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Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer
Author / Creator:Hessmann, E ; Patzak, M S ; Klein, L ; Chen, N ; Kari, V ; Ramu, I ; Bapiro, T E ; Frese, K K ; Gopinathan, A ; Richards, F M ; Jodrell, D I ; Verbeke, C ; Li, X ; Heuchel, R ; Löhr, J M ; Johnsen, S A ; Gress, T M ; Ellenrieder, V ; Neesse, A
Publisher:England: BMJ Publishing Group LTD
Journal title:Gut, 2018-03, Vol.67 (3), p.497-507
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Enzymatic rhamnosylation of anticancer drugs by an α-l-rhamnosidase from Alternaria sp. L1 for cancer-targeting and enzyme-activated prodrug therapy
Author / Creator:Xu, Li ; Liu, Xiaohong ; Li, Yinping ; Yin, Zhenhao ; Jin, Lan ; Lu, Lili ; Qu, Jingyao ; Xiao, Min
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Applied microbiology and biotechnology, 2019-10, Vol.103 (19), p.7997-8008
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A novel method for quantification of gemcitabine and its metabolites 2',2'-difluorodeoxyuridine and gemcitabine triphosphate in tumour tissue by LC-MS/MS: comparison with (19)F NMR spectroscopy
Author / Creator:Bapiro, Tashinga E ; Richards, Frances M ; Goldgraben, Mae A ; Olive, Kenneth P ; Madhu, Basetti ; Frese, Kristopher K ; Cook, Natalie ; Jacobetz, Michael A ; Smith, Donna-Michelle ; Tuveson, David A ; Griffiths, John R ; Jodrell, Duncan I
Publisher:Germany
Journal title:Cancer chemotherapy and pharmacology, 2011-11, Vol.68 (5), p.1243
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Pharmacokinetics and pharmacogenetics of capecitabine and its metabolites following replicate administration of two 500 mg tablet formulations
Author / Creator:Queckenberg, Christian ; Erlinghagen, V. ; Baken, B. C. M. ; Van Os, S. H. G. ; Wargenau, M. ; Kubeš, V. ; Peroutka, R. ; Novotný, V. ; Fuhr, U.
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Cancer chemotherapy and pharmacology, 2015-11, Vol.76 (5), p.1081-1091
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A thermostable pyrimidine nucleoside phosphorylase from Brevibacillus borstelensis LK01 for synthesizing halogenated nucleosides
Author / Creator:Liu, Ke ; Zhou, Youzhi ; Zhang, Jinsong ; Chu, Jianlin ; Zhang, Yewei ; He, Bingfang
Publisher:Dordrecht: Springer Netherlands
Journal title:Biotechnology letters, 2017-12, Vol.39 (12), p.1903-1910
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Green biosynthesis of floxuridine by immobilized microorganisms
Author / Creator:Rivero, Cintia W. ; Britos, Claudia N. ; Lozano, Mario E. ; Sinisterra, Jose V. ; Trelles, Jorge A.
Publisher:Oxford, UK: Blackwell Publishing Ltd
Journal title:FEMS microbiology letters, 2012-06, Vol.331 (1), p.31-36
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Attenuation of Phosphorylation by Deoxycytidine Kinase is Key to Acquired Gemcitabine Resistance in a Pancreatic Cancer Cell Line: Targeted Proteomic and Metabolomic Analyses in PK9 Cells
Author / Creator:Ohmine, Ken ; Kawaguchi, Kei ; Ohtsuki, Sumio ; Motoi, Fuyuhiko ; Egawa, Shinichi ; Unno, Michiaki ; Terasaki, Tetsuya
Publisher:Boston: Springer US
Journal title:Pharmaceutical research, 2012-07, Vol.29 (7), p.2006-2016
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Pathway-based pharmacogenomics of gemcitabine pharmacokinetics in patients with solid tumors
Author / Creator:Mitra, Amit K ; Kirstein, Mark N ; Khatri, Amit ; Skubitz, Keith M ; Dudek, Arkadiusz Z ; Greeno, Edward W ; Kratzke, Robert A ; Lamba, Jatinder K
Publisher:England: Future Medicine Ltd
Journal title:Pharmacogenomics, 2012-07, Vol.13 (9), p.1009-1021
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The feasibility of enzyme targeted activation for amino acid/dipeptide monoester prodrugs of floxuridine; cathepsin D as a potential targeted enzyme
Author / Creator:Tsume, Yasuhiro ; Amidon, Gordon L
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2012-04, Vol.17 (4), p.3672-3689
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Comparative in vitro evaluation of transportability and toxicity of capecitabine and its metabolites in cells derived from normal human kidney and renal cancers
Author / Creator:Damaraju, Vijaya L ; Mowles, Delores ; Wilson, Marnie ; Kuzma, Michelle ; Cass, Carol E ; Sawyer, Michael B
Publisher:Canada: NRC Research Press
Journal title:Biochemistry and cell biology, 2013-12, Vol.91 (6), p.419-427
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Amino acid ester prodrugs of floxuridine: synthesis and effects of structure, stereochemistry, and site of esterification on the rate of hydrolysis
Author / Creator:Vig, Balvinder S ; Lorenzi, Philip J ; Mittal, Sachin ; Landowski, Christopher P ; Shin, Ho-Chul ; Mosberg, Henry I ; Hilfinger, John M ; Amidon, Gordon L
Publisher:United States: Springer Nature B.V
Journal title:Pharmaceutical research, 2003-09, Vol.20 (9), p.1381-1388
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Highly regioselective galactosylation of floxuridine catalyzed by β-galactosidase from bovine liver
Author / Creator:Zeng, Quan-Ming ; Li, Ning ; Zong, Min-Hua
Publisher:Dordrecht: Dordrecht : Springer Netherlands
Journal title:Biotechnology letters, 2010-09, Vol.32 (9), p.1251-1254
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Increase of [18F]FLT Tumor Uptake In Vivo Mediated by FdUrd: Toward Improving Cell Proliferation Positron Emission Tomography
Author / Creator:Viertl, David ; Bischof Delaloye, Angelika ; Lanz, Bernard ; Poitry-Yamate, Carole ; Gruetter, Rolf ; Mlynarik, Vladimir ; Ametamey, Simon M. ; Ross, Tobias L. ; Lehr, Hans-Anton ; André, Pierre-Alain ; Perillo-Adamer, Florence ; Kosinski, Marek ; Dupertuis, Yves M. ; Buchegger, Franz
Publisher:New York: Springer-Verlag
Journal title:Molecular imaging and biology, 2011-04, Vol.13 (2), p.321-331
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Unexpected reversal of the regioselectivity in Thermomyces lanuginosus lipase-catalyzed acylation of floxuridine
Author / Creator:Li, Ning ; Zong, Min-Hua ; Ma, Ding
Publisher:Dordrecht: Dordrecht : Springer Netherlands
Journal title:Biotechnology letters, 2009-08, Vol.31 (8), p.1241-1244
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Analysis of mechanisms contributing to AraC-mediated chemoresistance and re-establishment of drug sensitivity by the novel heterodinucleoside phosphate 5-FdUrd-araC
Author / Creator:Maier, S ; Strasser, S ; Saiko, P ; Leisser, C ; Sasgary, S ; Grusch, M ; Madlener, S ; Bader, Y ; Hartmann, J ; Schott, H ; Mader, R M ; Szekeres, T ; Fritzer-Szekeres, M ; Krupitza, G
Publisher:Netherlands: Springer Nature B.V
Journal title:Apoptosis (London), 2006-03, Vol.11 (3), p.427-440
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Antiviral Activities and Phosphorylation of 5-halo-2'-Deoxyuridines and N-Methanocarbathymidine in Cells Infected with Vaccinia Virus
Author / Creator:Smee, Donald F ; Humphreys, Daniel E ; Hurst, Brett L ; Barnard, Dale L
Publisher:London, England: SAGE Publications
Journal title:Antiviral chemistry & chemotherapy, 2008-02, Vol.19 (1), p.15-24
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Effects of oxaliplatin and CPT-11 on cytotoxicity and nucleic acid incorporation of the fluoropyrimidines
Author / Creator:PATEL, Manish ; AGARWAL, Ram ; ARDALAN, Bach
Publisher:Berlin: Springer
Journal title:Journal of cancer research and clinical oncology, 2004-08, Vol.130 (8), p.453-459
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Cytosolic and microsomal activation of doxifluridine and tegafur to produce 5-fluorouracil in human liver
Author / Creator:OZAWA, Shogo ; HAMADA, Masashi ; MURAYAMA, Norie ; NAKAJIMA, Yukiko ; KANIWA, Nahoko ; MATSUMOTO, Yoshiaki ; FUKUOKA, Masamichi ; SAWADA, Jun-Ichi ; OHNO, Yasuo
Publisher:Berlin: Springer
Journal title:Cancer chemotherapy and pharmacology, 2002-12, Vol.50 (6), p.454-458
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ArticlesPeer ReviewedFull Text
Intra-aortal therapy with 5-fluorouracil-polyethylene glycol stealth liposomes : Does the metabolism of 5-fluorouracil into 5-fluoro-2'-deoxyuridine depend on pH value? An animal study in VX-2 liver t...
Author / Creator:POHLEN, U ; BINNENHEI, M ; RESZKA, R ; BUHR, H. J ; BERGER, G
Publisher:Basel: Karger
Journal title:Chemotherapy (Basel), 2004-06, Vol.50 (2), p.67-75
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ArticlesPeer ReviewedFull Text
Local disposition kinetics of floxuridine after intratumoral and subcutaneous injection as monitored by [19F]-nuclear magnetic resonance spectroscopy in vivo
Author / Creator:PORT, R ; HANISCH, F ; BECKER, M ; BACHERT, P ; ZELLER, J
Publisher:Berlin: Springer
Journal title:Cancer chemotherapy and pharmacology, 1999, Vol.44 (1), p.65-73
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Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer

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Enzymatic rhamnosylation of anticancer drugs by an α-l-rhamnosidase from Alternaria sp. L1 for cancer-targeting and enzyme-activated prodrug therapy

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A novel method for quantification of gemcitabine and its metabolites 2',2'-difluorodeoxyuridine and gemcitabine triphosphate in tumour tissue by LC-MS/MS: comparison with (19)F NMR spectroscopy

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Pharmacokinetics and pharmacogenetics of capecitabine and its metabolites following replicate administration of two 500 mg tablet formulations

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A thermostable pyrimidine nucleoside phosphorylase from Brevibacillus borstelensis LK01 for synthesizing halogenated nucleosides

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Green biosynthesis of floxuridine by immobilized microorganisms

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Attenuation of Phosphorylation by Deoxycytidine Kinase is Key to Acquired Gemcitabine Resistance in a Pancreatic Cancer Cell Line: Targeted Proteomic and Metabolomic Analyses in PK9 Cells

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Pathway-based pharmacogenomics of gemcitabine pharmacokinetics in patients with solid tumors

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The feasibility of enzyme targeted activation for amino acid/dipeptide monoester prodrugs of floxuridine; cathepsin D as a potential targeted enzyme

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Comparative in vitro evaluation of transportability and toxicity of capecitabine and its metabolites in cells derived from normal human kidney and renal cancers

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Amino acid ester prodrugs of floxuridine: synthesis and effects of structure, stereochemistry, and site of esterification on the rate of hydrolysis

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Highly regioselective galactosylation of floxuridine catalyzed by β-galactosidase from bovine liver

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Increase of [18F]FLT Tumor Uptake In Vivo Mediated by FdUrd: Toward Improving Cell Proliferation Positron Emission Tomography

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Unexpected reversal of the regioselectivity in Thermomyces lanuginosus lipase-catalyzed acylation of floxuridine

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Analysis of mechanisms contributing to AraC-mediated chemoresistance and re-establishment of drug sensitivity by the novel heterodinucleoside phosphate 5-FdUrd-araC

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Antiviral Activities and Phosphorylation of 5-halo-2'-Deoxyuridines and N-Methanocarbathymidine in Cells Infected with Vaccinia Virus

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Effects of oxaliplatin and CPT-11 on cytotoxicity and nucleic acid incorporation of the fluoropyrimidines

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Cytosolic and microsomal activation of doxifluridine and tegafur to produce 5-fluorouracil in human liver

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Intra-aortal therapy with 5-fluorouracil-polyethylene glycol stealth liposomes : Does the metabolism of 5-fluorouracil into 5-fluoro-2'-deoxyuridine depend on pH value? An animal study in VX-2 liver t...

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Local disposition kinetics of floxuridine after intratumoral and subcutaneous injection as monitored by [19F]-nuclear magnetic resonance spectroscopy in vivo

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