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ArticlesPeer ReviewedFull Text
Structure and function of retroviral integrase
Author / Creator:Maertens, Goedele N. ; Engelman, Alan N. ; Cherepanov, Peter
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Microbiology, 2022-01, Vol.20 (1), p.20-34
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Cryo-EM structures and atomic model of the HIV-1 strand transfer complex intasome
Author / Creator:Passos, Dario Oliveira ; Li, Min ; Yang, Renbin ; Rebensburg, Stephanie V. ; Ghirlando, Rodolfo ; Jeon, Youngmin ; Shkriabai, Nikoloz ; Kvaratskhelia, Mamuka ; Craigie, Robert ; Lyumkis, Dmitry
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2017-01, Vol.355 (6320), p.89-92
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ArticlesPeer ReviewedFull Text
Integrase Strand Transfer Inhibitors Are Effective Anti-HIV Drugs
Author / Creator:Smith, Steven J. ; Zhao, Xue Zhi ; Passos, Dario Oliveira ; Lyumkis, Dmitry ; Burke, Terrence R. ; Hughes, Stephen H.
Publisher:Switzerland: MDPI
Journal title:Viruses, 2021-01, Vol.13 (2), p.205
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ArticlesPeer ReviewedFull Text
A supramolecular assembly mediates lentiviral DNA integration
Author / Creator:Ballandras-Colas, Allison ; Maskell, Daniel P. ; Serrao, Erik ; Locke, Julia ; Swuec, Paolo ; Jónsson, Stefán R. ; Kotecha, Abhay ; Cook, Nicola J. ; Pye, Valerie E. ; Taylor, Ian A. ; Andrésdóttir, Valgerdur ; Engelman, Alan N. ; Costa, Alessandro ; Cherepanov, Peter
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2017-01, Vol.355 (6320), p.93-95
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Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication
Author / Creator:Christ, Frauke ; Voet, Arnout ; Marchand, Arnaud ; Nicolet, Stefan ; Desimmie, Belete A ; Marchand, Damien ; Bardiot, Dorothée ; Van der Veken, Nam Joo ; Van Remoortel, Barbara ; Strelkov, Sergei V ; De Maeyer, Marc ; Chaltin, Patrick ; Debyser, Zeger
Publisher:New York: Nature Publishing Group US
Journal title:Nature chemical biology, 2010-06, Vol.6 (6), p.442-448
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ArticlesPeer ReviewedFull Text
The structural biology of HIV-1: mechanistic and therapeutic insights
Author / Creator:Engelman, Alan ; Cherepanov, Peter
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Microbiology, 2012-04, Vol.10 (4), p.279-290
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ArticlesPeer ReviewedFull Text
Cellular TRIM33 restrains HIV-1 infection by targeting viral integrase for proteasomal degradation
Author / Creator:Ali, Hashim ; Mano, Miguel ; Braga, Luca ; Naseem, Asma ; Marini, Bruna ; Vu, Diem My ; Collesi, Chiara ; Meroni, Germana ; Lusic, Marina ; Giacca, Mauro
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2019-02, Vol.10 (1), p.926-926, Article 926
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ArticlesPeer ReviewedFull Text
HIV-1 Maturation: Lessons Learned from Inhibitors
Author / Creator:Kleinpeter, Alex B. ; Freed, Eric O.
Publisher:Switzerland: MDPI AG
Journal title:Viruses, 2020-08, Vol.12 (9), p.940
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ArticlesPeer ReviewedFull Text
Superresolution imaging of HIV in infected cells with FlAsH-PALM
Author / Creator:Lelek, Mickaël ; Di Nunzio, Francesca ; Henriques, Ricardo ; Charneau, Pierre ; Arhel, Nathalie ; Zimmer, Christophe
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2012-05, Vol.109 (22), p.8564-8569
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ArticlesPeer ReviewedFull Text
Complex of HIV-1 Integrase with Cellular Ku Protein: Interaction Interface and Search for Inhibitors
Author / Creator:Ilgova, Ekaterina ; Galkin, Simon ; Khrenova, Maria ; Serebryakova, Marina ; Gottikh, Marina ; Anisenko, Andrey
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2022-03, Vol.23 (6), p.2908
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ArticlesPeer ReviewedFull Text
Analyses of HIV-1 integrase sequences prior to South African national HIV-treatment program and available of integrase inhibitors in Cape Town, South Africa
Author / Creator:Brado, Dominik ; Obasa, Adetayo Emmanuel ; Ikomey, George Mondinde ; Cloete, Ruben ; Singh, Kamalendra ; Engelbrecht, Susan ; Neogi, Ujjwal ; Jacobs, Graeme Brendon
Publisher:England
Journal title:Scientific reports, 2018-03, Vol.8 (1), p.4709-4709
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ArticlesPeer ReviewedFull Text
Role of I182, R187, and K188 Amino Acid Residues in the Catalytic Domain of HIV-1 Integrase in the Processes of Reverse Transcription and Integration
Author / Creator:Kikhai, Tatiana F. ; Agapkina, Yulia Yu ; Prikazchikova, Tatiana A. ; Vdovina, Maria V. ; Shekhtman, Sofia P. ; Fomicheva, Sofia V. ; Korolev, Sergey P. ; Gottikh, Marina B.
Publisher:Moscow: Pleiades Publishing
Journal title:Biochemistry (Moscow), 2024-03, Vol.89 (3), p.462-473
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ArticlesPeer ReviewedFull Text
A Practical Approach to Bicyclic Carbamoyl Pyridones with Application to the Synthesis of HIV-1 Integrase Strand Transfer Inhibitors
Author / Creator:Mahajan, Pankaj S. ; Smith, Steven J. ; Hughes, Stephen H. ; Zhao, Xuezhi ; Burke, Terrence R.
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2023-02, Vol.28 (3), p.1428
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ArticlesPeer ReviewedFull Text
Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage
Author / Creator:Le Rouzic, Erwann ; Bonnard, Damien ; Chasset, Sophie ; Bruneau, Jean-Michel ; Chevreuil, Francis ; Le Strat, Frédéric ; Nguyen, Juliette ; Beauvoir, Roxane ; Amadori, Céline ; Brias, Julie ; Vomscheid, Sophie ; Eiler, Sylvia ; Lévy, Nicolas ; Delelis, Olivier ; Deprez, Eric ; Saïb, Ali ; Zamborlini, Alessia ; Emiliani, Stéphane ; Ruff, Marc ; Ledoussal, Benoit ; Moreau, François ; Benarous, Richard
Publisher:England: BioMed Central Ltd
Journal title:Retrovirology, 2013-11, Vol.10 (1), p.144-144, Article 144
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ArticlesPeer ReviewedFull Text
INI1/SMARCB1 Rpt1 domain mimics TAR RNA in binding to integrase to facilitate HIV-1 replication
Author / Creator:Dixit, Updesh ; Bhutoria, Savita ; Wu, Xuhong ; Qiu, Liming ; Spira, Menachem ; Mathew, Sheeba ; Harris, Richard ; Adams, Lucas J. ; Cahill, Sean ; Pathak, Rajiv ; Rajesh Kumar, P. ; Nguyen, Minh ; Acharya, Seetharama A. ; Brenowitz, Michael ; Almo, Steven C. ; Zou, Xiaoqin ; Steven, Alasdair C. ; Cowburn, David ; Girvin, Mark ; Kalpana, Ganjam V.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-05, Vol.12 (1), p.2743-2743, Article 2743
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ArticlesPeer ReviewedFull Text
HIV-1 Intasomes Assembled with Excess Integrase C-Terminal Domain Protein Facilitate Structural Studies by Cryo-EM and Reveal the Role of the Integrase C-Terminal Tail in HIV-1 Integration
Author / Creator:Li, Min ; Li, Zhen ; Chen, Xuemin ; Cui, Yanxiang ; Engelman, Alan N. ; Craigie, Robert
Publisher:Switzerland: MDPI AG
Journal title:Viruses, 2024-07, Vol.16 (7), p.1166
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ArticlesPeer ReviewedFull Text
Structural Basis for the Recognition between HIV-1 Integrase and Transcriptional Coactivator p75
Author / Creator:Cherepanov, Peter ; Andre L. B. Ambrosio ; Shaila Rahman ; Ellenberger, Tom ; Engelman, Alan ; Stroud, Robert M.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2005-11, Vol.102 (48), p.17308-17313
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HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors
Author / Creator:Koneru, Pratibha C ; Francis, Ashwanth C ; Deng, Nanjie ; Rebensburg, Stephanie V ; Hoyte, Ashley C ; Lindenberger, Jared ; Adu-Ampratwum, Daniel ; Larue, Ross C ; Wempe, Michael F ; Engelman, Alan N ; Lyumkis, Dmitry ; Fuchs, James R ; Levy, Ronald M ; Melikyan, Gregory B ; Kvaratskhelia, Mamuka
Publisher:England: eLife Science Publications, Ltd
Journal title:eLife, 2019-05, Vol.8
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ArticlesPeer ReviewedFull Text
The C-Terminal Domain of RNase H and the C-Terminus Amino Acid Residue Regulate Virus Release and Autoprocessing of a Defective HIV-1 Possessing M50I and V151I Changes in Integrase
Author / Creator:Imamichi, Tomozumi ; Chen, Qian ; Hao, Ming ; Chang, Weizhong ; Yang, Jun
Publisher:Switzerland: MDPI AG
Journal title:Viruses, 2022-11, Vol.14 (12), p.2687
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A Novel Co-Crystal Structure Affords the Design of Gain-of-Function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75
Author / Creator:Hare, Stephen ; Shun, Ming-Chieh ; Gupta, Saumya Shree ; Valkov, Eugene ; Engelman, Alan ; Cherepanov, Peter
Publisher:United States: Public Library of Science
Journal title:PLoS pathogens, 2009-01, Vol.5 (1), p.e1000259-e1000259
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Showing 1 to 20 of 128 results

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Structure and function of retroviral integrase

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Cryo-EM structures and atomic model of the HIV-1 strand transfer complex intasome

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Integrase Strand Transfer Inhibitors Are Effective Anti-HIV Drugs

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A supramolecular assembly mediates lentiviral DNA integration

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Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication

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The structural biology of HIV-1: mechanistic and therapeutic insights

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Cellular TRIM33 restrains HIV-1 infection by targeting viral integrase for proteasomal degradation

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HIV-1 Maturation: Lessons Learned from Inhibitors

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Superresolution imaging of HIV in infected cells with FlAsH-PALM

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Complex of HIV-1 Integrase with Cellular Ku Protein: Interaction Interface and Search for Inhibitors

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Analyses of HIV-1 integrase sequences prior to South African national HIV-treatment program and available of integrase inhibitors in Cape Town, South Africa

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Role of I182, R187, and K188 Amino Acid Residues in the Catalytic Domain of HIV-1 Integrase in the Processes of Reverse Transcription and Integration

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A Practical Approach to Bicyclic Carbamoyl Pyridones with Application to the Synthesis of HIV-1 Integrase Strand Transfer Inhibitors

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Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage

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INI1/SMARCB1 Rpt1 domain mimics TAR RNA in binding to integrase to facilitate HIV-1 replication

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HIV-1 Intasomes Assembled with Excess Integrase C-Terminal Domain Protein Facilitate Structural Studies by Cryo-EM and Reveal the Role of the Integrase C-Terminal Tail in HIV-1 Integration

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Structural Basis for the Recognition between HIV-1 Integrase and Transcriptional Coactivator p75

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HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors

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The C-Terminal Domain of RNase H and the C-Terminus Amino Acid Residue Regulate Virus Release and Autoprocessing of a Defective HIV-1 Possessing M50I and V151I Changes in Integrase

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A Novel Co-Crystal Structure Affords the Design of Gain-of-Function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75

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