlates of cisplatin-based chemotherapy response in muscle invasive bladder cancer by integrated multi-omics analysis
Author / Creator:Taber, Ann ; Christensen, Emil ; Lamy, Philippe ; Nordentoft, Iver ; Prip, Frederik ; Lindskrog, Sia Viborg ; Birkenkamp-Demtröder, Karin ; Okholm, Trine Line Hauge ; Knudsen, Michael ; Pedersen, Jakob Skou ; Steiniche, Torben ; Agerbæk, Mads ; Jensen, Jørgen Bjerggaard ; Dyrskjøt, Lars
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2020-09, Vol.11 (1), p.4858-15, Article 4858
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Ubiquitin-specific protease 21 stabilizes BRCA2 to control DNA repair and tumor growth
Author / Creator:Liu, Jinping ; Kruswick, Alex ; Dang, Hien ; Tran, Andy D. ; Kwon, So Mee ; Wang, Xin Wei ; Oberdoerffer, Philipp
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2017-07, Vol.8 (1), p.137-12, Article 137
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A mechanism for the suppression of homologous recombination in G1 cells
Author / Creator:Orthwein, Alexandre ; Noordermeer, Sylvie M ; Wilson, Marcus D ; Landry, Sébastien ; Enchev, Radoslav I ; Sherker, Alana ; Munro, Meagan ; Pinder, Jordan ; Salsman, Jayme ; Dellaire, Graham ; Xia, Bing ; Peter, Matthias ; Durocher, Daniel
Publisher:England: Nature Publishing Group
Journal title:Nature (London), 2015-12, Vol.528 (7582), p.422-426
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BRCA2 controls DNA:RNA hybrid level at DSBs by mediating RNase H2 recruitment
Author / Creator:D’Alessandro, Giuseppina ; Whelan, Donna Rose ; Howard, Sean Michael ; Vitelli, Valerio ; Renaudin, Xavier ; Adamowicz, Marek ; Iannelli, Fabio ; Jones-Weinert, Corey Winston ; Lee, MiYoung ; Matti, Valentina ; Lee, Wei Ting C. ; Morten, Michael John ; Venkitaraman, Ashok Raraakrishnan ; Cejka, Petr ; Rothenberg, Eli ; d’Adda di Fagagna, Fabrizio
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2018-12, Vol.9 (1), p.5376-17, Article 5376
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Homologous recombination deficiency status-based classification of high-grade serous ovarian carcinoma
Author / Creator:Takaya, Hisamitsu ; Nakai, Hidekatsu ; Takamatsu, Shiro ; Mandai, Masaki ; Matsumura, Noriomi
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2020-02, Vol.10 (1), p.2757-2757, Article 2757
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BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2
Author / Creator:Bhatia, Vaibhav ; Barroso, Sonia I. ; García-Rubio, María L. ; Tumini, Emanuela ; Herrera-Moyano, Emilia ; Aguilera, Andrés
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2014-07, Vol.511 (7509), p.362-365
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BRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity
Author / Creator:Heijink, Anne Margriet ; Talens, Francien ; Jae, Lucas T. ; van Gijn, Stephanie E. ; Fehrmann, Rudolf S. N. ; Brummelkamp, Thijn R. ; van Vugt, Marcel A. T. M.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2019-01, Vol.10 (1), p.100-14, Article 100
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Structural basis of homologous recombination
Author / Creator:Sun, Yueru ; McCorvie, Thomas J. ; Yates, Luke A. ; Zhang, Xiaodong
Publisher:Cham: Springer International Publishing
Journal title:Cellular and molecular life sciences : CMLS, 2020-01, Vol.77 (1), p.3-18
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POLθ-mediated end joining is restricted by RAD52 and BRCA2 until the onset of mitosis
Author / Creator:Llorens-Agost, Marta ; Ensminger, Michael ; Le, Hang Phuong ; Gawai, Anugrah ; Liu, Jie ; Cruz-García, Andrés ; Bhetawal, Sarita ; Wood, Richard D. ; Heyer, Wolf-Dietrich ; Löbrich, Markus
Publisher:London: Nature Publishing Group UK
Journal title:Nature cell biology, 2021-10, Vol.23 (10), p.1095-1104
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FANCM suppresses DNA replication stress at ALT telomeres by disrupting TERRA R-loops
Author / Creator:Pan, Xiaolei ; Chen, Yun ; Biju, Beena ; Ahmed, Naveed ; Kong, Joyce ; Goldenberg, Marti ; Huang, Judy ; Mohan, Nandakumar ; Klosek, Stephanie ; Parsa, Kian ; Guh, Chia-Yu ; Lu, Robert ; Pickett, Hilda A. ; Chu, Hsueh-Ping ; Zhang, Dong
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2019-12, Vol.9 (1), p.19110-14, Article 19110
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Characterization of the interplay between DNA repair and CRISPR/Cas9-induced DNA lesions at an endogenous locus
Author / Creator:Bothmer, Anne ; Phadke, Tanushree ; Barrera, Luis A. ; Margulies, Carrie M ; Lee, Christina S. ; Buquicchio, Frank ; Moss, Sean ; Abdulkerim, Hayat S. ; Selleck, William ; Jayaram, Hariharan ; Myer, Vic E. ; Cotta-Ramusino, Cecilia
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2017-01, Vol.8 (1), p.13905-13905, Article 13905
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ROS-induced R loops trigger a transcription-coupled but BRCA1/2-independent homologous recombination pathway through CSB
Author / Creator:Teng, Yaqun ; Yadav, Tribhuwan ; Duan, Meihan ; Tan, Jun ; Xiang, Yufei ; Gao, Boya ; Xu, Jianquan ; Liang, Zhuobin ; Liu, Yang ; Nakajima, Satoshi ; Shi, Yi ; Levine, Arthur S. ; Zou, Lee ; Lan, Li
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2018-10, Vol.9 (1), p.4115-12, Article 4115
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DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells

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MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells

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BRCAness revisited

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Replication fork reversal triggers fork degradation in BRCA2-defective cells

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Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance

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Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models

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EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation

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BRCA1–BARD1 promotes RAD51-mediated homologous DNA pairing

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Molecular correlates of cisplatin-based chemotherapy response in muscle invasive bladder cancer by integrated multi-omics analysis

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Ubiquitin-specific protease 21 stabilizes BRCA2 to control DNA repair and tumor growth

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A mechanism for the suppression of homologous recombination in G1 cells

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BRCA2 controls DNA:RNA hybrid level at DSBs by mediating RNase H2 recruitment

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Homologous recombination deficiency status-based classification of high-grade serous ovarian carcinoma

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BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2

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BRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity

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Structural basis of homologous recombination

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POLθ-mediated end joining is restricted by RAD52 and BRCA2 until the onset of mitosis

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FANCM suppresses DNA replication stress at ALT telomeres by disrupting TERRA R-loops

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Characterization of the interplay between DNA repair and CRISPR/Cas9-induced DNA lesions at an endogenous locus

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ROS-induced R loops trigger a transcription-coupled but BRCA1/2-independent homologous recombination pathway through CSB

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