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ArticlesPeer ReviewedFull Text
The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6
Author / Creator:Küffer, Alexander ; Lakkaraju, Asvin K. K. ; Mogha, Amit ; Petersen, Sarah C. ; Airich, Kristina ; Doucerain, Cédric ; Marpakwar, Rajlakshmi ; Bakirci, Pamela ; Senatore, Assunta ; Monnard, Arnaud ; Schiavi, Carmen ; Nuvolone, Mario ; Grosshans, Bianka ; Hornemann, Simone ; Bassilana, Frederic ; Monk, Kelly R. ; Aguzzi, Adriano
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2016-08, Vol.536 (7617), p.464-468
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ArticlesPeer ReviewedFull Text
Glial activation in prion diseases is selectively triggered by neuronal PrPSc
Author / Creator:Lakkaraju, Asvin K. K. ; Sorce, Silvia ; Senatore, Assunta ; Nuvolone, Mario ; Guo, Jingjing ; Schwarz, Petra ; Moos, Rita ; Pelczar, Pawel ; Aguzzi, Adriano
Publisher:Indianapolis: John Wiley & Sons, Inc
Journal title:Brain pathology (Zurich, Switzerland), 2022-09, Vol.32 (5), p.e13056-n/a
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ArticlesPeer ReviewedFull Text
Inhibition of group-I metabotropic glutamate receptors protects against prion toxicity
Author / Creator:Goniotaki, Despoina ; Lakkaraju, Asvin K. K. ; Shrivastava, Amulya N. ; Bakirci, Pamela ; Sorce, Silvia ; Senatore, Assunta ; Marpakwar, Rajlakshmi ; Hornemann, Simone ; Gasparini, Fabrizio ; Triller, Antoine ; Aguzzi, Adriano
Publisher:United States: Public Library of Science
Journal title:PLoS pathogens, 2017-11, Vol.13 (11), p.e1006733
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ArticlesPeer ReviewedFull Text
Soluble dimeric prion protein ligand activates Adgrg6 receptor but does not rescue early signs of demyelination in PrP-deficient mice
Author / Creator:Henzi, Anna ; Senatore, Assunta ; Lakkaraju, Asvin K. K. ; Scheckel, Claudia ; Mühle, Jonas ; Reimann, Regina ; Sorce, Silvia ; Schertler, Gebhard ; Toyka, Klaus V. ; Aguzzi, Adriano
Publisher:United States: Public Library of Science
Journal title:PloS one, 2020-11, Vol.15 (11), p.e0242137-e0242137
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ArticlesPeer ReviewedFull Text
Loss of PIKfyve drives the spongiform degeneration in prion diseases
Author / Creator:Lakkaraju, Asvin K K ; Frontzek, Karl ; Lemes, Emina ; Herrmann, Uli ; Losa, Marco ; Marpakwar, Rajlakshmi ; Aguzzi, Adriano
Publisher:London: Nature Publishing Group UK
Journal title:EMBO molecular medicine, 2021-09, Vol.13 (9), p.1-n/a
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ArticlesPeer ReviewedFull Text
Neurodegeneration and Unfolded-Protein Response in Mice Expressing a Membrane-Tethered Flexible Tail of PrP
Author / Creator:Dametto, Paolo ; Lakkaraju, Asvin K. K. ; Bridel, Claire ; Villiger, Lukas ; O’Connor, Tracy ; Herrmann, Uli S. ; Pelczar, Pawel ; Rülicke, Thomas ; McHugh, Donal ; Adili, Arlind ; Aguzzi, Adriano
Publisher:United States: Public Library of Science
Journal title:PloS one, 2015-02, Vol.10 (2), p.e0117412
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ArticlesPeer ReviewedFull Text
Glial activation in prion diseases is selectively triggered by neuronal PrP Sc
Author / Creator:Lakkaraju, Asvin K. K. ; Sorce, Silvia ; Senatore, Assunta ; Nuvolone, Mario ; Guo, Jingjing ; Schwarz, Petra ; Moos, Rita ; Pelczar, Pawel ; Aguzzi, Adriano
Publisher:Switzerland
Journal title:Brain pathology (Zurich, Switzerland), 2022-09, Vol.32 (5), p.e13056
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ArticlesPeer ReviewedFull Text
Palmitoylated calnexin is a key component of the ribosome-translocon complex
Author / Creator:Lakkaraju, Asvin KK ; Abrami, Laurence ; Lemmin, Thomas ; Blaskovic, Sanja ; Kunz, Béatrice ; Kihara, Akio ; Dal Peraro, Matteo ; van der Goot, Françoise Gisou
Publisher:Chichester, UK: John Wiley & Sons, Ltd
Journal title:The EMBO journal, 2012-04, Vol.31 (7), p.1823-1835
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ArticlesPeer ReviewedFull Text
The prion protein is an agonistic ligand of the G protein-coupled receptor Gpr126/Adgrg6
Author / Creator:Küffer, Alexander ; Lakkaraju, Asvin KK ; Mogha, Amit ; Petersen, Sarah C. ; Airich, Kristina ; Doucerain, Cédric ; Marpakwar, Rajlakshmi ; Bakirci, Pamela ; Senatore, Assunta ; Monnard, Arnaud ; Schiavi, Carmen ; Nuvolone, Mario ; Grosshans, Bianka ; Hornemann, Simone ; Bassilana, Frederic ; Monk, Kelly R. ; Aguzzi, Adriano
Journal title:Nature (London), 2016-08, Vol.536 (7617), p.464-468
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ArticlesPeer ReviewedFull Text
Palmitoylated calnexin is a key component of the ribosome-translocon complex: Palmitoylated calnexin is a key component of the RTC
Author / Creator:Lakkaraju, Asvin KK ; Abrami, Laurence ; Lemmin, Thomas ; Blaskovic, Sanja ; Kunz, Béatrice ; Kihara, Akio ; Dal Peraro, Matteo ; van der Goot, Françoise Gisou
Journal title:The EMBO journal, 2012-04, Vol.31 (7), p.1823-1835
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ArticlesFull Text
Dimeric prion protein ligand activates Adgrg6 but does not rescue myelinopathy of PrP-deficient mice
Author / Creator:Henzi, Anna ; Senatore, Assunta ; Lakkaraju, Asvin ; Scheckel, Claudia ; Mühle, Jonas ; Reimann, Regina ; Sorce, Silvia ; Gebhard Fx Schertler ; Toyka, Klaus V ; Aguzzi, Adriano
Publisher:Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title:bioRxiv, 2020-07
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The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6

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Glial activation in prion diseases is selectively triggered by neuronal PrPSc

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Inhibition of group-I metabotropic glutamate receptors protects against prion toxicity

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Soluble dimeric prion protein ligand activates Adgrg6 receptor but does not rescue early signs of demyelination in PrP-deficient mice

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Loss of PIKfyve drives the spongiform degeneration in prion diseases

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Neurodegeneration and Unfolded-Protein Response in Mice Expressing a Membrane-Tethered Flexible Tail of PrP

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Glial activation in prion diseases is selectively triggered by neuronal PrP Sc

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Palmitoylated calnexin is a key component of the ribosome-translocon complex

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The prion protein is an agonistic ligand of the G protein-coupled receptor Gpr126/Adgrg6

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Palmitoylated calnexin is a key component of the ribosome-translocon complex: Palmitoylated calnexin is a key component of the RTC

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Dimeric prion protein ligand activates Adgrg6 but does not rescue myelinopathy of PrP-deficient mice

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