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166 results for Neoplasm+Proteins+-+deficiency

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ArticlesPeer ReviewedFull Text
Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion
Author / Creator:He, Wan-ting ; Wan, Haoqiang ; Hu, Lichen ; Chen, Pengda ; Wang, Xin ; Huang, Zhe ; Yang, Zhang-Hua ; Zhong, Chuan-Qi ; Han, Jiahuai
Publisher:London: Nature Publishing Group UK
Journal title:Cell research, 2015-12, Vol.25 (12), p.1285-1298
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Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism
Author / Creator:Pan, Youdong ; Tian, Tian ; Park, Chang Ook ; Lofftus, Serena Y. ; Mei, Shenglin ; Liu, Xing ; Luo, Chi ; O’Malley, John T. ; Gehad, Ahmed ; Teague, Jessica E. ; Divito, Sherrie J. ; Fuhlbrigge, Robert ; Puigserver, Pere ; Krueger, James G. ; Hotamisligil, Gökhan S. ; Clark, Rachael A. ; Kupper, Thomas S.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2017-03, Vol.543 (7644), p.252-256
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Regulation of endoplasmic reticulum turnover by selective autophagy
Author / Creator:Khaminets, Aliaksandr ; Heinrich, Theresa ; Mari, Muriel ; Grumati, Paolo ; Huebner, Antje K. ; Akutsu, Masato ; Liebmann, Lutz ; Stolz, Alexandra ; Nietzsche, Sandor ; Koch, Nicole ; Mauthe, Mario ; Katona, Istvan ; Qualmann, Britta ; Weis, Joachim ; Reggiori, Fulvio ; Kurth, Ingo ; Hübner, Christian A. ; Dikic, Ivan
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2015-06, Vol.522 (7556), p.354-358
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Metastatic recurrence in colorectal cancer arises from residual EMP1+ cells
Author / Creator:Cañellas-Socias, Adrià ; Cortina, Carme ; Hernando-Momblona, Xavier ; Palomo-Ponce, Sergio ; Mulholland, Eoghan J. ; Turon, Gemma ; Mateo, Lidia ; Conti, Sefora ; Roman, Olga ; Sevillano, Marta ; Slebe, Felipe ; Stork, Diana ; Caballé-Mestres, Adrià ; Berenguer-Llergo, Antonio ; Álvarez-Varela, Adrián ; Fenderico, Nicola ; Novellasdemunt, Laura ; Jiménez-Gracia, Laura ; Sipka, Tamara ; Bardia, Lidia ; Lorden, Patricia ; Colombelli, Julien ; Heyn, Holger ; Trepat, Xavier ; Tejpar, Sabine ; Sancho, Elena ; Tauriello, Daniele V. F. ; Leedham, Simon ; Attolini, Camille Stephan-Otto ; Batlle, Eduard
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2022-11, Vol.611 (7936), p.603-613
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DHX9 suppresses RNA processing defects originating from the Alu invasion of the human genome
Author / Creator:Aktaş, Tuğçe ; Avşar Ilık, İbrahim ; Maticzka, Daniel ; Bhardwaj, Vivek ; Pessoa Rodrigues, Cecilia ; Mittler, Gerhard ; Manke, Thomas ; Backofen, Rolf ; Akhtar, Asifa
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2017-04, Vol.544 (7648), p.115-119
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SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef
Author / Creator:Usami, Yoshiko ; Wu, Yuanfei ; Göttlinger, Heinrich G.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2015-10, Vol.526 (7572), p.218-223
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CD155 loss enhances tumor suppression via combined host and tumor-intrinsic mechanisms
Author / Creator:Li, Xian-Yang ; Das, Indrajit ; Lepletier, Ailin ; Addala, Venkateswar ; Bald, Tobias ; Stannard, Kimberley ; Barkauskas, Deborah ; Liu, Jing ; Aguilera, Amelia Roman ; Takeda, Kazuyoshi ; Braun, Matthias ; Nakamura, Kyohei ; Jacquelin, Sebastien ; Lane, Steven W. ; Teng, Michele W.L. ; Dougall, William C. ; Smyth, Mark J.
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2018-06, Vol.128 (6), p.2613-2625
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Increased autophagy blocks HER2-mediated breast tumorigenesis
Author / Creator:Vega-Rubín-de-Celis, Silvia ; Zou, Zhongju ; Fernández, Álvaro F. ; Ci, Bo ; Kim, Min ; Xiao, Guanghua ; Xie, Yang ; Levine, Beth
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2018-04, Vol.115 (16), p.4176-4181
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ArticlesPeer ReviewedFull Text
Early loss of mitochondrial complex I and rewiring of glutathione metabolism in renal oncocytoma
Author / Creator:Gopal, Raj K. ; Calvo, Sarah E. ; Shih, Angela R. ; Chaves, Frances L. ; McGuone, Declan ; Mick, Eran ; Pierce, Kerry A. ; Li, Yang ; Garofalo, Andrea ; Van Allen, Eliezer M. ; Clish, Clary B. ; Oliva, Esther ; Mootha, Vamsi K.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2018-07, Vol.115 (27), p.E6283-E6290
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ArticlesPeer ReviewedFull Text
Inactivation of the PBRM1 tumor suppressor gene amplifies the HIF-response in VHL−/− clear cell renal carcinoma
Author / Creator:Gao, Wenhua ; Li, Wei ; Xiao, Tengfei ; Liu, Xiaole Shirley ; Kaelin, William G.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2017-01, Vol.114 (5), p.1027-1032
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ArticlesPeer ReviewedFull Text
DND1 maintains germline stem cells via recruitment of the CCR4–NOT complex to target mRNAs
Author / Creator:Yamaji, Masashi ; Jishage, Miki ; Meyer, Cindy ; Suryawanshi, Hemant ; Der, Evan ; Yamaji, Misaki ; Garzia, Aitor ; Morozov, Pavel ; Manickavel, Sudhir ; McFarland, Hannah L. ; Roeder, Robert G. ; Hafner, Markus ; Tuschl, Thomas
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2017-03, Vol.543 (7646), p.568-572
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ArticlesPeer ReviewedFull Text
FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation
Author / Creator:Feng, Yuqing ; Li, Conglei ; Stewart, Jessica A. ; Barbulescu, Philip ; Seija Desivo, Noé ; Álvarez-Quilón, Alejandro ; Pezo, Rossanna C. ; Perera, Madusha L. W. ; Chan, Katherine ; Tong, Amy Hin Yan ; Mohamad-Ramshan, Rukshana ; Berru, Maribel ; Nakib, Diana ; Li, Gavin ; Kardar, Gholam Ali ; Carlyle, James R. ; Moffat, Jason ; Durocher, Daniel ; Di Noia, Javier M. ; Bhagwat, Ashok S. ; Martin, Alberto
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2021-12, Vol.600 (7888), p.324-328
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ArticlesPeer ReviewedFull Text
Complement factor H–deficient mice develop spontaneous hepatic tumors
Author / Creator:Laskowski, Jennifer ; Renner, Brandon ; Pickering, Matthew C. ; Serkova, Natalie J. ; Smith-Jones, Peter M. ; Clambey, Eric T. ; Nemenoff, Raphael A. ; Thurman, Joshua M.
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2020-08, Vol.130 (8), p.4039-4054
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ArticlesPeer ReviewedFull Text
LRPPRC is necessary for polyadenylation and coordination of translation of mitochondrial mRNAs
Author / Creator:Ruzzenente, Benedetta ; Metodiev, Metodi D ; Wredenberg, Anna ; Bratic, Ana ; Park, Chan Bae ; Cámara, Yolanda ; Milenkovic, Dusanka ; Zickermann, Volker ; Wibom, Rolf ; Hultenby, Kjell ; Erdjument-Bromage, Hediye ; Tempst, Paul ; Brandt, Ulrich ; Stewart, James B ; Gustafsson, Claes M ; Larsson, Nils-Göran
Publisher:Chichester, UK: John Wiley & Sons, Ltd
Journal title:The EMBO journal, 2012-01, Vol.31 (2), p.443-456
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ArticlesPeer ReviewedFull Text
Intracrine VEGF signalling mediates colorectal cancer cell migration and invasion
Author / Creator:Bhattacharya, Rajat ; Fan, Fan ; Wang, Rui ; Ye, Xiangcang ; Xia, Ling ; Boulbes, Delphine ; Ellis, Lee M
Publisher:London: Nature Publishing Group UK
Journal title:British journal of cancer, 2017-09, Vol.117 (6), p.848-855
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ArticlesPeer ReviewedFull Text
Gated regulation of CRAC channel ion selectivity by STIM1
Author / Creator:McNally, Beth A. ; Somasundaram, Agila ; Yamashita, Megumi ; Prakriya, Murali
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2012-02, Vol.482 (7384), p.241-245
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Recurrent acute liver failure due to NBAS deficiency: phenotypic spectrum, disease mechanisms, and therapeutic concepts
Author / Creator:Staufner, Christian ; Haack, Tobias B. ; Köpke, Marlies G. ; Straub, Beate K. ; Kölker, Stefan ; Thiel, Christian ; Freisinger, Peter ; Baric, Ivo ; McKiernan, Patrick J. ; Dikow, Nicola ; Harting, Inga ; Beisse, Flemming ; Burgard, Peter ; Kotzaeridou, Urania ; Lenz, Dominic ; Kühr, Joachim ; Himbert, Urban ; Taylor, Robert W. ; Distelmaier, Felix ; Vockley, Jerry ; Ghaloul-Gonzalez, Lina ; Ozolek, John A. ; Zschocke, Johannes ; Kuster, Alice ; Dick, Anke ; Das, Anib M. ; Wieland, Thomas ; Terrile, Caterina ; Strom, Tim M. ; Meitinger, Thomas ; Prokisch, Holger ; Hoffmann, Georg F.
Publisher:Dordrecht: Springer Netherlands
Journal title:Journal of inherited metabolic disease, 2016-01, Vol.39 (1), p.3-16
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ArticlesPeer ReviewedFull Text
RNAi screens in mice identify physiological regulators of oncogenic growth
Author / Creator:Beronja, Slobodan ; Janki, Peter ; Heller, Evan ; Lien, Wen-Hui ; Keyes, Brice E. ; Oshimori, Naoki ; Fuchs, Elaine
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2013-09, Vol.501 (7466), p.185-190
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ArticlesPeer ReviewedFull Text
Immunosurveillance and therapy of multiple myeloma are CD226 dependent
Author / Creator:Guillerey, Camille ; Ferrari de Andrade, Lucas ; Vuckovic, Slavica ; Miles, Kim ; Ngiow, Shin Foong ; Yong, Michelle C.R. ; Teng, Michele W.L. ; Colonna, Marco ; Ritchie, David S. ; Chesi, Martha ; Bergsagel, P. Leif ; Hill, Geoffrey R. ; Smyth, Mark J. ; Martinet, Ludovic
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2015-05, Vol.125 (5), p.2077-2089
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ArticlesPeer ReviewedFull Text
Pten loss promotes MAPK pathway dependency in HER2/neu breast carcinomas
Author / Creator:Ebbesen, Saya H. ; Scaltriti, Maurizio ; Bialucha, Carl U. ; Morse, Natasha ; Kastenhuber, Edward R. ; Wen, Hannah Y. ; Dow, Lukas E. ; Baselga, José ; Lowe, Scott W.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2016-03, Vol.113 (11), p.3030-3035
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Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

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Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism

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Regulation of endoplasmic reticulum turnover by selective autophagy

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Metastatic recurrence in colorectal cancer arises from residual EMP1+ cells

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DHX9 suppresses RNA processing defects originating from the Alu invasion of the human genome

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SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef

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CD155 loss enhances tumor suppression via combined host and tumor-intrinsic mechanisms

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Increased autophagy blocks HER2-mediated breast tumorigenesis

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Early loss of mitochondrial complex I and rewiring of glutathione metabolism in renal oncocytoma

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Inactivation of the PBRM1 tumor suppressor gene amplifies the HIF-response in VHL−/− clear cell renal carcinoma

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DND1 maintains germline stem cells via recruitment of the CCR4–NOT complex to target mRNAs

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FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation

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Complement factor H–deficient mice develop spontaneous hepatic tumors

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LRPPRC is necessary for polyadenylation and coordination of translation of mitochondrial mRNAs

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Intracrine VEGF signalling mediates colorectal cancer cell migration and invasion

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Gated regulation of CRAC channel ion selectivity by STIM1

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Recurrent acute liver failure due to NBAS deficiency: phenotypic spectrum, disease mechanisms, and therapeutic concepts

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RNAi screens in mice identify physiological regulators of oncogenic growth

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Immunosurveillance and therapy of multiple myeloma are CD226 dependent

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Pten loss promotes MAPK pathway dependency in HER2/neu breast carcinomas

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