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α-Ketoglutarate links p53 to cell fate during tumour suppression
Author / Creator:Morris, John P. ; Yashinskie, Jossie J. ; Koche, Richard ; Chandwani, Rohit ; Tian, Sha ; Chen, Chi-Chao ; Baslan, Timour ; Marinkovic, Zoran S. ; Sánchez-Rivera, Francisco J. ; Leach, Steven D. ; Carmona-Fontaine, Carlos ; Thompson, Craig B. ; Finley, Lydia W. S. ; Lowe, Scott W.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2019-09, Vol.573 (7775), p.595-599
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2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases
Author / Creator:Nakashima, Yu ; Brewitz, Lennart ; Tumber, Anthony ; Salah, Eidarus ; Schofield, Christopher J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-11, Vol.12 (1), p.6478-6478, Article 6478
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Efficient Oxidative Desulfurization of High-Sulfur Diesel via Peroxide Oxidation Using Citric, Pimelic, and α-Ketoglutaric Acids
Author / Creator:Ahmed, Barham Sharif ; Hamasalih, Luqman Omar ; Aziz, Kosar Hikmat Hama ; Salih, Yousif M. ; Mustafa, Fryad S. ; Omer, Khalid Mohammad
Publisher:Basel: MDPI AG
Journal title:Separations, 2023-03, Vol.10 (3), p.206
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Pathways to defense metabolites and evading fruit bitterness in genus Solanum evolved through 2-oxoglutarate-dependent dioxygenases
Author / Creator:Cárdenas, Pablo D. ; Sonawane, Prashant D. ; Heinig, Uwe ; Jozwiak, Adam ; Panda, Sayantan ; Abebie, Bekele ; Kazachkova, Yana ; Pliner, Margarita ; Unger, Tamar ; Wolf, Dalia ; Ofner, Itai ; Vilaprinyo, Ester ; Meir, Sagit ; Davydov, Olga ; Gal-on, Amit ; Burdman, Saul ; Giri, Ashok ; Zamir, Dani ; Scherf, Tali ; Szymanski, Jedrzej ; Rogachev, Ilana ; Aharoni, Asaph
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2019-11, Vol.10 (1), p.5169-13, Article 5169
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Dietary alpha‐ketoglutarate promotes beige adipogenesis and prevents obesity in middle‐aged mice
Author / Creator:Tian, Qiyu ; Zhao, Junxing ; Yang, Qiyuan ; Wang, Bo ; Deavila, Jeanene M. ; Zhu, Mei-Jun ; Du, Min
Publisher:England: John Wiley & Sons, Inc
Journal title:Aging cell, 2020-01, Vol.19 (1), p.e13059-n/a
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α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming
Author / Creator:Liu, Pu-Ste ; Wang, Haiping ; Li, Xiaoyun ; Chao, Tung ; Teav, Tony ; Christen, Stefan ; Di Conza, Giusy ; Cheng, Wan-Chen ; Chou, Chih-Hung ; Vavakova, Magdalena ; Muret, Charlotte ; Debackere, Koen ; Mazzone, Massimiliano ; Huang, Hsien-Da ; Fendt, Sarah-Maria ; Ivanisevic, Julijana ; Ho, Ping-Chih
Publisher:New York: Nature Publishing Group US
Journal title:Nature immunology, 2017-09, Vol.18 (9), p.985-994
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Novofumigatonin biosynthesis involves a non-heme iron-dependent endoperoxide isomerase for orthoester formation
Author / Creator:Matsuda, Yudai ; Bai, Tongxuan ; Phippen, Christopher B. W. ; Nødvig, Christina S. ; Kjærbølling, Inge ; Vesth, Tammi C. ; Andersen, Mikael R. ; Mortensen, Uffe H. ; Gotfredsen, Charlotte H. ; Abe, Ikuro ; Larsen, Thomas O.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2018-07, Vol.9 (1), p.2587-10, Article 2587
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The metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8
Author / Creator:Zhang, Jia-yuan ; Zhou, Bo ; Sun, Ru-yue ; Ai, Yuan-li ; Cheng, Kang ; Li, Fu-nan ; Wang, Bao-rui ; Liu, Fan-jian ; Jiang, Zhi-hong ; Wang, Wei-jia ; Zhou, Dawang ; Chen, Hang-zi ; Wu, Qiao
Publisher:Singapore: Springer Singapore
Journal title:Cell research, 2021-09, Vol.31 (9), p.980-997
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Inhibition of fatty acid oxidation enables heart regeneration in adult mice
Author / Creator:Li, Xiang ; Wu, Fan ; Günther, Stefan ; Looso, Mario ; Kuenne, Carsten ; Zhang, Ting ; Wiesnet, Marion ; Klatt, Stephan ; Zukunft, Sven ; Fleming, Ingrid ; Poschet, Gernot ; Wietelmann, Astrid ; Atzberger, Ann ; Potente, Michael ; Yuan, Xuejun ; Braun, Thomas
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2023-10, Vol.622 (7983), p.619-626
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Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells
Author / Creator:Carey, Bryce W. ; Finley, Lydia W. S. ; Cross, Justin R. ; Allis, C. David ; Thompson, Craig B.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2015-02, Vol.518 (7539), p.413-416
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2-Oxoglutarate-dependent dioxygenases in cancer
Author / Creator:Losman, Julie-Aurore ; Koivunen, Peppi ; Kaelin, William G.
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Cancer, 2020-12, Vol.20 (12), p.710-726
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Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia
Author / Creator:Pollyea, Daniel A. ; Stevens, Brett M. ; Jones, Courtney L. ; Winters, Amanda ; Pei, Shanshan ; Minhajuddin, Mohammad ; D’Alessandro, Angelo ; Culp-Hill, Rachel ; Riemondy, Kent A. ; Gillen, Austin E. ; Hesselberth, Jay R. ; Abbott, Diana ; Schatz, Derek ; Gutman, Jonathan A. ; Purev, Enkhtsetseg ; Smith, Clayton ; Jordan, Craig T.
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2018-12, Vol.24 (12), p.1859-1866
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Glucose becomes one of the worst carbon sources for E.coli on poor nitrogen sources due to suboptimal levels of cAMP
Author / Creator:Bren, Anat ; Park, Junyoung O. ; Towbin, Benjamin D. ; Dekel, Erez ; Rabinowitz, Joshua D. ; Alon, Uri
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2016-04, Vol.6 (1), p.24834-24834, Article 24834
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L-2-Hydroxyglutarate production arises from noncanonical enzyme function at acidic pH
Author / Creator:Intlekofer, Andrew M ; Wang, Bo ; Liu, Hui ; Shah, Hardik ; Carmona-Fontaine, Carlos ; Rustenburg, Ariën S ; Salah, Salah ; Gunner, M R ; Chodera, John D ; Cross, Justin R ; Thompson, Craig B
Publisher:New York: Nature Publishing Group US
Journal title:Nature chemical biology, 2017-05, Vol.13 (5), p.494-500
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Breast cancer cells rely on environmental pyruvate to shape the metastatic niche
Author / Creator:Elia, Ilaria ; Rossi, Matteo ; Stegen, Steve ; Broekaert, Dorien ; Doglioni, Ginevra ; van Gorsel, Marit ; Boon, Ruben ; Escalona-Noguero, Carmen ; Torrekens, Sophie ; Verfaillie, Catherine ; Verbeken, Erik ; Carmeliet, Geert ; Fendt, Sarah-Maria
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2019-04, Vol.568 (7750), p.117-121
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Functional synergy of a human-specific and an ape-specific metabolic regulator in human neocortex development
Author / Creator:Xing, Lei ; Gkini, Vasiliki ; Nieminen, Anni I. ; Zhou, Hui-Chao ; Aquilino, Matilde ; Naumann, Ronald ; Reppe, Katrin ; Tanaka, Kohichi ; Carmeliet, Peter ; Heikinheimo, Oskari ; Pääbo, Svante ; Huttner, Wieland B. ; Namba, Takashi
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2024-04, Vol.15 (1), p.3468-3468, Article 3468
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Glutaminolysis‐related genes determine sensitivity to xCT‐targeted therapy in head and neck squamous cell carcinoma
Author / Creator:Okazaki, Shogo ; Umene, Kiyoko ; Yamasaki, Juntaro ; Suina, Kentaro ; Otsuki, Yuji ; Yoshikawa, Momoko ; Minami, Yushi ; Masuko, Takashi ; Kawaguchi, Sho ; Nakayama, Hideki ; Banno, Kouji ; Aoki, Daisuke ; Saya, Hideyuki ; Nagano, Osamu
Publisher:England: John Wiley & Sons, Inc
Journal title:Cancer science, 2019-11, Vol.110 (11), p.3453-3463
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Structural and stereoelectronic insights into oxygenase-catalyzed formation of ethylene from 2-oxoglutarate
Author / Creator:Zhang, Zhihong ; Smart, Tristan J. ; Choi, Hwanho ; Hardy, Florence ; Lohans, Christopher T. ; Abboud, Martine I. ; Richardson, Melodie S. W. ; Paton, Robert S. ; McDonough, Michael A. ; Schofield, Christopher J.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2017-05, Vol.114 (18), p.4667-4672
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A Study on the Efficient Preparation of α-Ketoglutarate with L-Glutamate Oxidase
Author / Creator:Niu, Shuhui ; Liu, Fang ; Wang, Yaping ; Rao, Ben ; Wang, Yueying
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2024-04, Vol.29 (8), p.1861
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Collagen prolyl 4-hydroxylase 1 is essential for HIF-1α stabilization and TNBC chemoresistance
Author / Creator:Xiong, Gaofeng ; Stewart, Rachel L. ; Chen, Jie ; Gao, Tianyan ; Scott, Timothy L. ; Samayoa, Luis M. ; O’Connor, Kathleen ; Lane, Andrew N. ; Xu, Ren
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2018-10, Vol.9 (1), p.4456-16, Article 4456
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Showing 1 to 20 of 2,086 results

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α-Ketoglutarate links p53 to cell fate during tumour suppression

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2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases

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Efficient Oxidative Desulfurization of High-Sulfur Diesel via Peroxide Oxidation Using Citric, Pimelic, and α-Ketoglutaric Acids

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Pathways to defense metabolites and evading fruit bitterness in genus Solanum evolved through 2-oxoglutarate-dependent dioxygenases

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Dietary alpha‐ketoglutarate promotes beige adipogenesis and prevents obesity in middle‐aged mice

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α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming

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Novofumigatonin biosynthesis involves a non-heme iron-dependent endoperoxide isomerase for orthoester formation

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The metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8

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Inhibition of fatty acid oxidation enables heart regeneration in adult mice

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Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells

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2-Oxoglutarate-dependent dioxygenases in cancer

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Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia

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Glucose becomes one of the worst carbon sources for E.coli on poor nitrogen sources due to suboptimal levels of cAMP

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L-2-Hydroxyglutarate production arises from noncanonical enzyme function at acidic pH

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Breast cancer cells rely on environmental pyruvate to shape the metastatic niche

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Functional synergy of a human-specific and an ape-specific metabolic regulator in human neocortex development

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Glutaminolysis‐related genes determine sensitivity to xCT‐targeted therapy in head and neck squamous cell carcinoma

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Structural and stereoelectronic insights into oxygenase-catalyzed formation of ethylene from 2-oxoglutarate

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A Study on the Efficient Preparation of α-Ketoglutarate with L-Glutamate Oxidase

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Collagen prolyl 4-hydroxylase 1 is essential for HIF-1α stabilization and TNBC chemoresistance

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