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ArticlesPeer ReviewedFull Text
mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H⁺-ATPase
Author / Creator:Zoncu, Roberto ; Bar-Peled, Liron ; Efeyan, Alejo ; Wang, Shuyu ; Sancak, Yasemin ; Sabatini, David M.
Publisher:Washington, DC: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2011-11, Vol.334 (6056), p.678-683
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mTORC1 and mTORC2 selectively regulate CD8⁺ T cell differentiation
Author / Creator:Pollizzi, Kristen N ; Patel, Chirag H ; Sun, Im-Hong ; Oh, Min-Hee ; Waickman, Adam T ; Wen, Jiayu ; Delgoffe, Greg M ; Powell, Jonathan D
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2015-05, Vol.125 (5), p.2090-2108
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A substrate-specific mTORC1 pathway underlies Birt–Hogg–Dubé syndrome
Author / Creator:Napolitano, Gennaro ; Di Malta, Chiara ; Esposito, Alessandra ; de Araujo, Mariana E. G. ; Pece, Salvatore ; Bertalot, Giovanni ; Matarese, Maria ; Benedetti, Valerio ; Zampelli, Angela ; Stasyk, Taras ; Siciliano, Diletta ; Venuta, Alessandro ; Cesana, Marcella ; Vilardo, Claudia ; Nusco, Edoardo ; Monfregola, Jlenia ; Calcagnì, Alessia ; Di Fiore, Pier Paolo ; Huber, Lukas A. ; Ballabio, Andrea
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2020-09, Vol.585 (7826), p.597-602
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Lysosomal cholesterol activates mTORC1 via an SLC38A9–Niemann-Pick C1 signaling complex
Author / Creator:Castellano, Brian M. ; Thelen, Ashley M. ; Moldavski, Ofer ; Feltes, McKenna ; van der Welle, Reini E. N. ; Mydock-McGrane, Laurel ; Jiang, Xuntian ; van Eijkeren, Robert J ; Davis, Oliver B. ; Louie, Sharon M. ; Perera, Rushika M. ; Covey, Douglas F. ; Nomura, Daniel K. ; Ory, Daniel S. ; Zoncu, Roberto
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2017-03, Vol.355 (6331), p.1306-1311
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SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway
Author / Creator:Gu, Xin ; Orozco, Jose M. ; Saxton, Robert A. ; Condon, Kendall J. ; Liu, Grace Y. ; Krawczyk, Patrycja A. ; Scaria, Sonia M. ; Harper, J. Wade ; Gygi, Steven P. ; Sabatini, David M.
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2017-11, Vol.358 (6364), p.813-818
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ER–lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signalling in Niemann–Pick type C
Author / Creator:Lim, Chun-Yan ; Davis, Oliver B. ; Shin, Hijai R. ; Zhang, Justin ; Berdan, Charles A. ; Jiang, Xuntian ; Counihan, Jessica L. ; Ory, Daniel S. ; Nomura, Daniel K. ; Zoncu, Roberto
Publisher:London: Nature Publishing Group UK
Journal title:Nature cell biology, 2019-10, Vol.21 (10), p.1206-1218
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Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibition
Author / Creator:Chung, Clive Yik-Sham ; Shin, Hijai R. ; Berdan, Charles A. ; Ford, Breanna ; Ward, Carl C. ; Olzmann, James A. ; Zoncu, Roberto ; Nomura, Daniel K.
Publisher:New York: Nature Publishing Group US
Journal title:Nature chemical biology, 2019-08, Vol.15 (8), p.776-785
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Asymmetric inheritance of mTORC1 kinase activity during division dictates CD8+ T cell differentiation
Author / Creator:Pollizzi, Kristen N ; Sun, Im-Hong ; Patel, Chirag H ; Lo, Ying-Chun ; Oh, Min-Hee ; Waickman, Adam T ; Tam, Ada J ; Blosser, Richard L ; Wen, Jiayu ; Delgoffe, Greg M ; Powell, Jonathan D
Publisher:New York: Nature Publishing Group US
Journal title:Nature immunology, 2016-06, Vol.17 (6), p.704-711
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SZT2 dictates GATOR control of mTORC1 signalling
Author / Creator:Peng, Min ; Yin, Na ; Li, Ming O.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2017-03, Vol.543 (7645), p.433-437
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Regulation of TFEB and V-ATPases by mTORC1
Author / Creator:Peña-Llopis, Samuel ; Vega-Rubin-de-Celis, Silvia ; Schwartz, Jacob C ; Wolff, Nicholas C ; Tran, Tram Anh T ; Zou, Lihua ; Xie, Xian-Jin ; Corey, David R ; Brugarolas, James
Publisher:Chichester, UK: John Wiley & Sons, Ltd
Journal title:The EMBO journal, 2011-08, Vol.30 (16), p.3242-3258
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LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control
Author / Creator:Gan, Wenjian ; Dai, Xiaoming ; Dai, Xiangpeng ; Xie, Jun ; Yin, Shasha ; Zhu, Junjie ; Wang, Chen ; Liu, Yuchen ; Guo, Jianping ; Wang, Min ; Liu, Jing ; Hu, Jia ; Quinton, Ryan J. ; Ganem, Neil J. ; Liu, Pengda ; Asara, John M. ; Pandolfi, Pier Paolo ; Yang, Yingzi ; He, Zhigang ; Gao, Guangping ; Wei, Wenyi
Publisher:London: Nature Publishing Group UK
Journal title:Nature cell biology, 2020-02, Vol.22 (2), p.246-256
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Feeding induces cholesterol biosynthesis via the mTORC1–USP20–HMGCR axis
Author / Creator:Lu, Xiao-Yi ; Shi, Xiong-Jie ; Hu, Ao ; Wang, Ju-Qiong ; Ding, Yi ; Jiang, Wei ; Sun, Ming ; Zhao, Xiaolu ; Luo, Jie ; Qi, Wei ; Song, Bao-Liang
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2020-12, Vol.588 (7838), p.479-484
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Sestrin2 is a leucine sensor for the mTORC1 pathway
Author / Creator:Wolfson, Rachel L. ; Chantranupong, Lynne ; Saxton, Robert A. ; Shen, Kuang ; Scaria, Sonia M. ; Cantor, Jason R. ; Sabatini, David M.
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2016-01, Vol.351 (6268), p.43-48
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Structure of the lysosomal mTORC1–TFEB–Rag–Ragulator megacomplex
Author / Creator:Cui, Zhicheng ; Napolitano, Gennaro ; de Araujo, Mariana E. G. ; Esposito, Alessandra ; Monfregola, Jlenia ; Huber, Lukas A. ; Ballabio, Andrea ; Hurley, James H.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2023-02, Vol.614 (7948), p.572-579
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Multiple amino acid sensing inputs to mTORC1
Author / Creator:Shimobayashi, Mitsugu ; Hall, Michael N
Publisher:London: Nature Publishing Group UK
Journal title:Cell research, 2016-01, Vol.26 (1), p.7-20
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Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40
Author / Creator:Yang, Haijuan ; Jiang, Xiaolu ; Li, Buren ; Yang, Hyo J. ; Miller, Meredith ; Yang, Angela ; Dhar, Ankita ; Pavletich, Nikola P.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2017-12, Vol.552 (7685), p.368-373
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SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1
Author / Creator:Rebsamen, Manuele ; Pochini, Lorena ; Stasyk, Taras ; de Araújo, Mariana E. G. ; Galluccio, Michele ; Kandasamy, Richard K. ; Snijder, Berend ; Fauster, Astrid ; Rudashevskaya, Elena L. ; Bruckner, Manuela ; Scorzoni, Stefania ; Filipek, Przemyslaw A. ; Huber, Kilian V. M. ; Bigenzahn, Johannes W. ; Heinz, Leonhard X. ; Kraft, Claudine ; Bennett, Keiryn L. ; Indiveri, Cesare ; Huber, Lukas A. ; Superti-Furga, Giulio
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2015-03, Vol.519 (7544), p.477-481
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475 mTORC1
Author / Creator:Guesthier, M ; Huang, J ; Zhao, X ; Burgos, S
Publisher:US: Oxford University Press
Journal title:Journal of animal science, 2018-12, Vol.96 (suppl_3), p.261-262
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SAR1B senses leucine levels to regulate mTORC1 signalling
Author / Creator:Chen, Jie ; Ou, Yuhui ; Luo, Rong ; Wang, Jie ; Wang, Dong ; Guan, Jialiang ; Li, Yi ; Xia, Peixue ; Chen, Peng R. ; Liu, Ying
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2021-08, Vol.596 (7871), p.281-284
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mTORC1 and mTORC2 in cancer and the tumor microenvironment
Author / Creator:Kim, L C ; Cook, R S ; Chen, J
Publisher:London: Nature Publishing Group UK
Journal title:Oncogene, 2017-04, Vol.36 (16), p.2191-2201
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mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H⁺-ATPase

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mTORC1 and mTORC2 selectively regulate CD8⁺ T cell differentiation

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A substrate-specific mTORC1 pathway underlies Birt–Hogg–Dubé syndrome

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Lysosomal cholesterol activates mTORC1 via an SLC38A9–Niemann-Pick C1 signaling complex

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SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway

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ER–lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signalling in Niemann–Pick type C

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Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibition

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Asymmetric inheritance of mTORC1 kinase activity during division dictates CD8+ T cell differentiation

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SZT2 dictates GATOR control of mTORC1 signalling

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Regulation of TFEB and V-ATPases by mTORC1

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LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control

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Feeding induces cholesterol biosynthesis via the mTORC1–USP20–HMGCR axis

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Sestrin2 is a leucine sensor for the mTORC1 pathway

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Structure of the lysosomal mTORC1–TFEB–Rag–Ragulator megacomplex

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Multiple amino acid sensing inputs to mTORC1

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Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40

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SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1

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475 mTORC1

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SAR1B senses leucine levels to regulate mTORC1 signalling

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mTORC1 and mTORC2 in cancer and the tumor microenvironment

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