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199 results for HIV+Integrase+Inhibitors+-+pharmacology

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ArticlesPeer ReviewedFull Text
Integrase Strand Transfer Inhibitors Are Effective Anti-HIV Drugs
Author / Creator:Smith, Steven J. ; Zhao, Xue Zhi ; Passos, Dario Oliveira ; Lyumkis, Dmitry ; Burke, Terrence R. ; Hughes, Stephen H.
Publisher:Switzerland: MDPI
Journal title:Viruses, 2021-01, Vol.13 (2), p.205
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Selective resistance profiles emerging in patient-derived clinical isolates with cabotegravir, bictegravir, dolutegravir, and elvitegravir
Author / Creator:Oliveira, Maureen ; Ibanescu, Ruxandra-Ilinca ; Anstett, Kaitlin ; Mésplède, Thibault ; Routy, Jean-Pierre ; Robbins, Marjorie A. ; Brenner, Bluma G.
Publisher:England: BioMed Central Ltd
Journal title:Retrovirology, 2018-08, Vol.15 (1), p.56-56, Article 56
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Impact of HIV infection and integrase strand transfer inhibitors-based treatment on the gut virome
Author / Creator:Villoslada-Blanco, Pablo ; Pérez-Matute, Patricia ; Íñiguez, María ; Recio-Fernández, Emma ; Jansen, Daan ; De Coninck, Lander ; Close, Lila ; Blanco-Navarrete, Pilar ; Metola, Luis ; Ibarra, Valvanera ; Alba, Jorge ; Matthijnssens, Jelle ; Oteo, José A.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2022-12, Vol.12 (1), p.21658-21658, Article 21658
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Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation
Author / Creator:Jurado, Kellie A. ; Wang, Hao ; Slaughter, Alison ; Feng, Lei ; Kessl, Jacques J. ; Koh, Yasuhiro ; Wang, Weifeng ; Ballandras-Colas, Allison ; Patel, Pratiq A. ; Fuchs, James R. ; Kvaratskhelia, Mamuka ; Engelman, Alan
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2013-05, Vol.110 (21), p.8690-8695
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HIV-1 replication and immune dynamics are affected by raltegravir intensification of HAART-suppressed subjects
Author / Creator:J Buzón, Maria ; Massanella, Marta ; Llibre, Josep M ; Esteve, Anna ; Dahl, Viktor ; Puertas, Maria C ; Gatell, Josep M ; Domingo, Pere ; Paredes, Roger ; Sharkey, Mark ; Palmer, Sarah ; Stevenson, Mario ; Clotet, Bonaventura ; Blanco, Julià ; Martinez-Picado, Javier
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2010-04, Vol.16 (4), p.460-465
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Second-Line Switch to Dolutegravir for Treatment of HIV Infection
Author / Creator:Ombajo, Loice A. ; Penner, Jeremy ; Nkuranga, Joseph ; Mecha, Jared ; Mburu, Margaret ; Odhiambo, Collins ; Ndinya, Florentius ; Aksam, Rukia ; Njenga, Richard ; Wahome, Simon ; Muiruri, Peter ; Eshiwani, Sheila ; Kimani, Maureen ; Ngugi, Catherine ; Pozniak, Anton
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2023-06, Vol.388 (25), p.2349-2359
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Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance
Author / Creator:Hare, Stephen ; Vos, Ann M. ; Clayton, Reginald F. ; Thuring, Jan W. ; Cummings, Maxwell D. ; Cherepanov, Peter ; Coffin, John M.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2010-11, Vol.107 (46), p.20057-20062
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HIV-1 causes CD4 cell death through DNA-dependent protein kinase during viral integration
Author / Creator:Cooper, Arik ; García, Mayra ; Petrovas, Constantinos ; Yamamoto, Takuya ; Koup, Richard A. ; Nabel, Gary J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2013-06, Vol.498 (7454), p.376-379
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ArticlesPeer ReviewedFull Text
Antiproliferative Effects of the Aptamer d(GGGT)4 and Its Analogues with an Abasic-Site Mimic Loop on Different Cancer Cells
Author / Creator:Virgilio, Antonella ; Pecoraro, Annalisa ; Benigno, Daniela ; Russo, Annapina ; Russo, Giulia ; Esposito, Veronica ; Galeone, Aldo
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2022-05, Vol.23 (11), p.5952
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ArticlesPeer ReviewedFull Text
Lack of an association between clinical INSTI-related body weight gain and direct interference with MC4 receptor (MC4R), a key central regulator of body weight
Author / Creator:McMahon, Carrie ; Trevaskis, James L. ; Carter, Christoph ; Holsapple, Kevin ; White, Kirsten ; Das, Moupali ; Collins, Sean ; Martin, Hal ; Burns-Naas, Leigh Ann
Publisher:United States: Public Library of Science
Journal title:PloS one, 2020-02, Vol.15 (2), p.e0229617-e0229617
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ArticlesPeer ReviewedFull Text
Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase
Author / Creator:Gupta, Kushol ; Turkki, Vesa ; Sherrill-Mix, Scott ; Hwang, Young ; Eilers, Grant ; Taylor, Louis ; McDanal, Charlene ; Wang, Ping ; Temelkoff, David ; Nolte, Robert T. ; Velthuisen, Emile ; Jeffrey, Jerry ; Van Duyne, Gregory D. ; Bushman, Frederic D.
Publisher:United States: Public Library of Science
Journal title:PLoS biology, 2016-12, Vol.14 (12), p.e1002584-e1002584
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ArticlesPeer ReviewedFull Text
A highly potent and safe pyrrolopyridine-based allosteric HIV-1 integrase inhibitor targeting host LEDGF/p75-integrase interaction site
Author / Creator:Maehigashi, Tatsuya ; Ahn, Seohyun ; Kim, Uk-Il ; Lindenberger, Jared ; Oo, Adrian ; Koneru, Pratibha C. ; Mahboubi, Bijan ; Engelman, Alan N. ; Kvaratskhelia, Mamuka ; Kim, Kyungjin ; Kim, Baek
Publisher:United States: Public Library of Science
Journal title:PLoS pathogens, 2021-07, Vol.17 (7), p.e1009671
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ArticlesPeer ReviewedFull Text
HIV-1 Maturation: Lessons Learned from Inhibitors
Author / Creator:Kleinpeter, Alex B. ; Freed, Eric O.
Publisher:Switzerland: MDPI AG
Journal title:Viruses, 2020-08, Vol.12 (9), p.940
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ArticlesPeer ReviewedFull Text
A New Class of Multimerization Selective Inhibitors of HIV-1 Integrase
Author / Creator:Sharma, Amit ; Slaughter, Alison ; Jena, Nivedita ; Feng, Lei ; Kessl, Jacques J. ; Fadel, Hind J. ; Malani, Nirav ; Male, Frances ; Wu, Li ; Poeschla, Eric ; Bushman, Frederic D. ; Fuchs, James R. ; Kvaratskhelia, Mamuka
Publisher:United States: Public Library of Science
Journal title:PLoS pathogens, 2014-05, Vol.10 (5), p.e1004171
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ArticlesPeer ReviewedFull Text
Treatment Emergent Dolutegravir Resistance Mutations in Individuals Naïve to HIV-1 Integrase Inhibitors: A Rapid Scoping Review
Author / Creator:Tao, Kaiming ; Rhee, Soo-Yon ; Chu, Carolyn ; Avalos, Ava ; Ahluwalia, Amrit K. ; Gupta, Ravindra K. ; Jordan, Michael R. ; Shafer, Robert W.
Publisher:Switzerland: MDPI AG
Journal title:Viruses, 2023-09, Vol.15 (9), p.1932
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ArticlesPeer ReviewedFull Text
Comparative Clinical Pharmacokinetics and Pharmacodynamics of HIV-1 Integrase Strand Transfer Inhibitors
Author / Creator:Podany, Anthony T. ; Scarsi, Kimberly K. ; Fletcher, Courtney V.
Publisher:Cham: Springer International Publishing
Journal title:Clinical pharmacokinetics, 2017-01, Vol.56 (1), p.25-40
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The Discovery of Indole-2-carboxylic Acid Derivatives as Novel HIV-1 Integrase Strand Transfer Inhibitors
Author / Creator:Wang, Yu-Chan ; Zhang, Wen-Li ; Zhang, Rong-Hong ; Liu, Chun-Hua ; Zhao, Yong-Long ; Yan, Guo-Yi ; Liao, Shang-Gao ; Li, Yong-Jun ; Zhou, Meng
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2023-12, Vol.28 (24), p.8020
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ArticlesPeer ReviewedFull Text
Resistance to HIV Integrase Strand Transfer Inhibitors Among Clinical Specimens in the United States, 2009–2012
Author / Creator:Hurt, Christopher B. ; Sebastian, Joseph ; Hicks, Charles B. ; Eron, Joseph J.
Publisher:Oxford: OXFORD UNIVERSITY PRESS
Journal title:Clinical infectious diseases, 2014-02, Vol.58 (3), p.423-431
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HIV transmission dynamics and population-wide drug resistance in rural South Africa
Author / Creator:Kemp, Steven A. ; Kamelian, Kimia ; Cuadros, Diego F. ; Cheng, Mark T. K. ; Okango, Elphas ; Hanekom, Willem ; Ndung’u, Thumbi ; Pillay, Deenan ; Bonsall, David ; Wong, Emily B. ; Tanser, Frank ; Siedner, Mark J. ; Gupta, Ravindra K.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2024-04, Vol.15 (1), p.3644-3644, Article 3644
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Structure of a HIV-1 IN-Allosteric inhibitor complex at 2.93 Å resolution: Routes to inhibitor optimization
Author / Creator:Eilers, Grant ; Gupta, Kushol ; Allen, Audrey ; Montermoso, Saira ; Murali, Hemma ; Sharp, Robert ; Hwang, Young ; Bushman, Frederic D. ; Van Duyne, Gregory
Publisher:United States: Public Library of Science
Journal title:PLoS pathogens, 2023-03, Vol.19 (3), p.e1011097
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Showing 1 to 20 of 199 results

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Integrase Strand Transfer Inhibitors Are Effective Anti-HIV Drugs

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Selective resistance profiles emerging in patient-derived clinical isolates with cabotegravir, bictegravir, dolutegravir, and elvitegravir

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Impact of HIV infection and integrase strand transfer inhibitors-based treatment on the gut virome

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Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation

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HIV-1 replication and immune dynamics are affected by raltegravir intensification of HAART-suppressed subjects

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Second-Line Switch to Dolutegravir for Treatment of HIV Infection

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Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance

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HIV-1 causes CD4 cell death through DNA-dependent protein kinase during viral integration

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Antiproliferative Effects of the Aptamer d(GGGT)4 and Its Analogues with an Abasic-Site Mimic Loop on Different Cancer Cells

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Lack of an association between clinical INSTI-related body weight gain and direct interference with MC4 receptor (MC4R), a key central regulator of body weight

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Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase

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A highly potent and safe pyrrolopyridine-based allosteric HIV-1 integrase inhibitor targeting host LEDGF/p75-integrase interaction site

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HIV-1 Maturation: Lessons Learned from Inhibitors

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A New Class of Multimerization Selective Inhibitors of HIV-1 Integrase

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Treatment Emergent Dolutegravir Resistance Mutations in Individuals Naïve to HIV-1 Integrase Inhibitors: A Rapid Scoping Review

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Comparative Clinical Pharmacokinetics and Pharmacodynamics of HIV-1 Integrase Strand Transfer Inhibitors

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The Discovery of Indole-2-carboxylic Acid Derivatives as Novel HIV-1 Integrase Strand Transfer Inhibitors

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Resistance to HIV Integrase Strand Transfer Inhibitors Among Clinical Specimens in the United States, 2009–2012

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HIV transmission dynamics and population-wide drug resistance in rural South Africa

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Structure of a HIV-1 IN-Allosteric inhibitor complex at 2.93 Å resolution: Routes to inhibitor optimization

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