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ArticlesPeer ReviewedFull Text
Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion
Author / Creator:Vergari, Elisa ; Knudsen, Jakob G. ; Ramracheya, Reshma ; Salehi, Albert ; Zhang, Quan ; Adam, Julie ; Asterholm, Ingrid Wernstedt ; Benrick, Anna ; Briant, Linford J. B. ; Chibalina, Margarita V. ; Gribble, Fiona M. ; Hamilton, Alexander ; Hastoy, Benoit ; Reimann, Frank ; Rorsman, Nils J. G. ; Spiliotis, Ioannis I. ; Tarasov, Andrei ; Wu, Yanling ; Ashcroft, Frances M. ; Rorsman, Patrik
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2019-01, Vol.10 (1), p.139-139, Article 139
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Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells
Author / Creator:Furuyama, Kenichiro ; Chera, Simona ; van Gurp, Léon ; Oropeza, Daniel ; Ghila, Luiza ; Damond, Nicolas ; Vethe, Heidrun ; Paulo, Joao A. ; Joosten, Antoinette M. ; Berney, Thierry ; Bosco, Domenico ; Dorrell, Craig ; Grompe, Markus ; Ræder, Helge ; Roep, Bart O. ; Thorel, Fabrizio ; Herrera, Pedro L.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2019-03, Vol.567 (7746), p.43-48
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Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets
Author / Creator:Adriaenssens, Alice E. ; Svendsen, Berit ; Lam, Brian Y. H. ; Yeo, Giles S. H. ; Holst, Jens J. ; Reimann, Frank ; Gribble, Fiona M.
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Diabetologia, 2016-10, Vol.59 (10), p.2156-2165
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Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells
Author / Creator:Ellingsgaard, Helga ; Hauselmann, Irina ; Schuler, Beat ; Habib, Abdella M ; Baggio, Laurie L ; Meier, Daniel T ; Eppler, Elisabeth ; Bouzakri, Karim ; Wueest, Stephan ; Muller, Yannick D ; Hansen, Ann Maria Kruse ; Reinecke, Manfred ; Konrad, Daniel ; Gassmann, Max ; Reimann, Frank ; Halban, Philippe A ; Gromada, Jesper ; Drucker, Daniel J ; Gribble, Fiona M ; Ehses, Jan A ; Donath, Marc Y
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2011-11, Vol.17 (11), p.1481-1489
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Glucagon blockade restores functional β-cell mass in type 1 diabetic mice and enhances function of human islets
Author / Creator:Wang, May-Yun ; Dean, E. Danielle ; Quittner-Strom, Ezekiel ; Zhu, Yi ; Chowdhury, Kamrul H. ; Zhang, Zhuzhen ; Zhao, Shangang ; Li, Na ; Ye, Reshing ; Lee, Young ; Zhang, Yiyi ; Chen, Shiuhwei ; Yu, Xinxin ; Leonard, Derek C. ; Poffenberger, Greg ; Von Deylen, Alison ; McCorkle, S. Kay ; Schlegel, Amnon ; Sloop, Kyle W. ; Efanov, Alexander M. ; Gimeno, Ruth E. ; Scherer, Philipp E. ; Powers, Alvin C. ; Unger, Roger H. ; Holland, William L.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2021-03, Vol.118 (9), p.1-8
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Paracrine regulation of somatostatin secretion by insulin and glucagon in mouse pancreatic islets
Author / Creator:Svendsen, Berit ; Holst, Jens J.
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Diabetologia, 2021-01, Vol.64 (1), p.142-151
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Alpha cells secrete acetylcholine as a non-neuronal paracrine signal priming beta cell function in humans
Author / Creator:Rodriguez-Diaz, Rayner ; Dando, Robin ; Jacques-Silva, M Caroline ; Fachado, Alberto ; Molina, Judith ; Abdulreda, Midhat H ; Ricordi, Camillo ; Roper, Stephen D ; Berggren, Per-Olof ; Caicedo, Alejandro
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2011-07, Vol.17 (7), p.888-892
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Single-cell RNA-seq with spike-in cells enables accurate quantification of cell-specific drug effects in pancreatic islets
Author / Creator:Marquina-Sanchez, Brenda ; Fortelny, Nikolaus ; Farlik, Matthias ; Vieira, Andhira ; Collombat, Patrick ; Bock, Christoph ; Kubicek, Stefan
Publisher:England: BioMed Central Ltd
Journal title:Genome Biology, 2020-05, Vol.21 (1), p.106-106, Article 106
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Paracrine GABA and insulin regulate pancreatic alpha cell proliferation in a mouse model of type 1 diabetes
Author / Creator:Feng, Allen L. ; Xiang, Yun-Yan ; Gui, Le ; Kaltsidis, Gesthika ; Feng, Qingping ; Lu, Wei-Yang
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Diabetologia, 2017-06, Vol.60 (6), p.1033-1042
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Improved glucose regulation in type 2 diabetic patients with DPP-4 inhibitors: focus on alpha and beta cell function and lipid metabolism
Author / Creator:Ahrén, Bo ; Foley, James E.
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Diabetologia, 2016-05, Vol.59 (5), p.907-917
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Resveratrol Prevents β-Cell Dedifferentiation in Nonhuman Primates Given a High-Fat/High-Sugar Diet
Author / Creator:FIORI, Jennifer L ; SHIN, Yu-Kyong ; DOYLE, Maire E ; PEARSON, Kevin J ; MATTISON, Julie A ; DE CABO, Rafael ; EGAN, Josephine M ; WOOK KIM ; KRZYSIK-WALKER, Susan M ; GONZALEZ-MARISCAL, Isabel ; CARLSON, Olga D ; SANGHVI, Mitesh ; MOADDEL, Ruin ; FARHANG, Kathleen ; GADKAREE, Shekhar K
Publisher:Alexandria, VA: American Diabetes Association
Journal title:Diabetes (New York, N.Y.), 2013-10, Vol.62 (10), p.3500-3513
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Glucokinase intrinsically regulates glucose sensing and glucagon secretion in pancreatic alpha cells
Author / Creator:Moede, Tilo ; Leibiger, Barbara ; Vaca Sanchez, Pilar ; Daré, Elisabetta ; Köhler, Martin ; Muhandiramlage, Thusitha P. ; Leibiger, Ingo B. ; Berggren, Per-Olof
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2020-11, Vol.10 (1), p.20145-20145, Article 20145
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Conversion of Mature Human β-Cells Into Glucagon-Producing α-Cells
Author / Creator:SIEBE SPIJKER, H ; RAVELLI, Raimond B. G ; MUMMERY, Christine L ; CARLOTTI, Françoise ; DE KONING, Eelco J. P ; MIEKE MOMMAAS-KIENHUIS, A ; VAN APELDOORN, Aart A ; ENGELSE, Marten A ; ZALDUMBIDE, Arnaud ; BONNER-WEIR, Susan ; RABELINK, Ton J ; HOEBEN, Rob C ; CLEVERS, Hans
Publisher:Alexandria, VA: American Diabetes Association
Journal title:Diabetes (New York, N.Y.), 2013-07, Vol.62 (7), p.2471-2480
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Human Glucagon Expression Is under the Control of miR-320a
Author / Creator:Jo, SeongHo ; Xu, Guanlan ; Jing, Gu ; Chen, Junqin ; Shalev, Anath
Publisher:US: Oxford University Press
Journal title:Endocrinology (Philadelphia), 2021-03, Vol.162 (3), p.1
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Impaired Insulin Action Is Associated With Increased Glucagon Concentrations in Nondiabetic Humans
Author / Creator:Sharma, Anu ; Varghese, Ron T ; Shah, Meera ; Man, Chiara Dalla ; Cobelli, Claudio ; Rizza, Robert A ; Bailey, Kent R ; Vella, Adrian
Publisher:United States: Copyright Oxford University Press
Journal title:The journal of clinical endocrinology and metabolism, 2018-01, Vol.103 (1), p.314-319
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Dapagliflozin stimulates glucagon secretion at high glucose: experiments and mathematical simulations of human A-cells
Author / Creator:Pedersen, Morten Gram ; Ahlstedt, Ingela ; El Hachmane, Mickaël F. ; Göpel, Sven O.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2016-08, Vol.6 (1), p.31214-31214, Article 31214
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Hyperglycemia in rodent models of type 2 diabetes requires insulin-resistant alpha cells
Author / Creator:Lee, Young ; Berglund, Eric D. ; Yu, Xinxin ; Wang, May-Yun ; Evans, Matthew R. ; Scherer, Philipp E. ; Holland, William L. ; Charron, Maureen J. ; Roth, Michael G. ; Unger, Roger H.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2014-09, Vol.111 (36), p.13217-13222
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Basal hypersecretion of glucagon and insulin from palmitate-exposed human islets depends on FFAR1 but not decreased somatostatin secretion
Author / Creator:Kristinsson, H. ; Sargsyan, E. ; Manell, H. ; Smith, D. M. ; Göpel, S. O. ; Bergsten, P.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2017-07, Vol.7 (1), p.4657-11, Article 4657
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Beneficial impact of Ac3IV, an AVP analogue acting specifically at V1a and V1b receptors, on diabetes islet morphology and transdifferentiation of alpha- and beta-cells
Author / Creator:Mohan, Shruti ; Lafferty, Ryan ; Tanday, Neil ; Flatt, Peter R ; Moffett, R Charlotte ; Irwin, Nigel
Publisher:United States: Public Library of Science
Journal title:PloS one, 2021-12, Vol.16 (12), p.e0261608-e0261608
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Glucose- and Hormone-Induced cAMP Oscillations in α- and β-Cells Within Intact Pancreatic Islets
Author / Creator:GENG TIAN ; SANDLER, Stellan ; GYLFE, Erik ; TENGHOLM, Anders
Publisher:Alexandria, VA: American Diabetes Association
Journal title:Diabetes (New York, N.Y.), 2011-05, Vol.60 (5), p.1535-1543
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Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion

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Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells

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Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets

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Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells

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Glucagon blockade restores functional β-cell mass in type 1 diabetic mice and enhances function of human islets

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Paracrine regulation of somatostatin secretion by insulin and glucagon in mouse pancreatic islets

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Alpha cells secrete acetylcholine as a non-neuronal paracrine signal priming beta cell function in humans

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Single-cell RNA-seq with spike-in cells enables accurate quantification of cell-specific drug effects in pancreatic islets

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Paracrine GABA and insulin regulate pancreatic alpha cell proliferation in a mouse model of type 1 diabetes

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Improved glucose regulation in type 2 diabetic patients with DPP-4 inhibitors: focus on alpha and beta cell function and lipid metabolism

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Resveratrol Prevents β-Cell Dedifferentiation in Nonhuman Primates Given a High-Fat/High-Sugar Diet

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Glucokinase intrinsically regulates glucose sensing and glucagon secretion in pancreatic alpha cells

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Conversion of Mature Human β-Cells Into Glucagon-Producing α-Cells

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Human Glucagon Expression Is under the Control of miR-320a

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Impaired Insulin Action Is Associated With Increased Glucagon Concentrations in Nondiabetic Humans

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Dapagliflozin stimulates glucagon secretion at high glucose: experiments and mathematical simulations of human A-cells

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Hyperglycemia in rodent models of type 2 diabetes requires insulin-resistant alpha cells

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Basal hypersecretion of glucagon and insulin from palmitate-exposed human islets depends on FFAR1 but not decreased somatostatin secretion

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Beneficial impact of Ac3IV, an AVP analogue acting specifically at V1a and V1b receptors, on diabetes islet morphology and transdifferentiation of alpha- and beta-cells

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Glucose- and Hormone-Induced cAMP Oscillations in α- and β-Cells Within Intact Pancreatic Islets

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